Ping Kang

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes
    Ping Kang
    Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 35:1081-8. 2007
  2. doi request reprint Bioactivation of flutamide metabolites by human liver microsomes
    Ping Kang
    Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, CA 92121, USA
    Drug Metab Dispos 36:1425-37. 2008
  3. ncbi request reprint Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 35:1593-602. 2007
  4. ncbi request reprint Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 34:1798-802. 2006
  5. doi request reprint Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs
    Robert L Walsky
    Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer, Inc, Groton, CT, USA
    Drug Metab Dispos 40:1686-97. 2012
  6. doi request reprint Interspecies variation in the metabolism of zoniporide by aldehyde oxidase
    Deepak Dalvie
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla, CA 92121, USA
    Xenobiotica 43:399-408. 2013
  7. doi request reprint Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO)
    Angelica Linton
    Pfizer Worldwide Research and Development, San Diego, CA 92121, USA
    J Med Chem 54:7705-12. 2011
  8. doi request reprint Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide
    Deepak Dalvie
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 40:1575-87. 2012
  9. ncbi request reprint Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, California 92121, USA
    Drug Metab Dispos 33:1920-4. 2005
  10. doi request reprint Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites
    Deepak Dalvie
    Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, San Diego, California 92121, USA
    Chem Res Toxicol 22:357-68. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes
    Ping Kang
    Pharmacokinetics Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 35:1081-8. 2007
    ..Even though the relationship of the GSH conjugate to flutamide-induced toxicity is unknown, the results have revealed the formation of a novel, hitherto unknown, GSH adduct of flutamide...
  2. doi request reprint Bioactivation of flutamide metabolites by human liver microsomes
    Ping Kang
    Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, CA 92121, USA
    Drug Metab Dispos 36:1425-37. 2008
    ..These findings suggested that, in addition to the direct bioactivation of flutamide, the metabolites of flutamide could also be bioactivated and contribute to flutamide-induced hepatotoxicity...
  3. ncbi request reprint Evaluation of capravirine as a CYP3A probe substrate: in vitro and in vivo metabolism of capravirine in rats and dogs
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 35:1593-602. 2007
    ....
  4. ncbi request reprint Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 34:1798-802. 2006
    ..Due to their relatively insignificant contributions of C19 and C20 to total capravirine metabolism, no attempt was made to determine relative contributions of cytochrome P450 enzymes to the formation of the two minor metabolites...
  5. doi request reprint Selective mechanism-based inactivation of CYP3A4 by CYP3cide (PF-04981517) and its utility as an in vitro tool for delineating the relative roles of CYP3A4 versus CYP3A5 in the metabolism of drugs
    Robert L Walsky
    Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer, Inc, Groton, CT, USA
    Drug Metab Dispos 40:1686-97. 2012
    ....
  6. doi request reprint Interspecies variation in the metabolism of zoniporide by aldehyde oxidase
    Deepak Dalvie
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla, CA 92121, USA
    Xenobiotica 43:399-408. 2013
    ..8. The domestic animals also showed marked species differences in the AO activity and affinity toward zoniporide...
  7. doi request reprint Systematic structure modifications of imidazo[1,2-a]pyrimidine to reduce metabolism mediated by aldehyde oxidase (AO)
    Angelica Linton
    Pfizer Worldwide Research and Development, San Diego, CA 92121, USA
    J Med Chem 54:7705-12. 2011
    ..These strategies may be useful for other drug discovery programs...
  8. doi request reprint Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide
    Deepak Dalvie
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 40:1575-87. 2012
    ..This combination method can be incorporated into a strategy for mitigating AO liabilities observed in the lead candidate or studying structure-metabolism relationships of other AO substrates...
  9. ncbi request reprint Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, California 92121, USA
    Drug Metab Dispos 33:1920-4. 2005
    ..These represent important findings in the bioactivation mechanism of CBZ...
  10. doi request reprint Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites
    Deepak Dalvie
    Pharmacokinetics, Dynamics and Metabolism Department, Pfizer Global Research and Development, San Diego, California 92121, USA
    Chem Res Toxicol 22:357-68. 2009
    ....
  11. doi request reprint Effect of intestinal glucuronidation in limiting hepatic exposure and bioactivation of raloxifene in humans and rats
    Deepak Dalvie
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, California 92121, USA
    Chem Res Toxicol 21:2260-71. 2008
    ....
  12. doi request reprint Pharmacokinetics, metabolism, and excretion of [14C]axitinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in humans
    Bill J Smith
    Pharmacokinetics, Dynamics and Metabolism B J S, H Z B, P K, W F P, E Y W, D K D, Pfizer Oncology Clinical Pharmacology Y P, B H, K J K, and Pharmaceutical Sciences A J D, Pfizer Inc, Worldwide Research and Development, La Jolla Laboratories, San Diego, CA
    Drug Metab Dispos 42:918-31. 2014
    ..In summary, the study characterized axitinib metabolites in circulation and primary elimination pathways of the drug, which were mainly oxidative in nature. ..
  13. doi request reprint Bioactivation of lumiracoxib by peroxidases and human liver microsomes: identification of multiple quinone imine intermediates and GSH adducts
    Ping Kang
    Pharmacokinetics Dynamics and Metabolism, Research Analytical, Pfizer Global Research and Development, 10724 Science Center Drive, San Diego, California 92121, USA
    Chem Res Toxicol 22:106-17. 2009
    ..These results suggest that bioactivation of lumiracoxib and M5 may result in GSH depletion, covalent binding to proteins, and oxidative stress and may potentially lead to hepatotoxicity...
  14. doi request reprint In Vitro Kinetic Characterization of Axitinib Metabolism
    Michael A Zientek
    Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Inc, San Diego, California M A Z, P K, Y J, S F, D N, B J S and Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Pfizer Inc, Groton, Connecticut T C G, E T, J L, J N B, G S W
    Drug Metab Dispos 44:102-14. 2016
    ..7 µM or 0.75 µM and 8.9 or 8.3 pmol·min(-1)·mg(-1), respectively. In summary, CYP3A4 is the major enzyme involved in axitinib clearance with lesser contributions from CYP3A5, CYP2C19, CYP1A2, and UGT1A1. ..
  15. ncbi request reprint Gender specific drug metabolism of PF-02341066 in rats--role of sulfoconjugation
    Wei Zhu Zhong
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Curr Drug Metab 11:296-306. 2010
    ..The human liver S9 study suggests that gender-related pharmacokinetics of PF-02341066 are unlikely to occur in humans...
  16. doi request reprint Metabolite profiling of dasatinib dosed to Wistar Han rats using automated dried blood spot collection
    Zhongzhou Shen
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 10628 Science Center Drive, San Diego, CA 92121, USA
    J Pharm Biomed Anal 67:92-7. 2012
    ..The results obtained from this study suggest that collection of study samples by DBS can be used for metabolite profiling, however, the availability of limited samples may be a concern for multiple injections...
  17. doi request reprint Discovery of aryloxy tetramethylcyclobutanes as novel androgen receptor antagonists
    Chuangxing Guo
    Pfizer Worldwide Research and Development, San Diego, CA 92121, USA
    J Med Chem 54:7693-704. 2011
    ....
  18. ncbi request reprint A simple sequential incubation method for deconvoluting the complicated sequential metabolism of capravirine in humans
    Hai Zhi Bu
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, San Diego, CA 92121, USA
    Drug Metab Dispos 33:1438-45. 2005
    ..e., nonlabeled parent and its other metabolites). This methodology should be applicable to mechanistic studies of other compounds involving complicated sequential metabolic reactions when radiolabeled materials are available...
  19. doi request reprint Solution-phase parallel synthesis of Hsp90 inhibitors
    Sujin Cho-Schultz
    Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, USA
    J Comb Chem 11:860-74. 2009
    ..The second library highlights the use of the (-)-sparteine-mediated enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine to prepare chiral 2-arylpyrrolidines in parallel...
  20. pmc CYP3A4-Mediated carbamazepine (CBZ) metabolism: formation of a covalent CBZ-CYP3A4 adduct and alteration of the enzyme kinetic profile
    Ping Kang
    Department of Cellular and Molecular Pharmacology, Liver Center, University of California, San Francisco, 600 16th Street N572F, San Francisco, CA 94158 2280, USA
    Drug Metab Dispos 36:490-9. 2008
    ....
  21. pmc A novel locus on the X chromosome regulates post-maturity bone density changes in mice
    Dorota Szumska
    Department of Geriatrics, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare Service, Little Rock, AR 72205, USA
    Bone 40:758-66. 2007
    ..Hum Mol Genet 2005;14:3141-8]. A second locus, on chromosome 7, was observed in only one cross. Single-nucleotide polymorphisms (SNPs) are highly clustered near these loci, distinguishing the parental strains over only limited spans...
  22. ncbi request reprint Formation of transient intermediates in low-temperature photosensitized oxidation of an 8-(13)C-guanosine derivative
    Ping Kang
    Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 124:4865-73. 2002
    ..The distribution of products estimated by (13)C NMR accounts for all the (13)C-containing products in the reaction mixture...
  23. ncbi request reprint Low-temperature photosensitized oxidation of a guanosine derivative and formation of an imidazole ring-opened product
    Chimin Sheu
    Department of Chemistry, University of California, Los Angeles, Los Angeles, California 90095 1569, USA
    J Am Chem Soc 124:3905-13. 2002
    ....