Eric C Petrie
- Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findingsEric C Petrie
Mail Code S 182 GRECC, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 66:632-7. 2009....
- Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluidSimona Vuletic
Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington School of Medicine, Seattle, WA 98109, USA
J Alzheimers Dis 15:409-17. 2008..Our data suggest that there is a significant physiological link between apoE and AbetaPP, as well as between apoE and tau in neurologically healthy, cognitively intact individuals...
- Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluidRobert G Riekse
Department of Medicine, Division of Geriatric Medicine, University of Washington School of Medicine, and VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 10:399-406. 2006..Putative neuroprotective effects of statins may vary in relation to their ability to penetrate into the central nervous system (CNS)...
- Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunctionJames S Meabon
Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System VA Puget Sound, Seattle, WA 98108, USA Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Sci Transl Med 8:321ra6. 2016..Together, these results argue that the cerebellum is vulnerable to repetitive mild TBI in both mice and humans. ..
- Cerebrospinal fluid norepinephrine and cognition in subjects across the adult age spanLucy Y Wang
Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
Neurobiol Aging 34:2287-92. 2013..0, SE 2.2, p = 0.024; Stroop Word-Color Interference task: regression coefficient 6.1, SE 2.0, p = 0.003). Findings are consistent with the earlier literature relating excess noradrenergic activity with cognitive impairment. ..
- Loss of olfactory tract integrity affects cortical metabolism in the brain and olfactory regions in aging and mild cognitive impairmentDonna J Cross
Department of Radiology, University of Washington, Seattle, Washington 98195 7115, USA
J Nucl Med 54:1278-84. 2013..We hypothesized that MCI subjects would show loss of olfactory tract integrity and may have altered associations with glucose metabolism...
- Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptomsElaine R Peskind
Northwest Network Mental Illness, Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Neuroimage 54:S76-82. 2011..Given the potential public health implications of these findings, further investigation of brain function in these Veterans appears warranted...
- Prazosin reduces nightmares in combat veterans with posttraumatic stress disorderMurray A Raskind
Northwest Network Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
J Clin Psychiatry 63:565-8. 2002..Preclinical and clinical observations suggest that the centrally active alpha1-adrenergic antagonist prazosin might alleviate trauma content nightmares and other symptoms in combat veterans with chronic posttraumatic stress disorder (PTSD)...
- Blast exposure causes early and persistent aberrant phospho- and cleaved-tau expression in a murine model of mild blast-induced traumatic brain injuryBertrand R Huber
Northwest Network Mental Illness, Research, Education, and Clinical Center MIRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
J Alzheimers Dis 37:309-23. 2013..These findings may have important implications for efforts to prevent blast-induced insults to the brain from progressing into long-term neurodegenerative disease processes. ..
- Lewy body pathology in late-onset familial Alzheimer's disease: a clinicopathological case seriesDebby W Tsuang
Mental Illness Research, Education, and Clinical Centers, Veteran Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 9:235-42. 2006..Lewy body pathology (LBP) is a common finding in Alzheimer's disease (AD), but the pathophysiology for this coexistent pathology remains unclear...
- Salivary cortisol and memory function in human agingGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Neurobiol Aging 27:1705-14. 2006..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
- Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled studyMurray A Raskind
Northwest Network VISN 20 Mental Illness Research, Eduation, and Clinical Center, VA Puget Sound Healthcare System, Seattle, USA
Am J Psychiatry 160:371-3. 2003..Prazosin is a centrally active alpha(1) adrenergic antagonist. The authors' goal was to evaluate prazosin efficacy for nightmares, sleep disturbance, and overall posttraumatic stress disorder (PTSD) in combat veterans...
- Neuroimaging in dementia with Lewy bodies: metabolism, neurochemistry, and morphologySatoshi Minoshima
Departments of Radiology, University of Washington School of Medicine, Seattle, Washington 98195 6004, USA
J Geriatr Psychiatry Neurol 15:200-9. 2002....