Kathleen Grant

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
  2. pmc Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration
    Kathleen A Grant
    Integrative Neuroscience Initiative on Alcoholism, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Alcohol Clin Exp Res 32:1824-38. 2008
  3. pmc Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys
    Kathleen A Grant
    Department of Behavioral Neuroscience, Oregon Health and Science University, Beaverton, OR 97006 6448, USA
    J Pharmacol Exp Ther 326:354-61. 2008
  4. pmc Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006 6448, USA
    J Pharmacol Exp Ther 331:142-52. 2009
  5. ncbi request reprint Impact of sex: determination of alcohol neuroadaptation and reinforcement
    Kristine M Wiren
    Oregon Health and Science University, VA Medical Center, Portland, Oregon 97239 2964, USA
    Alcohol Clin Exp Res 30:233-42. 2006
  6. pmc Gamma-hydroxybutyric acid in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Behav Pharmacol 19:317-24. 2008
  7. pmc Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors
    Nancy J Anderson
    Department of Physiology and Pharmacology and the Center for the Neurobehavioral Study for Alcohol, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 31:1061-70. 2007
  8. ncbi request reprint Advances in nonhuman primate alcohol abuse and alcoholism research
    Kathleen A Grant
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1083, USA
    Pharmacol Ther 100:235-55. 2003
  9. ncbi request reprint Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 30:1978-85. 2006
  10. ncbi request reprint Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis
    Priscilla Ivester
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Alcohol Clin Exp Res 31:144-55. 2007

Research Grants

  1. LIGAND GATED ION CHANNELS AND ETOH DISCRIMINATION
    Kathleen Grant; Fiscal Year: 2001
  2. DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL
    Kathleen Grant; Fiscal Year: 2004

Collaborators

Detail Information

Publications43

  1. pmc Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates
    Verginia C Cuzon Carlson
    Laboratory for Integrative Neuroscience, Section on Synaptic Pharmacology, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD, USA
    Neuropsychopharmacology 36:2513-28. 2011
    ..The resultant potential for increased putamen activation may underlie an alcohol-drinking phenotype of regulated drinking and sustained intoxication...
  2. pmc Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration
    Kathleen A Grant
    Integrative Neuroscience Initiative on Alcoholism, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Alcohol Clin Exp Res 32:1824-38. 2008
    ..g., flavored food). The induction schedule and ethanol polydipsia generated under these conditions affords the opportunity to investigate the development of drinking typologies that lead to chronic, excessive alcohol consumption...
  3. pmc Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys
    Kathleen A Grant
    Department of Behavioral Neuroscience, Oregon Health and Science University, Beaverton, OR 97006 6448, USA
    J Pharmacol Exp Ther 326:354-61. 2008
    ..0 g/kg). Furthermore, the discriminative stimulus effects of ethanol appear to be mediated by activity at binding sites that are particularly sensitive to 3alpha,5alpha-P...
  4. pmc Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes
    Christa M Helms
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, 97006 6448, USA
    J Pharmacol Exp Ther 331:142-52. 2009
    ..GABA(A) receptors with high affinity for Ro15-4513 (i.e., containing alpha(4/6) and alpha(5) subunits) may be particularly important mediators of the multiple discriminative stimulus effects of ethanol through GABA(A) receptor systems...
  5. ncbi request reprint Impact of sex: determination of alcohol neuroadaptation and reinforcement
    Kristine M Wiren
    Oregon Health and Science University, VA Medical Center, Portland, Oregon 97239 2964, USA
    Alcohol Clin Exp Res 30:233-42. 2006
    ..Devaud; (3) The Influence of Sex on Ethanol Consumption and Reward in C57BL/6 Mice, by Kimber L. Price and Lawrence D. Middaugh; and (4) Sex Differences in Alcohol Self-administration in Cynomolgus Monkeys, by Kathleen A. Grant...
  6. pmc Gamma-hydroxybutyric acid in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA
    Behav Pharmacol 19:317-24. 2008
    ..Furthermore, the data do not strongly support shared discriminative stimulus effects as the rationale for gamma-hydroxybutyric acid pharmacotherapy for alcoholism...
  7. pmc Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA(A) receptors
    Nancy J Anderson
    Department of Physiology and Pharmacology and the Center for the Neurobehavioral Study for Alcohol, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 31:1061-70. 2007
    ..Nonhuman primate models, particularly those employing long-term self-administration, are conceptually more similar to human alcoholic individuals...
  8. ncbi request reprint Advances in nonhuman primate alcohol abuse and alcoholism research
    Kathleen A Grant
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1083, USA
    Pharmacol Ther 100:235-55. 2003
    ....
  9. ncbi request reprint Ethanol-induced regulation of GABA-A subunit mRNAs in prefrontal fields of cynomolgus monkeys
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 30:1978-85. 2006
    ....
  10. ncbi request reprint Ethanol self-administration and alterations in the livers of the cynomolgus monkey, Macaca fascicularis
    Priscilla Ivester
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Alcohol Clin Exp Res 31:144-55. 2007
    ....
  11. pmc Long-term ethanol self-administration by cynomolgus macaques alters the pharmacology and expression of GABAA receptors in basolateral amygdala
    Donald W Floyd
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 311:1071-9. 2004
    ....
  12. pmc Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol
    Christa M Helms
    Department of Behavioral Neuroscience, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006 6448, USA
    Alcohol Clin Exp Res 32:1197-206. 2008
    ....
  13. ncbi request reprint Effects of chronic moderate alcohol consumption and novel environment on heart rate variability in primates (Macaca fascicularis)
    Carol A Shively
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Psychopharmacology (Berl) 192:183-91. 2007
    ..Although alcohol consumption often increases at times of stress, the interactive effects of stress and chronic moderate alcohol consumption on cardiac regulation have not been studied...
  14. ncbi request reprint Peripheral blood alpha-synuclein mRNA levels are elevated in cynomolgus monkeys that chronically self-administer ethanol
    Stephen J Walker
    Integrative Neuroscience Initiative on Alcoholism INIA Stress, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27156, USA
    Alcohol 38:1-4. 2006
    ....
  15. ncbi request reprint Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis)
    Carol A Shively
    Department of Pathology, Comparative Medicine Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychopharmacology (Berl) 165:1-8. 2002
    ..However, little is known about the chronic effects of moderate alcohol consumption. Alcohol, even in moderate doses, has immediate and robust effects on behavior...
  16. pmc Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys
    Glen Acosta
    Department of Physiology and Pharmacology, Wake Forest University, Winston Salem, NC 27157, USA
    Brain Res 1318:144-54. 2010
    ....
  17. ncbi request reprint Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys
    Carol A Shively
    Comparative Medicine Section, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 11:389-99. 2004
    ..To evaluate the effects of social subordination stress and chronic moderate alcohol consumption on indices of breast and endometrial cancer risk...
  18. ncbi request reprint The effects of moderate ethanol consumption on the liver of the monkey, Macaca fascicularis
    Priscilla Ivester
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1016, USA
    Alcohol Clin Exp Res 27:1831-7. 2003
    ....
  19. ncbi request reprint Discriminative stimulus effects of ethanol in mice lacking the gamma-aminobutyric acid type A receptor delta subunit
    Erin E Shannon
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Alcohol Clin Exp Res 28:906-13. 2004
    ....
  20. ncbi request reprint Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination
    Kari J Buck
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Alcohol Clin Exp Res 28:211-6. 2004
    ..Brodie; and (3) 5-HT(2C) Receptor Agonists in the Discriminative Stimulus Effects of Ethanol, by Laura M. Rogers, Ken Szeliga, and Kathleen Grant.
  21. pmc Nonhuman primate parthenogenetic stem cells
    Kent E Vrana
    Center for Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 100:11911-6. 2003
    ..These results suggest that stem cells derived from the parthenogenetically activated nonhuman primate egg provide a potential source for autologous cell therapy in the female and bypass the need for creating a competent embryo...
  22. ncbi request reprint Chronic ethanol exposure alters presynaptic dopamine function in the striatum of monkeys: a preliminary study
    Evgeny A Budygin
    Center for the Neurobehavioral Studies an Alcohol, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Synapse 50:266-8. 2003
  23. ncbi request reprint Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Nat Neurosci 5:169-74. 2002
    ..These data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction...
  24. ncbi request reprint Long versus short oligonucleotide microarrays for the study of gene expression in nonhuman primates
    Stephen J Walker
    Center for the Neurobehavioral Study of Alcohol, Wake Forest University School of Medicine, Winston Salem, NC 27101, USA
    J Neurosci Methods 152:179-89. 2006
    ....
  25. ncbi request reprint Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice
    Erin E Shannon
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157 1083, USA
    Alcohol 37:35-45. 2005
    ..NMDA receptor antagonism was suggested in the DBA/2J mice and may represent a heterogenous cue produced by the lower training dose of pregnanolone...
  26. ncbi request reprint Characterization of the discriminative stimulus effects of the neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice
    Erin E Shannon
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    J Pharmacol Exp Ther 314:675-85. 2005
    ..The present data suggest that many of the previously documented neurosteroid-induced behavioral differences between the DBA/2J and C57BL/6J are acute effects and are not apparent in a drug discrimination procedure...
  27. ncbi request reprint Long-acting depot formulation of luprolide acetate as a method of hypothalamic down regulation for controlled ovarian hyperstimulation and oocyte production in Macaca fascicularis
    April T Davenport
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Biol Reprod 68:2261-6. 2003
    ....
  28. pmc Quantification of ethanol methyl (1)H magnetic resonance signal intensity following intravenous ethanol administration in primate brain
    Graham S Flory
    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA
    Methods 50:189-98. 2010
    ..This methodology demonstrates the feasibility of ethanol MRS experiments and analysis in non-human primate subjects, and suggests GM may be a site of significant variation in ethanol MRS intensity between individuals...
  29. ncbi request reprint Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates
    W Breckinridge Carden
    Department Anatomical Sciences and Neurobiology, University of Louisville Health Sciences, Louisville, KY 40204, USA
    Brain Res 1089:92-100. 2006
    ..The T-type calcium current underlies burst responses in thalamic nuclei that are important to spindle propagation, and we recently observed that this current is sensitive to acute low doses of ethanol...
  30. ncbi request reprint Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes
    Daniel Goldowitz
    University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Alcohol Clin Exp Res 30:1066-78. 2006
    ..Jones and Tiffany A. Mathews; and (5) Defining Brain Region-Specific Gene Networks Relevant to Ethanol Behaviors, by Michael F. Miles and Robnet Kerns...
  31. ncbi request reprint Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination
    Clyde W Hodge
    Department of Psychiatry and Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 5679, USA
    Alcohol Clin Exp Res 30:203-13. 2006
    ....
  32. ncbi request reprint Characterization of the discriminative stimulus effects of N-methyl- D-aspartate ligands under different ethanol training conditions in the cynomolgus monkey ( Macaca fascicularis)
    Jeffrey A Vivian
    Present address Roche Bioscience, CNS Neurobehavior, 3401 Hillview Avenue, R2 101m, Palo Alto, CA 94304, USA
    Psychopharmacology (Berl) 162:273-81. 2002
    ..The current study was designed to extend our knowledge of the N-methyl- D-aspartate (NMDA) glutamate receptor system in mediating the discriminative stimulus effects of ethanol in non-human primates...
  33. ncbi request reprint Parthenogenetic stem cells in nonhuman primates
    Jose B Cibelli
    Advanced Cell Technology, One Innovation Drive, Worcester, MA 01605, USA
    Science 295:819. 2002
  34. ncbi request reprint Role of acetaldehyde in the discriminative stimulus effects of ethanol
    Etienne Quertemont
    Biologie du Comportement, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Alcohol Clin Exp Res 26:812-7. 2002
    ..However, a role for acetaldehyde in mediating the discriminative stimulus effects of ethanol remains unclear...
  35. ncbi request reprint Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice
    Keith L Shelton
    Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298 0613, USA
    Alcohol Clin Exp Res 26:747-57. 2002
    ..Examination of the discriminative stimulus effects of ethanol in B6 and D2 mouse strains may enhance our understanding of the relationship between the subjective effects of ethanol and other ethanol-induced behavioral effects...
  36. ncbi request reprint Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time
    Etienne Quertemont
    Laboratoire de Psychopharmacologie, Universite de Liege, Boulevard du Rectorat 5 B32, 4000, Liege, Belgium
    Psychopharmacology (Berl) 168:262-70. 2003
    ..The discriminative stimulus effects of ethanol are also time-dependent, although very few studies have investigated the time course of ethanol discriminations...
  37. ncbi request reprint Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis
    Patrizia Porcu
    Department of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Pharmacol Biochem Behav 84:618-27. 2006
    ..These data suggest that PREG responses to dexamethasone challenge may represent a trait marker of alcohol drinking. The lack of effect of ethanol on PREG levels suggests differential regulation in non-human primates vs. rodents...
  38. ncbi request reprint Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration
    Willard M Freeman
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, PO Box 850, Hershey, PA 17033 0850, USA
    Alcohol Alcohol 41:300-5. 2006
    ....
  39. ncbi request reprint Building bridges: the transdisciplinary study of craving from the animal laboratory to the lamppost
    Peter M Monti
    Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Alcohol Clin Exp Res 28:279-87. 2004
    ..Grant; (3) Craving and the Perception of Time, by Michael Sayette; (4) Ecological and Laboratory Assessment of Alcohol Urges and Drinking: Effects of Naltrexone, by Peter M. Monti; and (5) Discussion, by Damaris J. Rohsenow...
  40. ncbi request reprint Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys
    Patrizia Porcu
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, 27599 7178, USA
    Psychopharmacology (Berl) 186:293-301. 2006
    ..However, little data are available for male nonhuman primates...
  41. ncbi request reprint Neuroimaging of rodent and primate models of alcoholism: initial reports from the integrative neuroscience initiative on alcoholism
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences and Neuroscience Program, Stanford University School of Medicine, Stanford, California 94305 5723, USA
    Alcohol Clin Exp Res 29:287-94. 2005
    ....
  42. ncbi request reprint The role of acetaldehyde in the central effects of ethanol
    Etienne Quertemont
    Neuroscience Comportementale et Psychopharmacologie, University of Liege, Liege, Belgium
    Alcohol Clin Exp Res 29:221-34. 2005
    ..McBride, Zachary A. Rodd, Avram Goldstein, Alejandro Zaffaroni and Ting-Kai Li; and (5) Acetaldehyde increases dopaminergic transmission in the limbic system, by Milena Pisano and Marco Diana...
  43. pmc Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior
    A Leslie Morrow
    Department of Psychiatry, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7178, USA
    Dialogues Clin Neurosci 8:463-77. 2006
    ..Neurosteroids may have therapeutic use in alcohol withdrawal or for relapse prevention...

Research Grants2

  1. LIGAND GATED ION CHANNELS AND ETOH DISCRIMINATION
    Kathleen Grant; Fiscal Year: 2001
    ..These findings will suggest variables that determine the effectiveness of pharmacological agents to block ethanol's stimulus effects, and may suggest the appropriate receptor system(s) to target. ..
  2. DISCRIMINATIVE STIMULUS EFFECTS OF ETHANOL
    Kathleen Grant; Fiscal Year: 2004
    ..4) To characterize the 5-HT1D and 5-HT2C modulation of the discriminative stimulus effects of ethanol. ..