Affiliation: Pharmacia and Upjohn
- PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the ratR Maj
CNS Preclinical Research, Pharmacia and Upjohn SpA, Nerviano, MI, Italy
Eur J Pharmacol 359:27-32. 1998..Glutamate release inhibition may play a major role in neuroprotection, but an additional mechanism(s) of action might be relevant for the anticonvulsant activity of PNU-151774E in this model...
- Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moietyP Pevarello
Pharmacia and Upjohn, Chem Dept, Nerviano, Milan, Italy
Bioorg Med Chem Lett 9:1783-8. 1999..Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed alpha-amino amide anticonvulsant (3)...
- Safinamide: from molecular targets to a new anti-Parkinson drugC Caccia
Newron Pharmaceuticals SpA, Bresso, MI, Italy
Neurology 67:S18-23. 2006..Therefore, safinamide may be used in PD to reduce l-dopa dosage and also represents a valuable therapeutic drug to test disease-modifying potential...
- Receptor adaptive responsiveness in disease models: 6-OHDA lesioned and spontaneously hypertensive ratsC Caccia
Research and Development, CNS Line, Farmitalia Carlo Erba, Nerviano, Italy
J Recept Res 8:97-105. 1988..S-1 receptors too are up-regulated in SHR. We must notice that though receptor hypersensitivity in the 6-OHDA model is linked to massive decreases in neurotransmitter levels, this mechanism seems not to exist in the SHR model...