Jonghan Kim

Summary

Affiliation: Northeastern University
Country: USA

Publications

  1. pmc Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure
    Qi Ye
    Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue 148TF, Boston, MA 02115, USA
    Metallomics 8:618-27. 2016
  2. pmc Iron and mechanisms of emotional behavior
    Jonghan Kim
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA Electronic address
    J Nutr Biochem 25:1101-7. 2014
  3. pmc Absorption of manganese and iron in a mouse model of hemochromatosis
    Jonghan Kim
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64944. 2013
  4. pmc Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33533. 2012
  5. pmc Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo
    Shaina L Byrne
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e70199. 2013
  6. pmc Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring
    Ramon M Molina
    Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, United States
    Neurotoxicology 32:413-22. 2011
  7. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
  8. pmc Glucose metabolism in the Belgrade rat, a model of iron-loading anemia
    Xuming Jia
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 304:G1095-102. 2013
  9. pmc Severe postnatal iron deficiency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats
    Yuan Li
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA
    J Nutr 141:2133-8. 2011
  10. pmc Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    FASEB J 27:1657-63. 2013

Collaborators

Detail Information

Publications13

  1. pmc Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure
    Qi Ye
    Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue 148TF, Boston, MA 02115, USA
    Metallomics 8:618-27. 2016
    ..Together, our results suggest that the H67D mutation provides decreased susceptibility to Mn accumulation in the brain and neurotoxicity induced by inhaled Mn. ..
  2. pmc Iron and mechanisms of emotional behavior
    Jonghan Kim
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA Electronic address
    J Nutr Biochem 25:1101-7. 2014
    ..To better understand the role that brain iron plays in emotional behavior and mental health, this review discusses the pathologies associated with anxiety and other emotional disorders with respect to body iron status. ..
  3. pmc Absorption of manganese and iron in a mouse model of hemochromatosis
    Jonghan Kim
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, United States of America
    PLoS ONE 8:e64944. 2013
    ..These results show that manganese transport and metabolism can be modified by HFE deficiency...
  4. pmc Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e33533. 2012
    ..Enhanced olfactory manganese uptake during iron deficiency appears to be a programmed "rescue response" with beneficial influence on motor impairment due to low iron status...
  5. pmc Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo
    Shaina L Byrne
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS ONE 8:e70199. 2013
    ..The observed hypoferremia promoted by degradation of TfR1 by ferristatin II appears to be due to induced hepcidin gene expression. ..
  6. pmc Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring
    Ramon M Molina
    Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, United States
    Neurotoxicology 32:413-22. 2011
    ..The data suggest that perturbation in Fe metabolism may contribute to the pathophysiologic consequences of Mn and Pb exposure during early development...
  7. pmc Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 10:97. 2011
    ..Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism...
  8. pmc Glucose metabolism in the Belgrade rat, a model of iron-loading anemia
    Xuming Jia
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 304:G1095-102. 2013
    ..Thus, loss of DMT1 appears to protect the pancreas from injury but damages the integrity of kidney structure and function...
  9. pmc Severe postnatal iron deficiency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats
    Yuan Li
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA
    J Nutr 141:2133-8. 2011
    ..0 vs. 110 ± 14 ng/L; P < 0.05; n = 4). Altered dopaminergic signaling in the prefrontal cortex most likely contributes to the anxious behavior observed in young male rats with severe iron deficiency...
  10. pmc Iron loading impairs lipoprotein lipase activity and promotes hypertriglyceridemia
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    FASEB J 27:1657-63. 2013
    ..001). This study explains the relationship between iron status and lipid metabolism and provides mechanistic support for interventions that reduce serum iron levels in individuals at risk for hypertriglyceridemia...
  11. pmc The small molecule ferristatin II induces hepatic hepcidin expression in vivo and in vitro
    Ahmed A Alkhateeb
    Department of Genetic and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts
    Am J Physiol Gastrointest Liver Physiol 308:G1019-26. 2015
    ..However, this synergy was not due to activation of either Smad or Stat3 signaling, raising the possibility that ferristatin II may activate a novel pathway for hepcidin regulation. ..
  12. pmc Influence of DMT1 and iron status on inflammatory responses in the lung
    Jonghan Kim
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Physiol Lung Cell Mol Physiol 300:L659-65. 2011
    ..Loss of DMT1 alters pulmonary responses necessary for lung homeostasis in the basal state and enhances LPS-induced inflammation and therefore would contribute to progression of lung injury...
  13. pmc Effect of olfactory manganese exposure on anxiety-related behavior in a mouse model of iron overload hemochromatosis
    Qi Ye
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Environ Toxicol Pharmacol 40:333-41. 2015
    ..Together, our data indicate that loss of HFE function alters manganese-associated emotional behavior and further suggest that HFE could be a potential molecular target to alleviate affective disorders induced by manganese inhalation...