Sean M Bugel

Summary

Affiliation: Oregon State University
Country: USA

Publications

  1. pmc Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, and the Sinnhuber Aquatic Research Laboratory
    Toxicol Sci 154:55-68. 2016
  2. pmc Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, OR 97331, United States Electronic address
    Toxicol Appl Pharmacol 296:31-41. 2016
  3. pmc Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, United States Electronic address
    Aquat Toxicol 152:222-31. 2014
  4. doi request reprint Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio)
    Sean M Bugel
    Department of Environmental Sciences, Rutgers, The State University of New Jersey, New Brunswick, 08901, United States
    Aquat Toxicol 126:1-8. 2013
  5. pmc Optimizing multi-dimensional high throughput screening using zebrafish
    Lisa Truong
    Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA
    Reprod Toxicol 65:139-147. 2016
  6. pmc Decreased vitellogenin inducibility and 17β-estradiol levels correlated with reduced egg production in killifish (Fundulus heteroclitus) from Newark Bay, NJ
    Sean M Bugel
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, United States
    Aquat Toxicol 105:1-12. 2011
  7. doi request reprint Impaired reproductive health of killifish (Fundulus heteroclitus) inhabiting Newark Bay, NJ, a chronically contaminated estuary
    Sean M Bugel
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, United States
    Aquat Toxicol 96:182-93. 2010
  8. pmc PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression
    Carrie E Jantzen
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, New Brunswick, NJ, USA Electronic address
    Aquat Toxicol 175:160-70. 2016

Collaborators

Detail Information

Publications8

  1. pmc Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, and the Sinnhuber Aquatic Research Laboratory
    Toxicol Sci 154:55-68. 2016
    ..This integrative zebrafish platform provides a useful framework for evaluating flavonoid developmental toxicity and hazard prioritization...
  2. pmc Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Sinnhuber Aquatic Research Laboratory, Oregon State University, Corvallis, OR 97331, United States Electronic address
    Toxicol Appl Pharmacol 296:31-41. 2016
    ..These studies help advance our understanding of tamoxifen's non-classical mode of action and implicate a possible role for MMPs in tissues such as skin...
  3. pmc Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes
    Sean M Bugel
    Department of Environmental and Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97331, United States Electronic address
    Aquat Toxicol 152:222-31. 2014
    ....
  4. doi request reprint Inhibition of vitellogenin gene induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by aryl hydrocarbon receptor 2 (AHR2) in zebrafish (Danio rerio)
    Sean M Bugel
    Department of Environmental Sciences, Rutgers, The State University of New Jersey, New Brunswick, 08901, United States
    Aquat Toxicol 126:1-8. 2013
    ..This work provides evidence for AHR2 dependent cross-talk inhibition of vitellogenin genes and offers insight into anti-estrogenic reproductive effects observed in oviparous species exposed to AHR agonist contaminants...
  5. pmc Optimizing multi-dimensional high throughput screening using zebrafish
    Lisa Truong
    Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA
    Reprod Toxicol 65:139-147. 2016
    ..Adaptation of these better practices for zebrafish HTS should increase reproducibility across laboratories...
  6. pmc Decreased vitellogenin inducibility and 17β-estradiol levels correlated with reduced egg production in killifish (Fundulus heteroclitus) from Newark Bay, NJ
    Sean M Bugel
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, United States
    Aquat Toxicol 105:1-12. 2011
    ..These studies demonstrate that contaminants within Newark Bay exert both estrogenic and anti-estrogenic responses which results in an overtly anti-estrogenic phenotype (reduced egg production due to inhibition of vitellogenesis)...
  7. doi request reprint Impaired reproductive health of killifish (Fundulus heteroclitus) inhabiting Newark Bay, NJ, a chronically contaminated estuary
    Sean M Bugel
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, United States
    Aquat Toxicol 96:182-93. 2010
    ..Similar effects on the reproductive development in less resilient species may limit their ability to repopulate the NY-NJ Harbor Estuary and similarly contaminated water systems...
  8. pmc PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression
    Carrie E Jantzen
    Rutgers, The State University of New Jersey, Department of Environmental Sciences, New Brunswick, NJ, USA Electronic address
    Aquat Toxicol 175:160-70. 2016
    ..PFOS, PFNA, and PFOA exposure resulted in significantly altered responses in terms of morphometric, locomotion, and gene expression endpoints, which could be manifested in field exposed teleosts. ..