Pennington Biomedical Research Center

Summary

Organization: Pennington Biomedical Research Center
Country: USA

Top Publications

  1. pmc Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Pathol 177:1436-47. 2010
  2. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
  3. ncbi Poverty and food intake in rural America: diet quality is lower in food insecure adults in the Mississippi Delta
    Catherine M Champagne
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    J Am Diet Assoc 107:1886-94. 2007
  4. pmc Tumor necrosis factor and stroke: role of the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Prog Neurobiol 83:363-74. 2007
  5. pmc Ghrelin promotes thymopoiesis during aging
    Vishwa Deep Dixit
    Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
    J Clin Invest 117:2778-90. 2007
  6. ncbi Hormonal responses to a fast-food meal compared with nutritionally comparable meals of different composition
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Ann Nutr Metab 51:163-71. 2007
  7. ncbi Slower eating rate reduces the food intake of men, but not women: implications for behavioral weight control
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Behav Res Ther 45:2349-59. 2007
  8. ncbi Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
  9. ncbi Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats
    Christy L White
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:624-31. 2007
  10. pmc TNFalpha trafficking in cerebral vascular endothelial cells
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Neuroimmunol 185:47-56. 2007

Research Grants

Scientific Experts

Detail Information

Publications62

  1. pmc Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Pathol 177:1436-47. 2010
    ..This should be considered in the selection of endpoints for future clinical trials of 12/15-lipoxygenase inhibitors...
  2. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
    ....
  3. ncbi Poverty and food intake in rural America: diet quality is lower in food insecure adults in the Mississippi Delta
    Catherine M Champagne
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    J Am Diet Assoc 107:1886-94. 2007
    ..To determine if measures of diet quality differ between food insecure and food secure adults in a rural high-risk population...
  4. pmc Tumor necrosis factor and stroke: role of the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Prog Neurobiol 83:363-74. 2007
    ..As we better understand how peripheral TNFalpha affects its own transport and modulates neuroregeneration, we may be in a better position to pharmacologically manipulate its regulatory transport system to treat stroke...
  5. pmc Ghrelin promotes thymopoiesis during aging
    Vishwa Deep Dixit
    Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
    J Clin Invest 117:2778-90. 2007
    ....
  6. ncbi Hormonal responses to a fast-food meal compared with nutritionally comparable meals of different composition
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Ann Nutr Metab 51:163-71. 2007
    ..Fast food is consumed in large quantities each day. Whether there are differences in the acute metabolic response to these meals as compared to 'healthy' meals with similar composition is unknown...
  7. ncbi Slower eating rate reduces the food intake of men, but not women: implications for behavioral weight control
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Behav Res Ther 45:2349-59. 2007
    ..Ratings of desire to eat, normalized for the amount of food consumed, were lower during the combined-rate meal for men and women. Thus, this basic premise of behavioral weight control was supported for men, but not for women...
  8. ncbi Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
    ....
  9. ncbi Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats
    Christy L White
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:624-31. 2007
    ....
  10. pmc TNFalpha trafficking in cerebral vascular endothelial cells
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Neuroimmunol 185:47-56. 2007
    ..The vesicular trafficking of TNFalpha reflects the immunomodulatory potential of peripheral cytokines for the CNS...
  11. ncbi Importance of diagnosing and treating the metabolic syndrome in reducing cardiovascular risk
    Steven R Smith
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:128S-134S. 2006
    ..Further research is needed to define the etiology of the metabolic syndrome...
  12. ncbi Permeation of hepatocyte growth factor across the blood-brain barrier
    Weihong Pan
    Pennington Biomedical Research Center, LSU System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 201:99-104. 2006
    ..The amount of HGF that crossed the BBB in intact form was substantial and could be physiologically important in the CNS...
  13. ncbi Procolipase gene expression in the rat brain: source of endogenous enterostatin production in the brain
    David A York
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 1087:52-9. 2006
    ..These data suggest that procolipase and enterostatin are synthesized within specific regions of the brain that function in the regulation of food intake centrally...
  14. ncbi Effects of consuming mycoprotein, tofu or chicken upon subsequent eating behaviour, hunger and safety
    Donald A Williamson
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
    Appetite 46:41-8. 2006
    ..These findings have significant implications for the development of foods that are low in kilojoules, but are also filling...
  15. pmc Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial
    C K Martin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Psychopharmacol 23:814-25. 2009
    ..Research testing VPA on short-term (1 week) EI, metabolism, and substrate partitioning is warranted...
  16. pmc A novel method to remotely measure food intake of free-living individuals in real time: the remote food photography method
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Br J Nutr 101:446-56. 2009
    ..6 % (P = 0.017). Bias did not differ by body weight or age. The RFPM is a promising new method for accurately measuring the EI of free-living individuals. Error associated with the method is small compared with self-report methods...
  17. ncbi Cytokine transport across the injured blood-spinal cord barrier
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Pharm Des 14:1620-4. 2008
    ..The increased transport of TNF and LIF after SCI remains saturable and does not coincide with generalized BBB disruption, highlighting a pivotal regulatory role for the blood-spinal cord barrier...
  18. pmc Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
    Jeffrey M Gimble
    Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Stem Cell Res Ther 1:19. 2010
    ..Future directions and challenges facing the field are discussed and evaluated...
  19. pmc Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 26:135-42. 2010
    ..The results identify AR as an important therapeutic target for diseases involving IR injury, and provide the rationale for development of fidarestat and other AR inhibitors...
  20. pmc Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Metab 11:412-26. 2010
    ..We propose that lower PARL expression may contribute to the mitochondrial abnormalities seen in aging and T2DM...
  21. pmc Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats
    S D Primeaux
    Dietary Obesity Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:1427-33. 2010
    ..GLP-1 is produced in the small intestine and is released in response to a meal. The current experiments examined the role of GLP-1 in OM and S5B rats...
  22. pmc Quantification of food intake using food image analysis
    Corby K Martin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6869-72. 2009
    ..Herein, we describe the development of a semi-automated computer imaging application to estimate food intake based on pictures captured by participants...
  23. doi Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?
    J M Gimble
    Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Rev 10:46-51. 2009
    ..Together, these observations suggest that GILZ is an attractive candidate for future studies evaluating the role of circadian mechanisms in adipose tissue physiology and pathology...
  24. pmc Changes in C-reactive protein from low-fat diet and/or physical activity in men and women with and without metabolic syndrome
    Sarah M Camhi
    Population Science, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 59:54-61. 2010
    ..Low-fat diet may be the most effective treatment for reducing CRP in women with metabolic syndrome...
  25. pmc Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Diabetes Complications 24:289-96. 2010
    ..Pioglitazone (Pio) treatment induces weight gain in Type 2 diabetes mellitus (T2DM), which could worsen hepatic lipid accumulation, and alter adiponectin and high-sensitivity C-reactive protein (hs-CRP)...
  26. pmc DNA repair efficiency in transgenic mice over expressing ribosomal protein S3
    Vijay Hegde
    DNA Damage and Repair Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mutat Res 666:16-22. 2009
    ....
  27. pmc The 4th dimension and adult stem cells: Can timing be everything?
    Jeffrey M Gimble
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Cell Biochem 107:569-78. 2009
    ....
  28. ncbi The "Rolling Store:" an economical and environmental approach to the prevention of weight gain in African American women
    Betty M Kennedy
    The Pennington Biomedical Research Center, 6400 Perkins Rd, PO Box 80025, Baton Rouge, LA 70898, USA
    Ethn Dis 19:7-12. 2009
    ....
  29. pmc Exercise dose and quality of life: a randomized controlled trial
    Corby K Martin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Arch Intern Med 169:269-78. 2009
    ..Improved quality of life (QOL) is a purported benefit of exercise, but few randomized controlled trials and no dose-response trials have been conducted to examine this assertion...
  30. pmc Obesity and vulnerability of the CNS
    Annadora J Bruce-Keller
    Inflammation and Neurodegeneration Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Biochim Biophys Acta 1792:395-400. 2009
    ..Thus, enhanced understanding of the effects of obesity and obesity-related metabolic dysfunction on the brain are especially critical as increasing numbers of obese individuals approach advanced age...
  31. ncbi Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
    ....
  32. ncbi Drug Insight: appetite suppressants
    George A Bray
    Division of Clinical Obesity and Metabolism, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Nat Clin Pract Gastroenterol Hepatol 2:89-95. 2005
    ..Several new mechanisms for drug action are under investigation. Appetite suppressants should be viewed as useful adjuncts to diet and physical activity and might help selected patients to achieve and maintain weight loss...
  33. ncbi Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Endocrinol Metab 282:E95-E106. 2002
    ..01 at 70 h). These results suggest that a certain quantity of dietary fat is required to replenish IMCL after endurance running...
  34. ncbi Functional and chemical anatomy of the afferent vagal system
    H R Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Auton Neurosci 85:1-17. 2000
    ..Furthermore, these functions are in line with a general defensive character ascribed to the vagal afferent, paraventricular system in lower vertebrates...
  35. ncbi Clinical evaluation of the overweight patient
    G A Bray
    Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
    Endocrine 13:167-86. 2000
    ..After assessing risk, the therapeutic choices can be selected from the age category of the patient. With any therapeutic activity, involvement of the patient in a realistic approach to the treatment process is essential...
  36. ncbi Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men
    T Rankinen
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
    Thromb Res 99:453-9. 2000
    ..6%, 9.7%, 5.5%, and 2.3%, respectively. WHR, serum triglycerides, and age did not enter the model. These data suggest that increased lipid peroxidation is associated with elevated plasma fibrinogen level in middle-aged men...
  37. ncbi Changes in body composition with conjugated linoleic acid
    J P DeLany
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Am Coll Nutr 19:487S-493S. 2000
    ..Most of the studies conducted so far must be repeated using the purified isomers in order to determine which isomers are responsible for each of the identified actions of CLA...
  38. ncbi Fatty acids and immune responses--a new perspective in searching for clues to mechanism
    D Hwang
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Annu Rev Nutr 20:431-56. 2000
    ..Elucidating the mechanism of actions of fatty acids on receptor-mediated signaling pathways in immuno-competent cells will provide a new insight for understanding the immuno-modulatory roles of dietary fatty acids...
  39. ncbi Concurrent physical activity increases fat oxidation during the shift to a high-fat diet
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 72:131-8. 2000
    ..We hypothesized that concurrent physical activity would accelerate fat oxidation during an isoenergetic high-fat diet...
  40. ncbi The role of nitric oxide in reproduction
    S M McCann
    Pennington Biomedical Research Cente, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Braz J Med Biol Res 32:1367-79. 1999
    ..In the gonad, NO plays an important role in inducing ovulation and in causing luteolysis, whereas in the reproductive tract, it relaxes uterine muscle via cGMP and constricts it via prostaglandins (PG)...
  41. ncbi Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine
    D H Ryan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:313-22. 1999
    ..We studied 86 patients who had echocardiograms before treatment with appetite suppressants to determine the incidence of new cases and to evaluate the clinical implication of the echocardiographic findings...
  42. ncbi Testosterone administration preserves protein balance but not muscle strength during 28 days of bed rest
    J J Zachwieja
    Exercise and Nutrition Program and Inpatient Clinical Trials Unit, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 84:207-12. 1999
    ..These results suggest that in the absence of daily ambulatory activity, T administration will not increase or, in the case of this bed rest model, preserve muscle strength...
  43. ncbi Reliability and validity of a macronutrient self-selection paradigm and a food preference questionnaire
    P J Geiselman
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    Physiol Behav 63:919-28. 1998
    ..In addition, this paradigm detected a large range of sugar and total caloric intake. It is anticipated that the use of these laboratory tools can enhance our understanding of the relationship between dietary fat intake and obesity...
  44. ncbi Body perception index: benefits, pitfalls, ideas
    M A Smeets
    Department of Psychonomics, Utrecht University, The Netherlands
    J Psychosom Res 44:457-64. 1998
    ..Hence, overestimation of body size in AN can only partially be accounted for by the smaller body size of anorexic patients. Recommendations for future use of the BPI are put forward...
  45. ncbi ApoE genotype does not predict lipid response to changes in dietary saturated fatty acids in a heterogeneous normolipidemic population. The DELTA Research Group. Dietary Effects on Lipoproteins and Thrombogenic Activity
    M Lefevre
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Arterioscler Thromb Vasc Biol 17:2914-23. 1997
    ..Thus, in a heterogeneous, normolipidemic study population, apoE genotype does not predict the magnitude of lipid response to reductions in dietary saturated fat...
  46. ncbi The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent
    F L Greenway
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Obes Rev 2:199-211. 2001
    ..Restriction of dietary herbal supplements containing caffeine and ephedrine, often with other ingredients, should be based on controlled clinical trials of these products...
  47. ncbi The relation of gender, race and socioeconomic status to obesity and obesity comorbidities in a sample of US adults
    S Paeratakul
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Int J Obes Relat Metab Disord 26:1205-10. 2002
    ..To examine the obesity-related chronic diseases in the US adult population according to gender, race and socioeconomic status...
  48. ncbi The underlying basis for obesity: relationship to cancer
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:3451S-3455S. 2002
    ..Efforts to control obesity through preventive strategies and treatment can be expected to have a benefit in reducing the risk of cancer...
  49. ncbi Selective tissue uptake of agouti-related protein(82-131) and its modulation by fasting
    Weihong Pan
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 70808, USA
    Endocrinology 146:5533-9. 2005
    ..Thus, the differential uptake of AgRP by peripheral organs could be a regulated process that is modulated by food deprivation...
  50. ncbi A pilot church-based weight loss program for African-American adults using church members as health educators: a comparison of individual and group intervention
    Betty M Kennedy
    Health Behavior Dept, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Ethn Dis 15:373-8. 2005
    ..The purpose of this study was to examine a church-based intervention employing a 6-month pilot weight loss program as a strategy to improve health of African-American adults...
  51. ncbi Beyond energy balance: there is more to obesity than kilocalories
    George A Bray
    Louisiana State University System, USA
    J Am Diet Assoc 105:S17-23. 2005
    ..Reversing the current trends of obesity requires a new look at the limits of the energy balance concept, and a better understanding of how environmental factors acutely and chronically change the responses of susceptible hosts...
  52. ncbi Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons
    Kirsteen N Browning
    Dept of Neuroscience, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Gastrointest Liver Physiol 289:G209-19. 2005
    ....
  53. ncbi Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Histochem Cell Biol 123:147-56. 2005
    ....
  54. ncbi Class discovery analysis of the lung cancer gene expression data
    Andrey Ptitsyn
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    DNA Cell Biol 23:715-21. 2004
    ..These subtypes should be taken into account in diagnostics, drug testing, and treatment development for lung cancer patients...
  55. ncbi (n-3) fatty acids and cancer therapy
    W Elaine Hardman
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    J Nutr 134:3427S-3430S. 2004
    ..Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies...
  56. ncbi Metabolic syndrome targets
    Steven R Smith
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Drug Targets CNS Neurol Disord 3:431-9. 2004
    ..The advantages and pitfalls of these targets will be discussed with an eye towards the relevant literature...
  57. ncbi Anatomy and function of sensory hepatic nerves
    Hans Rudolf Berthoud
    Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Anat Rec A Discov Mol Cell Evol Biol 280:827-35. 2004
    ..Great caution is therefore necessary when interpreting functional outcomes of so-called specific hepatic denervation studies...
  58. ncbi Basic fibroblast growth factor has rapid bone anabolic effects in ovariectomized rats
    R A Power
    Department of Transgenics, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Osteoporos Int 15:716-23. 2004
    ..The rapid increase in osteoblast surface in bFGF-treated OVX rats suggests that the growth factor induces conversion of bone lining cells to osteoblasts...
  59. ncbi Concept, strategies, and feasibility of noninvasive insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont, USA
    Diabetes Care 27:239-46. 2004
    ..To comprehensively review the progress to date on the development of alternative routes for insulin delivery...
  60. ncbi A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana Baylor Hospital, Dallas, Texas, USA
    Obes Res 11:722-33. 2003
    ..To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects...
  61. ncbi Clinical research trials: a comparison of African Americans who have and have not participated
    Betty M Kennedy
    Pennington Biomedical Research Center, P O Box 80025, Baton Rouge, Louisiana 70898 0025, USA
    J Cult Divers 9:95-101. 2002
    ....
  62. ncbi Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70803, USA
    J Clin Endocrinol Metab 81:2198-203. 1996
    ..We conclude that administration of exogenous androgens modulates body composition in obese postmenopausal women and independently affects visceral and sc abdominal fat...

Research Grants62

  1. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
  2. Post-DPP Follow-up-Study
    George Bray; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
  3. Health Outcomes of Weight loss: Look AHEAD -Action for Health in Diabetes
    George Bray; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..
  4. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2007
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. ..
  5. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2010
    ..Their interactions with the blood-brain barrier largely determine the final outcome of these blood-borne cytokines. ..
  6. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  7. LA Health:Primary and Secondary Obesity Prevention
    Donald Williamson; Fiscal Year: 2007
    ..The results of this investigation will significantly impact public health policy related to obesity prevention in rural communities, minority communities, and in children from families that are economically disadvantaged. ..
  8. Wise Mind: Environmental Approach for Obesity Prevention
    Donald Williamson; Fiscal Year: 2004
    ..abstract_text> ..
  9. LA Health:Primary and Secondary Obesity Prevention
    Donald Williamson; Fiscal Year: 2009
    ..The results of this investigation will significantly impact public health policy related to obesity prevention in rural communities, minority communities, and in children from families that are economically disadvantaged. ..
  10. INTERNET-BASED OBESITY PREVENTION FOR BLACK ADOLESCENTS
    Donald Williamson; Fiscal Year: 2002
    ..We have assembled a multidisciplinary team of scientists from the Pennington Biomedical Research Center and from Louisiana State University to test the efficacy of an internet-based secondary prevention ..
  11. Neural mechanisms controlling food intake and body weight after bariatric surgery
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..This will result in more optimal surgical procedures, behavioral tips helping patients to cope with different eating habits, and development of new drugs. ..
  12. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..abstract_text> ..
  13. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2010
    ..abstract_text> ..
  14. AUTONOMIC REGULATION OF FOOD INTAKE AND METABOLISM
    Hans Rudolf Berthoud; Fiscal Year: 2002
    ....
  15. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  16. Non-Homeostatic Neural Controls of Food Intake
    Hans Rudolf Berthoud; Fiscal Year: 2007
    ..framework of how the different psychological processes involved in food reward are neurologically organized, and (3) the development of pharmacological and behavioral therapeutic tools to counteract "common" obesity in a world of plenty ..
  17. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010
    ..Investigators from the Pennington Biomedical Research Center and from Washington University are submitting a single revised application to continue the close ..
  18. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
    The HYPGENE Study is a collaborative effort between the Pennington Biomedical Research Center, the Cooper Institute, and Washington University in St. Louis...
  19. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2009
    ..Investigators from the Pennington Biomedical Research Center and from Washington University are submitting a single revised application to continue the close ..