J T Downs
Affiliation: Pfizer Global Research and Development
- Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISAJ T Downs
Inflammation Biology, Pfizer Central Research, Pfizer Inc, Groton, CT 06340 8002, USA
J Immunol Methods 247:25-34. 2001..This assay can be used for monitoring type II collagen metabolism in patients with osteoarthritis...
- Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibodyI G Otterness
Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research Division, Pfizer Inc, Groton, CT 06340, USA
Matrix Biol 18:331-41. 1999..By contrast, in the group with damaged collagen, the cartilage was fibrillated in all animals and in half of those, the cartilage failed and bony eburnation resulted...
- Inhibition of interleukin 1 synthesis by tenidap: a new drug for arthritisI G Otterness
Department of Immunology and Infectious Diseases, Pfizer Inc, Groton, CT 06340
Cytokine 3:277-83. 1991..As the appearance of IL-1 was inhibited both intracellularly and extracellularly, the primary drug effect cannot be on secretion...