Shu Xiao

Summary

Affiliation: Old Dominion University
Country: USA

Publications

  1. doi request reprint Subnanosecond electric pulses cause membrane permeabilization and cell death
    Shu Xiao
    Frank Reidy Research Center for Bioelectrics, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23529, USA
    IEEE Trans Biomed Eng 58:1239-45. 2011
  2. pmc Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Cell Calcium 54:145-50. 2013
  3. pmc Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Arch Biochem Biophys 527:55-64. 2012
  4. pmc Electroporation-induced electrosensitization
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 6:e17100. 2011
  5. pmc Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability
    Stephen J Beebe
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 7:e51349. 2012
  6. pmc Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Biochim Biophys Acta 1828:981-9. 2013
  7. doi request reprint Nanosecond pulse electric field (nanopulse): a novel non-ligand agonist for platelet activation
    Jue Zhang
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Arch Biochem Biophys 471:240-8. 2008
  8. pmc Ion transport into cells exposed to monopolar and bipolar nanosecond pulses
    Karl H Schoenbach
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA Electronic address
    Bioelectrochemistry 103:44-51. 2015
  9. pmc Cancellation of cellular responses to nanoelectroporation by reversing the stimulus polarity
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Suite 300, Norfolk, VA, 23508, USA
    Cell Mol Life Sci 71:4431-41. 2014
  10. pmc Cell permeabilization and inhibition of voltage-gated Ca(2+) and Na(+) channel currents by nanosecond pulsed electric field
    Vasyl Nesin
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Bioelectromagnetics 33:394-404. 2012

Collaborators

Detail Information

Publications22

  1. doi request reprint Subnanosecond electric pulses cause membrane permeabilization and cell death
    Shu Xiao
    Frank Reidy Research Center for Bioelectrics, Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA 23529, USA
    IEEE Trans Biomed Eng 58:1239-45. 2011
    ..This means that the cell membrane behaves like a rectifying diode. This increase in membrane conductance is a nonthermal process, since the temperature rise due to the pulsing is negligible...
  2. pmc Recruitment of the intracellular Ca2+ by ultrashort electric stimuli: the impact of pulse duration
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Cell Calcium 54:145-50. 2013
    ..We conclude that nanosecond stimuli mimic Ca2+ signaling while bypassing the usual receptor- and channels-mediated cascades. The recruitment of the intracellular Ca2+ can be controlled by the duration of the stimulus...
  3. pmc Oxidative effects of nanosecond pulsed electric field exposure in cells and cell-free media
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Arch Biochem Biophys 527:55-64. 2012
    ..Therefore, bioeffects of nsPEF are not limited to electropermeabilization; concurrent ROS formation may lead to cell stimulation and/or oxidative cell damage...
  4. pmc Electroporation-induced electrosensitization
    Olga N Pakhomova
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 6:e17100. 2011
    ..No studies have accounted for the biological consequences of electroporation as a factor that alters the cell's susceptibility to forthcoming EPs...
  5. pmc Transient features in nanosecond pulsed electric fields differentially modulate mitochondria and viability
    Stephen J Beebe
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 7:e51349. 2012
    ....
  6. pmc Primary pathways of intracellular Ca(2+) mobilization by nanosecond pulsed electric field
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Biochim Biophys Acta 1828:981-9. 2013
    ..NsPEF stimulation may serve as a unique method to mobilize [Ca(2+)](i) and activate downstream cascades while bypassing the plasma membrane receptors...
  7. doi request reprint Nanosecond pulse electric field (nanopulse): a novel non-ligand agonist for platelet activation
    Jue Zhang
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Arch Biochem Biophys 471:240-8. 2008
    ..We conclude that nsPEFs dose-dependently cause platelets to rapidly aggregate, like other platelet agonists, and this is most likely initiated by the nsPEFs increasing [Ca2+]i, however by a different mechanism...
  8. pmc Ion transport into cells exposed to monopolar and bipolar nanosecond pulses
    Karl H Schoenbach
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA Electronic address
    Bioelectrochemistry 103:44-51. 2015
    ..The measured calcium ion uptake obtained with bipolar pulses also allowed us to determine the membrane pore recovery time. The calculated recovery time constants are on the order of 10 μs...
  9. pmc Cancellation of cellular responses to nanoelectroporation by reversing the stimulus polarity
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Suite 300, Norfolk, VA, 23508, USA
    Cell Mol Life Sci 71:4431-41. 2014
    ..Cancellation impacts nsEP applications in cancer therapy, electrostimulation, and biotechnology, and provides new insights into effects of more complex waveforms, including pulsed electromagnetic emissions. ..
  10. pmc Cell permeabilization and inhibition of voltage-gated Ca(2+) and Na(+) channel currents by nanosecond pulsed electric field
    Vasyl Nesin
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Bioelectromagnetics 33:394-404. 2012
    ..The causal relation of nsPEF inhibitory effects on VG currents and permeabilization of the plasma membrane is discussed...
  11. pmc Manipulation of cell volume and membrane pore comparison following single cell permeabilization with 60- and 600-ns electric pulses
    Olena M Nesin
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Biochim Biophys Acta 1808:792-801. 2011
    ..For both the 60- and 600-ns exposures, cell volume changes were determined by pores smaller than 0.9 nm in diameter; however, the diameter increased with increasing the nsEP intensity...
  12. pmc Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes
    P Thomas Vernier
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Norfolk, VA, 23508, USA
    J Membr Biol 248:837-47. 2015
    ....
  13. pmc Cell stimulation and calcium mobilization by picosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA
    Bioelectrochemistry 105:65-71. 2015
    ..06 K per psEP), or membrane depolarization by opening of VG Na(+) channels...
  14. pmc Diffuse, non-polar electropermeabilization and reduced propidium uptake distinguish the effect of nanosecond electric pulses
    Iurii Semenov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Biochim Biophys Acta 1848:2118-25. 2015
    ..In a stark contrast, nsEP evoked a "supra-electroporation" pattern of slower but spatially uniform Ca2+ entry. Thus nsEP and msEP had comparable dose efficiency, but differed profoundly in the size and localization of electropores...
  15. pmc Ablation of Myocardial Tissue With Nanosecond Pulsed Electric Fields
    Fei Xie
    Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, United States of America
    PLoS ONE 10:e0144833. 2015
    ..We demonstrate that ablation with nanosecond pulsed electric fields (nsPEFs) can potentially overcome these limitations...
  16. pmc Multiple nanosecond electric pulses increase the number but not the size of long-lived nanopores in the cell membrane
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Biochim Biophys Acta 1848:958-66. 2015
    ..The constant YP/Pr influx ratio for trains of 5 to 100 pulses suggests that increasing the number of pulses permeabilizes cells to a greater extent by increasing the pore number and not the pore diameter. ..
  17. pmc Disassembly of actin structures by nanosecond pulsed electric field is a downstream effect of cell swelling
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, USA Electronic address
    Bioelectrochemistry 100:88-95. 2014
    ..We conclude that disintegration of the actin cytoskeleton was a result of cell swelling, which, in turn, was caused by cell permeabilization by nsPEF and transmembrane diffusion of solutes which led to the osmotic imbalance...
  18. doi request reprint Model study of time-dependent muscle response to pulsed electrical stimulation
    Ravindra P Joshi
    Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, Virginia, USA
    Bioelectromagnetics 31:361-70. 2010
    ..Other possibilities such as calcium release at nerve end endings also exist. It is also proposed that multipulsing strategies and changing the electric field direction by using multielectrode systems would be useful...
  19. pmc Electrosensitization assists cell ablation by nanosecond pulsed electric field in 3D cultures
    Claudia Muratori
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Sci Rep 6:23225. 2016
    ..The results suggest that engaging electrosensitization may assist in vivo cancer ablation by reducing the voltage or number of pulses required, or by enabling larger inter-electrode distances without losing the ablation efficiency. ..
  20. ncbi request reprint Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF)
    Andrei G Pakhomov
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, Virginia, USA
    Bioelectromagnetics 28:655-63. 2007
    ..The phenomenon of long-lived membrane permeabilization provides new insights on the nature of nsPEF-opened conductance pores and on molecular mechanisms that underlie nsPEF bioeffects...
  21. pmc Electroporation of mammalian cells by nanosecond electric field oscillations and its inhibition by the electric field reversal
    Elena C Gianulis
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA
    Sci Rep 5:13818. 2015
    ..Instead, the data indicate that the electric field polarity reversals reduced the pore yield...
  22. doi request reprint Scaling of surface-plasma reactors with a significantly increased energy density for NO conversion
    Muhammad Arif Malik
    Frank Reidy Research Center for Bioelectrics, Old Dominion University, 4211 Monarch Way, Suite 300, Norfolk, VA 23508, USA
    J Hazard Mater 209:293-8. 2012
    ..02 L/J in both the shielded and unshielded cases...