Affiliation: Oregon Health and Science University
- Interferon-gamma release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in childrenDeborah A Lewinsohn
Division of Infectious Disease, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
Curr Opin Pediatr 22:71-6. 2010..Until recently, diagnosis has relied upon the tuberculin skin test (TST). New interferon-gamma release assays (IGRAs) offer improvements over TST, but these tests have not been studied in children until recently...
- Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egressM C Gold
Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
Mucosal Immunol 6:35-44. 2013..MAIT cells, an evolutionarily conserved T-cell subset that detects a variety of intracellular infections, share features of innate and adaptive immunity...
- Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in UgandaDeborah A Lewinsohn
Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA
PLoS ONE 3:e3407. 2008..The objective of this study was to compare whole blood IFN-gamma production in response to mycobacterial antigens between children and adults in Uganda...
- HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cellsDeborah A Lewinsohn
Department of Pediatrics, Oregon Health and Sciences University, 707 SW Gaines Road, CDRCP, Portland, OR 97201, USA
Virology 294:13-21. 2002..Furthermore, we confirm that HIV-1 Nef is able to provide partial protection from CTL recognition of infected cells. Thus, the inability of CTL to control HIV-1 infection is likely not due to direct inhibition of CTL-mediated apoptosis...
- Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunitiesD A Lewinsohn
Department of Pediatrics, Oregon Health and Science University, Portland 97239, USA
Int J Tuberc Lung Dis 8:658-74. 2004..tuberculosis-specific T-cell immunity in children, and potential application to immunodiagnostics and vaccine development will be reviewed...
- Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cellsDeborah A Lewinsohn
Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
Am J Respir Crit Care Med 168:1346-52. 2003....
- Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primatesLuka Cicin-Sain
Vaccine and Gene Therapy Institute, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
J Immunol 184:6739-45. 2010..Therefore, our results argue that T cell repertoire constriction and naive cell loss have prognostic value for global immune function in aging primates...
- HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cellsAmy S Heinzel
Division of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health Sciences University, Portland, OR 97201, USA
J Exp Med 196:1473-81. 2002..This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis...
- The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelleJeff E Grotzke
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR, USA
PLoS Pathog 5:e1000374. 2009..This is, to our knowledge, the first description of this presentation pathway for an intracellular pathogen. Moreover, these data suggest that HLA-E may play a unique role in the presentation of phagosomal antigens...
- Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-BDeborah A Lewinsohn
Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon, USA
PLoS Pathog 3:1240-9. 2007..These findings provide an improved understanding of immunodominance in humans and may contribute to a development of an effective TB vaccine and improved immunodiagnostics...
- Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathwayJeff E Grotzke
Division of Infectious Diseases, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 185:4336-43. 2010..Taken together, these data demonstrate that immunodominant M. tuberculosis CD8(+) Ags are processed and presented using a cytosolic pathway...
- Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytesMarielle C Gold
Department of Pulmonary and Critical Care Medicine, Portland VA Medical Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS Pathog 4:e39. 2008..Furthermore, this is the first demonstration of a human innate pathogen-specific alphabetaTCR(+) T cell and is likely to inspire further investigation into innate T cells recognizing other important human pathogens...
- Interferon-gamma release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patientsKevin L Winthrop
Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin J Am Soc Nephrol 3:1357-63. 2008..This study sought to determine whether IFN-gamma release assay results are more closely associated with recent TB exposure than TST results...
- TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient diseaseDavid M Lewinsohn
Division of Pulmonary and Critical Care Medicine, Department of Molecular Microbiology and Immunology, Oregon Health and Science University Portland VA Medical Center, Portland, OR 97201, USA
Semin Respir Infect 18:320-38. 2003....
- Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis--specific CD8+ T cellsDeborah A Lewinsohn
Division of Pediatric Infectious Diseases, Department of Molecular Microbiology and Immunology, Oregon Health and Science University Portland VA Medical Center, Portland, OR, USA
Am J Respir Crit Care Med 166:843-8. 2002..The technique will be useful in defining CD8+ T cell antigens and in measuring immunogenicity of tuberculosis vaccines...
- Human neonatal dendritic cells are competent in MHC class I antigen processing and presentationMarielle C Gold
Department of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA
PLoS ONE 2:e957. 2007....
- High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaqueDavid M Lewinsohn
Pulmonary and CCM, R and D 11, Portland VA Medical Center, 3710 SW US Veterans Road, Portland, OR 97239, USA
Microbes Infect 8:2587-98. 2006..In summary, computed tomography scanning in conjunction with immunologic monitoring provides a non-invasive, accurate, and rapid assessment of tuberculosis in the non-human primate...
- Human mucosal associated invariant T cells detect bacterially infected cellsMarielle C Gold
Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS Biol 8:e1000407. 2010..Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection...
- New diagnostic methods for tuberculosisMelissa R Nyendak
Division of Infectious Diseases, Oregon Health and Science University, Portland, OR 97239, USA
Curr Opin Infect Dis 22:174-82. 2009..Improvements in the ability to detect latent infection with Mtb, disease associated with Mtb, and strains resistant to commonly used antibiotics are reviewed...
- Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulationMarielle C Gold
Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
Pediatr Res 60:34-7. 2006..These results are consistent with the observation that vaccines that effect strong adjuvant activity on dendritic cells can induce protective responses in neonates...
- Immunologic susceptibility of young children to Mycobacterium tuberculosisDeborah A Lewinsohn
Pediatr Res 63:115. 2008
- EVALUATION OF ADOPTIVE T CELL THERAPY FOR HIVDEBORAH LEWINSOHN; Fiscal Year: 2002..My long-term goal is to work in an academic medical center as a physician scientist with a primary focus on the immunopathogenesis of HIV infection. ..
- Tuberculosis Immunity in Young ChildrenDEBORAH LEWINSOHN; Fiscal Year: 2006..These studies may contribute to a more complete understanding of TB immunity in young children, and hence 'facilitate the development of an improved TB vaccine for this vulnerable population. ..