Willard M Freeman

Summary

Affiliation: Oregon Health and Science University
Country: USA

Publications

  1. ncbi request reprint Changes in rat frontal cortex gene expression following chronic cocaine
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Brain Res Mol Brain Res 104:11-20. 2002
  2. ncbi request reprint An interactive database of cocaine-responsive gene expression
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    ScientificWorldJournal 2:701-6. 2002
  3. ncbi request reprint Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem NC 27157 1083, USA
    Neurochem Res 27:1181-92. 2002
  4. ncbi request reprint Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats
    Travis J Worst
    Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    J Neurosci Res 80:529-38. 2005
  5. ncbi request reprint Manganese-induced cytotoxicity in dopamine-producing cells
    Denise L Stredrick
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 25:543-53. 2004
  6. ncbi request reprint Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity
    Alan H Stokes
    Department of Physiology and Pharmacology, Center for Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:675-84. 2002
  7. ncbi request reprint Functional genomic analysis in pain research using hybridization arrays
    Stephen J Walker
    Center for the Neurobiological Investigation of Drug Abuse and Neurobehavioral Study of Alcohol, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Med 99:239-53. 2004
  8. ncbi request reprint Systematic screening of gene expression using a cDNA macroarray
    Travis J Worst
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Med 79:243-59. 2003
  9. ncbi request reprint Use of microarray technologies in toxicology research
    Kent E Vrana
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 27157 1083, Winston Salem, NC, USA
    Neurotoxicology 24:321-32. 2003
  10. pmc Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration
    Willard M Freeman
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Neuropsychopharmacology 33:1807-17. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Changes in rat frontal cortex gene expression following chronic cocaine
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Brain Res Mol Brain Res 104:11-20. 2002
    ..This study also validates the use of hybridization arrays for screening of neuronal gene expression changes and the utility of relative protein quantification as a post-hoc confirmation tool...
  2. ncbi request reprint An interactive database of cocaine-responsive gene expression
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    ScientificWorldJournal 2:701-6. 2002
    ..Furthermore, this method of organizing large volumes of scientific information can easily be adapted to assist researchers in fields outside of drug abuse...
  3. ncbi request reprint Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem NC 27157 1083, USA
    Neurochem Res 27:1181-92. 2002
    ..These changes share commonalities and exhibit differences with previous reports of gene expression changes in the frontal cortex after noncontingent cocaine administration...
  4. ncbi request reprint Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats
    Travis J Worst
    Center for the Neurobehavioral Study of Alcohol, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    J Neurosci Res 80:529-38. 2005
    ..Such alterations, however, might not be a universal characteristic of all animal models of alcohol abuse and will also require further investigation in post-mortem human samples...
  5. ncbi request reprint Manganese-induced cytotoxicity in dopamine-producing cells
    Denise L Stredrick
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 25:543-53. 2004
    ..In conclusion, DA content was not responsible for the enhanced sensitivity of CATH.a cells to Mn toxicity, but oxidative stress was implicated as a probable mechanism of cytotoxicity...
  6. ncbi request reprint Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity
    Alan H Stokes
    Department of Physiology and Pharmacology, Center for Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neurotoxicology 23:675-84. 2002
    ..Other genes that displayed changes, but that have not been subjected to post-hoc confirmation, include clusterin (increased), ubiquitin (increased), CD27 ligand (increased), CD27BP (increased), and rac-PK-beta (decreased)...
  7. ncbi request reprint Functional genomic analysis in pain research using hybridization arrays
    Stephen J Walker
    Center for the Neurobiological Investigation of Drug Abuse and Neurobehavioral Study of Alcohol, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Med 99:239-53. 2004
    ..The experimental description in this chapter explains, in detail, how to perform a hybridization array using the macroarray platform...
  8. ncbi request reprint Systematic screening of gene expression using a cDNA macroarray
    Travis J Worst
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Methods Mol Med 79:243-59. 2003
  9. ncbi request reprint Use of microarray technologies in toxicology research
    Kent E Vrana
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, 27157 1083, Winston Salem, NC, USA
    Neurotoxicology 24:321-32. 2003
    ....
  10. pmc Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration
    Willard M Freeman
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Neuropsychopharmacology 33:1807-17. 2008
    ..This incubation is accompanied by changes in gene expression that persist long after cessation of drug administration and may be regulated by chromatin remodeling...
  11. pmc Alterations in ionotropic glutamate receptor subunits during binge cocaine self-administration and withdrawal in rats
    Wenxue Tang
    Department of Pharmacology, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    J Neurochem 89:1021-33. 2004
    ..Because subunit composition determines the functional properties of iGluRs, the observed changes may indicate alterations in the excitability of dopamine transmission underlying long-term biochemical and behavioral effects of cocaine...
  12. doi request reprint Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior
    KARA L KUNTZ
    Department of Pharmacology, Pennsylvania State University College of Medicine, R130, 500 University Drive, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 90:349-56. 2008
    ..These latter observations of persistent changes in gene expression following abstinence may reflect molecular correlates of relapse liability...
  13. pmc Proteomics for protein expression profiling in neuroscience
    Willard M Freeman
    Department of Pharmacology, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    Neurochem Res 29:1065-81. 2004
    ..Although there are many challenges in proteomic neuroscience, this field promises many rewards in the future...
  14. ncbi request reprint Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration
    Willard M Freeman
    Department of Pharmacology, H078, Penn State College of Medicine, 500 University Drive, PO Box 850, Hershey, PA 17033 0850, USA
    Alcohol Alcohol 41:300-5. 2006
    ....
  15. ncbi request reprint Depletion of abundant proteins from non-human primate serum for biomarker studies
    Willard M Freeman
    Department of Pharmacology H078, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Proteomics 6:3109-13. 2006
    ..Depleted serum also demonstrated greater sensitivity for previously masked, lower-abundance proteins...