Affiliation: Pennington Biomedical Research Center
- Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposalRashmi Krishnapuram
Infections and Obesity Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
PLoS ONE 8:e60651. 2013..This stable cell line offers a valuable resource to carefully study the novel signaling pathways E4orf1 uses to enhance cellular glucose disposal independent of insulin...
- E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemiaEmily J Dhurandhar
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States of America
PLoS ONE 7:e47813. 2012..Elucidating the underlying molecular mechanism may help develop therapeutic approaches for treating diabetes or non-alcoholic fatty liver disease(NAFLD)...
- E4orf1: a novel ligand that improves glucose disposal in cell cultureEmily J Dhurandhar
Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
PLoS ONE 6:e23394. 2011..Thus, the highly attractive anti-hyperglycemic effect of Ad36 is mirrored by E4orf1 protein, which may offer a novel ligand to develop anti-hyperglycemic drugs...
- Insulin sparing action of adenovirus 36 and its E4orf1 proteinNikhil V Dhurandhar
Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
J Diabetes Complications 27:191-9. 2013....
- Long-term changes in adiposity and glycemic control are associated with past adenovirus infectionWan Yu Lin
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
Diabetes Care 36:701-7. 2013..This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults...
- Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TXRohina Rubicz
Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245 0549, USA
BMC Res Notes 4:433. 2011..abstract:..
- Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 geneP M Rogers
Department of Infections and Obesity, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Int J Obes (Lond) 32:397-406. 2008..Therefore, we investigated the role of Ad-36 as a novel regulator of the adipogenic process...
- A framework for identification of infections that contribute to human obesityNikhil V Dhurandhar
Infection and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Lancet Infect Dis 11:963-9. 2011..Clinicians should be aware of infectobesity (obesity of infectious origin), and its potential importance in effective obesity management...
- Template to improve glycemic control without reducing adiposity or dietary fatR Krishnapuram
Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Am J Physiol Endocrinol Metab 300:E779-89. 2011..This metabolic engineering by Ad36 appears relevant to humans for developing more practical and effective antidiabetic approaches...
- PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cellsOlga Dubuisson
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Endocrinology 152:3648-60. 2011..In conclusion, Ad36 provides a novel template to metabolically remodel human adipose tissue to enhance glycemic control without the concomitant increase in adiposity or PPARγ induction associated with TZD actions...
- Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36Pamela M Rogers
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
Diabetes 57:2321-31. 2008..To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue...
- Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signalingZhong Q Wang
Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
Diabetes 57:1805-13. 2008..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
- Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cellsMagdalena Pasarica
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Stem Cells 26:969-78. 2008..Thus, Ad-36 has the potential to induce adipogenesis in hASC, which may contribute to adiposity induced by the virus...
- Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in ratsMagdalena Pasarica
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Obesity (Silver Spring) 14:1905-13. 2006..Involvement of the central nervous system (CNS) or adipose tissue in the mechanism of Ad-36-induced adiposity is unknown. The effects of Ad-36 on adiposity and on the neuroendocrine system were investigated in a rat model...
- A human adenovirus enhances preadipocyte differentiationSharada D Vangipuram
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
Obes Res 12:770-7. 2004..The metabolic and molecular mechanisms responsible for Ad-36-induced adipogenesis are unknown. As a potential adipogenic mechanism, this study examined if Ad-36 enhanced differentiation of preadipocytes...
- Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeysNikhil V Dhurandhar
Department of Nutrition and Food Science and the Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
J Nutr 132:3155-60. 2002..These studies illustrate that the adiposity-promoting effect of Ad-36 occurs in two nonhuman primate species and demonstrates the usefulness of nonhuman primates for further evaluation of Ad-36-induced adiposity...
- Mechanism of Promotion of Adipogenesis by Adenovirus-36NIKHIL DHURANDHAR; Fiscal Year: 2007..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. [unreadable] [unreadable]..