Lewis J Smith

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Serum adiponectin is positively associated with lung function in young adults, independent of obesity: the CARDIA study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55455, USA
    Respir Res 11:176. 2010
  2. pmc Longitudinal association of body mass index with lung function: the CARDIA study
    Bharat Thyagarajan
    Dept of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    Respir Res 9:31. 2008
  3. pmc Spirometry guidelines influence lung function results in a longitudinal study of young adults
    Lewis J Smith
    Northwestern University, Chicago, IL 60611, USA
    Respir Med 104:858-64. 2010
  4. ncbi request reprint Comparative efficacy of inhaled corticosteroids and antileukotriene drugs in asthma
    L J Smith
    Northwestern University, Office of Clinical Research and Training, Division of Pulmonary and Critical Care Medicine, 710 N Lake Shore Drive, Chicago, IL 60611, USA
    BioDrugs 15:239-49. 2001
  5. ncbi request reprint Dietary intake of soy genistein is associated with lung function in patients with asthma
    Lewis J Smith
    Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    J Asthma 41:833-43. 2004
  6. doi request reprint Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial
    Lewis J Smith
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    JAMA 313:2033-43. 2015
  7. pmc Systemic inflammation in young adults is associated with abnormal lung function in middle age
    Ravi Kalhan
    Asthma Chronic Obstructive Pulmonary Disease Program, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e11431. 2010
  8. pmc Low serum adiponectin predicts future risk for asthma in women
    Akshay Sood
    Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center, School of Medicine, Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    Am J Respir Crit Care Med 186:41-7. 2012
  9. pmc Effect of obesity on asthma phenotype is dependent upon asthma severity
    Stacy Raviv
    Department of Pulmonary and Critical Care Medicine, NorthShore University Health System, Evanston, IL, USA
    J Asthma 48:98-104. 2011
  10. pmc Risk factors for montelukast treatment failure in step-down therapy for controlled asthma
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Asthma 48:1051-7. 2011

Collaborators

Detail Information

Publications23

  1. pmc Serum adiponectin is positively associated with lung function in young adults, independent of obesity: the CARDIA study
    Bharat Thyagarajan
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota Minneapolis, MN 55455, USA
    Respir Res 11:176. 2010
    ..Adipose tissue produces adiponectin, an anti-inflammatory protein. Adiponectin deficiency in mice is associated with abnormal post-natal alveolar development...
  2. pmc Longitudinal association of body mass index with lung function: the CARDIA study
    Bharat Thyagarajan
    Dept of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
    Respir Res 9:31. 2008
    ..Lung function at the end of life depends on its peak and subsequent decline. Because obesity is epidemic in young adulthood, we quantified age-related changes in lung function relative to body mass index (BMI)...
  3. pmc Spirometry guidelines influence lung function results in a longitudinal study of young adults
    Lewis J Smith
    Northwestern University, Chicago, IL 60611, USA
    Respir Med 104:858-64. 2010
    ..Epidemiology studies initiated before adoption of the 1987 American Thoracic Society (ATS) guidelines typically used a 1 or 2 s plateau on the volume-time curve, not a minimum test duration of 6 s, to terminate a test...
  4. ncbi request reprint Comparative efficacy of inhaled corticosteroids and antileukotriene drugs in asthma
    L J Smith
    Northwestern University, Office of Clinical Research and Training, Division of Pulmonary and Critical Care Medicine, 710 N Lake Shore Drive, Chicago, IL 60611, USA
    BioDrugs 15:239-49. 2001
    ..Antileukotriene drugs should be considered as add-on therapy, especially in view of their possible complementary effects on reducing airway inflammation...
  5. ncbi request reprint Dietary intake of soy genistein is associated with lung function in patients with asthma
    Lewis J Smith
    Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    J Asthma 41:833-43. 2004
    ..Thus, increasing consumption of genistein is associated with better lung function in patients with asthma. Further studies are needed to determine whether dietary supplementation with genistein can reduce asthma severity...
  6. doi request reprint Effect of a soy isoflavone supplement on lung function and clinical outcomes in patients with poorly controlled asthma: a randomized clinical trial
    Lewis J Smith
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
    JAMA 313:2033-43. 2015
    ..Some data suggest that supplementation with soy isoflavone may be an effective treatment for patients with poor asthma control...
  7. pmc Systemic inflammation in young adults is associated with abnormal lung function in middle age
    Ravi Kalhan
    Asthma Chronic Obstructive Pulmonary Disease Program, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e11431. 2010
    ..Whether systemic inflammation in healthy young adults is associated with future impairment in lung health is uncertain...
  8. pmc Low serum adiponectin predicts future risk for asthma in women
    Akshay Sood
    Division of Pulmonary and Critical Care Medicine, University of New Mexico Health Sciences Center, School of Medicine, Department of Medicine, University of New Mexico, Albuquerque, NM 87131, USA
    Am J Respir Crit Care Med 186:41-7. 2012
    ..However, it is not known if serum adiponectin predicts future development of asthma or if asthma affects subsequent serum adiponectin concentrations among women...
  9. pmc Effect of obesity on asthma phenotype is dependent upon asthma severity
    Stacy Raviv
    Department of Pulmonary and Critical Care Medicine, NorthShore University Health System, Evanston, IL, USA
    J Asthma 48:98-104. 2011
    ..Understanding how obesity affects asthmatics of differing severity can provide insights into the pathogenesis of asthma in the obese and a rationale for the therapeutic approach to such patients...
  10. pmc Risk factors for montelukast treatment failure in step-down therapy for controlled asthma
    M Bradley Drummond
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Asthma 48:1051-7. 2011
    ..Because some patients fail montelukast step-down therapy, it would be helpful for clinicians to be able to predict the risk of treatment failure...
  11. pmc A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis
    R Kalhan
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Clin Exp Allergy 38:103-12. 2008
    ..Dietary intake of the soy isoflavone genistein is associated with reduced severity of asthma, but the mechanisms responsible for this effect are unknown...
  12. doi request reprint Pulmonary hypertension in advanced chronic obstructive pulmonary disease
    Randy Orr
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, USA
    Curr Opin Pulm Med 18:138-43. 2012
    ..The purpose of this review is to summarize some exciting findings from the last several years that address these holes in our knowledge...
  13. ncbi request reprint A risk-benefit assessment of antileukotrienes in asthma
    L J Smith
    Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Drug Saf 19:205-18. 1998
    ..The exact role of the antileukotrienes in the treatment of asthma remains to be determined, as does the relative potency of the various agents...
  14. pmc Right heart structural changes are independently associated with exercise capacity in non-severe COPD
    Michael J Cuttica
    Pulmonary Hypertension Program, Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 6:e29069. 2011
    ..Data regarding the functional consequence of PH in less severe COPD are limited. Whether echocardiographic evidence of right sided heart pathology is associated with functional outcomes in patients with non-severe COPD is unknown...
  15. pmc Lung function in young adults predicts airflow obstruction 20 years later
    Ravi Kalhan
    Northwestern University, Chicago, IL 60611, USA
    Am J Med 123:468.e1-7. 2010
    ..To determine in a prospective cohort of generally healthy young adults the influence of early adult lung function on the presence of airflow obstruction in middle age...
  16. ncbi request reprint The role of platelet-activating factor in asthma
    L J Smith
    Department of Medicine, Northwestern University, Chicago, IL 60611
    Am Rev Respir Dis 143:S100-2. 1991
    ..Finally, identification of the basis for the variable response to PAF in normal subjects and in patients with asthma should provide further insight into PAF's mechanism of action and the pathogenesis of asthma and airway hyperreactivity...
  17. doi request reprint Prospective measurements of intra-abdominal volume and pulmonary function after repair of massive ventral hernias with the components separation technique
    Sonya P Agnew
    Division of Plastic and Reconstructive Surgery, Department of Radiation Oncology, Northwestern University, Evanston, IL, USA
    Ann Surg 251:981-8. 2010
    ..To assess the effect of components separation on abdominal volume and pulmonary function after repair of hernias with loss of domain...
  18. doi request reprint Diet and asthma
    Stacy Raviv
    Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Pulm Med 16:71-6. 2010
    ....
  19. ncbi request reprint The bronchoconstrictor properties of platelet-activating factor in humans
    A H Rubin
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois
    Am Rev Respir Dis 136:1145-51. 1987
    ..Finally, PAF sensitized the airways of all normal subjects to methacholine, including the one PAF nonresponder (p less than 0.02), but it did not sensitize the airways of the asthmatic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)..
  20. ncbi request reprint Effects of inhaled leukotriene D4 and platelet-activating factor on airway reactivity in normal subjects
    M G Kaye
    Department of Medicine, Northwestern University, Chicago, Illinois
    Am Rev Respir Dis 141:993-7. 1990
    ..After inhaling LTD4, six of eight subjects also developed increased airway reactivity, which was maximal at 7 days and persisted for 14 days in two.(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. ncbi request reprint Inhibition of leukotriene D4-induced bronchoconstriction in normal subjects by the oral LTD4 receptor antagonist ICI 204,219
    L J Smith
    Department of Medicine, Northwestern University, Chicago, IL 60611
    Am Rev Respir Dis 141:988-92. 1990
    ..83, p less than 0.001), but imperfectly within groups. No adverse effects (symptoms or abnormal laboratory test results) were noted after ingesting the drug.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint Randomized comparison of strategies for reducing treatment in mild persistent asthma
    Stephen P Peters
    Wake Forest University, Winston Salem, NC, USA
    N Engl J Med 356:2027-39. 2007
    ....
  23. ncbi request reprint Effect of obesity on clinical presentation and response to treatment in asthma
    Anne E Dixon
    University of Vermont, Burlington, VT 05401, USA
    J Asthma 43:553-8. 2006
    ..Obese and non-obese asthmatics have similar lung function abnormalities, but comorbidities and altered responses to medications may significantly affect asthma control in obese people...