Adam J Prus

Summary

Affiliation: Northern Michigan University
Country: USA

Publications

  1. ncbi request reprint The neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux: potentiation of risperidone-, but not haloperidol-, induced dopamine efflux
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI 49855, USA
    Brain Res 1184:354-64. 2007
  2. doi request reprint Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA Electronic address
    Brain Res 1648:298-305. 2016
  3. ncbi request reprint The Discriminative Stimulus Properties of Drugs Used to Treat Depression and Anxiety
    Adam J Prus
    Department of Psychology, Northern Michigan University, Marquette, MI, USA
    Curr Top Behav Neurosci . 2016
  4. pmc Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 49:78-84. 2014
  5. pmc Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice
    Scott D Philibin
    Department of Psychology, Virginia Commonwealth University, 808 West Franklin Street, PO Box 842018, Richmond, VA 23284 2018, USA
    Psychopharmacology (Berl) 180:49-56. 2005
  6. doi request reprint The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats
    Adam J Prus
    Department of Psychology, Northern Michigan University, Marquette, MI, USA
    Psychopharmacology (Berl) 203:295-301. 2009
  7. ncbi request reprint Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms
    Adam J Prus
    Department of Psychology, Virginia Commonwealth University, 808 W Franklin, Box 842018, Richmond, VA 23284 2018, USA
    Pharmacol Biochem Behav 77:199-208. 2004
  8. pmc The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats
    Elizabeth N Holly
    Psychology Department, Northern Michigan University, 1401 Presque Isle Ave, Marquette, Michigan, USA
    Eur Neuropsychopharmacol 21:526-31. 2011
  9. pmc Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA
    Pharmacol Biochem Behav 91:150-4. 2008
  10. doi request reprint Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies
    Joseph H Porter
    Department of Psychology, Virginia Commonwealth University, 806 West Franklin Street, P O Box 842018, Richmond, VA, USA
    Psychopharmacology (Berl) 203:279-94. 2009

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The neurotensin analog NT69L enhances medial prefrontal cortical dopamine and acetylcholine efflux: potentiation of risperidone-, but not haloperidol-, induced dopamine efflux
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI 49855, USA
    Brain Res 1184:354-64. 2007
    ..0 mg/kg failed to alter the effects of haloperidol (0.1 mg/kg) on DA or ACh efflux in either region. These findings further suggest that NT analogs may be useful alone or adjunctively for the treatment of schizophrenia...
  2. doi request reprint Discriminative stimulus properties of 1.25mg/kg clozapine in rats: Mediation by serotonin 5-HT2 and dopamine D4 receptors
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA Electronic address
    Brain Res 1648:298-305. 2016
    ..25mg/kg clozapine in rats, and further confirm that clozapine produces a complex compound discriminative stimulus. ..
  3. ncbi request reprint The Discriminative Stimulus Properties of Drugs Used to Treat Depression and Anxiety
    Adam J Prus
    Department of Psychology, Northern Michigan University, Marquette, MI, USA
    Curr Top Behav Neurosci . 2016
    ..We conclude that drug discrimination is an informative preclinical procedure that reveals the interoceptive effects of pharmacological mechanisms as they relate to behaviors that are not captured in other preclinical models...
  4. pmc Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 49:78-84. 2014
    ..These findings further support an anxiolytic profile for PD149163. However, tolerance to these effects may limit the utility of these drugs for the treatment of anxiety. ..
  5. pmc Serotonin receptor mechanisms mediate the discriminative stimulus properties of the atypical antipsychotic clozapine in C57BL/6 mice
    Scott D Philibin
    Department of Psychology, Virginia Commonwealth University, 808 West Franklin Street, PO Box 842018, Richmond, VA 23284 2018, USA
    Psychopharmacology (Berl) 180:49-56. 2005
    ..The atypical antipsychotic drug (APD) clozapine (CLZ) has been shown to have a robust discriminative cue in rats, pigeons, and monkeys in two-choice drug discrimination procedures...
  6. doi request reprint The role of M1 muscarinic cholinergic receptors in the discriminative stimulus properties of N-desmethylclozapine and the atypical antipsychotic drug clozapine in rats
    Adam J Prus
    Department of Psychology, Northern Michigan University, Marquette, MI, USA
    Psychopharmacology (Berl) 203:295-301. 2009
    ..Recent studies have indicated that the active CLZ metabolite N-desmethylclozapine (NDMC) may play a role in mediating the cognitive efficacy of CLZ and may also have atypical antipsychotic properties...
  7. ncbi request reprint Discriminative stimulus properties of 1.25 and 5.0 mg/kg doses of clozapine in rats: examination of the role of dopamine, serotonin, and muscarinic receptor mechanisms
    Adam J Prus
    Department of Psychology, Virginia Commonwealth University, 808 W Franklin, Box 842018, Richmond, VA 23284 2018, USA
    Pharmacol Biochem Behav 77:199-208. 2004
    ..25 mg/kg CLZ cue, but only partial substitution for the 5.0 mg/kg CLZ cue. These results provide evidence that antagonism at the muscarinic M(1) receptor is sufficient to provide 1.25 mg/kg CLZ-like discriminative stimulus effects...
  8. pmc The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in rats
    Elizabeth N Holly
    Psychology Department, Northern Michigan University, 1401 Presque Isle Ave, Marquette, Michigan, USA
    Eur Neuropsychopharmacol 21:526-31. 2011
    ..Finally, D-amphetamine (1.0 mg/kg), serving as a negative control, failed to suppress CAR or increase catalepsy scores. These data further suggest that PD149163 may have atypical antipsychotic-like properties...
  9. pmc Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats
    Adam J Prus
    Psychology Department, Northern Michigan University, Marquette, MI, USA
    Pharmacol Biochem Behav 91:150-4. 2008
    ..These results further clarify the behavioral sensitivity of the LEW strain of rat to nicotine exposure and lend credence to the role of genetics in the individual susceptibility to nicotine dependence...
  10. doi request reprint Discriminative stimulus properties of atypical and typical antipsychotic drugs: a review of preclinical studies
    Joseph H Porter
    Department of Psychology, Virginia Commonwealth University, 806 West Franklin Street, P O Box 842018, Richmond, VA, USA
    Psychopharmacology (Berl) 203:279-94. 2009
    ....
  11. ncbi request reprint Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats
    Joseph H Porter
    Department of Psychology, Virginia Commonwealth University, PO Box 842018, 808 West Franklin Street, Richmond, VA 23284 2018, USA
    Psychopharmacology (Berl) 178:67-77. 2005
    ..The atypical antipsychotic drug (APD) clozapine elicits a robust discriminative cue that is generally selective for other atypical APDS in two-choice drug discrimination (DD) procedures...
  12. doi request reprint Evaluation of the effects of α2 adrenoceptor antagonism with the D2 receptor antagonist raclopride on conditioned avoidance responding in rats
    Sarah M Jacobson
    Department of Psychology, Northern Michigan University, Marquette, MI 49855, USA
    Behav Pharmacol 21:654-9. 2010
    ....
  13. doi request reprint The antidepressant drugs fluoxetine and duloxetine produce anxiolytic-like effects in a schedule-induced polydipsia paradigm in rats: enhancement of fluoxetine's effects by the α2 adrenoceptor antagonist yohimbine
    Adam J Prus
    aDepartment of Psychology, Northern Michigan University, Marquette, Michigan bExternal Sourcing and Scientific Excellence, Lundbeck Research USA Inc, Paramus, New Jersey cDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA
    Behav Pharmacol 26:489-94. 2015
    ..The results for the α2 antagonist yohimbine (in combination with fluoxetine) also indicate that α2 adrenoceptor antagonism may significantly enhance anxiolytic-like effects of SSRIs. ..
  14. pmc Effects of the neurotensin NTS₁ receptor agonist PD149163 on visual signal detection in rats
    Todd M Hillhouse
    Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA
    Eur J Pharmacol 721:201-7. 2013
    ..The present findings suggest that neurotensin NTS1 receptor agonists, like antipsychotic drugs, may inhibit sustained attention in this task despite having different pharmacological mechanisms of action. ..
  15. ncbi request reprint Reevaluation of PNU-99194A discriminative stimulus effects: potentiation by both a D2 antagonist and a D3/D2 agonist
    Lisa E Baker
    Department of Psychology, Western Michigan University, Kalamazoo, MI 49008, USA
    Pharmacol Biochem Behav 73:753-8. 2002
    ..These data, along with other recent findings, suggest that the discriminative stimulus effects of PNU-99194A appear to involve complex pharmacological actions and are not solely mediated by D(3) receptor antagonism...
  16. doi request reprint The quetiapine active metabolite N-desalkylquetiapine and the neurotensin NTS₁ receptor agonist PD149163 exhibit antidepressant-like effects on operant responding in male rats
    Todd M Hillhouse
    Psychology Department, Northern Michigan University
    Exp Clin Psychopharmacol 22:548-56. 2014
    ..These data suggest that N-desalkylquetiapine likely contributes to quetiapine's antidepressant efficacy and identify NTS₁ receptor activation as a potential novel pharmacologic strategy for antidepressant drugs...
  17. ncbi request reprint ACP-103, a 5-HT2A/2C inverse agonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens
    Zhu Li
    Psychiatry Department, Psychopharmacology Division, Vanderbilt University School of Medicine, Suite 306, 1601 23rd Ave S, Nashville, TN 37212, USA
    Psychopharmacology (Berl) 183:144-53. 2005
    ..However, pretreatment with the 5-HT(2A/2C) receptor antagonist SR46349-B with haloperidol increased both mPFC and NAC DA release, suggesting that both 5-HT(2A) and 5-HT(2C) properties may be important for atypical APD effects...
  18. ncbi request reprint 5-HT6 receptor antagonist SB-399885 potentiates haloperidol and risperidone-induced dopamine efflux in the medial prefrontal cortex or hippocampus
    Zhu Li
    Psychopharmacology Division, Psychiatry Department, Vanderbilt University School of Medicine, 1601 23rd Ave South, Suite 306, Nashville, TN 37212, USA
    Brain Res 1134:70-8. 2007
    ..The present data provides additional evidence in support of a possible therapeutic role for 5-HT6 receptor antagonism, as an addition on therapy, to enhance cognitive function in schizophrenia...
  19. ncbi request reprint AC260584 (4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one), a selective muscarinic M1 receptor agonist, increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus
    Zhu Li
    Psychiatry Department, Vanderbilt University School of Medicine, Nashville, TN USA
    Eur J Pharmacol 572:129-37. 2007
    ..Therefore, AC260584, as well as other muscarinic M1 receptor agonists, may be a valuable target for the development of drugs which can improve the cognitive deficits in schizophrenia and perhaps other neuropsychiatric disorders, as well...