J Bass

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Targeting Time in Metabolic Therapeutics
    Joseph Bass
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA Electronic address
    Cell Metab 23:575-7. 2016
  2. ncbi request reprint Circadian time signatures of fitness and disease
    Joseph Bass
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 354:994-999. 2016
  3. pmc Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    Biliana Marcheva
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 466:627-31. 2010
  4. doi request reprint Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
  5. pmc Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors
    J Bass
    Howard Hughes Medical Institute, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 97:11905-9. 2000
  6. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
  7. pmc Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice
    A D Laposky
    Department of Neurobiology and Physiology, Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R2059-66. 2008
  8. pmc Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization
    J Bass
    The Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 141:637-46. 1998
  9. ncbi request reprint Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
  10. pmc The molecular clock as a metabolic rheostat
    M Perelis
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Diabetes Obes Metab 17:99-105. 2015

Research Grants

Collaborators

  • S S Sisodia
  • G Thinakaran
  • Joseph S Takahashi
  • F W Turek
  • A D Laposky
  • R Wang
  • K M Ramsey
  • M Perelis
  • C B Peek
  • Biliana Marcheva
  • D C Levine
  • B Marcheva
  • Chiaki Omura
  • Ganka Ivanova
  • Ethan D Buhr
  • Christopher A Bradfield
  • Seth D Crosby
  • Kathryn Moynihan Ramsey
  • Hong Su
  • James P Lopez
  • Louis H Philipson
  • Martha H Vitaterna
  • Yumiko Kobayashi
  • Shelley Mo
  • Lellean Jebailey
  • Xiaozhong Wang
  • Caroline H Ko
  • S H Kim
  • D J Gordon
  • D G Lynn
  • D F Steiner
  • S C Meredith

Detail Information

Publications12

  1. doi request reprint Targeting Time in Metabolic Therapeutics
    Joseph Bass
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA Electronic address
    Cell Metab 23:575-7. 2016
    ..Studies of He et al. (2016) identify a small molecule clock modulator that improves metabolism, revealing that enhancing circadian function benefits health. ..
  2. ncbi request reprint Circadian time signatures of fitness and disease
    Joseph Bass
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 354:994-999. 2016
    ..Here, we consider advances in understanding how regulatory networks emergent in clocks give rise to cell type-specific functions within tissues to affect homeostasis...
  3. pmc Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    Biliana Marcheva
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 466:627-31. 2010
    ..These results demonstrate a role for the beta-cell clock in coordinating insulin secretion with the sleep-wake cycle, and reveal that ablation of the pancreatic clock can trigger the onset of diabetes mellitus...
  4. doi request reprint Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
    ..Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level...
  5. pmc Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors
    J Bass
    Howard Hughes Medical Institute, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 97:11905-9. 2000
    ..Together, these results suggest that processing and degradation occur sequentially for mutant proreceptors...
  6. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  7. pmc Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice
    A D Laposky
    Department of Neurobiology and Physiology, Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R2059-66. 2008
    ..In summary, leptin may represent an important molecular component in the integration of sleep, circadian rhythms, and energy metabolism...
  8. pmc Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization
    J Bass
    The Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 141:637-46. 1998
    ..Together, these studies demonstrate a chaperone function for Cnx/Crt in HIR folding in vivo and also provide evidence that folding efficiency and homodimerization are counterbalanced...
  9. ncbi request reprint Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
    ..Collectively, our results support the view that enhanced furin-mediated processing of mutant BRI generates fibrillogenic peptides that initiate the pathogenesis of FBD...
  10. pmc The molecular clock as a metabolic rheostat
    M Perelis
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Diabetes Obes Metab 17:99-105. 2015
    ..These studies indicate that clock transcription is a determinant of tissue function and provide a reference for understanding molecular pathologies linking circadian desynchrony to metabolic disease. ..
  11. pmc Circadian clocks in fuel harvesting and energy homeostasis
    K M Ramsey
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine and Department of Neurobiology and Physiology, Northwestern University, Chicago, Illinois 60611 3015, USA
    Cold Spring Harb Symp Quant Biol 76:63-72. 2011
    ..Experimental genetic studies have pointed toward extensive interplay between circadian and metabolic systems and offer a means to dissect the impact of local tissue molecular clocks on fuel utilization across the sleep-wake cycle...
  12. pmc Circadian regulation of cellular physiology
    C B Peek
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Chicago, Illinois, USA Department of Neurobiology, Northwestern University, Evanston, Illinois, USA
    Methods Enzymol 552:165-84. 2015
    ..In this chapter, we review current state-of-the-art methods to analyze circadian cycles in mitochondrial bioenergetics, glycolysis, and nucleotide metabolism in both cell-based and animal models. ..

Research Grants3

  1. MOLECULAR COMPONENTS OF INSULIN RECEPTOR BIOGENESIS
    Joseph Bass; Fiscal Year: 2003
    ..abstract_text> ..
  2. MOLECULAR COMPONENENTS OF INSULIN RECEPTOR BIOGENESIS
    Joseph Bass; Fiscal Year: 2003
    ..Steiner, in addition to Drs. Graeme Bell, Susan Lindquist and other excellent scientists at the University of Chicago will promote his continued development as an independent researcher. ..
  3. Impact of Sleep on Feeding and the Metabolic Syndrome
    Joseph Bass; Fiscal Year: 2006
    ..Insight gained from these studies will provide new strategies to prevent metabolic complications associated with sleep deprivation and uncover novel metabolic targets for treatment of obesity and its co-morbidities. ..