Philippe Haouzi

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide?
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 500 University Drive, H041, Hershey, PA 17033 USA Electronic address
    Respir Physiol Neurobiol 229:5-10. 2016
  2. pmc Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity
    Annick Judenherc-Haouzi
    Heart and Vascular Institute, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 310:R1030-44. 2016
  3. doi request reprint Persistent reduced oxygen requirement following blood transfusion during recovery from hemorrhagic shock
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr, Hershey, PO Box 850, Hershey, PA 17033, USA Electronic address
    Respir Physiol Neurobiol 215:39-46. 2015
  4. pmc In vivo interactions between cobalt or ferric compounds and the pools of sulphide in the blood during and after H2S poisoning
    Philippe Haouzi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State University College of Medicine, Hershey, PA 17033
    Toxicol Sci 141:493-504. 2014
  5. pmc Oxygen-related chemoreceptor drive to breathe during H₂S infusion
    Philippe Haouzi
    Pennsylvania State University, College of Medicine Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hershey, PA, USA Electronic address
    Respir Physiol Neurobiol 201:24-30. 2014
  6. pmc Tracking pulmonary gas exchange by breathing control during exercise: role of muscle blood flow
    Philippe Haouzi
    Pennsylvania State University College of Medicine, Department of Medicine, 500 University Drive, H041, Hershey, PA 17033, USA
    J Physiol 592:453-61. 2014
  7. doi request reprint Uncoupling mitochondrial activity maintains body [Formula: see text] during hemorrhage-induced O2 deficit in the anesthetized rat
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, Hershey, PA, United States
    Respir Physiol Neurobiol 186:87-94. 2013
  8. doi request reprint Breathing during cardiac arrest following exercise: a new function of the respiratory system?
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Penn State Hershey Medical Center, United States
    Respir Physiol Neurobiol 181:220-7. 2012
  9. doi request reprint Hypoxia-induced arterial chemoreceptor stimulation and hydrogen sulfide: too much or too little?
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States
    Respir Physiol Neurobiol 179:97-102. 2011
  10. doi request reprint Ventilatory and metabolic effects of exogenous hydrogen sulfide
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr, Hershey, PA, USA
    Respir Physiol Neurobiol 184:170-7. 2012

Collaborators

Detail Information

Publications39

  1. pmc Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide?
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Department of Medicine, 500 University Drive, H041, Hershey, PA 17033 USA Electronic address
    Respir Physiol Neurobiol 229:5-10. 2016
    ....
  2. pmc Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity
    Annick Judenherc-Haouzi
    Heart and Vascular Institute, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania
    Am J Physiol Regul Integr Comp Physiol 310:R1030-44. 2016
    ....
  3. doi request reprint Persistent reduced oxygen requirement following blood transfusion during recovery from hemorrhagic shock
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr, Hershey, PO Box 850, Hershey, PA 17033, USA Electronic address
    Respir Physiol Neurobiol 215:39-46. 2015
    ..The mechanism of slow recovery of O2 requirement/demand following BT and the resulting effects on tissues exposed to relatively high O2 partial pressure are discussed...
  4. pmc In vivo interactions between cobalt or ferric compounds and the pools of sulphide in the blood during and after H2S poisoning
    Philippe Haouzi
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State University College of Medicine, Hershey, PA 17033
    Toxicol Sci 141:493-504. 2014
    ..These results are discussed in the context of a relevant scenario, wherein antidotes can only be administered after H2S exposure. ..
  5. pmc Oxygen-related chemoreceptor drive to breathe during H₂S infusion
    Philippe Haouzi
    Pennsylvania State University, College of Medicine Department of Medicine, Division of Pulmonary and Critical Care Medicine, Hershey, PA, USA Electronic address
    Respir Physiol Neurobiol 201:24-30. 2014
    ..It is concluded that the ventilatory depression induced by high O2 appears to be limited to the tonic background peripheral chemosensory drive to breathe, but has little or no impact on the CB stimulation produced by low levels of H2S...
  6. pmc Tracking pulmonary gas exchange by breathing control during exercise: role of muscle blood flow
    Philippe Haouzi
    Pennsylvania State University College of Medicine, Department of Medicine, 500 University Drive, H041, Hershey, PA 17033, USA
    J Physiol 592:453-61. 2014
    ....
  7. doi request reprint Uncoupling mitochondrial activity maintains body [Formula: see text] during hemorrhage-induced O2 deficit in the anesthetized rat
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, Hershey, PA, United States
    Respir Physiol Neurobiol 186:87-94. 2013
    ..In conclusion, cellular and systemic mechanisms, decreasing O2demand, account for a large part of HS induced [Formula: see text] decline resulting in an additional reduction in [Formula: see text] ...
  8. doi request reprint Breathing during cardiac arrest following exercise: a new function of the respiratory system?
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Penn State Hershey Medical Center, United States
    Respir Physiol Neurobiol 181:220-7. 2012
    ....
  9. doi request reprint Hypoxia-induced arterial chemoreceptor stimulation and hydrogen sulfide: too much or too little?
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States
    Respir Physiol Neurobiol 179:97-102. 2011
    ..While the effects of the endogenous H(2)S on breathing remains to be established, the effects exogenous sulfide can be accounted for by its long established toxicity on cytochrome C oxidase...
  10. doi request reprint Ventilatory and metabolic effects of exogenous hydrogen sulfide
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr, Hershey, PA, USA
    Respir Physiol Neurobiol 184:170-7. 2012
    ..The demarcation between effects reflecting a putative physiological function and those related to H(2)S poisoning remains however to be established...
  11. doi request reprint Hydrogen sulfide oxidation and the arterial chemoreflex: effect of methemoglobin
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Penn State Milton Hershey Medical Centre, Hershey, PA, USA
    Respir Physiol Neurobiol 177:273-83. 2011
    ..Our results demonstrate that the ventilatory chemoreflex is not depressed in the presence of a high oxidative capacity for sulfide and challenge the view that H(2)S transduces the effects of hypoxia in the CB...
  12. doi request reprint Murine models in critical care research
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Penn State Milton Hershey Medical Centre, Pennsylvania State University, Hershey, PA, USA
    Crit Care Med 39:2290-3. 2011
    ..However, the results of studies in mice cannot disregard the unique ability of small rodents to adjust their temperature and high metabolic rate and the corresponding respiratory and circulatory requirements in response to hypoxia...
  13. doi request reprint Breathing patterns during cardiac arrest
    Philippe Haouzi
    Div of Pulmonary Medicine, Pennsylvania State Univ, 500 University Dr, PO Box 850, MC H047, Hershey, PA 17033 0850, USA
    J Appl Physiol (1985) 109:405-11. 2010
    ..These findings challenge the notions that 1) ventilation stops as pulmonary blood flow/cardiac output ceases and 2) the presence of eupneic breathing is a reliable sign of effective cardiac pumping activity...
  14. ncbi request reprint H2S induced hypometabolism in mice is missing in sedated sheep
    Philippe Haouzi
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States
    Respir Physiol Neurobiol 160:109-15. 2008
    ..Therefore, the proposed use of H(2)S administration as a way of protecting vital organs should be reconsidered in view of the lack of hypometabolic effect in a large sedated mammal and of H(2)S established toxicity...
  15. doi request reprint Control of breathing and volitional respiratory rhythm in humans
    Philippe Haouzi
    Department of Pulmonary Medicine, Penn State Milton Hershey Medical Center, 1College of Medicine, Heart and Vascular Institute, Pennsylvania State University, Hershey, Pennsylvania 17033 0850, USA
    J Appl Physiol (1985) 106:904-10. 2009
    ..The implications of our findings are discussed in the context of our current understanding of the central generation of breathing rhythm...
  16. doi request reprint Respiratory effects of changing the volume load imposed on the peripheral venous system
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Division of Pulmonary Medicine, Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, USA
    Respir Physiol Neurobiol 171:175-80. 2010
    ..Further, the respiratory drive from this sensory mechanism is subject to modulation via changes in the circulatory status, most likely within the arterial side...
  17. doi request reprint Comparison of the metabolic and ventilatory response to hypoxia and H2S in unsedated mice and rats
    Philippe Haouzi
    Pennsylvania State University, College of Medicine, Heart and Vascular Institute, 500 University Drive, Hershey, PA 17033, USA
    Respir Physiol Neurobiol 167:316-22. 2009
    ..H(2)S had, therefore, no stimulatory effect on the arterial chemoreflex. The ventilatory depression during hypoxia and H(2)S in small mammals appears to be dependent upon the ability to decrease metabolism...
  18. doi request reprint Inhibitory effects of hyperoxia and methemoglobinemia on H(2)S induced ventilatory stimulation in the rat
    Andry Van de Louw
    Pennsylvania State University, College of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center, 500 University Dr, Hershey, PO Box 850, MC H047, PA 17033 0850, USA
    Respir Physiol Neurobiol 181:326-34. 2012
    ..The implications of these results on the role of endogenous H(2)S in the arterial chemoreflex are discussed...
  19. pmc Sulfide Intoxication-Induced Circulatory Failure is Mediated by a Depression in Cardiac Contractility
    Takashi Sonobe
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, 500 University Drive, H041, Hershey, PA, 17033, USA
    Cardiovasc Toxicol 16:67-78. 2016
    ..The immediate and long-term neurological effects of specifically counteracting sulfide-induced cardiac contractility depression following H2S exposure remain to be investigated...
  20. doi request reprint Hypocapnia increases the prevalence of hypoxia-induced augmented breaths
    Harold J Bell
    Penn State University College of Medicine, Heart and Vascular Institute, Milton S Hershey Medical Center, 500 Univ Dr, P O Box 850, Mail Code H047, Hershey, PA 17033 0850, USA
    Am J Physiol Regul Integr Comp Physiol 296:R334-44. 2009
    ..Our results, therefore, reveal a means by which CO2 exerts a stabilizing influence on breathing, which may be of particular relevance during sleep in conditions commonly associated with respiratory instability...
  21. doi request reprint Acetazolamide suppresses the prevalence of augmented breaths during exposure to hypoxia
    Harold J Bell
    Penn State College of Medicine, Heart and Vascular Institute, Milton S Hershey Medical Center, 500 Univ Dr, PO Box 850, Mail Code H047, Hershey, PA 17033 0850, USA
    Am J Physiol Regul Integr Comp Physiol 297:R370-81. 2009
    ....
  22. doi request reprint The "other" respiratory effect of opioids: suppression of spontaneous augmented ("sigh") breaths
    Harold J Bell
    Div of Pulmonary and Critical Care Medicine, Penn State College of Medicine, Hershey, PA 17033 0850, USA
    J Appl Physiol (1985) 111:1296-303. 2011
    ....
  23. doi request reprint Control of breathing during acute change in cardiac preload in a patient with partial cardiopulmonary bypass
    Edgar Bekteshi
    Division of Pulmonary Critical Care Medicine, Penn State University, College of Medicine, Hershey, PA 17033 0850, USA
    Respir Physiol Neurobiol 170:37-43. 2010
    ..This observation suggests that the change in venous return affects breathing by encoding some of the consequences of the changes in cardiac preload. The possible sites of mediation are discussed...
  24. doi request reprint The hypoxia-induced facilitation of augmented breaths is suppressed by the common effect of carbonic anhydrase inhibition
    Harold J Bell
    Department of Medicine, Penn State University College of Medicine, Milton S Hershey Medical Centre, Hershey, PA, USA
    Respir Physiol Neurobiol 171:201-11. 2010
    ..We discuss these results as they pertain to the mechanisms regulating augmented breath production, and the possible association between hypocapnia/alkalosis and sleep disordered breathing...
  25. pmc Circulatory Failure During Non-Inhaled Forms of Cyanide Intoxication
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine Heart and Vascular Institute, Pennsylvania State University, College of Medicine, Hershey, PA Southwest Research Institute, San Antonio, TX
    Shock . 2016
    ..At higher level of intoxication, cardiac depression is to be treated as a specific and spontaneously irreversible consequence of CN exposure, leading to a pulseless electrical activity...
  26. pmc H2S concentrations in the arterial blood during H2S administration in relation to its toxicity and effects on breathing
    Candice M Klingerman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Penn State University College of Medicine, Hershey, Pennsylvania and
    Am J Physiol Regul Integr Comp Physiol 305:R630-8. 2013
    ..These data provide a frame of reference for studying the putative effects of endogenous H2S and for testing antidotes against its deadly effects. ..
  27. pmc Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations
    Philippe Haouzi
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania
    Ann N Y Acad Sci 1374:29-40. 2016
    ....
  28. pmc Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue
    Takashi Sonobe
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, United States of America
    PLoS ONE 10:e0131340. 2015
    ....
  29. pmc High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep
    Philippe Haouzi
    Division of Pulmonary and Critical Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Clin Toxicol (Phila) 53:28-36. 2015
    ..Severe H2S poisoning leads to death by rapid respiratory and cardiac arrest, the latter can occur within seconds or minutes in severe forms of intoxication...
  30. pmc H2S concentrations in the heart after acute H2S administration: methodological and physiological considerations
    Takashi Sonobe
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania
    Am J Physiol Heart Circ Physiol 311:H1445-H1458. 2016
    ....
  31. pmc H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores
    Takashi Sonobe
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Pennsylvania State University, College of Medicine, Hershey, PA, USA
    Clin Toxicol (Phila) 53:525-39. 2015
    ..Methylene blue (MB), a phenothiazinium dye, can antagonize the effects of the inhibition of mitochondrial electron transport chain, a major effect of H2S toxicity...
  32. doi request reprint Ferric Iron and Cobalt (III) Compounds to Safely Decrease Hydrogen Sulfide in the Body?
    Andry Van de Louw
    Division of Pulmonary and Critical Care Medicine, College of Medicine, Penn State Hershey Medical Center, Pennsylvania State University, Pennsylvania
    Antioxid Redox Signal 19:510-6. 2013
    ..Our observations lead to the hypothesis that innocuous levels of MetHb and vit.B12 could be a used as an effective and safe way to test the role of endogenous H2S in vivo. Antioxid. Redox Signal. 19, 510-516. ..
  33. ncbi request reprint Isolation of the arterial supply to the carotid and central chemoreceptors in the sheep
    Philippe Haouzi
    Laboratoire de Physiologie, EA 3450, Faculte de Medecine de Nancy, Université Henry Poincaré, 54505 Vandoeuvre Les Nancy Cedex, France
    Exp Physiol 88:581-94. 2003
    ..Nevertheless, this preparation provides an easy method of maintaining chemical and circulatory homeostasis at the chemoreceptor level...
  34. ncbi request reprint Control of breathing during cortical substitution of the spontaneous automatic respiratory rhythm
    Philippe Haouzi
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, EA 3450, Université H Poincaré, France
    Respir Physiol Neurobiol 159:211-8. 2007
    ..It is suggested that, during volitional control of breathing rhythm, the signal used for adjusting the magnitude to the timing of the ventilatory output is derived from information contained in the duration of preceding expiration...
  35. ncbi request reprint Theories on the nature of the coupling between ventilation and gas exchange during exercise
    Philippe Haouzi
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, avenue de la Forêt de Haye, B P 184, 54505 Vandoeuvre Les Nancy Cedex, France
    Respir Physiol Neurobiol 151:267-79. 2006
    ..More recent models based on somatic information of circulatory origin are presented and discussed...
  36. pmc Control of arterial PCO2 by somatic afferents in sheep
    Philippe Haouzi
    Laboratoire de Physiologie, Faculte de Medecine de Nancy, avenue de la Forêt de Haye, B P 184, 54505 Vandoeuvre Les Nancy Cedex, France
    J Physiol 569:975-87. 2005
    ....
  37. ncbi request reprint Frequency response of the input reaching the respiratory centres during moderate intensity exercise
    Philippe Haouzi
    Laboratoire de Physiologie, Faculté Médecine de Nancy, avenue de la Forêt de Haye, BP 184, 54505 Vandoeuvre lès Nancy Cedex France
    Adv Exp Med Biol 551:287-90. 2004
  38. pmc The control of ventilation is dissociated from locomotion during walking in sheep
    Philippe Haouzi
    Laboratoire de Physiologie, EA 3450, Faculte de Medecine de Nancy, France
    J Physiol 559:315-25. 2004
    ..Locomotion thus appears unlikely to cause a simple parallel and proportional increase in ventilation in walking sheep...