Lauren Pachman

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Clinical manifestations and pathogenesis of hydroxyapatite crystal deposition in juvenile dermatomyositis
    Lauren M Pachman
    Molecular and Cellular Pathobiology Program, The Children s Memorial Research Center, Chicago, IL 60614, USA
    Curr Rheumatol Rep 8:236-43. 2006
  2. pmc Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis
    Yi Wen Chen
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    BMC Immunol 9:43. 2008
  3. pmc Ovarian teratoma mimicking features of juvenile dermatomyositis in a child
    Maria Ibarra
    Division of Rheumatology, Children s Memorial Hospital, Chicago, IL 60614, USA
    Pediatrics 128:e1293-6. 2011
  4. pmc Composition of calcifications in children with juvenile dermatomyositis: association with chronic cutaneous inflammation
    Lauren M Pachman
    Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Arthritis Rheum 54:3345-50. 2006
  5. ncbi History of infection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry
    Lauren M Pachman
    The Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Arthritis Rheum 53:166-72. 2005
  6. ncbi Duration of illness is an important variable for untreated children with juvenile dermatomyositis
    Lauren M Pachman
    Department of Pediatrics, Division of Immunology Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Pediatr 148:247-53. 2006
  7. pmc Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy
    Timothy B Niewold
    University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Arthritis Rheum 60:1815-24. 2009
  8. pmc MxA gene expression in juvenile dermatomyositis peripheral blood mononuclear cells: association with muscle involvement
    Kevin A O'Connor
    Molecular and Cellular Pathobiology Program, Children s Memorial Research Center, Box 212, Chicago, IL 60614, USA
    Clin Immunol 120:319-25. 2006
  9. pmc Juvenile dermatomyositis calcifications selectively displayed markers of bone formation
    Annette L Urganus
    Children s Memorial Research Center, Chicago, Illinois, USA
    Arthritis Rheum 61:501-8. 2009
  10. pmc The role of aggressive corticosteroid therapy in patients with juvenile dermatomyositis: a propensity score analysis
    Roopa Seshadri
    Feinberg School of Medicine, Northwestern University, and Children s Memorial Research Center, Chicago, Illinois, USA
    Arthritis Rheum 59:989-95. 2008

Research Grants

Collaborators

  • Timothy B Niewold
  • Adele L Boskey
  • Kelly A Rouster-Stevens
  • Yongdong Zhao
  • Brian M Feldman
  • R K Bode
  • Amy Paller
  • Yukiko Kimura
  • Eric Hoffman
  • Vittorio Sartorelli
  • Yi Wen Chen
  • E Pegoraro
  • Sara T Winokur
  • Lisa G Rider
  • A Ravelli
  • Y Nevo
  • Roopa Seshadri
  • Brian M Feldman
  • Po Zhao
  • Maria Ibarra
  • Nikki N Kim
  • Gabrielle A Morgan
  • Rochella A Ostrowski
  • Sheela Shrestha
  • Annette L Urganus
  • Stephanie Christen-Zaech
  • Joyce Sundberg
  • Kevin A O'Connor
  • Marina Bakay
  • Rachel Lynne Smith
  • Alan Dyer
  • Eduardo P Mendez
  • Gulbu Uzel
  • Jennica Lutz
  • Zivana Tezak
  • Margherita Massa
  • James N Jarvis
  • Pauline Chou
  • Peter A Lio
  • Christine L Sullivan
  • Barry Wershil
  • Teresa Philipp
  • John F Sarwark
  • Norman Ilowite
  • Ann M Reed
  • Gail Cawkwell
  • Jinwook Seo
  • Louis Schiltz
  • Corrado Angelini
  • Kathy A Abbott
  • Stephanie Mitchell
  • Gisela Melcon
  • Yitan Zhu
  • Diana Escolar
  • Zuyi Wang
  • Jianhua Xuan
  • Maxine Kuroda
  • Ben Shneiderman
  • Chenguang Fan
  • Brad Sabin
  • Raul Mandler
  • Erynn Gordon
  • Giuseppina Caretti
  • Yibin Dong
  • Yue Wang
  • Wallace L McKeehan
  • Eli Shamiyah
  • Rebecca Lipton
  • Phil Roettcher
  • Rosalind Ramsey-Goldman
  • Susan Bowyer
  • Irina Krasnoselska-Riz
  • Fabrizio De Benedetti
  • Kristin G Huwiler
  • Nick Costouros
  • Ajit Kumar
  • Tamara Fedczyna
  • Tamara O Fedczyna
  • Tho Le
  • Susan Crawford
  • Isme de Kleer
  • Jennica L Lutz
  • Sarah Roord
  • Dietrich Stephan
  • Salvatore Albani
  • Federica Mazzoli
  • Toula S Lechman
  • Charles Berry
  • Antonio La Cava
  • Margaret Liotta

Detail Information

Publications31

  1. ncbi Clinical manifestations and pathogenesis of hydroxyapatite crystal deposition in juvenile dermatomyositis
    Lauren M Pachman
    Molecular and Cellular Pathobiology Program, The Children s Memorial Research Center, Chicago, IL 60614, USA
    Curr Rheumatol Rep 8:236-43. 2006
    ..This paper discusses the influence of inflammation on the deposition of hydroxyapatite, with emphasis on the clinical and environmental factors that may facilitate the formation of calcific deposits in JDM...
  2. pmc Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis
    Yi Wen Chen
    Center for Genetic Medicine Research, Children s National Medical Center, Washington, DC, USA
    BMC Immunol 9:43. 2008
    ....
  3. pmc Ovarian teratoma mimicking features of juvenile dermatomyositis in a child
    Maria Ibarra
    Division of Rheumatology, Children s Memorial Hospital, Chicago, IL 60614, USA
    Pediatrics 128:e1293-6. 2011
    ..Pelvic ultrasound confirmed a solid mass of the left ovary consistent with a mature teratoma. After surgical removal of the teratoma, the myositis, synovitis, and cutaneous findings resolved over 4 months without further therapy...
  4. pmc Composition of calcifications in children with juvenile dermatomyositis: association with chronic cutaneous inflammation
    Lauren M Pachman
    Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Arthritis Rheum 54:3345-50. 2006
    ..This study was undertaken to define the structure and composition of these deposits and to characterize their association with chronic inflammation...
  5. ncbi History of infection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Research Registry
    Lauren M Pachman
    The Northwestern University s Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Arthritis Rheum 53:166-72. 2005
    ..To obtain data concerning a history of infection occurring in the 3 months before recognition of the typical weakness and rash associated with juvenile dermatomyositis (JDM)...
  6. ncbi Duration of illness is an important variable for untreated children with juvenile dermatomyositis
    Lauren M Pachman
    Department of Pediatrics, Division of Immunology Rheumatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Pediatr 148:247-53. 2006
    ..To evaluate the impact of duration of untreated symptoms in children with juvenile dermatomyositis (JDM) on clinical and laboratory status at diagnosis...
  7. pmc Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy
    Timothy B Niewold
    University of Chicago Pritzker School of Medicine, Chicago, Illinois 60637, USA
    Arthritis Rheum 60:1815-24. 2009
    ..The aim of this study was to examine serum IFNalpha activity in a cohort of children with juvenile DM to determine relationships between IFNalpha and indicators of disease activity and severity...
  8. pmc MxA gene expression in juvenile dermatomyositis peripheral blood mononuclear cells: association with muscle involvement
    Kevin A O'Connor
    Molecular and Cellular Pathobiology Program, Children s Memorial Research Center, Box 212, Chicago, IL 60614, USA
    Clin Immunol 120:319-25. 2006
    ..During the course of clinically effective treatment, decrease in muscle symptoms was associated with a decrease in PBMC MxA mRNA expression...
  9. pmc Juvenile dermatomyositis calcifications selectively displayed markers of bone formation
    Annette L Urganus
    Children s Memorial Research Center, Chicago, Illinois, USA
    Arthritis Rheum 61:501-8. 2009
    ..To determine the presence of small integrin-binding ligand N-linked glycoprotein (SIBLING) and bone components in juvenile dermatomyositis (DM) pathologic calcifications...
  10. pmc The role of aggressive corticosteroid therapy in patients with juvenile dermatomyositis: a propensity score analysis
    Roopa Seshadri
    Feinberg School of Medicine, Northwestern University, and Children s Memorial Research Center, Chicago, Illinois, USA
    Arthritis Rheum 59:989-95. 2008
    ..To compare outcomes at 36 months in patients newly diagnosed with juvenile dermatomyositis (DM) treated with aggressive versus standard therapy...
  11. pmc Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells
    Sheela Shrestha
    Children s Memorial Research Center, Chicago, Illinois 60614 3363, USA
    Arthritis Rheum 62:2813-22. 2010
    ..To investigate the distribution of mast cells and dendritic cell (DC) subsets in paired muscle and skin (lesional/nonlesional) from untreated children with juvenile dermatomyositis (DM)...
  12. ncbi Skin involvement in juvenile dermatomyositis is associated with loss of end row nailfold capillary loops
    Rachel Lynne Smith
    Department of Pediatrics, Division of Immunology Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Rheumatol 31:1644-9. 2004
    ..To determine associations of dermatological findings in children with juvenile dermatomyositis (JDM) with specific nailfold capillary (NFC) structural abnormalities...
  13. pmc Persistent association of nailfold capillaroscopy changes and skin involvement over thirty-six months with duration of untreated disease in patients with juvenile dermatomyositis
    Stephanie Christen-Zaech
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Arthritis Rheum 58:571-6. 2008
    ..To determine the association of changes on nailfold capillaroscopy with clinical findings and genotype in children with juvenile dermatomyositis (DM), in order to identify potential differences in disease course over 36 months...
  14. pmc Characterization of dystrophic calcification induced in mice by cardiotoxin
    Yongdong Zhao
    Center of Excellence in Clinical Immunology, Children s Memorial Research Center, 2300 Children s Plaza, Box 212, Chicago, IL 60614, USA
    Calcif Tissue Int 85:267-75. 2009
    ..The dystrophic mechanism was validated as cell death, and mitochondrial calcifications occurred soon after skeletal muscle injury in the three murine strains...
  15. pmc Apoptosis in the skeletal muscle of untreated children with juvenile dermatomyositis: impact of duration of untreated disease
    Yongdong Zhao
    Molecular and Cellular Pathobiology Program, Children s Memorial Research Center, USA
    Clin Immunol 125:165-72. 2007
    ..We conclude that the duration of untreated disease (chronic inflammation) influences the mode of continuing cell damage and death in children with JDM...
  16. ncbi Juvenile dermatomyositis: immunogenetics, pathophysiology, and disease expression
    Lauren M Pachman
    Division of Immunology Rheumatology, Department of Pediatrics, Children s Memorial Institute for Education and Research, Feinberg School of Medicine, Northwestern University, 2300 Children s Plaza, Box 50, Chicago, IL 60614, USA
    Rheum Dis Clin North Am 28:579-602, vii. 2002
    ..Continued immune-mediated inflammation, resulting in partial lipodystrophy and pathological calcifications, may be fanned by the increased production of TNF alpha usually associated with the TNF alpha-308A allele...
  17. pmc Association of normal nailfold end row loop numbers with a shorter duration of untreated disease in children with juvenile dermatomyositis
    Rochella A Ostrowski
    Loyola University Chicago, Chicago, Illinois, USA
    Arthritis Rheum 62:1533-8. 2010
    ....
  18. ncbi US incidence of juvenile dermatomyositis, 1995-1998: results from the National Institute of Arthritis and Musculoskeletal and Skin Diseases Registry
    Eduardo P Mendez
    Children s Memorial Hospital, Chicago, Illinois, USA
    Arthritis Rheum 49:300-5. 2003
    ..To estimate the incidence of juvenile dermatomyositis (juvenile DM) in the United States between 1995 and 1998...
  19. doi Double trouble: therapeutic challenges in patients with both juvenile dermatomyositis and psoriasis
    Nikki N Kim
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Arch Dermatol 147:831-5. 2011
    ..Although 13% of patients with JDM have a family history of psoriasis there is little information concerning children with JDM and psoriasis...
  20. ncbi RANKL:osteoprotegerin ratio and bone mineral density in children with untreated juvenile dermatomyositis
    Kelly A Rouster-Stevens
    Children s Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA
    Arthritis Rheum 56:977-83. 2007
    ....
  21. pmc Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis
    Timothy B Niewold
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Pritzker School of Medicine, Chicago, IL 60637, USA
    J Pediatr 157:653-7. 2010
    ..To detect genetic polymorphisms associated with high serum interferon alpha (IFN-alpha) levels in juvenile dermatomyositis (JDM) and explore interactions in associated polymorphisms...
  22. ncbi Cytokines in juvenile dermatomyositis pathophysiology: potential and challenge
    Gulbu Uzel
    Feinberg School of Medicine, Northwestern University, Department of Pediatrics, Chicago, Illinois, USA
    Curr Opin Rheumatol 15:691-7. 2003
    ..Cytokines are criticalmediators of the immune response. This review focuses on cytokine-specific information from children with juvenile dermatomyositis, and includes pertinent data from adults with polymyositis and dermatomyositis...
  23. ncbi Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNF alpha-308A allele in children with juvenile dermatomyositis
    Jennica Lutz
    Division of Immunology Rheumatology, Children s Memorial Hospital, Department of Pediatrics, Northwestern University Medical School, Children s Memorial Institute for Education and Research, Chicago, Illinois 60614, USA
    Clin Immunol 103:260-3. 2002
    ....
  24. ncbi Disease activity score for children with juvenile dermatomyositis: reliability and validity evidence
    Rita K Bode
    Northwestern University Medical School, Chicago, Illinois, USA
    Arthritis Rheum 49:7-15. 2003
    ..To assess the reliability and validity of the Disease Activity Score (DAS), an instrument used to evaluate children with juvenile dermatomyositis (JDM)...
  25. pmc Pharmacokinetic study of oral prednisolone compared with intravenous methylprednisolone in patients with juvenile dermatomyositis
    Kelly A Rouster-Stevens
    Wake Forest University Baptist Medical Center, Pediatric Rheumatology, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 59:222-6. 2008
    ..Patients with active disease have fewer ERLs that possibly occur in the gastrointestinal tract, impairing absorption of oral medications...
  26. doi Juvenile dermatomyositis and other idiopathic inflammatory myopathies of childhood
    Brian M Feldman
    Departments of Pediatrics, Health Policy Management and Evaluation, and Public Health Sciences, University of Toronto, Division of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada
    Lancet 371:2201-12. 2008
    ..Disease outcome, if treatment is initiated early, is generally good. Randomised controlled trials are needed to define the most effective treatments...
  27. ncbi Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis
    Margherita Massa
    IRCCS Policlinico San Matteo, Pavia, Italy
    Arthritis Rheum 46:3015-25. 2002
    ..The long-term objective of the project is to identify suitable targets for immunotherapy of the disease...
  28. ncbi Nuclear envelope dystrophies show a transcriptional fingerprint suggesting disruption of Rb-MyoD pathways in muscle regeneration
    Marina Bakay
    Research Center for Genetic Medicine, Children s National Medical Center, Washington DC 20010, USA
    Brain 129:996-1013. 2006
    ..Our data is consistent with mutations of nuclear lamina components leading to destabilization of the transcriptome in differentiated cells...
  29. pmc Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway
    Po Zhao
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    J Biol Chem 281:429-38. 2006
    ..This activation was greatly reduced when the two E-boxes were mutated. Our data suggest a novel MyoD-Tead2-Fgfr4 pathway important for effective muscle regeneration...
  30. ncbi Clarifying the boundaries between the inflammatory and dystrophic myopathies: insights from molecular diagnostics and microarrays
    Eric P Hoffman
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    Rheum Dis Clin North Am 28:743-57. 2002
    ..It is hoped that novel approaches for treating the inflammatory myopathies and dystrophies can be derived from intimate knowledge of the pathways involved in each disease, and the key molecules that provide cross-talk between pathways...
  31. ncbi Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: a novel model of pathogenesis
    Zivana Tezak
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    J Immunol 168:4154-63. 2002
    ..We hypothesize that these data support a model of Ag (?viral) induction of an apparent autoimmune disease based on dynamic interaction between the muscle, vascular, and immune systems in the genetically susceptible (DQA1*0501(+)) child...

Research Grants1

  1. Untreated DQA1*0501+JDM:Clinical and Genetic Profiles
    Lauren Pachman; Fiscal Year: 2006
    ..Understanding the function of these expressed genes should lead to novel therapies specific for JDM. ..