Tanya Simuni

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?
    Tanya Simuni
    Northwestern University Feinberg School of Medicine, United States Electronic address
    Parkinsonism Relat Disord 28:62-7. 2016
  2. pmc Rankin scale as a potential measure of global disability in early Parkinson's disease
    Tanya Simuni
    Northwestern University Feinberg School of Medicine, Abbott Hall 11th Floor, 710 North Lake Shore Drive, Chicago, IL 60611, USA
    J Clin Neurosci 20:1200-3. 2013
  3. doi request reprint Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation study
    Tanya Simuni
    Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Mov Disord 25:2863-6. 2010
  4. doi request reprint Treatment of early Parkinson's disease. Part 2
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill, USA
    Eur Neurol 61:206-15. 2009
  5. doi request reprint Treatment of early Parkinson's disease. Part 1
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill 60611, USA
    Eur Neurol 61:193-205. 2009
  6. doi request reprint Nonmotor manifestations of Parkinson's disease
    Tanya Simuni
    Department of Neurology, Northwestern University, Chicago, IL, USA
    Ann Neurol 64:S65-80. 2008
  7. ncbi request reprint Somnolence and other sleep disorders in Parkinson's disease: the challenge for the practicing neurologist
    Tanya Simuni
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Feinberg School of Medicine, Northwestern University, 675 North St Clair Street, Suite 20 100, Chicago, IL 60611, USA
    Neurol Clin 22:S107-26. 2004
  8. doi request reprint Perturbations of ground support alter posture and locomotion coupling during step initiation in Parkinson's disease
    Mark W Rogers
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Exp Brain Res 208:557-67. 2011
  9. pmc Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mov Disord 24:1162-9. 2009
  10. pmc Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease
    Aleksandar Videnovic
    Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Northwestern University, Chicago, Illinois
    JAMA Neurol 71:463-9. 2014

Detail Information

Publications40

  1. doi request reprint How stable are Parkinson's disease subtypes in de novo patients: Analysis of the PPMI cohort?
    Tanya Simuni
    Northwestern University Feinberg School of Medicine, United States Electronic address
    Parkinsonism Relat Disord 28:62-7. 2016
    ..To determine the frequency and stability over time of the subgroup characterization of the tremor dominant (TD) versus postural instability gait disorder dominant (PIGD) Parkinson's disease (PD) in de novo patients...
  2. pmc Rankin scale as a potential measure of global disability in early Parkinson's disease
    Tanya Simuni
    Northwestern University Feinberg School of Medicine, Abbott Hall 11th Floor, 710 North Lake Shore Drive, Chicago, IL 60611, USA
    J Clin Neurosci 20:1200-3. 2013
    ..The sensitivity of the mRS to change and performance of the scale in more advanced PD will have to be established longitudinally...
  3. doi request reprint Tolerability of isradipine in early Parkinson's disease: a pilot dose escalation study
    Tanya Simuni
    Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Mov Disord 25:2863-6. 2010
    ..The two most common reasons for dose reduction were leg edema (7) and dizziness (3). There was no difference in isradipine tolerability between subjects with and without dopaminergic treatment, or with and without hypertension...
  4. doi request reprint Treatment of early Parkinson's disease. Part 2
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill, USA
    Eur Neurol 61:206-15. 2009
    ..Part 2 of the article, presented here, reviews key data relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms...
  5. doi request reprint Treatment of early Parkinson's disease. Part 1
    Tanya Simuni
    Department of Neurology, Northwestern University, Parkinson s Disease and Movement Disorders Center, Chicago, Ill 60611, USA
    Eur Neurol 61:193-205. 2009
    ..Safety and tolerability data are also reviewed. Part 2 of the article reviews key findings relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms...
  6. doi request reprint Nonmotor manifestations of Parkinson's disease
    Tanya Simuni
    Department of Neurology, Northwestern University, Chicago, IL, USA
    Ann Neurol 64:S65-80. 2008
    ..This article reviews depression, sleep, and autonomic dysfunction in PD...
  7. ncbi request reprint Somnolence and other sleep disorders in Parkinson's disease: the challenge for the practicing neurologist
    Tanya Simuni
    Parkinson s Disease and Movement Disorders Center, Department of Neurology, Feinberg School of Medicine, Northwestern University, 675 North St Clair Street, Suite 20 100, Chicago, IL 60611, USA
    Neurol Clin 22:S107-26. 2004
  8. doi request reprint Perturbations of ground support alter posture and locomotion coupling during step initiation in Parkinson's disease
    Mark W Rogers
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Exp Brain Res 208:557-67. 2011
    ..Moreover, impaired step initiation in PD may at least acutely be enhanced by augmenting the coupling between posture and locomotion...
  9. pmc Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mov Disord 24:1162-9. 2009
    ....
  10. pmc Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease
    Aleksandar Videnovic
    Neurological Clinical Research Institute, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts2Department of Neurology, Northwestern University, Chicago, Illinois
    JAMA Neurol 71:463-9. 2014
    ..However, surprisingly little is known regarding circadian function in PD and whether circadian dysfunction is involved in the development of sleep-wake disturbances in PD...
  11. doi request reprint Short-term effects of posture-assisted step training on rapid step initiation in Parkinson's disease
    Marie Laure Mille
    Department of Physical Therapy, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Neurol Phys Ther 33:88-95. 2009
    ..Ground reaction forces and step kinematics were recorded...
  12. pmc Rate-dependent impairments in repetitive finger movements in patients with Parkinson's disease are not due to peripheral fatigue
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurosci Lett 482:1-6. 2010
    ....
  13. doi request reprint A longitudinal program for biomarker development in Parkinson's disease: a feasibility study
    Bernard Ravina
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Mov Disord 24:2081-90. 2009
    ..The PostCEPT cohort and associated studies strongly support the feasibility of the LABS-PD approach of retaining and repurposing clinical trial cohorts to collect longitudinal clinical and biomarker data...
  14. pmc Amantadine for freezing of gait in patients with Parkinson disease
    Roneil Malkani
    Department of Neurology, Northwestern University, Chicago, IL, USA
    Clin Neuropharmacol 35:266-8. 2012
    ..Treatment studies of levodopa and selegiline have shown limited benefit for FOG. Limited data suggest that amantadine, an N-methyl-D-aspartate receptor antagonist, may be beneficial for FOG in PD...
  15. doi request reprint Brain donation--what do patients with movement disorders know and how do they feel about it?
    Teresa Kuhta
    Parkinson s Disease and Movement Disorders Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Parkinsonism Relat Disord 17:204-7. 2011
    ..We advocate proactive education of patients with various movement disorders about the purpose and benefits of brain donation...
  16. pmc Implicit perceptual-motor skill learning in mild cognitive impairment and Parkinson's disease
    Eric W Gobel
    Interdepartmental Neuroscience Program, Northwestern University, Evanston, IL, USA
    Neuropsychology 27:314-21. 2013
    ..Patients with Parkinson's disease (PD) often exhibit impaired sequence learning, but this impairment is not universally observed...
  17. ncbi request reprint Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's disease
    Andrew Siderowf
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA
    Mov Disord 21:746-53. 2006
    ..01). In this selected group of patients, many of the short-term gains in HRQL persist beyond 18 months after STN implantation. Benefits in nonmotor aspects of HRQL such as bodily discomfort and stigma appear to be among the most durable...
  18. pmc Correlates of excessive daytime sleepiness in de novo Parkinson's disease: A case control study
    Tanya Simuni
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Mov Disord 30:1371-81. 2015
    ..This study was undertaken to determine the frequency and correlates of excessive daytime sleepiness in de novo, untreated Parkinson's disease (PD) patients compared with the matched healthy controls...
  19. pmc The effects of Parkinson's disease and age on syncopated finger movements
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Brain Res 1290:12-20. 2009
    ....
  20. doi request reprint Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease
    Steven R Schwid
    Department of Neurology, University of Rochester, Rochester, New York, USA
    Mov Disord 25:1801-8. 2010
    ..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted...
  21. pmc A recommended scale for cognitive screening in clinical trials of Parkinson's disease
    Kelvin L Chou
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 5316, USA
    Mov Disord 25:2501-7. 2010
    ..Widespread adoption of a single instrument such as the MoCA in clinical trials can improve comparability between research studies on PD...
  22. doi request reprint A review of the clinical evidence for complementary and alternative therapies in Parkinson's disease
    Danny Bega
    Northwestern University Feinberg School of Medicine, 710 N Lake Shore Drive, 11th Floor, Chicago, IL, 60611, USA
    Curr Treat Options Neurol 16:314. 2014
    ....
  23. doi request reprint Altered premotor cortical oscillations during repetitive movement in persons with Parkinson's disease
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA Depart of Kinesiology, Iowa State University, Ames, IA, 50011, USA Electronic address
    Behav Brain Res 317:141-146. 2017
    ....
  24. doi request reprint Motor cortical oscillations are abnormally suppressed during repetitive movement in patients with Parkinson's disease
    Elizabeth L Stegemoller
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA Department of Kinesiology, Iowa State University, Ames, IA 50011, USA Electronic address
    Clin Neurophysiol 127:664-74. 2016
    ..This study examined the effects of movement rate and medication on movement-related cortical oscillations in persons with PD...
  25. pmc Diffusion tensor imaging of Parkinson's disease, atypical parkinsonism, and essential tremor
    Janey Prodoehl
    Physical Therapy Program, Midwestern University, Downers Grove, Illinois, USA
    Mov Disord 28:1816-22. 2013
    ....
  26. doi request reprint Piloting the NPF data-driven quality improvement initiative
    Michael S Okun
    National Parkinson Foundation Center of Excellence, University of Florida, Movement Disorders Center, McKnight Brain Institute, Department of Neurology, Gainesville, FL 32611, USA
    Parkinsonism Relat Disord 16:517-21. 2010
    ..To pilot a data-driven quality care program in National Parkinson Foundation (NPF) Centers of Excellence...
  27. doi request reprint A computerized survey of pain in Parkinson's disease patients: A pilot feasibility study
    David B Page
    Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA
    Parkinsonism Relat Disord 16:139-41. 2010
    ..PAINReportIt was feasible as a data-collection modality among our PD cohort, and with modifications may be used as both an investigative instrument and clinical tool for the evaluation of PD-related pain syndromes...
  28. ncbi request reprint Regular Exercise, Quality of Life, and Mobility in Parkinson's Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data
    Miriam R Rafferty
    Center for Education in Health Sciences Northwestern University, Chicago, IL, USA
    J Parkinsons Dis . 2016
    ..Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD)...
  29. ncbi request reprint Acute effects of a lateral postural assist on voluntary step initiation in patients with Parkinson's disease
    Marie Laure Mille
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mov Disord 22:20-7. 2007
    ..001), and the speed of the first step became faster for PD subjects. Postural assistance affecting the interaction between posture and locomotion may have therapeutic potential for improving movement function in patients with PD...
  30. doi request reprint Laughter is the best medicine: The Second City® improvisation as an intervention for Parkinson's disease
    Danny Bega
    Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA Electronic address
    Parkinsonism Relat Disord . 2016
    ..Expressive therapies are increasingly incorporated into the management of Parkinson's disease (PD), although there are little objective data assessing their benefits...
  31. doi request reprint Neuro-QoL health-related quality of life measurement system: Validation in Parkinson's disease
    Cindy J Nowinski
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Mov Disord 31:725-33. 2016
    ..We present results of Neuro-QoL clinical validation using a sample of PD patients...
  32. doi request reprint Predictors of Functional Decline in Early Parkinson's Disease: NET-PD LS1 Cohort
    Danny Bega
    Northwestern University, Chicago, IL, USA
    J Parkinsons Dis 5:773-82. 2015
    ..Data on predictors of decline in PD are largely based on de-novo populations and limited to the use of motor outcomes that fail to capture the full scope of disease...
  33. doi request reprint Is There a Role for DAT-SPECT Imaging in a Specialty Movement Disorders Practice?
    Danny Bega
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Neurodegener Dis 15:81-6. 2015
    ..Analyze indications for ordering DAT-SPECT scans and the clinical impact of scan results on patients evaluated in a movement disorders practice...
  34. doi request reprint Cost of deep brain stimulation for the treatment of Parkinson's disease by surgical stimulation sites
    Kevin T Stroupe
    Hines VA Hospital, Center for Management of Complex Chronic Healthcare, Hines, Illinois, USA Loyola University Stritch School of Medicine, Maywood, Illinois, USA
    Mov Disord 29:1666-74. 2014
    ....
  35. doi request reprint Parkinson's disease medication use and costs following deep brain stimulation
    Frances M Weaver
    Hines VA Hospital, Center for Management of Complex Chronic Care, Hines, Illinois 60141, USA
    Mov Disord 27:1398-403. 2012
    ..However, cumulative medication costs over 36 months were lower for the STN than for GPi patients. PD medication use and costs decreased following DBS in either target over 36 months, but cumulative costs were less for STN than for GPi...
  36. ncbi request reprint Pathways mediating abnormal intracortical inhibition in Parkinson's disease
    Colum D MacKinnon
    Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann Neurol 58:516-24. 2005
    ..These findings show that the low threshold inhibitory pathways mediating SICI are normal in PD. The suppression of SICI observed at higher CSIs suggests that the threshold of intracortical facilitatory pathways is decreased in PD...
  37. ncbi request reprint Bilateral stimulation of the subthalamic nucleus in patients with Parkinson disease: a study of efficacy and safety
    Tanya Simuni
    Parkinson s Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, USA
    J Neurosurg 96:666-72. 2002
    ..The present study was designed to investigate the safety and efficacy of bilateral stimulation of the STN for the treatment of PD...
  38. ncbi request reprint Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findings
    George J Counelis
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 18:1062-5. 2003
    ....
  39. pmc Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
    Arch Neurol 65:716-23. 2008
    ..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD...
  40. ncbi request reprint Long-term outcomes of bilateral subthalamic nucleus stimulation in patients with advanced Parkinson's disease
    Grace S Liang
    The Parkinson s Institute, Sunnyvale, CA, USA
    Stereotact Funct Neurosurg 84:221-7. 2006
    ..However, the long-term benefits of DBS are not yet established...