Alaa S Awad

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Arginase-2 mediates diabetic renal injury
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:3015-22. 2011
  2. pmc Macrophages directly mediate diabetic renal injury
    Hanning You
    Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, PO Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F1719-27. 2013
  3. pmc Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury
    Alaa S Awad
    Associate Professor of Medicine, and Cellular and Molecular Physiology, Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, P O Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F891-900. 2013
  4. pmc Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury
    Alaa S Awad
    College of Medicine, Division of Nephrology, Penn State University Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 301:F1358-66. 2011
  5. pmc Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism
    Hanning You
    Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 84:1189-97. 2013
  6. pmc Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury
    Alaa S Awad
    Division of Nephrology, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Kidney Int 75:689-98. 2009
  7. pmc Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury
    Alaa S Awad
    Department of Medicine, Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 10:e0133777. 2015
  8. pmc Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy
    Hanning You
    Department of Medicine, Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania
    Am J Physiol Renal Physiol 309:F447-55. 2015
  9. pmc Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury
    Alaa S Awad
    Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 88:722-33. 2015
  10. pmc Therapeutic modalities in diabetic nephropathy: standard and emerging approaches
    Emaad M Abdel-Rahman
    Department of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, USA
    J Gen Intern Med 27:458-68. 2012

Collaborators

Detail Information

Publications12

  1. pmc Arginase-2 mediates diabetic renal injury
    Sidney M Morris
    Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:3015-22. 2011
    ..To determine 1) whether renal arginase activity or expression is increased in diabetes and 2) whether arginase plays a role in development of diabetic nephropathy (DN)...
  2. pmc Macrophages directly mediate diabetic renal injury
    Hanning You
    Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, PO Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F1719-27. 2013
    ..Attenuating the deleterious effects of macrophages on podocytes could provide a new therapeutic approach to the treatment of DN. ..
  3. pmc Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury
    Alaa S Awad
    Associate Professor of Medicine, and Cellular and Molecular Physiology, Penn State Univ, Hershey Medical Center, College of Medicine, Division of Nephrology, H040, 500 Univ Drive, P O Box 850, BMR Bldg, C5830, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F891-900. 2013
    ..These findings highlight the importance of P78-PEDF peptide as a potential therapeutic modality in early phase diabetic renal injury. ..
  4. pmc Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury
    Alaa S Awad
    College of Medicine, Division of Nephrology, Penn State University Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 301:F1358-66. 2011
    ..These findings provide evidence that CCR2 is necessary for monocyte/macrophage-induced diabetic renal injury and suggest that blocking CCR2 could be a novel therapeutic approach in the treatment of DN...
  5. pmc Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism
    Hanning You
    Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 84:1189-97. 2013
    ..Thus, arginase inhibition mediates renal tissue protection in diabetic nephropathy by an eNOS-dependent mechanism and has an eNOS-independent effect on kidney macrophage recruitment. ..
  6. pmc Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury
    Alaa S Awad
    Division of Nephrology, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Kidney Int 75:689-98. 2009
    ..Our findings suggest there is a sequential recruitment and transmigration of neutrophils from the vasculature into the kidney interstitium at the site of tissue injury following renal ischemia-reperfusion...
  7. pmc Delayed Treatment with a Small Pigment Epithelium Derived Factor (PEDF) Peptide Prevents the Progression of Diabetic Renal Injury
    Alaa S Awad
    Department of Medicine, Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 10:e0133777. 2015
    ..These findings highlight the importance of P78-PEDF peptide as a potential therapeutic modality in both the development and progression of diabetic renal injury...
  8. pmc Arginase inhibition: a new treatment for preventing progression of established diabetic nephropathy
    Hanning You
    Department of Medicine, Division of Nephrology, Penn State University College of Medicine, Hershey, Pennsylvania
    Am J Physiol Renal Physiol 309:F447-55. 2015
    ..These findings highlight the importance of arginase inhibition as a new potential therapeutic intervention in both early and late stages of diabetic renal injury. ..
  9. pmc Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury
    Alaa S Awad
    Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania, USA
    Kidney Int 88:722-33. 2015
    ..Thus, production of TNF-α by macrophages plays a major role in diabetic renal injury. Hence, blocking TNF-α could be a novel therapeutic approach for treatment of diabetic nephropathy...
  10. pmc Therapeutic modalities in diabetic nephropathy: standard and emerging approaches
    Emaad M Abdel-Rahman
    Department of Medicine, Division of Nephrology, University of Virginia, Charlottesville, VA, USA
    J Gen Intern Med 27:458-68. 2012
    ..Finally, we will summarize the recommendations of these interventions for the primary care practitioner...
  11. pmc Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation
    Hanning You
    Division of Nephrology, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania
    Am J Physiol Renal Physiol 307:F1292-301. 2014
    ..These findings demonstrate that chronic L-arginine or L-citrulline supplementation does not prevent or reduce renal injury in a model of type 1 diabetes...
  12. pmc Activation of adenosine 2A receptors preserves structure and function of podocytes
    Alaa S Awad
    Division of Nephrology, Box 133, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 19:59-68. 2008
    ..It was concluded that A(2A)R activation reduces glomerular proteinuria, at least in part, by preserving the normal structure of podocyte foot processes, slit diaphragms, and actin cytoskeleton...