Mian Zhou

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia
    Mian Zhou
    Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA Hofstra North Shore LIJ School of Medicine, Manhasset, NY 11030, USA Electronic address
    Biochim Biophys Acta 1840:2253-61. 2014
  2. pmc Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    PLoS ONE 4:e5504. 2009
  3. ncbi request reprint Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis
    Shinya Higuchi
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    J Surg Res 137:46-52. 2007
  4. pmc Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein
    Rongqian Wu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, United States of America
    Mol Med 15:28-33. 2009
  5. pmc Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice
    Akihisa Matsuda
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 39:2039-47. 2011
  6. pmc Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Ann Surg 242:115-23. 2005
  7. pmc Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats
    Juntao Yang
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, United States
    Peptides 31:872-7. 2010
  8. pmc Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion
    Juntao Yang
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Ann Surg 249:310-7. 2009
  9. pmc Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research and Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 22:743-8. 2008
  10. pmc Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, New York, USA
    Am J Respir Crit Care Med 176:805-13. 2007

Collaborators

  • Ping Wang
  • Rongqian Wu
  • Weng Lang Yang
  • Huan Yang
  • Haichao Wang
  • Akihisa Matsuda
  • Jun Fujita
  • Luis Ulloa
  • Maowen Hu
  • Yow Pin Lim
  • Yingjie Cui
  • Asha Jacob
  • Weifeng Dong
  • Monowar Aziz
  • Xiaoling Qiang
  • Cletus Cheyuo
  • Michael Miksa
  • Thanjavur S Ravikumar
  • Yohei Hirano
  • Youxin Ji
  • Zhimin Wang
  • Juntao Yang
  • Xiaoxuan Cui
  • Gene F Coppa
  • Shinya Higuchi
  • Mahendar Ochani
  • Adam Khader
  • Maria Lufrano
  • H Hank Simms
  • Jeffrey Nicastro
  • Michael A Ajakaiye
  • Tianpen Cui
  • Subir R Maitra
  • Fangming Zhang
  • Jennifer Leong
  • Corrado P Marini
  • Kevin J Tracey
  • Aqeel M Siddiqui
  • Archna Sharma
  • Shingo Matsuo
  • Michael Kuncewitch
  • Wayne W Chaung
  • Gene Coppa
  • Wayne Chaung
  • Derry Rajan
  • Adam Hartman
  • Betsy Pathickal
  • Hidefumi Komura
  • Steven A Blau
  • Imran Balouch
  • Sanna M Goyert
  • Padmalaya Das
  • Dhruv Amin
  • Vivienne J Halpern

Detail Information

Publications57

  1. pmc Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia
    Mian Zhou
    Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA Hofstra North Shore LIJ School of Medicine, Manhasset, NY 11030, USA Electronic address
    Biochim Biophys Acta 1840:2253-61. 2014
    ..Here, we examine the involvement of CIRP in brain injury during ischemic stroke...
  2. pmc Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsis
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    PLoS ONE 4:e5504. 2009
    ..e., alpha(2A), alpha(2B) or alpha(2C)) is responsible for the upregulation of TNF-alpha production. The aim of this study was to determine the contribution of alpha(2A)-AR in this process...
  3. ncbi request reprint Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis
    Shinya Higuchi
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    J Surg Res 137:46-52. 2007
    ..We hypothesized that hemorrhage down-regulates CYP isoforms and PPAR-gamma in the liver, which plays an important role in producing tissue injury and proinflammatory responses after the subsequent sepsis (i.e., double-hit)...
  4. pmc Reversing established sepsis in rats with human vasoactive hormone adrenomedullin and its binding protein
    Rongqian Wu
    The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York 11030, United States of America
    Mol Med 15:28-33. 2009
    ..Thus, human AM/AMBP-1 can be further developed as a safe and effective therapy for patients with established sepsis...
  5. pmc Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice
    Akihisa Matsuda
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 39:2039-47. 2011
    ..The purpose of this study was to determine whether administration of MFG-E8 attenuates renal ischemia-reperfusion injury...
  6. pmc Mechanisms responsible for vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Ann Surg 242:115-23. 2005
    ..Our aim was to determine whether vascular responsiveness to AM is reduced after hemorrhage and, if so, to elucidate the possible mechanism responsible for such hyporesponsiveness...
  7. pmc Human adrenomedullin and its binding protein ameliorate sepsis-induced organ injury and mortality in jaundiced rats
    Juntao Yang
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, United States
    Peptides 31:872-7. 2010
    ..Thus, human AM/AMBP-1 ameliorates sepsis-induced organ injury and mortality in jaundiced rats. Human AM/AMBP-1 can be further developed as a novel treatment for sepsis in jaundiced patients...
  8. pmc Human adrenomedullin and its binding protein attenuate organ injury and reduce mortality after hepatic ischemia-reperfusion
    Juntao Yang
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Ann Surg 249:310-7. 2009
    ..To determine whether administration of a vasoactive peptide, human adrenomedullin (AM), in combination with its binding protein (ie, AMBP-1), prevents or minimizes hepatic ischemia-reperfusion (I/R) injury...
  9. pmc Maturation-induced down-regulation of MFG-E8 impairs apoptotic cell clearance and enhances endotoxin response
    Michael Miksa
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research and Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 22:743-8. 2008
    ..These results provide a potential mechanistic insight into the benefit of promoting apoptotic cell clearance via MFG-E8 under inflammatory conditions...
  10. pmc Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, New York, USA
    Am J Respir Crit Care Med 176:805-13. 2007
    ..However, it remains unknown whether ghrelin has any protective effects on severe sepsis-induced acute lung injury (ALI) and, if so, whether inhibition of NF-kappaB plays any role in it...
  11. ncbi request reprint The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma
    Aqeel M Siddiqui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, USA
    Crit Care Med 34:1874-82. 2006
    ..The purpose of this study was to demonstrate whether curcumin protects septic animals and, if so, whether activation of peroxisome proliferator-activated receptor (PPAR)-gamma, an anti-inflammatory nuclear receptor, plays any role...
  12. ncbi request reprint Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 35:912-8. 2007
    ..We therefore hypothesized that administration of AM/AMBP-1 would prevent metabolic acidosis after uncontrolled hemorrhage via down-regulation of endothelin-1...
  13. pmc Orexigenic hormone ghrelin attenuates local and remote organ injury after intestinal ischemia-reperfusion
    Rongqian Wu
    The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 3:e2026. 2008
    ..In this study, we investigated the regulation of the cholinergic anti-inflammatory pathway by the novel gastrointestinal hormone, ghrelin, after gut I/R...
  14. pmc Accelerated apoptosis contributes to aging-related hyperinflammation in endotoxemia
    Mian Zhou
    The Feinstein Institute for Medical Research, and Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 25:929-35. 2010
    ..Thus, there is substantial evidence that the Fas/Fas-L pathway may play an important role in LPS-induced accelerated apoptosis and hyperinflammation in aged animals...
  15. pmc Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-α production in macrophages via STAT3-mediated SOCS3 activation
    Monowar Aziz
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, United States of America
    PLoS ONE 6:e27685. 2011
    ..Our findings strongly suggest that MFG-E8 is a direct anti-inflammatory molecule, and that it could be developed as a therapy in attenuating inflammation and tissue injury...
  16. pmc Upregulation of Kupffer cell α2A-Adrenoceptors and downregulation of MKP-1 mediate hepatic injury in chronic alcohol exposure
    Michael A Ajakaiye
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY 11030, United States
    Biochem Biophys Res Commun 409:406-11. 2011
    ..In summary, chronic alcohol exposure elevates NE and upregulates KC α(2A)-AR to release TNF-α. Alcohol induced downregulation of MKP-1 leads to further release of TNF-α and hepatic injury...
  17. pmc The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis
    Mian Zhou
    Department of Surgery, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Int J Mol Med 21:423-8. 2008
    ....
  18. ncbi request reprint Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center and The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Am J Physiol Regul Integr Comp Physiol 294:R84-92. 2008
    ..We, therefore, conclude that LPS downregulates PPAR-gamma expression during sepsis via an increase in TNF-alpha release...
  19. pmc Milk fat globule--EGF factor VIII ameliorates liver injury after hepatic ischemia-reperfusion
    Akihisa Matsuda
    Department of Surgery, Hofstra North Shore LIJ School of Medicine, Manhasset, New York, USA
    J Surg Res 180:e37-46. 2013
    ....
  20. pmc Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion
    Tianpen Cui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Am J Respir Crit Care Med 181:238-46. 2010
    ..Ischemia-reperfusion (I/R) injury of the gut results in severe inflammation, apoptosis, and remote organ damage, including acute lung injury (ALI)...
  21. pmc Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis
    Xiaoling Qiang
    1 Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA 2
    Nat Med 19:1489-95. 2013
    ..In particular, human CIRP amino acid residues 106-125 bind to MD2 with high affinity. Thus, CIRP is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis. ..
  22. pmc Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats
    Rongqian Wu
    Department of Surgery, The Feinstein Institute for Medical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Alcohol Clin Exp Res 34:1625-33. 2010
    ..The purpose of this study was to determine whether recombinant murine MFG-E8 (rmMFG-E8) attenuates organ injury after acute alcohol exposure and subsequent sepsis...
  23. pmc The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-1
    Asha Jacob
    Laboratory of Surgical Research, Department of Surgery North Shore University Hospital and Long Island Jewish Medical Center, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Int J Mol Med 25:159-64. 2010
    ..Infusion with NE produced a significant 73.7% decrease in MKP-1 mRNA. Therefore, ghrelin's inhibitory effect on gut-derived NE release in sepsis leading to the downregulation of pro-inflammatory cytokines is mediated by MKP-1...
  24. ncbi request reprint Differential expression of cytochrome P450 isoforms in the lungs of septic animals
    Xiaoxuan Cui
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Crit Care Med 32:1186-91. 2004
    ....
  25. ncbi request reprint Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage
    Xiaoxuan Cui
    Division of Surgical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 33:391-8. 2005
    ..We therefore hypothesized that administration of AM/AMBP-1 during fluid resuscitation in hemorrhaged animals (i.e., posttreatment) attenuates tissue injury and the proinflammatory response...
  26. doi request reprint Ghrelin suppresses inflammation and neuronal nitric oxide synthase in focal cerebral ischemia via the vagus nerve
    Cletus Cheyuo
    The Feinstein Institute for Medical Research, Community Dr, Manhasset, NY 11030, USA
    Shock 35:258-65. 2011
    ..Human ghrelin is thus a neuroprotective agent that inhibits inflammation, nNOS activity, and apoptosis in focal cerebral ischemia through a vagal pathway...
  27. pmc Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Manhasset, NY 11030, USA
    Ann Surg 245:480-6. 2007
    ..To test the hypothesis that administration of ghrelin attenuates inflammatory responses in sepsis through vagal nerve stimulation...
  28. pmc Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsis
    Fangming Zhang
    The Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA
    J Mol Med (Berl) 88:289-96. 2010
    ..In conclusion, modulation of the sympathetic nervous system by blocking alpha(2A)-AR appears to be a novel treatment for inflammatory conditions such as sepsis...
  29. ncbi request reprint Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 32:1747-52. 2004
    ..We therefore hypothesized that IalphaIp and its active component bikunin are reduced in sepsis and that the delayed administration of IalphaIp also improves survival rate...
  30. pmc Ghrelin hyporesponsiveness contributes to age-related hyperinflammation in septic shock
    Rongqian Wu
    Department of Surgery, Long Island Jewish Medical Center, North Shore University Hospital, Manhasset, New York 11030, USA
    Ann Surg 250:126-33. 2009
    ..To test the hypothesis that hyporesponsiveness to ghrelin due to reduced growth hormone (GH) contributes to the aging-related hyperinflammatory state in sepsis...
  31. pmc Sphingosine kinase‑1 mediates endotoxemia‑induced hyperinflammation in aged animals
    Maria Lufrano
    Laboratory of Surgical Research, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Mol Med Rep 8:645-9. 2013
    ..Results of the present study indicated that increased Sphk‑1 expression in the liver in response to endotoxemia mediates the hyperinflammatory state observed in aged animals...
  32. ncbi request reprint A novel approach to maintaining cardiovascular stability after hemorrhagic shock: beneficial effects of adrenomedullin and its binding protein
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, 350 Community Drive, Manhasset, NY 11030, USA
    Surgery 137:200-8. 2005
    ..Therefore, we hypothesize that administration of AM/AMBP-1 improves cardiovascular responses after hemorrhagic shock and resuscitation...
  33. pmc Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways
    Jennifer Leong
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Life Sci 86:740-6. 2010
    ....
  34. pmc Downregulation of protein disulfide isomerase in sepsis and its role in tumor necrosis factor-alpha release
    Mian Zhou
    The Feinstein Institute for Medical Research, North Shore University Hospital and Long Island Jewish Medical Center, 350 Community Drive, Manhasset, NY 11030, USA
    Crit Care 12:R100. 2008
    ..We therefore hypothesized that sepsis downregulates PDI expression and that the inhibition of PDI promotes proinflammatory cytokine production...
  35. pmc Pro-inflammatory cytokines from Kupffer cells downregulate hepatocyte expression of adrenomedullin binding protein-1
    Asha Jacob
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Biochim Biophys Acta 1772:766-72. 2007
    ..The results indicated that both cytokines significantly inhibited AMBP-1 protein levels. Thus, pro-inflammatory cytokines released from Kupffer cells are responsible for downregulation of AMBP-1...
  36. pmc Purification and characterization of human adrenomedullin binding protein-1
    Xiaoling Qiang
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 14:443-50. 2008
    ..This technique will enable us to further develop human AM/AMBP-1 as a novel treatment for safe and effective therapy of patients with hemorrhagic shock, sepsis, and ischemic injury...
  37. pmc Adrenomedullin and adrenomedullin binding protein-1 protect endothelium-dependent vascular relaxation in sepsis
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 13:488-94. 2007
    ....
  38. ncbi request reprint Upregulation of cardiovascular ghrelin receptor occurs in the hyperdynamic phase of sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA
    Am J Physiol Heart Circ Physiol 287:H1296-302. 2004
    ..These results demonstrate that GHSR-1a expression is upregulated and vascular sensitivity to ghrelin stimulation is increased in the hyperdynamic phase of sepsis...
  39. pmc Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury
    Yohei Hirano
    Department of Surgery, Hofstra North Shore LIJ School of Medicine and Center for Translational Research, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA
    Crit Care 19:53. 2015
    ..However, its role in ALI caused by sepsis remains unexplored. We hypothesize that treatment with an OPN-neutralizing antibody (anti-OPN Ab) protects mice against ALI during sepsis...
  40. ncbi request reprint Ghrelin inhibits sympathetic nervous activity in sepsis
    Rongqian Wu
    The Feinstein Institute for Medical Research, 350 Community Dr, Manhasset, NY 11030, USA
    Am J Physiol Endocrinol Metab 293:E1697-702. 2007
    ..Ghrelin's inhibitory effect on TNF-alpha production in sepsis is partially because of its modulation of the overstimulated sympathetic nerve activation...
  41. pmc Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury
    Akihisa Matsuda
    Laboratory of Surgical Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 17:126-33. 2011
    ..In this review, we describe novel information available about the involvement of MFG-E8 in the pathophysiology of sepsis and I/R injury, and the therapeutic potential of exogenous MFG-E8 treatment for those conditions...
  42. pmc Human vasoactive hormone adrenomedullin and its binding protein rescue experimental animals from shock
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, United States
    Peptides 29:1223-30. 2008
    ..8 min and 1.68 h, respectively. Thus, administration of human AM/AMBP-1 may be a useful approach for attenuating organ injury, and reducing mortality after hemorrhagic shock...
  43. ncbi request reprint Sympathetic excitotoxicity in sepsis: pro-inflammatory priming of macrophages by norepinephrine
    Michael Miksa
    Division of Surgical Research, North Shore Hospital and Long Island Jewish Medical Center, Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Front Biosci 10:2217-29. 2005
    ..Furthermore, we will introduce the new concept of "sympathetic excitotoxicity in sepsis" characterized by the neurogenic priming of the systemic pro-inflammatory response...
  44. pmc The parasympathetic nervous system in the quest for stroke therapeutics
    Cletus Cheyuo
    Center for Immunology and Inflammation, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Cereb Blood Flow Metab 31:1187-95. 2011
    ..This review discusses the anatomical basis and molecular mechanisms involved in activation of the PNS, and assesses the strength of available evidence for the further development of this modality into a stroke therapy...
  45. ncbi request reprint Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10
    Mian Zhou
    Division of Surgical Research, Department of Surgery, North Shore University Hospital, Manhasset, NY 11030, USA
    Biochim Biophys Acta 1740:446-52. 2005
    ....
  46. pmc Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia
    Cletus Cheyuo
    Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 10:e0122833. 2015
    ..Our findings suggest MFG-E8 to promote neural stem cell proliferation and migration, which therefore establishes a promising therapeutic strategy for cerebral ischemia. ..
  47. pmc Microglial CD14 activated by iNOS contributes to neuroinflammation in cerebral ischemia
    Mian Zhou
    Department of Surgery, Hofstra North Shore LIJ School of Medicine, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Brain Res 1506:105-14. 2013
    ..These results suggest that the upregulation of TNF-α production in ischemic stroke is partially through increasing iNOS, and then CD14 expression leading to the activation of the NF-κB pathway in microglia...
  48. pmc Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis
    Mian Zhou
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Ann Surg 240:321-30. 2004
    ....
  49. doi request reprint Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury
    Yohei Hirano
    Department of Surgery, Hofstra North Shore LIJ School of Medicine and Center for Translational Research, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA
    Crit Care 19:782. 2015
    ..However, its role in ALI caused by sepsis remains unexplored. We hypothesize that treatment with an OPN-neutralizing antibody (anti-OPN Ab) protects mice against ALI during sepsis...
  50. pmc Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis
    Monowar Aziz
    Center for Translational Research, Feinstein Institute for Medical Research, Manhasset, NY 11030
    J Immunol 192:2305-14. 2014
    ..Our findings reveal a novel association of the increased GRAIL expression with impaired CD4 T cell proliferation, implicating an emerging therapeutic tool in sepsis. ..
  51. ncbi request reprint Increased gut-derived norepinephrine release in sepsis: up-regulation of intestinal tyrosine hydroxylase
    Mian Zhou
    Division of Surgical Research, Department of Surgery, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Biochim Biophys Acta 1689:212-8. 2004
    ..Thus, the increased TH gene and protein expression appears to be responsible for the increased gut-derived NE in sepsis...
  52. ncbi request reprint Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines
    Rongqian Wu
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 18:339-46. 2006
    ..The reduction of AhR/Arnt may be the underlying mechanism for such downregulation. Inhibition of proinflammatory cytokines by curcumin may provide a novel approach to modulate the hepatic CYP function in sepsis...
  53. ncbi request reprint Adrenomedullin and adrenomedullin binding protein-1 downregulate TNF-alpha in macrophage cell line and rat Kupffer cells
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore Long Island Jewish Medical Center and New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    Regul Pept 112:19-26. 2003
    ....
  54. pmc Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation
    Asha Jacob
    Division of Surgical Research, North Shore University Hospital and Long Island Jewish Medical Center, 350 Community Drive, Manhasset, NY 11030, USA
    PPAR Res 2007:89369. 2007
    ....
  55. ncbi request reprint Ghrelin clearance is reduced at the late stage of polymicrobial sepsis
    Rongqian Wu
    Division of Surgical Research, Department of Surgery, North Shore Long Island Jewish Medical Center and New York University School of Medicine, Manhasset, NY 11030, USA
    Int J Mol Med 12:777-81. 2003
    ..In addition, the liver also plays a role in the clearance of ghrelin, which was also reduced in late sepsis. The decreased clearance of ghrelin by the kidneys and liver may be due to renal and hepatic dysfunctions under such conditions...
  56. pmc Modulation of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in sepsis
    Subir R Maitra
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, and The Feinstein Institute for Medical Research Manhasset, NY 11030, USA
    Int J Clin Exp Med 3:180-5. 2010
    ..Our results indicate that MMP-9 and TIMP-1 expressions are increased and they may serve as useful markers to predict the outcome of sepsis...
  57. ncbi request reprint Adrenomedullin binding protein-1 is downregulated during polymicrobial sepsis in the rat
    Yingjie Cui
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Int J Mol Med 17:925-9. 2006
    ..Administration of PMB, however, prevented the downregulation of AMBP-1 expression at 20 h after CLP. Thus, AMBP-1 is downregulated in the late phase of sepsis, and LPS plays a critical role in the reduction of AMBP-1...