- Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamicsJohn P Harrelson
School of Pharmacy, Pacific University, HPC Ste 451, Hillsboro, Oregon 97123, USA
Biochemistry 47:2978-88. 2008..That is, the accommodation of a second xylene molecule in the active site leads to a decrease in substrate dynamics...
- A comparison of substrate dynamics in human CYP2E1 and CYP2A6John P Harrelson
Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
Biochem Biophys Res Commun 352:843-9. 2007..Speculatively, if this explanation is valid, then intramolecular isotope effect experiments should be useful in the mechanistic investigation of P450 cooperativity...
- Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunitiesJohn P Harrelson
Pacific University, School of Pharmacy, 222 SE 8th Avenue, HPC Ste 451, Hillsboro, OR 97123, United States Electronic address
Pharmacol Ther . 2016..In this review we bring together these two sides of metabolism, discuss the evidence underpinning their role in breast cancer development and bring to light promising therapeutic targets and up and coming pharmacologic agents...
- Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophenJohn P Harrelson
School of Pharmacy, Pacific University Oregon, 222 S E 8th Ave, Ste 451, Hillsboro, OR 97123, USA
Drug Metab Dispos 40:1460-5. 2012..This study reports the first direct evidence of AMAP-derived hydroquinone metabolites bound to human CYP2E1...