Lei Wang

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1155-67. 2016
  2. pmc Integrated cortical structural marker for Alzheimer's disease
    Jing Ming
    Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, USA Electronic address
    Neurobiol Aging 36:S53-9. 2015
  3. pmc Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type
    Lei Wang
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611
    Alzheimer Dis Assoc Disord 26:314-21. 2012
  4. pmc Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Biol Psychiatry 64:1060-8. 2008
  5. pmc Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arch Neurol 67:99-106. 2010
  6. pmc Fully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Hippocampus 19:541-8. 2009
  7. pmc Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia
    Matthew J Smith
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, USA
    Schizophr Res 131:174-83. 2011
  8. pmc Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit
    Matthew P Schroeder
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Learn Mem 23:161-8. 2016
  9. pmc Cortical thickness in neuropsychologically near-normal schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario St, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 133:68-76. 2011
  10. pmc Thalamic morphology in schizophrenia and schizoaffective disorder
    Matthew J Smith
    Departments of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 1000, Chicago, IL 60611, United States
    J Psychiatr Res 45:378-85. 2011

Collaborators

Detail Information

Publications28

  1. pmc SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1155-67. 2016
    ..It is our hope that SchizConnect can facilitate testing new hypotheses through aggregated datasets, promoting discovery related to the mechanisms underlying schizophrenic dysfunction...
  2. pmc Integrated cortical structural marker for Alzheimer's disease
    Jing Ming
    Biomedical Engineering, University of Illinois at Chicago, Chicago, IL, USA Electronic address
    Neurobiol Aging 36:S53-9. 2015
    ....
  3. pmc Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type
    Lei Wang
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611
    Alzheimer Dis Assoc Disord 26:314-21. 2012
    ..The present study was conducted to assess the relationship between CSF Aβ and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the Alzheimer type...
  4. pmc Progressive deformation of deep brain nuclei and hippocampal-amygdala formation in schizophrenia
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Biol Psychiatry 64:1060-8. 2008
    ..Progressive decreases in cortical gray matter volume have been reported in schizophrenia. However, studies of progressive change in deep brain nuclei and hippocampal-amygdala formation have not yielded consistent findings...
  5. pmc Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Arch Neurol 67:99-106. 2010
    ..To compare longitudinal changes in the hippocampal structure in subjects with very mild dementia of the Alzheimer type (DAT) treated with donepezil hydrochloride, untreated subjects with very mild DAT, and controls without dementia...
  6. pmc Fully-automated, multi-stage hippocampus mapping in very mild Alzheimer disease
    Lei Wang
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Hippocampus 19:541-8. 2009
    ..Some direct comparisons of the two procedures are also presented...
  7. pmc Alcohol use disorders contribute to hippocampal and subcortical shape differences in schizophrenia
    Matthew J Smith
    Northwestern University Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL 60611, USA
    Schizophr Res 131:174-83. 2011
    ..However, the neurobiological basis of this co-morbid interaction is unknown. The aim of this study was to determine the relationship of co-morbid alcohol use disorder (AUD) with brain structure abnormalities in schizophrenia patients...
  8. pmc Pretrial functional connectivity differentiates behavioral outcomes during trace eyeblink conditioning in the rabbit
    Matthew P Schroeder
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Learn Mem 23:161-8. 2016
    ..Online analysis of network fluctuations has the potential to be used as the basis for therapeutic interventions to facilitate learning and memory. ..
  9. pmc Cortical thickness in neuropsychologically near-normal schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario St, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 133:68-76. 2011
    ..While generally supportive of distinct etiological processes for cognitive subtypes, results provide direction for further examination of additional neuroanatomical differences...
  10. pmc Thalamic morphology in schizophrenia and schizoaffective disorder
    Matthew J Smith
    Departments of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, 446 East Ontario Street, Suite 1000, Chicago, IL 60611, United States
    J Psychiatr Res 45:378-85. 2011
    ..In this study, we examine whether individuals with schizoaffective disorder have a pattern of thalamic deformation that is similar or different to the pattern found in individuals with schizophrenia...
  11. pmc Longitudinal progression of frontal and temporal lobe changes in schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario, Suite 7 100, Chicago, IL 60611, USA
    Schizophr Res 139:1-6. 2012
    ..Maintenance of neuropsychological performance and clinical stability in the face of changing neuroanatomical structure suggests the involvement of alternative compensatory mechanisms...
  12. pmc Cannabis-related working memory deficits and associated subcortical morphological differences in healthy individuals and schizophrenia subjects
    Matthew J Smith
    To whom correspondence should be addressed Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, 13th Floor, Abbott Hall, Chicago, IL 60611, US tel 1 312 503 2542, fax 1 312 503 0527, E mail
    Schizophr Bull 40:287-99. 2014
    ..Future longitudinal studies could help determine whether cannabis use contributes to these observed shape differences or whether they are biomarkers of a vulnerability to the effects of cannabis that predate its misuse. ..
  13. pmc Intrinsic connectivity of neural networks in the awake rabbit
    Matthew P Schroeder
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward Building 7 140, Chicago, IL 60611, USA Electronic address
    Neuroimage 129:260-7. 2016
    ..g., temporary or permanent network disruption, learning-related changes, and drug administration). ..
  14. pmc Lower Total and Regional Grey Matter Brain Volumes in Youth with Perinatally-Acquired HIV Infection: Associations with HIV Disease Severity, Substance Use, and Cognition
    C Paula Lewis-De Los Angeles
    Northwestern University Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL
    Brain Behav Immun . 2017
    ....
  15. pmc Cannabis-related episodic memory deficits and hippocampal morphological differences in healthy individuals and schizophrenia subjects
    Matthew J Smith
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Hippocampus 25:1042-51. 2015
    ....
  16. pmc Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD
    Katherine Reiter
    Department of Psychiatry and Behavioral Sciences, Northwestern University, Feinberg School of Medicine, Chicago, IL 60614, USA
    Neuroimage 61:525-32. 2012
    ..These results suggest that as AD offspring age, cortical atrophy is more prominent, particularly if the parent with AD is mother or if the AD offspring is female...
  17. pmc Symmetric abnormalities in sulcal patterning in schizophrenia
    John G Csernansky
    Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, 446 E Ontario Suite 7 200, Chicago, IL 60611, USA
    Neuroimage 43:440-6. 2008
    ..In individuals with schizophrenia, sulcal depth in the left hemisphere was correlated with the severity of impaired performance on tests of working memory and executive function...
  18. pmc Structural pathology underlying neuroendocrine dysfunction in schizophrenia
    Morris B Goldman
    Northwestern University, Department of Psychiatry, 446 East Ontario, Suite 7 100, Chicago, IL 60611, United States
    Behav Brain Res 218:106-13. 2011
    ..The relationship of these findings to the underlying mental illness remains to be established...
  19. pmc The Northwestern University Neuroimaging Data Archive (NUNDA)
    Kathryn Alpert
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1131-6. 2016
    ..NUNDA can be integrated with other research databases to simplify data exploration and discovery. And data on NUNDA can be confidently shared for secure collaboration. ..
  20. pmc Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub
    Katherine D Blizinsky
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611
    Proc Natl Acad Sci U S A 113:8520-5. 2016
    ..Pharmacological targeting of ERK reversed dendritic alterations associated with dp/+ neurons, outlining a strategy for the analysis and reversal of cellular phenotypes in CNV-related psychiatric disorders. ..
  21. pmc Progressive deterioration of thalamic nuclei relates to cortical network decline in schizophrenia
    Derin J Cobia
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario, Suite 7 100, Chicago, IL 60611, USA Electronic address
    Schizophr Res 180:21-27. 2017
    ..Overall, findings revealed a pattern of persistent progressive abnormalities in thalamic nuclei that relate to advancing cortical decline in schizophrenia, but not with measures of behavior...
  22. pmc Cortical thickness of neural substrates supporting cognitive empathy in individuals with schizophrenia
    Suena H Massey
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, 446 E Ontario, Suite 7 100, Chicago, IL 60611, USA Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N Saint Clair Street, 19th Floor, Chicago, IL 60611, USA
    Schizophr Res 179:119-124. 2017
    ..As cognitive empathy is impaired in schizophrenia, we examined whether reduced cortical thickness in these regions was associated with poorer cognitive empathy in this population...
  23. pmc Reduced prefrontal activation during working and long-term memory tasks and impaired patient-reported cognition among cancer survivors postchemotherapy compared with healthy controls
    Lei Wang
    Division of Clinical Psychology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
    Cancer 122:258-68. 2016
    ..The objective of this study was to demonstrate that cancer-related cognitive impairments are associated with the under recruitment of brain regions involved in working and recognition memory compared with controls...
  24. pmc A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness
    Theron A Russell
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Commun 5:4858. 2014
    ..These data suggest that single amino acid changes in proteins involved in dendritic spine function can have significant effects on the structure and function of the cerebral cortex. ..
  25. pmc Activity-induced manganese-dependent MRI (AIM-MRI) and functional MRI in awake rabbits during somatosensory stimulation
    Matthew P Schroeder
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Ward Building 7 140, Chicago, IL 60611, USA Electronic address
    Neuroimage 126:72-80. 2016
    ....
  26. doi request reprint Northwestern University schizophrenia data sharing for SchizConnect: A longitudinal dataset for large-scale integration
    Alex Kogan
    Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Electronic address
    Neuroimage 124:1196-201. 2016
    ..xnat.org/). With the creation of SchizConnect, we were able to link NUSDAST to other neuroimaging data sources and create a powerful, federated neuroimaging resource. ..
  27. pmc White matter microstructure among youth with perinatally acquired HIV is associated with disease severity
    Kristina A Uban
    aDepartment of Pediatrics, Children s Hospital Los Angeles, Los Angeles, California bCenter for Biostatistics in AIDS Research, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts cFeinberg School of Medicine, Northwestern University, Chicago, Illinois dDepartment of Neurosciences, Division of Pediatric Neurology, University of California San Diego, La Jolla eKeck School of Medicine, University of Southern California, Los Angeles, California, USA
    AIDS 29:1035-44. 2015
    ..We investigated whether HIV disease severity was associated with alterations in structural brain connectivity, and whether those alterations in turn were associated with cognitive deficits in youth with perinatally acquired HIV (PHIV)...