Barry S Komm

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. doi request reprint An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis
    Barry S Komm
    Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USA
    Maturitas 71:221-6. 2012
  2. doi request reprint An overview of current and emerging SERMs
    Barry S Komm
    Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USA Electronic address
    J Steroid Biochem Mol Biol 143:207-22. 2014
  3. doi request reprint Development of conjugated estrogens/bazedoxifene, the first tissue selective estrogen complex (TSEC) for management of menopausal hot flashes and postmenopausal bone loss
    Barry S Komm
    Pfizer Inc, Collegeville, PA, United States Electronic address
    Steroids 90:71-81. 2014
  4. pmc Incorporating bazedoxifene/conjugated estrogens into the current paradigm of menopausal therapy
    Barry S Komm
    Pfizer Inc, Collegeville, PA, USA
    Int J Womens Health 4:129-40. 2012
  5. doi request reprint Evolution of the tissue selective estrogen complex (TSEC)
    Barry S Komm
    Pfizer, Inc, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 228:1423-7. 2013
  6. doi request reprint Skeletal effects of bazedoxifene paired with conjugated estrogens in ovariectomized rats
    Barry S Komm
    Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, USA
    Bone 49:376-86. 2011
  7. ncbi request reprint Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity
    Barry S Komm
    Wyeth Research, Women s Health Research Institute, Collegeville, Pennsylvania 19426, USA
    Endocrinology 146:3999-4008. 2005
  8. doi request reprint A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bone 44:1063-8. 2009
  9. doi request reprint Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens
    Ken C N Chang
    Wyeth Research, Transcriptional Targets, Tissue Repair, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 118:117-24. 2010
  10. ncbi request reprint Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
    Ramesh A Bhat
    Women s Health and Musculoskeletal Biology Division, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 102:1519-28. 2007

Detail Information

Publications35

  1. doi request reprint An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis
    Barry S Komm
    Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USA
    Maturitas 71:221-6. 2012
    ..Future directions in selective estrogen receptor modulator research include ospemifene and RAD 1901...
  2. doi request reprint An overview of current and emerging SERMs
    Barry S Komm
    Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USA Electronic address
    J Steroid Biochem Mol Biol 143:207-22. 2014
    ....
  3. doi request reprint Development of conjugated estrogens/bazedoxifene, the first tissue selective estrogen complex (TSEC) for management of menopausal hot flashes and postmenopausal bone loss
    Barry S Komm
    Pfizer Inc, Collegeville, PA, United States Electronic address
    Steroids 90:71-81. 2014
    ..Therefore, CE 0.45 mg/BZA 20 mg is an effective, well-tolerated alternative to EPT for menopausal symptom relief and osteoporosis prevention for postmenopausal women with a uterus...
  4. pmc Incorporating bazedoxifene/conjugated estrogens into the current paradigm of menopausal therapy
    Barry S Komm
    Pfizer Inc, Collegeville, PA, USA
    Int J Womens Health 4:129-40. 2012
    ..BZA/CE may be a promising alternative to hormone therapy for the treatment of menopausal symptoms and prevention of osteoporosis in nonhysterectomized postmenopausal women...
  5. doi request reprint Evolution of the tissue selective estrogen complex (TSEC)
    Barry S Komm
    Pfizer, Inc, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 228:1423-7. 2013
    ..Overall, preclinical studies have shown that estrogens, SERMs, and TSECs each exert distinct and tissue specific molecular and pharmacologic effects...
  6. doi request reprint Skeletal effects of bazedoxifene paired with conjugated estrogens in ovariectomized rats
    Barry S Komm
    Pfizer Inc, 500 Arcola Rd, Collegeville, PA 19426, USA
    Bone 49:376-86. 2011
    ..In conclusion, 12months of treatment with BZA/CE in OVX rats effectively maintained BMD, bone microstructure, and bone quality; and the pairing of BZA with CE prevented CE-induced uterine stimulation...
  7. ncbi request reprint Bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity
    Barry S Komm
    Wyeth Research, Women s Health Research Institute, Collegeville, Pennsylvania 19426, USA
    Endocrinology 146:3999-4008. 2005
    ..Controlled clinical trial data will be needed to confirm these effects...
  8. doi request reprint A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bone 44:1063-8. 2009
    ..0001 microM. This work demonstrates the feasibility of developing small molecules that inhibit sFRP-1 and stimulate canonical Wnt signaling to increase bone formation...
  9. doi request reprint Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens
    Ken C N Chang
    Wyeth Research, Transcriptional Targets, Tissue Repair, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 118:117-24. 2010
    ....
  10. ncbi request reprint Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function
    Ramesh A Bhat
    Women s Health and Musculoskeletal Biology Division, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 102:1519-28. 2007
    ..The structure-function analysis studies of sFRP-1 clearly demonstrate the interaction of several functional domains for its optimal Wnt antagonist function...
  11. doi request reprint Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland
    Bryan J Peano
    Department of Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    Endocrinology 150:1897-903. 2009
    ....
  12. ncbi request reprint Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 210:352-7. 2007
    ..Moreover, as the effects of sFRP-1 deletion on vBMD increase, the ability of PTH to enhance vBMD declines suggesting that there are overlapping mechanisms of action...
  13. ncbi request reprint The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation
    Yan Liu
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 21:376-87. 2007
    ..Finally, using a mouse calvariae ex vivo organ culture model, we demonstrate that these effects of Ror2 result in increased bone formation, suggesting that it may also activate mature osteoblasts...
  14. doi request reprint Activity of three selective estrogen receptor modulators on hormone-dependent responses in the mouse uterus and mammary gland
    Judy S Crabtree
    Endocrinology and Reproductive Disorders Division, Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA
    Mol Cell Endocrinol 287:40-6. 2008
    ....
  15. ncbi request reprint Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc
    Frank Barletta
    Department of Women s Health and Bone Research, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 18:1096-108. 2004
    ..Our findings also demonstrate that MNAR is a scaffold protein that mediates ER-Src interaction and plays an important role in the integration of ER action in Src-mediated signaling...
  16. ncbi request reprint Regulated expression of sFRP-1 protein by the GeneSwitch system
    Ramesh A Bhat
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Protein Expr Purif 37:327-35. 2004
    ..The regulated expression of sFRP-1 utilizing adenovirus vectors provides an opportunity to address the contribution of sFRP-1 in the regulation of stem cell differentiation, maturation, and their function by modulating the Wnt signaling...
  17. ncbi request reprint Molecular determinants of ER alpha and ER beta involved in selectivity of 16 alpha-iodo-7 beta estradiol
    Ramesh A Bhat
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    J Steroid Biochem Mol Biol 88:17-26. 2004
    ..The ER beta mutant Ile373 Met behaved like ER alpha with 16 alpha IE2. The results clearly demonstrate the role of ER alpha Met421 in the ER alpha selectivity of 16 alpha IE2...
  18. ncbi request reprint The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 96:1212-30. 2005
    ..Likewise, over-expression of sFRP-1 in HOBs accelerated the rate of cell death threefold. These results establish sFRP-1 as an important negative regulator of human osteoblast and osteocyte survival...
  19. doi request reprint The pairing of a selective estrogen receptor modulator, bazedoxifene, with conjugated estrogens as a new paradigm for the treatment of menopausal symptoms and osteoporosis prevention
    Yogendra Kharode
    Wyeth Research, Women s Health and Musculoskeletal Biology, Collegeville, Pennsylvania 19426, USA
    Endocrinology 149:6084-91. 2008
    ..These preclinical findings showed that the appropriate dose combination of bazedoxifene/CE exhibits positive vasomotor, lipid, and skeletal responses with minimal uterine stimulation...
  20. doi request reprint Bazedoxifene/conjugated estrogens for managing the burden of estrogen deficiency symptoms
    Sebastian Mirkin
    Pfizer Inc, Collegeville, PA, United States Electronic address
    Maturitas 77:24-31. 2014
    ....
  21. doi request reprint Tissue-selective estrogen complexes for postmenopausal women
    Sebastian Mirkin
    Pfizer Inc, 500 Arcola Road, Collegeville, PA 19426, USA Electronic address
    Maturitas 76:213-20. 2013
    ....
  22. doi request reprint Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination
    Thomas J Berrodin
    Nuclear Receptor Biology, Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 23:74-85. 2009
    ....
  23. ncbi request reprint Wnt signaling and osteoblastogenesis
    Peter V N Bodine
    Women s Heath and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Rev Endocr Metab Disord 7:33-9. 2006
    ....
  24. ncbi request reprint Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone
    John A Robinson
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Biol Chem 281:31720-8. 2006
    ....
  25. ncbi request reprint Evaluation of an estrogen receptor-beta agonist in animal models of human disease
    Heather A Harris
    Women s Health Research Institute, RN 3256, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Endocrinology 144:4241-9. 2003
    ..These data suggest that one function of ERbeta may be to modulate the immune response, and that ERbeta-selective ligands may be therapeutically useful agents to treat chronic intestinal and joint inflammation...
  26. ncbi request reprint The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 18:1222-37. 2004
    ..Our findings demonstrate that deletion of sFRP-1 preferentially activates Wnt signaling in osteoblasts, leading to enhanced trabecular bone formation in adults...
  27. doi request reprint A new approach to menopausal therapy: the tissue selective estrogen complex
    Barry S Komm
    Women s Health and Musculoskeletal Biology Research, Discovery Liaison, Wyeth Research, Collegeville, Pennsylvania 01242, USA
    Reprod Sci 15:984-92. 2008
    ..Here, we introduce the concept of a tissue selective estrogen complex and the rationale for its development as a next generation menopausal therapy...
  28. doi request reprint Bazedoxifene acetate: a novel selective estrogen receptor modulator for the prevention and treatment of postmenopausal osteoporosis
    Arkadi A Chines
    Wyeth Research, Collegeville, Pennsylvania, USA
    Drugs Today (Barc) 45:507-20. 2009
    ..Bazedoxifene represents an important new treatment option for women at risk for osteoporosis and fracture...
  29. pmc Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
    Chi Wai Wong
    Department of Cell Biology, Women s Health Research Institute, Wyeth Pharmaceuticals, 500 Arcolla Road, Collegeville, PA 19426, USA
    Proc Natl Acad Sci U S A 99:14783-8. 2002
    ..These data reveal that MNAR mediates the crosstalk between two important classes of signal transducing molecules and suggest that ER "genomic" and "nongenomic" activities are interrelated...
  30. doi request reprint Recent advances help understand and improve the safety of menopausal therapies
    Sebastian Mirkin
    From the 1Women s Health, Pfizer Inc, Collegeville, PA 2Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA and 3Department of Obstetrics and Gynecology, Columbia University, New York, NY
    Menopause 22:351-60. 2015
    ..This review provides updates on HT and reviews newer menopausal therapies, focusing on recent safety data...
  31. ncbi request reprint Estrogenic effects of 7alpha-methyl-17alpha-ethynylestradiol: a newly discovered tibolone metabolite
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, PA 19426, USA
    Steroids 67:681-6. 2002
    ..This steroid appears to be the most potent estrogenic metabolite of tibolone identified to date, and additional studies are, therefore, warranted regarding the role of this metabolite in the biological actions of the drug...
  32. doi request reprint Effects of conjugated estrogens/bazedoxifene on lipid and coagulation variables: a randomized placebo- and active-controlled trial
    Sven O Skouby
    From the 1Department of Obstetrics and Gynecology, Herlev Hospital, Copenhagen University Hospital, Denmark 2Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark and 3Pfizer Inc, Collegeville, PA
    Menopause 22:640-9. 2015
    ....
  33. doi request reprint The safety and tolerability profile of therapies for the prevention and treatment of osteoporosis in postmenopausal women
    Barry S Komm
    a Pfizer Inc, Collegeville, PA, USA
    Expert Rev Clin Pharmacol 8:769-84. 2015
    ..Here, we review the safety and tolerability of available therapies for postmenopausal osteoporosis. Taking into consideration their relative efficacy, we also provide strategies for optimization of the risk:benefit ratio. ..
  34. doi request reprint Conjugated estrogens for the treatment of menopausal symptoms: a review of safety data
    Sebastian Mirkin
    Pfizer, Inc, 500 Arcola Rd, Room B 4207, Collegeville, PA 19426, USA 1 484 865 4121 1 484 865 8161
    Expert Opin Drug Saf 13:45-56. 2014
    ..The safety profile of CEE has been extensively published over the past 20 years...