H Payami

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype
    H Payami
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Am J Hum Genet 60:948-56. 1997
  2. ncbi request reprint Parkinson's disease, CYP2D6 polymorphism, and age
    H Payami
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 56:1363-70. 2001
  3. ncbi request reprint Familial aggregation of Parkinson disease: a comparative study of early-onset and late-onset disease
    Haydeh Payami
    Department of Neurology, CR131, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Arch Neurol 59:848-50. 2002
  4. ncbi request reprint Predictors of healthy brain aging
    M Gonzales Mc Neal
    Departments of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    J Gerontol A Biol Sci Med Sci 56:B294-301. 2001
  5. ncbi request reprint Apolipoprotein E epsilon4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease
    R Camicioli
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Dement Geriatr Cogn Disord 10:437-41. 1999
  6. ncbi request reprint Segregation analysis of Parkinson disease
    S Zareparsi
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Am J Med Genet 80:410-7. 1998
  7. ncbi request reprint HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease
    S Zareparsi
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 58:973-5. 2002
  8. pmc Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study
    R N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 78:1434-40. 2012
  9. ncbi request reprint Age at onset of Parkinson disease and apolipoprotein E genotypes
    Sepideh Zareparsi
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Am J Med Genet 107:156-61. 2002
  10. ncbi request reprint Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease
    S Zareparsi
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Neurosci Lett 272:140-2. 1999

Collaborators

Detail Information

Publications36

  1. pmc A prospective study of cognitive health in the elderly (Oregon Brain Aging Study): effects of family history and apolipoprotein E genotype
    H Payami
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Am J Hum Genet 60:948-56. 1997
    ..These observations suggest that the rate of cognitive decline increases with age and that APOE and other familial/genetic factors influence the onset age throughout life...
  2. ncbi request reprint Parkinson's disease, CYP2D6 polymorphism, and age
    H Payami
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 56:1363-70. 2001
    ..The aim of this study was to test if the CYP2D6*4 allele (poor metabolizer phenotype) is associated with earlier age at onset...
  3. ncbi request reprint Familial aggregation of Parkinson disease: a comparative study of early-onset and late-onset disease
    Haydeh Payami
    Department of Neurology, CR131, Oregon Health Sciences University, 3181 SW Sam Jackson Park Rd, Portland, OR 97201, USA
    Arch Neurol 59:848-50. 2002
    ..Evidence for familial aggregation is key to whether research should focus on gene discovery or search for environmental factors...
  4. ncbi request reprint Predictors of healthy brain aging
    M Gonzales Mc Neal
    Departments of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    J Gerontol A Biol Sci Med Sci 56:B294-301. 2001
    ..In this population, absence of apolipoprotein E-epsilon4 and male gender were associated with delayed onset, whereas estrogen use and education had no detectable effect on cognitive outcome...
  5. ncbi request reprint Apolipoprotein E epsilon4 is associated with neuronal loss in the substantia nigra in Alzheimer's disease
    R Camicioli
    Department of Neurology, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Dement Geriatr Cogn Disord 10:437-41. 1999
    ..04). These findings confirm that cell loss in the substantia nigra is associated with epsilon4 in AD. Copyrightz1999S.KargerAG,Basel..
  6. ncbi request reprint Segregation analysis of Parkinson disease
    S Zareparsi
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Am J Med Genet 80:410-7. 1998
    ....
  7. ncbi request reprint HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease
    S Zareparsi
    Department of Neurology, Oregon Health Sciences University, Portland 97201, USA
    Neurology 58:973-5. 2002
    ..4 years, p = 0.002) or those without A2 (5.2 years, p = 0.003). The "recessive" nature of this association suggests that loss of function at the HLA-A locus or a closely linked gene is associated with AD...
  8. pmc Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study
    R N Alcalay
    Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Neurology 78:1434-40. 2012
    ..To assess the cognitive phenotype of glucocerebrosidase (GBA) mutation carriers with early-onset Parkinson disease (PD)...
  9. ncbi request reprint Age at onset of Parkinson disease and apolipoprotein E genotypes
    Sepideh Zareparsi
    Department of Neurology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Am J Med Genet 107:156-61. 2002
    ..There was a trend for earlier onset of PD in varepsilon2varepsilon3 patients than in varepsilon3varepsilon3 patients only in the Oregon sample. In conclusion, APOE is associated with age at onset of PD...
  10. ncbi request reprint Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease
    S Zareparsi
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA
    Neurosci Lett 272:140-2. 1999
    ..We found no evidence for linkage and excluded the 6cM candidate region which suggest that in our families, PD is not caused by dominant mutations within tau...
  11. ncbi request reprint Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease
    Kiri L Brickell
    Department of Neurology, VA Puget Sound Health Care System, University of Washington, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 63:1307-11. 2006
    ..Genetic influences on the development of late-onset Alzheimer disease (LOAD) are heterogeneous and ill defined...
  12. ncbi request reprint SCA2 may present as levodopa-responsive parkinsonism
    Haydeh Payami
    Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA
    Mov Disord 18:425-9. 2003
    ..The absence of borderline mutations in the normal population, and the co-segregation of the expanded allele with neurological signs in one kindred suggest that SCA2 mutations may be responsible for a subset of familial parkinsonism...
  13. pmc DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease
    Lani S Chun
    Department of Neurology, University of Washington School of Medicine, Seattle, WA 98108, USA
    Ann Neurol 62:99-101. 2007
    ..Furthermore, we found no evidence for an effect of genotype on age at onset among patients. Our findings argue against DBH -1021C-->T as a risk factor or age at onset modifier in PD...
  14. ncbi request reprint Escaping Parkinson's disease: a neurologically healthy octogenarian with the LRRK2 G2019S mutation
    Denise M Kay
    Mov Disord 20:1077-8. 2005
  15. ncbi request reprint One step closer to fixing association studies: evidence for age- and gender-specific allele frequency variations and deviations from Hardy-Weinberg expectations in controls
    Haydeh Payami
    New York State Department of Health Wadsworth Center, Genomics Institute, P O Box 22002, 12201 2002, Albany, NY, USA
    Hum Genet 118:322-30. 2005
    ..We recommend that population genetic studies be performed on commonly used candidate markers and that rigorous standards be applied for case-control matching...
  16. ncbi request reprint Parkinson's disease and LRRK2: frequency of a common mutation in U.S. movement disorder clinics
    Denise M Kay
    Genomics Institute, Wadsworth Center, New York State Department of Health, Albany, 12201, USA
    Mov Disord 21:519-23. 2006
    ..Age at onset of mutation carriers ranged from 28 to 71 years. Mutation carriers were clinically indistinguishable from idiopathic PD. LRRK2 G2019S is the single most common pathogenic mutation linked to neurodegenerative disease to date...
  17. pmc Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease
    Cyrus P Zabetian
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Ann Neurol 62:137-44. 2007
    ..We sought to replicate these findings...
  18. ncbi request reprint Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinations
    Richard Camicioli
    University of Alberta, Edmonton, Alberta, Canada
    Mov Disord 20:989-94. 2005
    ..Psychosis risk was not associated with ApoE4, COMT, or sex. The observation that males have increased dementia risk and the trend for ApoE4 requires confirmation in larger prospective autopsy studies...
  19. ncbi request reprint Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients
    Denise M Kay
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Ann Neurol 61:47-54. 2007
    ..We present a comprehensive sequence analysis of parkin in control subjects...
  20. pmc Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease
    Carolyn M Hutter
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Eur J Neurol 15:134-9. 2008
    ..Our results suggest that UCHL1 S18Y is not a major susceptibility factor for PD in white populations although we cannot exclude the possibility that the S18Y variant exerts weak effects on risk, particularly in early-onset disease...
  21. ncbi request reprint parkin mutation analysis in clinic patients with early-onset Parkinson [corrected] disease
    P Poorkaj
    Geriatric Research Education Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, WA, USA
    Am J Med Genet A 129:44-50. 2004
    ..It is unclear whether heterozygous mutations are pathogenic. parkin-based diagnosis and counseling require a better understanding of the mode of inheritance, penetrance, and carrier frequencies...
  22. pmc Evidence for a novel late-onset Alzheimer disease locus on chromosome 19p13.2
    Ellen M Wijsman
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Am J Hum Genet 75:398-409. 2004
    ..We also obtained weak evidence of linkage to chromosome 10 at the same location as a previous report of linkage but found no evidence for linkage of LOFAD age-at-onset loci to chromosomes 9, 12, or 21...
  23. ncbi request reprint Evidence of linkage and association on chromosome 20 for late-onset Alzheimer disease
    Katrina A B Goddard
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 7281, USA
    Neurogenetics 5:121-8. 2004
    ..002 and 0.08 for two-locus haplotypes. These results support the presence of a susceptibility locus for AD in the vicinity of CST3 for very elderly subjects with AD...
  24. doi request reprint Exploring gene-environment interactions in Parkinson's disease
    Colin C McCulloch
    Applied Statistics Laboratory, General Electric Global Research Center, Niskayuna, NY, USA
    Hum Genet 123:257-65. 2008
    ..The novel findings of this study that warrant replication are the evidence for interaction of coffee with APOE, and of smoking with REP1 on PD risk...
  25. doi request reprint Genetic association between alpha-synuclein and idiopathic Parkinson's disease
    Denise M Kay
    New York State Department of Health, Division of Genetic Disorders, Wadsworth Center, Albany, New York 12208, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1222-30. 2008
    ..1 for 261/261 to 59.4 +/- 11.5 for 257/257, displaying a trend of decreasing onset age with increasing allele size (P = 0.055). Genetic variation in SNCA and its regulatory regions play an important role in both familial and sporadic PD...
  26. ncbi request reprint Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease
    Julie P Taylor
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurogenetics 8:95-102. 2007
    ..Comparison of evolutionary interspecies sequences of LRRK1 and LRRK2 suggests they diverged from a common founder gene...
  27. ncbi request reprint Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk
    Karen M Powers
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Mov Disord 23:88-95. 2008
    ..13, 95% CI = 0.06-0.29). Whether this finding reflects true biologic protection needs to be investigated...
  28. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
  29. ncbi request reprint Validity and utility of a LRRK2 G2019S mutation test for the diagnosis of Parkinson's disease
    Denise M Kay
    Wadsworth Center, New York State Department of Health, Albany, NY 12201 2002, USA
    Genet Test 10:221-7. 2006
    ..Test results can have psychological, social, and economical ramifications; thus, proper counseling is essential...
  30. pmc LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago
    Cyrus P Zabetian
    Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Hum Genet 79:752-8. 2006
    ..Our data suggest two separate founding events for G2019S in these populations, beginning at a time that coincides with the Jewish Diasporas...
  31. pmc Analysis of the LRRK2 G2019S mutation in Alzheimer Disease
    Cyrus P Zabetian
    Arch Neurol 63:156-7. 2006
  32. ncbi request reprint False-positive SCA8 gene test in a patient with pathologically proven multiple system atrophy
    Stewart A Factor
    Ann Neurol 57:462-3. 2005
  33. pmc Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations
    Jennifer Kachergus
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Am J Hum Genet 76:672-80. 2005
    ..Our work highlights the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis...
  34. pmc A linkage study of candidate loci in familial Parkinson's Disease
    Karin Wirdefeldt
    Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Neurol 3:6. 2003
    ..These loci have been implicated in familial Parkinson's disease or in syndromes with a clinical presentation that overlaps with parkinsonism, as well as potentially in the pathogenesis of the disease...
  35. ncbi request reprint Accurate determination of ataxin-2 polyglutamine expansion in patients with intermediate-range repeats
    Jennifer Hussey
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Genet Test 6:217-20. 2002
    ..Using cloning and sequencing methods, we have constructed a ladder of ATX2 alleles of known size and sequence composition. This freely available size ladder will facilitate future quantification of expansions of the ATX2 locus...
  36. ncbi request reprint Independent predictors of cognitive decline in healthy elderly persons
    Scott Marquis
    Department of Medicine Neurology, University of Alberta, 2E3 08, 8440 112th St, Edmonton, Alberta, Canada T6G 2B7
    Arch Neurol 59:601-6. 2002
    ..Several studies have shown that individually memory, hippocampal volume, and motor measures presage the onset of dementia. It is unclear if these independently contribute to the prediction of mild cognitive impairment...