Affiliation: Northwestern University
- Clinical manifestations and pathogenesis of hydroxyapatite crystal deposition in juvenile dermatomyositisLauren M Pachman
Molecular and Cellular Pathobiology Program, The Children s Memorial Research Center, Chicago, IL 60614, USA
Curr Rheumatol Rep 8:236-43. 2006..This paper discusses the influence of inflammation on the deposition of hydroxyapatite, with emphasis on the clinical and environmental factors that may facilitate the formation of calcific deposits in JDM...
- Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositisYi Wen Chen
Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
BMC Immunol 9:43. 2008....
- Ovarian teratoma mimicking features of juvenile dermatomyositis in a childMaria Ibarra
Division of Rheumatology, Children s Memorial Hospital, Chicago, IL 60614, USA
Pediatrics 128:e1293-6. 2011..Pelvic ultrasound confirmed a solid mass of the left ovary consistent with a mature teratoma. After surgical removal of the teratoma, the myositis, synovitis, and cutaneous findings resolved over 4 months without further therapy...
- Composition of calcifications in children with juvenile dermatomyositis: association with chronic cutaneous inflammationLauren M Pachman
Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
Arthritis Rheum 54:3345-50. 2006..This study was undertaken to define the structure and composition of these deposits and to characterize their association with chronic inflammation...
- History of infection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research RegistryLauren M Pachman
The Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60614, USA
Arthritis Rheum 53:166-72. 2005..To obtain data concerning a history of infection occurring in the 3 months before recognition of the typical weakness and rash associated with juvenile dermatomyositis (JDM)...
- Duration of illness is an important variable for untreated children with juvenile dermatomyositisLauren M Pachman
Department of Pediatrics, Division of Immunology Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
J Pediatr 148:247-53. 2006..To evaluate the impact of duration of untreated symptoms in children with juvenile dermatomyositis (JDM) on clinical and laboratory status at diagnosis...
- Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapyTimothy B Niewold
University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
Arthritis Rheum 60:1815-24. 2009..The aim of this study was to examine serum IFNalpha activity in a cohort of children with juvenile DM to determine relationships between IFNalpha and indicators of disease activity and severity...
- MxA gene expression in juvenile dermatomyositis peripheral blood mononuclear cells: association with muscle involvementKevin A O'Connor
Molecular and Cellular Pathobiology Program, Children s Memorial Research Center, Box 212, Chicago, IL 60614, USA
Clin Immunol 120:319-25. 2006..During the course of clinically effective treatment, decrease in muscle symptoms was associated with a decrease in PBMC MxA mRNA expression...
- Juvenile dermatomyositis calcifications selectively displayed markers of bone formationAnnette L Urganus
Children s Memorial Research Center, Chicago, Illinois, USA
Arthritis Rheum 61:501-8. 2009..To determine the presence of small integrin-binding ligand N-linked glycoprotein (SIBLING) and bone components in juvenile dermatomyositis (DM) pathologic calcifications...
- The role of aggressive corticosteroid therapy in patients with juvenile dermatomyositis: a propensity score analysisRoopa Seshadri
Feinberg School of Medicine, Northwestern University, and Children s Memorial Research Center, Chicago, Illinois, USA
Arthritis Rheum 59:989-95. 2008..To compare outcomes at 36 months in patients newly diagnosed with juvenile dermatomyositis (DM) treated with aggressive versus standard therapy...
- Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cellsSheela Shrestha
Children s Memorial Research Center, Chicago, Illinois 60614 3363, USA
Arthritis Rheum 62:2813-22. 2010..To investigate the distribution of mast cells and dendritic cell (DC) subsets in paired muscle and skin (lesional/nonlesional) from untreated children with juvenile dermatomyositis (DM)...
- Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loopsRachel Lynne Smith
Department of Pediatrics, Division of Immunology Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Rheumatol 31:1644-9. 2004..To determine associations of dermatological findings in children with juvenile dermatomyositis (JDM) with specific nailfold capillary (NFC) structural abnormalities...
- Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositisStephanie Christen-Zaech
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
Arthritis Rheum 58:571-6. 2008..To determine the association of changes on nailfold capillaroscopy with clinical findings and genotype in children with juvenile dermatomyositis (DM), in order to identify potential differences in disease course over 36 months...
- Characterization of dystrophic calcification induced in mice by cardiotoxinYongdong Zhao
Center of Excellence in Clinical Immunology, Children s Memorial Research Center, 2300 Children s Plaza, Box 212, Chicago, IL 60614, USA
Calcif Tissue Int 85:267-75. 2009..The dystrophic mechanism was validated as cell death, and mitochondrial calcifications occurred soon after skeletal muscle injury in the three murine strains...
- Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated diseaseYongdong Zhao
Molecular and Cellular Pathobiology Program, Children s Memorial Research Center, USA
Clin Immunol 125:165-72. 2007..We conclude that the duration of untreated disease (chronic inflammation) influences the mode of continuing cell damage and death in children with JDM...
- Juvenile dermatomyositis: immunogenetics, pathophysiology, and disease expressionLauren M Pachman
Division of Immunology Rheumatology, Department of Pediatrics, Children s Memorial Institute for Education and Research, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Box 50, Chicago, IL 60614, USA
Rheum Dis Clin North Am 28:579-602, vii. 2002..Continued immune-mediated inflammation, resulting in partial lipodystrophy and pathological calcifications, may be fanned by the increased production of TNF alpha usually associated with the TNF alpha-308A allele...
- Association of normal nailfold end row loop numbers with a shorter duration of untreated disease in children with juvenile dermatomyositisRochella A Ostrowski
Loyola University Chicago, Chicago, Illinois, USA
Arthritis Rheum 62:1533-8. 2010....
- US incidence of juvenile dermatomyositis, 1995-1998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases RegistryEduardo P Mendez
Children s Memorial Hospital, Chicago, Illinois, USA
Arthritis Rheum 49:300-5. 2003..To estimate the incidence of juvenile dermatomyositis (juvenile DM) in the United States between 1995 and 1998...
- Double trouble: therapeutic challenges in patients with both juvenile dermatomyositis and psoriasisNikki N Kim
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Arch Dermatol 147:831-5. 2011..Although 13% of patients with JDM have a family history of psoriasis there is little information concerning children with JDM and psoriasis...
- RANKL:osteoprotegerin ratio and bone mineral density in children with untreated juvenile dermatomyositisKelly A Rouster-Stevens
Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
Arthritis Rheum 56:977-83. 2007....
- Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositisTimothy B Niewold
Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
J Pediatr 157:653-7. 2010..To detect genetic polymorphisms associated with high serum interferon alpha (IFN-alpha) levels in juvenile dermatomyositis (JDM) and explore interactions in associated polymorphisms...
- Cytokines in juvenile dermatomyositis pathophysiology: potential and challengeGulbu Uzel
Feinberg School of Medicine, Northwestern University, Department of Pediatrics, Chicago, Illinois, USA
Curr Opin Rheumatol 15:691-7. 2003..Cytokines are criticalmediators of the immune response. This review focuses on cytokine-specific information from children with juvenile dermatomyositis, and includes pertinent data from adults with polymyositis and dermatomyositis...
- Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositisJennica Lutz
Division of Immunology Rheumatology, Children s Memorial Hospital, Department of Pediatrics, Northwestern University Medical School, Children s Memorial Institute for Education and Research, Chicago, Illinois 60614, USA
Clin Immunol 103:260-3. 2002....
- Disease activity score for children with juvenile dermatomyositis: reliability and validity evidenceRita K Bode
Northwestern University Medical School, Chicago, Illinois, USA
Arthritis Rheum 49:7-15. 2003..To assess the reliability and validity of the Disease Activity Score (DAS), an instrument used to evaluate children with juvenile dermatomyositis (JDM)...
- Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositisKelly A Rouster-Stevens
Wake Forest University Baptist Medical Center, Pediatric Rheumatology, Winston Salem, North Carolina 27157, USA
Arthritis Rheum 59:222-6. 2008..Patients with active disease have fewer ERLs that possibly occur in the gastrointestinal tract, impairing absorption of oral medications...
- Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhoodBrian M Feldman
Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
Lancet 371:2201-12. 2008..Disease outcome, if treatment is initiated early, is generally good. Randomised controlled trials are needed to define the most effective treatments...
- Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositisMargherita Massa
IRCCS Policlinico San Matteo, Pavia, Italy
Arthritis Rheum 46:3015-25. 2002..The long-term objective of the project is to identify suitable targets for immunotherapy of the disease...
- Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regenerationMarina Bakay
Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
Brain 129:996-1013. 2006..Our data is consistent with mutations of nuclear lamina components leading to destabilization of the transcriptome in differentiated cells...
- Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathwayPo Zhao
Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
J Biol Chem 281:429-38. 2006..This activation was greatly reduced when the two E-boxes were mutated. Our data suggest a novel MyoD-Tead2-Fgfr4 pathway important for effective muscle regeneration...
- Clarifying the boundaries between the inflammatory and dystrophic myopathies: insights from molecular diagnostics and microarraysEric P Hoffman
Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
Rheum Dis Clin North Am 28:743-57. 2002..It is hoped that novel approaches for treating the inflammatory myopathies and dystrophies can be derived from intimate knowledge of the pathways involved in each disease, and the key molecules that provide cross-talk between pathways...
- Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesisZivana Tezak
Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
J Immunol 168:4154-63. 2002..We hypothesize that these data support a model of Ag (?viral) induction of an apparent autoimmune disease based on dynamic interaction between the muscle, vascular, and immune systems in the genetically susceptible (DQA1*0501(+)) child...
- Untreated DQA1*0501+JDM:Clinical and Genetic ProfilesLauren Pachman; Fiscal Year: 2006..Understanding the function of these expressed genes should lead to novel therapies specific for JDM. ..