M Z Hossain

Summary

Affiliation: Northwest Hospital
Country: USA

Publications

  1. ncbi request reprint Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor
    M Z Hossain
    Department of Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 174:66-77. 1998
  2. ncbi request reprint Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen-activated protein kinase
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 176:332-41. 1998
  3. ncbi request reprint Impaired expression and posttranslational processing of connexin43 and downregulation of gap junctional communication in neoplastic human prostate cells
    M Z Hossain
    Department of Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    Prostate 38:55-9. 1999
  4. ncbi request reprint Mitogen-activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet-derived growth factor and tetradecanoylphorbol acetate
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 179:87-96. 1999
  5. ncbi request reprint Regulation of Cx43 gap junctions: the gatekeeper and the password
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, WA, USA
    Sci STKE 2000:pe1. 2000
  6. ncbi request reprint Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
    R P Huang
    Northwest Hospital, Seattle, Washington 98125, USA or
    Cancer Res 58:5089-96. 1998
  7. ncbi request reprint Tumor promotion by hydrogen peroxide in rat liver epithelial cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, WA 98125, USA
    Carcinogenesis 20:485-92. 1999
  8. ncbi request reprint Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Biol Chem 274:10489-96. 1999
  9. ncbi request reprint Reduced connexin43 expression in high-grade human brain glioma cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 70:21-4. 1999

Collaborators

  • A Sehgal
  • R P Huang
  • A L Boynton
  • Y Fan
  • A Peng
  • A Jagdale
  • Z L Zeng

Detail Information

Publications9

  1. ncbi request reprint Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor
    M Z Hossain
    Department of Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 174:66-77. 1998
    ..This report describes a suitable cell system which is currently being utilized for the characterization of the PDGF signaling pathway responsible for the inhibition of GJC...
  2. ncbi request reprint Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen-activated protein kinase
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 176:332-41. 1998
    ..Based on these results we postulate that the activation of PKC and MAPK are required in PDGF-mediated Cx43 phosphorylation and junctional closure...
  3. ncbi request reprint Impaired expression and posttranslational processing of connexin43 and downregulation of gap junctional communication in neoplastic human prostate cells
    M Z Hossain
    Department of Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    Prostate 38:55-9. 1999
    ..Lack of adequate information on the status of gap junctions during prostate neoplasia prompted us to examine this form of cancer, which comprises about 14% of male cancer deaths in America...
  4. ncbi request reprint Mitogen-activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet-derived growth factor and tetradecanoylphorbol acetate
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Cell Physiol 179:87-96. 1999
    ..This complex mode of regulation is perhaps essential for the proposed functional role of GJC...
  5. ncbi request reprint Regulation of Cx43 gap junctions: the gatekeeper and the password
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, WA, USA
    Sci STKE 2000:pe1. 2000
    ..The COOH-terminal domain of connexin 43 appears to be a key player in regulating gap junctional communication (GJC) because many divergent signals in many different cell types modify this domain to inhibit GJC...
  6. ncbi request reprint Reversion of the neoplastic phenotype of human glioblastoma cells by connexin 43 (cx43)
    R P Huang
    Northwest Hospital, Seattle, Washington 98125, USA or
    Cancer Res 58:5089-96. 1998
    ..We conclude that the loss of cx43 expression may play a role in the development of human gliomas and that cx43 acts as a tumor suppressor gene to human glioblastoma...
  7. ncbi request reprint Tumor promotion by hydrogen peroxide in rat liver epithelial cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, WA 98125, USA
    Carcinogenesis 20:485-92. 1999
    ..These results suggest that H2O2 acts as a tumor promoter in rat liver non-neoplastic epithelial cells and that the induction of IE genes and disruption of GJC are two possible targets of H2O2 during the tumor promotion process...
  8. ncbi request reprint Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways
    M Z Hossain
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Biol Chem 274:10489-96. 1999
    ..The results of our study demonstrate that PDGF-induced disruption of GJC can be mediated by multiple signaling pathways and requires participation of multiple components...
  9. ncbi request reprint Reduced connexin43 expression in high-grade human brain glioma cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 70:21-4. 1999
    ..To further investigate the role of cx43 in the development of human gliomas, we performed the present study on human glioma grades I-IV...