Gregg D Cappon

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development
    G D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:38-46. 2003
  2. ncbi request reprint Combined treatment potentiates the developmental toxicity of ibuprofen and acetazolamide in rats
    Gregg D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Drug Chem Toxicol 28:409-21. 2005
  3. ncbi request reprint Reproductive toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in male rats
    Gregg D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 71:142-9. 2004
  4. ncbi request reprint Embryo/fetal development studies with hydroxypropyl methylcellulose acetate succinate (HPMCAS) in rats and rabbits
    Gregg D Cappon
    Pfizer Global Research and Development, Building 274 MS 1260, Eastern Point Road, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:421-7. 2003
  5. ncbi request reprint Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure
    G D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:47-56. 2003
  6. doi request reprint Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:250-61. 2012
  7. doi request reprint Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT, USA
    Reprod Toxicol 38:16-24. 2013
  8. doi request reprint Sensitive windows of skeletal development in rabbits determined by hydroxyurea exposure at different times throughout gestation
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:238-49. 2012
  9. doi request reprint Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats
    Aleasha M Coburn
    Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:267-75. 2012
  10. doi request reprint Impaired reproduction in adult male, but not female, rats following juvenile treatment with the aromatase inhibitor, exemestane
    Gregg D Cappon
    Drug Safety Research and Development, Pfizer Inc Groton Laboratories, Eastern Point Rd, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 92:304-13. 2011

Detail Information

Publications23

  1. ncbi request reprint Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development
    G D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:38-46. 2003
    ....
  2. ncbi request reprint Combined treatment potentiates the developmental toxicity of ibuprofen and acetazolamide in rats
    Gregg D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Drug Chem Toxicol 28:409-21. 2005
    ..Therefore, while concurrent inhibition of COX and carbonic anhydrase did not produce DH, potentiation was noted for the induction of VSD and appendicular anomalies...
  3. ncbi request reprint Reproductive toxicity assessment of lasofoxifene, a selective estrogen receptor modulator (SERM), in male rats
    Gregg D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 71:142-9. 2004
    ..The purpose of this study was to evaluate the effects of lasofoxifene on male reproduction in rats in light of the known effects of estrogen modulating compounds on male reproductive ability...
  4. ncbi request reprint Embryo/fetal development studies with hydroxypropyl methylcellulose acetate succinate (HPMCAS) in rats and rabbits
    Gregg D Cappon
    Pfizer Global Research and Development, Building 274 MS 1260, Eastern Point Road, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:421-7. 2003
    ..Therefore, to definitively establish the potential of HPMCAS to produce developmental toxicity, embryo/fetal development studies were carried out in rats and rabbits...
  5. ncbi request reprint Relationship between cyclooxygenase 1 and 2 selective inhibitors and fetal development when administered to rats and rabbits during the sensitive periods for heart development and midline closure
    G D Cappon
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 68:47-56. 2003
    ....
  6. doi request reprint Developmental toxicity of lersivirine in rabbits when administered throughout organogenesis and when limited to sensitive windows of axial skeletal development
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:250-61. 2012
    ..An embryo-fetal development study was performed to evaluate the potential for maternal and developmental toxicity of lersivirine...
  7. doi request reprint Comparative assessment of the timing of sexual maturation in male Wistar Han and Sprague-Dawley rats
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT, USA
    Reprod Toxicol 38:16-24. 2013
    ..Based on these endpoints, WH rats were determined to be sexually mature at PND 70, and many of these endpoints evaluated in SD rats exhibited nearly identical trends...
  8. doi request reprint Sensitive windows of skeletal development in rabbits determined by hydroxyurea exposure at different times throughout gestation
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:238-49. 2012
    ..The results of this study provide a better understanding of the critical developmental window for different segments of the rabbit skeleton, which will aid in the design of window studies to investigate teratogenicity in rabbits...
  9. doi request reprint Reproductive toxicity assessment of sunitinib, a multitargeted receptor tyrosine kinase inhibitor, in male and female rats
    Aleasha M Coburn
    Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:267-75. 2012
    ..We investigated the effects of sunitinib on male and female fertility and early embryonic development in the rat...
  10. doi request reprint Impaired reproduction in adult male, but not female, rats following juvenile treatment with the aromatase inhibitor, exemestane
    Gregg D Cappon
    Drug Safety Research and Development, Pfizer Inc Groton Laboratories, Eastern Point Rd, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 92:304-13. 2011
    ..Given the increased interest in treating children with aromatase inhibitors, we undertook a study in rats to assess the potential for exemestane to alter reproductive development and function when administered to juveniles...
  11. doi request reprint Developmental toxicity study of lersivirine in mice
    Gregg D Cappon
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:225-30. 2012
    ..The results of these studies indicate that lersivirine is not teratogenic in mice...
  12. doi request reprint Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Global Research and Development, Groton Laboratories, Eastern Point Rd, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 92:323-32. 2011
    ....
  13. ncbi request reprint Postnatal closure of membranous ventricular septal defects in Sprague-Dawley rat pups after maternal exposure with trimethadione
    Tammye L Fleeman
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 71:185-90. 2004
    ..The objective of this study was to determine if treatment-induced VSD persist throughout postnatal development...
  14. ncbi request reprint Tolterodine does not affect memory assessed by passive-avoidance response test in mice
    Gregg D Cappon
    Pfizer Global Research and Development, Drug Safety Research and Development, Groton, CT 06340, United States
    Eur J Pharmacol 579:225-8. 2008
    ..Therefore, at a dose exceeding therapeutic exposure by six-fold, tolterodine had no effect on memory in the mouse passive-avoidance model, indicating that tolterodine does not disrupt cognitive function in this testing paradigm...
  15. doi request reprint Decreased maternal and fetal cholesterol following maternal bococizumab (anti-PCSK9 monoclonal antibody) administration does not affect rat embryo-fetal development
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, CT, USA
    Regul Toxicol Pharmacol 73:562-70. 2015
    ....
  16. doi request reprint Object discrimination reversal as a method to assess cognitive impairment in nonhuman primate enhanced pre- and postnatal developmental (ePPND) studies: statistical power analysis
    Gregg D Cappon
    Worldwide Research and Development, Pfizer Inc, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 95:354-62. 2012
    ..Due to the limitations on the number of animals, the ODR-WGTA may not be suitable for assessing cognitive impairment in NHP ePPND studies...
  17. doi request reprint Nonclinical support of pediatric drug development in a global context: an industry perspective
    Gregg D Cappon
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Rd, Groton, CT 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 92:269-72. 2011
    ..This presentation illustrated the challenges faced in developing a strategy regarding the need to perform a toxicity study in juvenile animals and the design of any necessary study that will receive global regulatory agreement...
  18. doi request reprint Isoflurane reduces motile sperm counts in the Sprague-Dawley rat
    Sarah N Campion
    Drug Safety Research and Development, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Drug Chem Toxicol 35:20-4. 2012
    ..Given these findings, it is important that careful consideration be taken to select an appropriate anesthesia/euthanasia method...
  19. doi request reprint Juvenile animal toxicity study designs to support pediatric drug development
    Gregg D Cappon
    Pfizer Global Research and Development, Groton Laboratories, Connecticut 06340, USA
    Birth Defects Res B Dev Reprod Toxicol 86:463-9. 2009
    ..These juvenile animal toxicity studies are designed on a case-by-case basis. General design considerations and examples of study designs for assessment of juvenile animal toxicity are discussed...
  20. doi request reprint Histologic and cytologic detection of endocrine and reproductive tract effects of exemestane in female rats treated for up to twenty-eight days
    Michael L Mirsky
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Toxicol Pathol 39:589-605. 2011
    ..While early histologic changes were evident on day 5, only after 8 days of treatment were findings considered sufficient to clearly identify exemestane-induced estrous cycle disruption using microscopy alone...
  21. ncbi request reprint Postnatal growth and morphological development of the brain: a species comparison
    Rebecca E Watson
    Mitretek Systems, Falls Church, Virginia
    Birth Defects Res B Dev Reprod Toxicol 77:471-84. 2006
    ....
  22. ncbi request reprint Postnatal development of the gastrointestinal system: a species comparison
    Karen Walthall
    Aclairo Pharmaceutical Development Group, Inc, Sterling, Virginia, USA
    Birth Defects Res B Dev Reprod Toxicol 74:132-56. 2005
  23. ncbi request reprint Species comparison of postnatal CNS development: functional measures
    Sandra L Wood
    Safety Assessment, Merck Research Laboratories, WP45 103, West Point, PA 19486, USA
    Birth Defects Res B Dev Reprod Toxicol 68:391-407. 2003