Genomes and Genes
Affiliation: Oregon Health and Science University
- Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expressionSoren Impey
Oregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA
BMC Genomics 17:825. 2016....
- Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampusSoren Impey
Oregon Stem Cell Center and Department of Pediatrics, Oregon Health and Science University, Portland, OR, 97239, USA
BMC Genomics 17:273. 2016..In addition, we used published RNAseq data to assess whether differentially methylated regions were linked to changes in gene expression...
- CREB signaling--timing is everythingS Impey
Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA
Sci STKE 2001:pe1. 2001..The continuing debate about the involvement of calmodulin kinase IV is also described...
- Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IVSoren Impey
The Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, L 474, Portland, OR 97201, USA
Neuron 34:235-44. 2002..Additionally, mutation of Ser301 impaired NMDA- and CaMKIV-stimulated transcription. These findings demonstrate that activity-induced CaMKIV signaling contributes to CREB/CBP-dependent transcription by phosphorylating CBP at Ser301...
- An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signalingSoren Impey
Oregon Stem Cell Center, Oregon Health and Science University, Portland, OR, USA
Mol Cell Neurosci 43:146-56. 2010..These data suggest that neuronal activity regulates spine formation, in part, by increasing miR132 transcription, which in turn activates a Rac1-Pak actin remodeling pathway...
- A histone deacetylase regulates addictionSoren Impey
Department of Cell and Developmental Biology, Oregon Health and Sciences University, Portland, OR 97239, USA
Neuron 56:415-7. 2007..In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine...
- Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regionsSoren Impey
Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
Cell 119:1041-54. 2004..A large fraction of the SACO loci delineated bidirectional promoters and novel antisense transcripts. This study represents the most comprehensive definition of transcription factor binding sites in a metazoan species...
- A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesisNgan Vo
Vollum Institute, Oregon Health and Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 102:16426-31. 2005..These data reveal that a CREB-regulated miRNA regulates neuronal morphogenesis by responding to extrinsic trophic cues...
- Cell-type-specific binding of the transcription factor CREB to the cAMP-response elementHyunjoo Cha-Molstad
Vollum Institute, Oregon Health and Sciences University, Portland, OR 97239, USA
Proc Natl Acad Sci U S A 101:13572-7. 2004..We conclude that the family of CREB target genes differs from one cell type to another and that the ability of CREB to bind to a particular CRE represents an important component of gene regulation...
- KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcriptionLiangqi Xie
Oregon Stem Cell Center, Department of Pediatrics, Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR, USA
EMBO J 30:1473-84. 2011..We propose that KDM5B activates self-renewal-associated gene expression by repressing cryptic initiation and maintaining an H3K4me3 gradient important for productive transcriptional elongation...
- The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulationAdam Lesiak
Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington 99164, Department of Molecular Biosciences, University of California, Davis, California 95616, and Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon 97239
J Neurosci 34:717-25. 2014..In light of recent evidence implicating miR132 dysregulation in Rett syndrome and schizophrenia, these findings identify NDL PCBs as potential environmental risk factors for neurodevelopmental disorders. ..
- Homeostatic regulation of MeCP2 expression by a CREB-induced microRNAMatthew E Klein
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
Nat Neurosci 10:1513-4. 2007..This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression...
- Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2Gary A Wayman
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Neuron 50:897-909. 2006..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
- An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAPGary A Wayman
Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
Proc Natl Acad Sci U S A 105:9093-8. 2008..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
- Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesisAmy S Farrell
Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, Oregon, USA
Mol Cell Biol 33:2930-49. 2013....
- Leptin induces hippocampal synaptogenesis via CREB-regulated microRNA-132 suppression of p250GAPMatasha Dhar
Department of Integrative Physiology and Neuroscience M D, M Z, T J L, T B, I N K, S M A, G A W, Program in Neuroscience, Washington State University, Pullman, Washington 99164 Oregon Stem Cell Center S I, Oregon Health and Sciences University, Portland, Oregon 97239 and Department of Neurophysiology T N, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033 Japan
Mol Endocrinol 28:1073-87. 2014....
- Role reversal: the regulation of neuronal gene expression by microRNAsMatthew E Klein
Reed College and Vollum Institute, Oregon Health and Sciences University, Portland OR, USA
Curr Opin Neurobiol 15:507-13. 2005..The combined actions of microRNAs and transcription factors are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone...
- CREB-mediated Bcl-2 protein expression after ischemic preconditioningRobert Meller
RS Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon 97232, USA
J Cereb Blood Flow Metab 25:234-46. 2005..H89, KN62, and U0126 reduced CREB activation and Bcl-2 expression. Taken together, these data suggest that after ischemic preconditioning CREB activation regulates the expression of the prosurvival protein Bcl-2...
- Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase IGary A Wayman
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3011, USA
J Neurosci 24:3786-94. 2004..These results identify CaMKI as a positive transducer of growth cone motility and axon outgrowth and provide a new physiological role for the CaMKK-CaMKI pathway...
- Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogrammingAnne E Powell
Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Stem Cell Center, Portland, Oregon, USA
Cancer Res 71:1497-505. 2011..As such, cell fusion may represent a promising novel mechanism underlying the metastatic conversion of cancer cells...
- Oxymetholone therapy of fanconi anemia suppresses osteopontin transcription and induces hematopoietic stem cell cyclingQing Shuo Zhang
Oregon Stem Cell Center, Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA Electronic address
Stem Cell Reports 4:90-102. 2015..These results expand our knowledge of the regulation of hematopoietic stem cell proliferation and have direct clinical implications for the treatment of bone marrow failure. ..
- Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding proteinD M Fass
Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA
J Biol Chem 276:2992-7. 2001..Thus, we propose that the C/EBP sites in the PEPCK promoter allow CREMalpha to activate transcription despite its lack of Q regions...
- Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawalTamara Z Shaw-Lutchman
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 22:3663-72. 2002..CRE-mediated transcription may itself contribute to re-establishing homeostasis in the organism through target gene regulation in these regions...
- cAMP response element-mediated gene expression in transgenic reporter gene mouse strainKarl Obrietan
Neuroscience Department, Ohio State University, Columbus, Ohio 43210, USA
Methods Enzymol 345:570-84. 2002
- Brain-derived neurotrophic factor protection of cortical neurons from serum withdrawal-induced apoptosis is inhibited by cAMPSteven Poser
Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
J Neurosci 23:4420-7. 2003..This study indicates that cAMP may inhibit some forms of neurotrophin-mediated neuronal survival and suggests that a number of PI3-kinase-regulated processes in neurons may be inhibited by cAMP...
- Patterned vision causes CRE-mediated gene expression in the visual cortex through PKA and ERKLaura Cancedda
Institute of Neuroscience of Consiglio Nazionale delle Ricerche, 56100 Pisa, Italy
J Neurosci 23:7012-20. 2003..Finally, because CRE-mediated gene expression was totally dependent on ERK activation, we suggest that PKA action on CRE-mediated gene expression is mediated by ERK...
- Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophinsJ Simon C Arthur
Medical Research Council Protein Phosphorylation Unit, MSI WTB complex, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
J Neurosci 24:4324-32. 2004..These results indicate that MSK1 is the major neurotrophin-activated Ser133 kinase in CNS neurons...
- Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133Boyoung Lee
Department of Neuroscience, The Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 25:1137-48. 2005..Together these data provide a framework to begin to understand how the neuroprotective and excitotoxic effects of NMDA receptor activity function in an antagonistic manner at the level of the CREB/CRE transcriptional pathway...
- Antioxidants modulate mitochondrial PKA and increase CREB binding to D-loop DNA of the mitochondrial genome in neuronsHoon Ryu
Geriatric Research Education and Clinical Center, Veteran s Affairs Medical Center, Bedford, MA 01730, USA
Proc Natl Acad Sci U S A 102:13915-20. 2005..These results suggest that the regulation of mitochondrial function via the mitochondrial PKA and CREB pathways may underlie some of the salutary effects of DFO in neurons...
- Hippocampal CRE-mediated gene expression is required for contextual memory formationJaime Athos
Department of Pharmacology, Box 357280, Health Sciences Building, University of Washington, Seattle, Washington 98195 7280, USA
Nat Neurosci 5:1119-20. 2002
- Epigenetic mechanisms and gene networks in the nervous systemChristine M Colvis
Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA
J Neurosci 25:10379-89. 2005
- Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulationSunita K Agarwal
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1802, USA
Neoplasia 9:101-7. 2007..These unbiased data also suggest that menin could play a broad role in transcriptional regulation...
- microRNA modulation of circadian-clock period and entrainmentHai Ying M Cheng
Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
Neuron 54:813-29. 2007..Collectively, these data reveal miRNAs as clock- and light-regulated genes and provide a mechanistic examination of their roles as effectors of pacemaker activity and entrainment...
- A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functionsStefanie J Otto
Howard Hughes Medical Institute, Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
J Neurosci 27:6729-39. 2007..Unexpectedly, genes considered exclusively non-neuronal also contained an RE1 motif and were expressed in neurons. This supports the model that REST binding is a critical determinant of neuronal phenotype...
- Regulation of CRE-mediated transcription in mouse brain by amphetamineTamara Z Shaw-Lutchman
Deparment of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
Synapse 48:10-7. 2003..This study identifies several brain regions where CRE-mediated transcription may play a key role in the development of neuronal plasticity associated with amphetamine administration...
- CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuliMichel Barrot
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 99:11435-40. 2002..This control appears to be independent of the intrinsic appetitive or aversive value of the stimulus. The potential relevance of these data to addiction and mood disorders is discussed...
- Regulation of CBP by Synaptic ActivitySoren Impey; Fiscal Year: 2005..This will be accomplished by conducting the above described research, attending and presenting at local and national seminars and meetings, and participating in courses teaching molecular biology and neurophysiology techniques. ..
- Genomic-wide Analysis of Oct 3/4 and Nanog TargetsSoren Impey; Fiscal Year: 2010..This set of studies will represent the most comprehensive analysis to date of the regulation of transcription factor binding in any metazoan system. ..