- Identification of a small-molecule entry inhibitor for filovirusesArnab Basu
Microbiotix, Inc, One Innovation Drive, Worcester, MA 01605, USA
J Virol 85:3106-19. 2011..In summary, we have identified a novel series of benzodiazepine compounds that are suitable for optimization as potential inhibitors of filoviral infection...
- New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusionArnab Basu
Microbiotix Inc, Worcester, Massachusetts, USA
J Virol 88:1447-60. 2014..Therefore, MBX2329 and MBX2546 represent new starting points for chemical optimization and have the potential to provide valuable future therapeutic options and research tools to study the HA-mediated entry process...
- Novel Small Molecule Entry Inhibitors of Ebola VirusArnab Basu
Microbiotix, Inc, Worcester, Massachusetts
J Infect Dis 212:S425-34. 2015..We report the identification of 2 novel EBOV inhibitors targeting viral entry...
- High-throughput screening of viral entry inhibitors using pseudotyped virusArnab Basu
Microbiotix, Worcester, Massachusetts, USA
Curr Protoc Pharmacol . 2010..This unit includes protocols for preparing pseudotyped viruses using lentiviral vectors and use of pseudotyped viruses for high-throughput screening of viral entry inhibitors...
- Identification of HCV E1 an E2 InhibitorsArnab Basu; Fiscal Year: 2006..The most promising compound will advance to IND-enabling toxicology and pharmacology studies in two species (Phase III). [unreadable] [unreadable]..
- Identification of Ebola Virus Entry InhibitorsArnab Basu; Fiscal Year: 2007..Prioritize screening hits based on spectrum, cytotoxicity and mechanism. The end result of Phase 1 work will be identification of hits specific for EBOV entry inhibition. [unreadable] [unreadable] [unreadable]..