John P Harrelson

Summary

Affiliation: Pacific University
Country: USA

Publications

  1. doi request reprint Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics
    John P Harrelson
    School of Pharmacy, Pacific University, HPC Ste 451, Hillsboro, Oregon 97123, USA
    Biochemistry 47:2978-88. 2008
  2. pmc A comparison of substrate dynamics in human CYP2E1 and CYP2A6
    John P Harrelson
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 352:843-9. 2007
  3. doi request reprint Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities
    John P Harrelson
    Pacific University, School of Pharmacy, 222 SE 8th Avenue, HPC Ste 451, Hillsboro, OR 97123, United States Electronic address
    Pharmacol Ther . 2016
  4. doi request reprint Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen
    John P Harrelson
    School of Pharmacy, Pacific University Oregon, 222 S E 8th Ave, Ste 451, Hillsboro, OR 97123, USA
    Drug Metab Dispos 40:1460-5. 2012

Collaborators

Detail Information

Publications4

  1. doi request reprint Multiple-ligand binding in CYP2A6: probing mechanisms of cytochrome P450 cooperativity by assessing substrate dynamics
    John P Harrelson
    School of Pharmacy, Pacific University, HPC Ste 451, Hillsboro, Oregon 97123, USA
    Biochemistry 47:2978-88. 2008
    ..That is, the accommodation of a second xylene molecule in the active site leads to a decrease in substrate dynamics...
  2. pmc A comparison of substrate dynamics in human CYP2E1 and CYP2A6
    John P Harrelson
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Biophys Res Commun 352:843-9. 2007
    ..Speculatively, if this explanation is valid, then intramolecular isotope effect experiments should be useful in the mechanistic investigation of P450 cooperativity...
  3. doi request reprint Expanding the view of breast cancer metabolism: Promising molecular targets and therapeutic opportunities
    John P Harrelson
    Pacific University, School of Pharmacy, 222 SE 8th Avenue, HPC Ste 451, Hillsboro, OR 97123, United States Electronic address
    Pharmacol Ther . 2016
    ..In this review we bring together these two sides of metabolism, discuss the evidence underpinning their role in breast cancer development and bring to light promising therapeutic targets and up and coming pharmacologic agents...
  4. doi request reprint Covalent modification and time-dependent inhibition of human CYP2E1 by the meta-isomer of acetaminophen
    John P Harrelson
    School of Pharmacy, Pacific University Oregon, 222 S E 8th Ave, Ste 451, Hillsboro, OR 97123, USA
    Drug Metab Dispos 40:1460-5. 2012
    ..This study reports the first direct evidence of AMAP-derived hydroquinone metabolites bound to human CYP2E1...