Scott A Kelly

Summary

Affiliation: Ohio Wesleyan University
Country: USA

Publications

  1. doi request reprint Effects of activity, genetic selection, and their interaction on muscle metabolic capacities and organ masses in mice
    Scott A Kelly
    Department of Biology, University of California, Riverside, Riverside, California 92521, USA
    J Exp Biol . 2017
  2. pmc Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Schimmel Conrades Science Center 346, 61 S Sandusky St, Delaware, OH, 43015, USA
    J Negat Results Biomed 14:13. 2015
  3. pmc Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Delaware, Ohio
    Physiol Genomics 46:593-601. 2014
  4. doi request reprint Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running
    Scott A Kelly
    Ohio Wesleyan University, Schimmel Conrades Science Center 346, 61 S Sandusky Street, Delaware, OH 43015, USA
    Exp Physiol 99:403-13. 2014
  5. doi request reprint Phenotypic plasticity: molecular mechanisms and adaptive significance
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Compr Physiol 2:1417-39. 2012
  6. pmc Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain
    Scott A Kelly
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Genetics 191:643-54. 2012
  7. pmc Fine mapping of "mini-muscle," a recessive mutation causing reduced hindlimb muscle mass in mice
    John Hartmann
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hered 99:679-87. 2008
  8. pmc Genetic architecture of voluntary exercise in an advanced intercross line of mice
    Scott A Kelly
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Rd, Chapel Hill, NC 27599 7264, USA
    Physiol Genomics 42:190-200. 2010
  9. pmc How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels
    Theodore Garland
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Biol Sci 278:574-81. 2011
  10. pmc Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Physiol Genomics 43:199-212. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint Effects of activity, genetic selection, and their interaction on muscle metabolic capacities and organ masses in mice
    Scott A Kelly
    Department of Biology, University of California, Riverside, Riverside, California 92521, USA
    J Exp Biol . 2017
    ..e., "more pain, more gain"). For hematocrit and large intestine length, differences were not related to amount of wheel running and instead indicate inherently greater adaptive plasticity in HR lines...
  2. pmc Maternal exercise before and during pregnancy does not impact offspring exercise or body composition in mice
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Schimmel Conrades Science Center 346, 61 S Sandusky St, Delaware, OH, 43015, USA
    J Negat Results Biomed 14:13. 2015
    ..Additionally, we examined the effects of ~6 weeks of maternal exercise (prior to and during gestation) on offspring exercise levels at ~9 weeks of age...
  3. pmc Quantitative genomics of voluntary exercise in mice: transcriptional analysis and mapping of expression QTL in muscle
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Delaware, Ohio
    Physiol Genomics 46:593-601. 2014
    ..We discuss three plausible candidate genes (Insig2, Prcp, Sparc) and their potential regulatory role. ..
  4. doi request reprint Exercise training effects on hypoxic and hypercapnic ventilatory responses in mice selected for increased voluntary wheel running
    Scott A Kelly
    Ohio Wesleyan University, Schimmel Conrades Science Center 346, 61 S Sandusky Street, Delaware, OH 43015, USA
    Exp Physiol 99:403-13. 2014
    ..We tentatively conclude that exercise 'training' alters respiratory behaviours, but these changes may not be necessary to achieve high levels of wheel running...
  5. doi request reprint Phenotypic plasticity: molecular mechanisms and adaptive significance
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Compr Physiol 2:1417-39. 2012
    ..Finally, we highlight examples of phenotypic plasticity from a human health perspective and underscore the use of mouse models as a powerful tool in understanding the genetic architecture of phenotypic plasticity...
  6. pmc Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain
    Scott A Kelly
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Genetics 191:643-54. 2012
    ..These results develop a potential initial model of the underlying functional genomic architecture of predisposition to voluntary exercise and its effects on body weight and composition within a neurophysiological framework...
  7. pmc Fine mapping of "mini-muscle," a recessive mutation causing reduced hindlimb muscle mass in mice
    John Hartmann
    Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hered 99:679-87. 2008
    ..Identification of the genetic variation that underlies MM could potentially be very important in understanding both normal muscle function and disregulation of muscle physiology leading to disease...
  8. pmc Genetic architecture of voluntary exercise in an advanced intercross line of mice
    Scott A Kelly
    Department of Genetics, University of North Carolina at Chapel Hill, 120 Mason Farm Rd, Chapel Hill, NC 27599 7264, USA
    Physiol Genomics 42:190-200. 2010
    ....
  9. pmc How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels
    Theodore Garland
    Department of Biology, University of California, Riverside, CA 92521, USA
    Proc Biol Sci 278:574-81. 2011
    ..These results demonstrate that uniform selection on a complex trait can cause consistent responses in the trait under direct selection while promoting divergence in the lower-level components of that trait...
  10. pmc Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Physiol Genomics 43:199-212. 2011
    ..Finally, we present unique QTL providing insight regarding variation in weight loss and reduction in adiposity in response to exercise...
  11. pmc Parent-of-origin effects on voluntary exercise levels and body composition in mice
    Scott A Kelly
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599 7264, USA
    Physiol Genomics 40:111-20. 2010
    ..e., X-linked or mtDNA variations), epigenetic (i.e., genomic imprinting), and environmental (i.e., in utero environment or maternal care) phenomena potentially modulating these effects...
  12. pmc Exercise and diet affect quantitative trait loci for body weight and composition traits in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Physiol Genomics 44:1141-53. 2012
    ..It was concluded that the indirect effects of these QTLs provide an underlying genetic basis for the considerable variability in weight or fat loss typically found among individuals on the same diet and/or exercise regimen...
  13. doi request reprint Phenotypic effects of the "mini-muscle" allele in a large HR x C57BL/6J mouse backcross
    Robert M Hannon
    Department of Biology, University of California, Riverside, CA 92521, USA
    J Hered 99:349-54. 2008
    ....
  14. pmc Glycogen storage and muscle glucose transporters (GLUT-4) of mice selectively bred for high voluntary wheel running
    Fernando R Gomes
    Department of Biology, University of California, Riverside, CA 92521, USA
    J Exp Biol 212:238-48. 2009
    ..All mice showed some glycogen depletion during nightly wheel running, in muscles and/or liver, but the magnitude of this depletion was not large and hence does not seem to be limiting to the evolution of even-higher wheel running...
  15. pmc Quantitative trait loci for bone mineral density and femoral morphology in an advanced intercross population of mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Bone 55:222-9. 2013
    ..Several QTLs showed significant interactions with sex, although only two QTLs interacted with diet, both affecting only mice fed the high-fat diet...
  16. pmc A novel intronic single nucleotide polymorphism in the myosin heavy polypeptide 4 gene is responsible for the mini-muscle phenotype characterized by major reduction in hind-limb muscle mass in mice
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Delaware, Ohio 43015
    Genetics 195:1385-95. 2013
    ..Using next-generation sequencing, our approach can be extended to identify causative mutations arising in mouse inbred lines and thus offers a great avenue to overcome one of the most challenging steps in quantitative genetics. ..
  17. ncbi request reprint Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice
    Scott A Kelly
    Department of Biology, University of California, Riverside, Riverside, 92521, USA
    J Morphol 267:360-74. 2006
    ..First, no differences were found in the MT/F ratio (the classic indicator of cursoriality). Second, we did not find a significant interaction between linetype and wheel access for any trait, despite the higher running rate of S mice...
  18. doi request reprint Mice from lines selectively bred for high voluntary wheel running exhibit lower blood pressure during withdrawal from wheel access
    Erik M Kolb
    Department of Biology, University of California, Riverside, CA 92521, USA
    Physiol Behav 112:49-55. 2013
    ..This is the first characterization of a cardiovascular withdrawal response in an animal model of high voluntary exercise...
  19. ncbi request reprint Effects of size, sex, and voluntary running speeds on costs of locomotion in lines of laboratory mice selectively bred for high wheel-running activity
    Enrico L Rezende
    Department of Biology, University of California, Riverside, CA, 92521, USA
    Physiol Biochem Zool 79:83-99. 2006
    ..Our results highlight how differences in size and running speed can account for lower COT in S lines and suggest that lower COT may have coadapted in response to selection for higher running distances in these lines...
  20. ncbi request reprint Phenotypic plasticity and experimental evolution
    Theodore Garland
    Department of Biology, University of California, Riverside, Riverside, CA 92521, USA
    J Exp Biol 209:2344-61. 2006
    ..We suggest that any selection experiment in which the selective event is more than instantaneous should explore whether plasticity in the appropriate (adaptive) direction has increased as a component of the response to selection...
  21. pmc Long-term exercise in mice has sex-dependent benefits on body composition and metabolism during aging
    Rachel C McMullan
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
    Physiol Rep 4:. 2016
    ..g. sex, age) modulating these effects. These findings will facilitate studies on relationships between exercise and health in aging populations, including genetic predisposition and genotype-by-environment interactions...
  22. doi request reprint Selective breeding as a tool to probe skeletal response to high voluntary locomotor activity in mice
    KEVIN M MIDDLETON
    Department of Biology, California State University San Bernardino, San Bernardino, CA 92507, USA
    Integr Comp Biol 48:394-410. 2008
    ..Based on previously observed differences in distributions of myosin isoforms in adult MM mice, we hypothesize that a reduction of myosin heavy-chain type-IIb isoforms with accounts for our observed ontogenetic changes in muscle mass...
  23. pmc Genetic determinants of voluntary exercise
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Delaware, OH 43015, USA
    Trends Genet 29:348-57. 2013
    ..Finally, we explore potential regulation of physical activity through epigenetic mechanisms, including those that persist across multiple generations...
  24. doi request reprint The 'Omics' of Voluntary Exercise: Systems Approaches to a Complex Phenotype
    Scott A Kelly
    Department of Zoology, Ohio Wesleyan University, Delaware, OH 43015, USA
    Trends Endocrinol Metab 26:673-5. 2015
    ..Here, we discuss murine systems approaches, focusing on 'omics', relevant to revealing the architecture of voluntary activity. ..
  25. doi request reprint Advances in comparative genetics: influence of genetics on obesity
    Wendy Foulds Mathes
    Department of Genetics, University of North Carolina at Chapel Hill, NC, USA
    Br J Nutr 106:S1-10. 2011
    ..Knowledge obtained from advances in mouse models will inform human health and provide insight into inter-individual variability in the aetiology of obesity-related diseases...