Xuemei Huang

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Short communication: genetic variations of SLC2A9 in relation to Parkinson's disease
    Jianjun Gao
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Transl Neurodegener 2:5. 2013
  2. pmc Both coordination and symmetry of arm swing are reduced in Parkinson's disease
    Xuemei Huang
    Department of Neurology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Gait Posture 35:373-7. 2012
  3. pmc Serum cholesterol and the progression of Parkinson's disease: results from DATATOP
    Xuemei Huang
    Department of Neurology, Pennsylvania State University Milton Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 6:e22854. 2011
  4. pmc Imaging nigral pathology and clinical progression in Parkinson's disease
    Guangwei Du
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Mov Disord 27:1636-43. 2012
  5. pmc Serum cholesterol and nigrostriatal R2* values in Parkinson's disease
    Guangwei Du
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 7:e35397. 2012
  6. pmc Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients
    Eun Young Lee
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Parkinsonism Relat Disord 19:1088-93. 2013
  7. pmc Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson's disease
    Eun Young Lee
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Parkinsonism Relat Disord 21:465-70. 2015
  8. pmc Increased R2* in the Caudate Nucleus of Asymptomatic Welders
    Eun Young Lee
    Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
    Toxicol Sci 150:369-77. 2016
  9. pmc Dopaminergic modulation of arm swing during gait among Parkinson's disease patients
    Nicholas W Sterling
    Department of Neurology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA Department of Public Health Sciences, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    J Parkinsons Dis 5:141-50. 2015
  10. pmc Microstructural changes in the substantia nigra of asymptomatic agricultural workers
    Guangwei Du
    Departments of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Neurotoxicol Teratol 41:60-4. 2014

Collaborators

Detail Information

Publications25

  1. pmc Short communication: genetic variations of SLC2A9 in relation to Parkinson's disease
    Jianjun Gao
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Transl Neurodegener 2:5. 2013
    ....
  2. pmc Both coordination and symmetry of arm swing are reduced in Parkinson's disease
    Xuemei Huang
    Department of Neurology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Gait Posture 35:373-7. 2012
    ....
  3. pmc Serum cholesterol and the progression of Parkinson's disease: results from DATATOP
    Xuemei Huang
    Department of Neurology, Pennsylvania State University Milton Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 6:e22854. 2011
    ..Recent studies have suggested that higher serum cholesterol may be associated with lower occurrence of Parkinson's disease (PD). This study is to test the hypothesis that higher serum cholesterol correlates with slower PD progression...
  4. pmc Imaging nigral pathology and clinical progression in Parkinson's disease
    Guangwei Du
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Mov Disord 27:1636-43. 2012
    ..These findings suggest that fractional anisotropy changes may mark early pathological changes in caudal SN, whereas the changes in R2* may more closely track PD's clinical progression after symptom onset...
  5. pmc Serum cholesterol and nigrostriatal R2* values in Parkinson's disease
    Guangwei Du
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania, United States of America
    PLoS ONE 7:e35397. 2012
    ....
  6. pmc Early cortical gray matter loss and cognitive correlates in non-demented Parkinson's patients
    Eun Young Lee
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Parkinsonism Relat Disord 19:1088-93. 2013
    ..This study tested the hypothesis that cognitive changes in non-demented PD may be related to cortical gray matter (GM) loss...
  7. pmc Side of motor onset is associated with hemisphere-specific memory decline and lateralized gray matter loss in Parkinson's disease
    Eun Young Lee
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Parkinsonism Relat Disord 21:465-70. 2015
    ..The present study examined whether the asymmetric motor presentation is associated with hemisphere-specific cognitive decline and lateralized gray matter volume loss...
  8. pmc Increased R2* in the Caudate Nucleus of Asymptomatic Welders
    Eun Young Lee
    Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
    Toxicol Sci 150:369-77. 2016
    ..Further studies are needed to replicate the findings and determine the neurobehavioral relevance. ..
  9. pmc Dopaminergic modulation of arm swing during gait among Parkinson's disease patients
    Nicholas W Sterling
    Department of Neurology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA Department of Public Health Sciences, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    J Parkinsons Dis 5:141-50. 2015
    ..Reduced arm swing amplitude, symmetry, and coordination during gait have been reported in Parkinson's disease (PD), but the relationship between dopaminergic depletion and these upper limb gait changes remains unclear...
  10. pmc Microstructural changes in the substantia nigra of asymptomatic agricultural workers
    Guangwei Du
    Departments of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Neurotoxicol Teratol 41:60-4. 2014
    ..Further human studies assisted by these imaging markers may be useful in understanding the etiology of PD. ..
  11. pmc Higher iron in the red nucleus marks Parkinson's dyskinesia
    Mechelle M Lewis
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Neurobiol Aging 34:1497-503. 2013
    ..The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development...
  12. pmc Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease
    Guangwei Du
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Mov Disord 26:1627-32. 2011
    ..Further studies are warranted to evaluate the pathophysiological correlations of these magnetic resonance imaging measurements and their effectiveness in assisting in diagnosing Parkinson's disease and following its progression...
  13. pmc History of smoking and olfaction in Parkinson's disease
    Elisabeth B Lucassen
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    Mov Disord 29:1069-74. 2014
    ..Olfactory dysfunction is the most common pre-motor symptom in Parkinson's disease (PD), and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD...
  14. pmc Olfactory-related cortical atrophy is associated with olfactory dysfunction in Parkinson's disease
    Eun Young Lee
    Departments of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Mov Disord 29:1205-8. 2014
    ..The present study examined whether olfactory dysfunction is associated with gray matter (GM) volume in brain regions subserving primary and secondary olfactory processing...
  15. pmc Striatal shape in Parkinson's disease
    Nicholas W Sterling
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA 17033 0850, USA
    Neurobiol Aging 34:2510-6. 2013
    ..005). This spatial distribution of striatal atrophy is consistent with the known pattern of dopamine depletion in PD and may reflect global consequences of known cellular remodeling phenomena...
  16. doi request reprint Quantitative susceptibility mapping of the midbrain in Parkinson's disease
    Guangwei Du
    Department of Neurology, Penn State University Milton S Hershey Medical Center, Hershey, Pennsylvania, United States
    Mov Disord 31:317-24. 2016
    ..Because quantitative susceptibility mapping is a novel MRI approach to measure iron content, we compared it with R2* for assessing midbrain changes in PD...
  17. pmc T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure
    Eun Young Lee
    Department of Neurology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania
    Toxicol Sci 146:281-9. 2015
    ..Moreover, the nonlinear relationship between welding exposure and Mn brain accumulation should be considered in future studies and policies. ..
  18. ncbi request reprint The role of the cerebellum in the pathophysiology of Parkinson's disease
    Mechelle M Lewis
    Department of Neurology, Pennsylvania State University Milton S Hershey Medical Center, Hershey PA, USA Department of Pharmacology, Pennsylvania State University Milton S Hershey Medical Center, Hershey PA, USA
    Can J Neurol Sci 40:299-306. 2013
    ..It is clear that the cerebellum participates in compensatory mechanisms associated with the disease and must be considered an essential contributor to the overall pathophysiology of PD...
  19. pmc The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease
    Izel Tekin
    Department of Pharmacology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, PA, USA
    Parkinsonism Relat Disord 23:86-90. 2016
    ..Many of the symptoms and signs of Parkinson's disease (PD) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (TH) as the rate-limiting enzyme in catecholamine biosynthesis...
  20. pmc Statins, plasma cholesterol, and risk of Parkinson's disease: a prospective study
    Xuemei Huang
    Department of Neurology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    Mov Disord 30:552-9. 2015
    ..02). Statin use may be associated with a higher PD risk, whereas higher total cholesterol may be associated with lower risk. These data are inconsistent with the hypothesis that statins are protective against PD...
  21. ncbi request reprint Asymmetrical ventricular enlargement in Parkinson's disease
    Xuemei Huang
    Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7025, USA, and University Hospital, Vancouver, British Columbia, Canada
    Mov Disord 22:1657-60. 2007
    ..This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study...
  22. doi request reprint Low LDL cholesterol and increased risk of Parkinson's disease: prospective results from Honolulu-Asia Aging Study
    Xuemei Huang
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7025, USA
    Mov Disord 23:1013-8. 2008
    ..2, 0.9). This prospective study supports the hypothesis that low LDL-C is associated with an increased risk of PD. Although confirmation is required, the underlying mechanisms may be useful in understanding key aspects of PD...
  23. pmc Manganese accumulation in the olfactory bulbs and other brain regions of "asymptomatic" welders
    Suman Sen
    Department of Neurology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 121:160-7. 2011
    ..Further investigations of subclinical Mn exposure are warranted...
  24. pmc Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease
    Xuemei Huang
    Department of Neurology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Mov Disord 22:377-81. 2007
    ..Thus, our data provide preliminary evidence that low LDL-C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation...
  25. pmc The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA Department of Pharmacology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    J Biochem Mol Toxicol 28:191-7. 2014
    ....