Haichao Wang

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. doi request reprint Analysis of the released nuclear cytokine HMGB1 in human serum
    Haichao Wang
    Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, 11030, Manhasset, NY, USA
    Methods Mol Biol 1172:13-25. 2014
  2. pmc It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis
    Shu Zhu
    Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA Department of Emergency Medicine, North Shore University Hospital, The Hofstra North Shore LIJ School of Medicine at the Hofstra University, Manhasset, NY 11030, USA
    Evid Based Complement Alternat Med 2012:498467. 2012
  3. pmc A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, United States of America
    PLoS ONE 2:e1153. 2007
  4. pmc Targeting HMGB1 in the treatment of sepsis
    Haichao Wang
    The Feinstein Institute for Medical Research and North Shore University Hospital, The Hofstra North Shore LIJ School of Medicine, Laboratory of Emergency Medicine, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA 1 516 562 2823 1 516 562 1022
    Expert Opin Ther Targets 18:257-68. 2014
  5. pmc Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes
    Lin Zhao
    Department of Emergency Medicine, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Inflamm Allergy Drug Targets 12:308-14. 2013
  6. pmc Anti-inflammatory role of fetuin-A in injury and infection
    H Wang
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Mol Med 12:625-33. 2012
  7. ncbi request reprint Extracellular role of HMGB1 in inflammation and sepsis
    H Wang
    Laboratory of Emergency Medicine, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Intern Med 255:320-31. 2004
  8. pmc Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats
    Haichao Wang
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    J Cereb Blood Flow Metab 30:493-504. 2010
  9. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
  10. pmc Novel HMGB1-inhibiting therapeutic agents for experimental sepsis
    Haichao Wang
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Community Drive, Manhasset, NY 11030, USA
    Shock 32:348-57. 2009

Research Grants

Collaborators

Detail Information

Publications82

  1. doi request reprint Analysis of the released nuclear cytokine HMGB1 in human serum
    Haichao Wang
    Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, 11030, Manhasset, NY, USA
    Methods Mol Biol 1172:13-25. 2014
    ..Here, we describe a semiquantitative immuno-blotting method to measure the released HMGB1 in human serum, in comparison with a commercially available HMGB1 ELISA technique...
  2. pmc It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis
    Shu Zhu
    Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA Department of Emergency Medicine, North Shore University Hospital, The Hofstra North Shore LIJ School of Medicine at the Hofstra University, Manhasset, NY 11030, USA
    Evid Based Complement Alternat Med 2012:498467. 2012
    ..Conclusion. MBC extract is protective against lethal sepsis possibly by stimulating autophagic HMGB1 degradation...
  3. pmc A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York, United States of America
    PLoS ONE 2:e1153. 2007
    ..We previously reported that green tea brewed from the leaves of the plant Camellia sinensis is effective in inhibiting endotoxin-induced HMGB1 release...
  4. pmc Targeting HMGB1 in the treatment of sepsis
    Haichao Wang
    The Feinstein Institute for Medical Research and North Shore University Hospital, The Hofstra North Shore LIJ School of Medicine, Laboratory of Emergency Medicine, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA 1 516 562 2823 1 516 562 1022
    Expert Opin Ther Targets 18:257-68. 2014
    ..The pathogenesis of sepsis is complex, but partly mediated by a newly identified alarmin molecule, the high mobility group box 1 (HMGB1)...
  5. pmc Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes
    Lin Zhao
    Department of Emergency Medicine, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Inflamm Allergy Drug Targets 12:308-14. 2013
    ..This possibility can now be explored by screening other fluorescence-quenching agents for possible antimicrobial activities. ..
  6. pmc Anti-inflammatory role of fetuin-A in injury and infection
    H Wang
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Mol Med 12:625-33. 2012
    ..Collectively, these findings have reinforced an essential role for fetuin-A in counter-regulating injury- or infection-elicited inflammatory responses...
  7. ncbi request reprint Extracellular role of HMGB1 in inflammation and sepsis
    H Wang
    Laboratory of Emergency Medicine, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Intern Med 255:320-31. 2004
    ..Strategies to inhibit HMGB1 activity and release are being investigated in these and other preclinical models of acute and chronic inflammation...
  8. pmc Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats
    Haichao Wang
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    J Cereb Blood Flow Metab 30:493-504. 2010
    ..Taken together, these experimental data suggest that fetuin-A protects against early cerebral ischemic injury partly by attenuating the brain inflammatory response...
  9. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
    ..sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1...
  10. pmc Novel HMGB1-inhibiting therapeutic agents for experimental sepsis
    Haichao Wang
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Community Drive, Manhasset, NY 11030, USA
    Shock 32:348-57. 2009
    ....
  11. pmc Potential role of high mobility group box 1 in viral infectious diseases
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, New York 11030, USA
    Viral Immunol 19:3-9. 2006
    ..In light of observations that many viruses (e.g., West Nile virus, Salmon anemia virus) can induce passive HMGB1 release, we propose a potential pathogenic role of HMGB1 in viral infectious diseases...
  12. pmc Therapeutic potential of HMGB1-targeting agents in sepsis
    Haichao Wang
    Laboratory of Emergency Medicine, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Expert Rev Mol Med 10:e32. 2008
    ....
  13. pmc Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers
    Shu Zhu
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, United States of America
    Mol Med 15:275-82. 2009
    ..Thus, spermine confers protection against lethal sepsis partly by attenuating sepsis- and HMGB1-induced inflammatory responses...
  14. pmc A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    Huan Yang
    Laboratory of Biomedical Science and Department of Medicinal Chemistry, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 107:11942-7. 2010
    ..These results have implications for rationale, design, and development of experimental therapeutics for use in sterile and infectious inflammation...
  15. ncbi request reprint Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  16. pmc A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 178:3856-64. 2007
    ..Taken together, these data re-enforce the pathogenic role of HMGB1 in lethal sepsis, and support a therapeutic potential for TSNIIA-SS in the treatment of human sepsis...
  17. ncbi request reprint Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Lipid Res 46:623-7. 2005
    ..Thus, stearoyl LPC confers protection against lethal experimental sepsis partly by facilitating the elimination of the invading pathogens and partly by inhibiting endotoxin-induced release of a late proinflammatory cytokine, HMGB1...
  18. pmc Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  19. ncbi request reprint Recombinant HMGB1 with cytokine-stimulating activity
    Jianhua Li
    Laboratories of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol Methods 289:211-23. 2004
    ..This strategy provides an important advance in methodology to facilitate future HMGB1 studies...
  20. pmc Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis
    Xiaoling Qiang
    1 Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, New York, USA 2
    Nat Med 19:1489-95. 2013
    ..In particular, human CIRP amino acid residues 106-125 bind to MD2 with high affinity. Thus, CIRP is a damage-associated molecular pattern molecule that promotes inflammatory responses in shock and sepsis. ..
  21. pmc Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Immunol 181:3535-9. 2008
    ..These findings indicate that apoptosis in the spleen is essential to the pathogenesis of HMGB1-mediated sepsis lethality...
  22. ncbi request reprint Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 35:2762-8. 2007
    ..Here we developed a method of transcutaneous mechanical vagus nerve stimulation and then investigated whether this therapy can protect mice against sepsis lethality...
  23. pmc EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages
    Wei Li
    The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Biochem Pharmacol 81:1152-63. 2011
    ..Taken together, the present study has suggested a possibility that EGCG inhibits HMGB1 release by stimulating its autophagic degradation...
  24. ncbi request reprint Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
    ....
  25. pmc Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    ..These observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating that HMGB1 inhibitors can be administered in a clinically relevant time frame...
  26. ncbi request reprint HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
    Man Yu
    Laboratories of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Shock 26:174-9. 2006
    ..Taken together, our data suggest that there is a differential usage of TLR2 and TLR4 in HMGB1 signaling in primary cells and in established cell lines, adding complexity to studies of HMGB1 signaling which was not previously expected...
  27. pmc ╬▒7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release
    Ben Lu
    Department of Hematology, The 3rd Xiangya Hospital, Central South University, Changsha, Hunan Province, P R China Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    Mol Med 20:350-8. 2014
    ....
  28. pmc A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation
    Wei Li
    The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    PLoS ONE 6:e16945. 2011
    ....
  29. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
    ..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism...
  30. ncbi request reprint Bench to bedside: HMGB1-a novel proinflammatory cytokine and potential therapeutic target for septic patients in the emergency department
    Andrew E Sama
    Department of Emergency Medicine, North Shore University Hospital NYU School of Medicine, Manhasset, NY 11030, USA
    Acad Emerg Med 11:867-73. 2004
    ..Here the authors review the studies that led to the discovery of HMGB1 as a late mediator of systemic inflammation and discuss the possibility of HMGB1 as a therapeutic target for septic patients in the emergency department...
  31. pmc Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis
    Cletus Cheyuo
    The Feinstein Institute for Medical Research, Elmezzi Graduate School of Molecular Medicine, United States
    Neuropharmacology 62:890-900. 2012
    ..Thus, rhMFG-E8 treatment is neuroprotective against cerebral ischemia through suppression of inflammation and apoptosis. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  32. pmc Serum Amyloid A Stimulates PKR Expression and HMGB1 Release Possibly through TLR4/RAGE Receptors
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York, United States of America
    Mol Med 21:515-25. 2015
    ....
  33. pmc JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation
    Ben Lu
    The Elmezzi Graduate School of Molecular Medicine, North Shore LIJ Health System, Manhasset, NY 11030
    Proc Natl Acad Sci U S A 111:3068-73. 2014
    ..Together, these results identify a critical role of the JAK/STAT1 pathway in mediating HMGB1 cytoplasmic accumulation for subsequent release, suggesting that the JAK/STAT1 pathway is a potential drug target for inhibiting HMGB1 release. ..
  34. pmc Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake
    Yusong Zhang
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Biochem Pharmacol 84:1492-500. 2012
    ..Taken together, these findings suggest that TSN-SS may facilitate HMGB1 endocytic uptake, and subsequently delivered it to LC3-positive vacuoles (possibly amphisomes) for degradation via a lysosome-dependent pathway...
  35. pmc Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]
    Michael Miksa
    The Feinstein Institute for Medical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    J Immunol 183:5983-90. 2009
    ..We conclude that IDC-derived exosomes attenuate the acute systemic inflammatory response in sepsis by enhancing apoptotic cell clearance via MFGE8...
  36. ncbi request reprint Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  37. ncbi request reprint The cytokine activity of HMGB1
    Huan Yang
    Laboratory of Biomedical Science, Institute for Medical Research at North Shore Long Island Jewish System, Manhasset, NY 11030, USA
    J Leukoc Biol 78:1-8. 2005
    ..Finally, the therapeutic potential of blocking HMGB1 in the treatment of inflammatory diseases is discussed...
  38. pmc More tea for septic patients?--Green tea may reduce endotoxin-induced release of high mobility group box 1 and other pro-inflammatory cytokines
    Xiaotian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    Med Hypotheses 66:660-3. 2006
    ....
  39. pmc Novel role of PKR in inflammasome activation and HMGB1 release
    Ben Lu
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 488:670-4. 2012
    ..These results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation...
  40. pmc Peripheral administration of human adrenomedullin and its binding protein attenuates stroke-induced apoptosis and brain injury in rats
    Wayne W Chaung
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 17:1075-83. 2011
    ..Thus, human AM/AMBP-1 has the ability to reduce stroke-induced brain injury in rats. AM/AMBP-1 can be developed as a novel therapeutic agent for patients with ischemic stroke...
  41. pmc Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats
    Rongqian Wu
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York, USA
    Crit Care Med 37:2421-6. 2009
    ..We hypothesized that ghrelin decreases HMGB1 release and attenuates sepsis-induced gut barrier dysfunction through central ghrelin receptors...
  42. ncbi request reprint HMGB1 as a cytokine and therapeutic target
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 8:469-72. 2002
    ..Thus, strategies that target HMGB1 with specific antibodies or antagonists have potential for treating lethal systemic inflammatory diseases characterized by excessive HMGB1 release...
  43. ncbi request reprint Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    ..8+/-10.9 ng/mL, vs. cerebral ischemia serum HMGB1, 218+/-18.8 ng/mL; P<0.001). These results suggest that systemic HMGB1 levels are elevated in human ischemic disease...
  44. ncbi request reprint Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage
    Xiaoxuan Cui
    Division of Surgical Research, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    Crit Care Med 33:391-8. 2005
    ..We therefore hypothesized that administration of AM/AMBP-1 during fluid resuscitation in hemorrhaged animals (i.e., posttreatment) attenuates tissue injury and the proinflammatory response...
  45. ncbi request reprint HMGB1 as a potential therapeutic target
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, USA
    Novartis Found Symp 280:73-85; discussion 85-91, 160-4. 2007
    ..Taken together, these experimental data establish HMGB1 as a late mediator of lethal endotoxaemia and sepsis with a wider therapeutic window for the clinical management of lethal systemic inflammatory diseases...
  46. pmc Identification of CD163 as an antiinflammatory receptor for HMGB1-haptoglobin complexes
    Huan Yang
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, USA
    JCI Insight 1:. 2016
    ..These findings reveal a mechanism for haptoglobin modulation of the inflammatory action of HMGB1, with significant implications for developing experimental strategies targeting HMGB1-dependent inflammatory diseases...
  47. pmc MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
    Huan Yang
    Department of Biomedical Science and Department of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, NY 11030
    J Exp Med 212:5-14. 2015
    ..The results may direct toward strategies aimed at attenuating DAMP-mediated inflammation while preserving antimicrobial immune responsiveness. ..
  48. pmc Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release
    Wei Li
    The Feinstein Institute for Medical Research, Manhasset, New York, USA
    Mol Med 19:203-11. 2013
    ..Collectively, these results suggested that CBX blocks LPS-induced HMGB1 release possibly through impairing PKR activation, supporting the involvement of PKR in the regulation of HMGB1 release...
  49. ncbi request reprint Extracellular HMGB1 as a proinflammatory cytokine
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    J Interferon Cytokine Res 24:329-33. 2004
    ..Therapeutic agents that inhibit HMGB1 release or action confer significant protection against endotoxemia, sepsis, and arthritis in animal models and thus hold potential for the clinical management of various inflammatory diseases...
  50. pmc High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation
    Shu Zhu
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Inflamm Allergy Drug Targets 9:60-72. 2010
    ..Here we review emerging evidence that support extracellular HMGB1 as a proinflammatory alarmin(g) danger signal, and discuss a wide array of HMGB1 inhibitors as potential therapeutic agents for sepsis and ischemic injury...
  51. ncbi request reprint Pathogenic role of HMGB1 in SARS?
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    Med Hypotheses 63:691-5. 2004
    ....
  52. ncbi request reprint Globin attenuates the innate immune response to endotoxin
    Huan Yang
    Laboratory of Biomedical Science, North Shore University Hospital New York University School of Medicine, New York 11030, USA
    Shock 17:485-90. 2002
    ..Thus, the heme-iron moiety of hemoglobin, and not the binding of LPS to globin, enhanced macrophage responses to LPS...
  53. pmc High-Density Lipoprotein (HDL) Counter-Regulates Serum Amyloid A (SAA)-Induced sPLA2-IIE and sPLA2-V Expression in Macrophages
    Shu Zhu
    Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York, United States of America
    PLoS ONE 11:e0167468. 2016
    ..Collectively, these findings suggest that HDL counter-regulates SAA-induced upregulation and secretion of sPLA2-IIE/V in addition to other TLR4-dependent cytokines and chemokines in macrophage cultures...
  54. pmc EGCG induces G-CSF expression and neutrophilia in experimental sepsis
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, 350 Community Drive, Manhasset, NY, 11030, USA
    Immunol Res 63:144-52. 2015
    ..Based on our preliminary data, it may be important to search for anti-inflammatory and G-CSF-stimulating agents for the clinical management of inflammatory diseases. ..
  55. pmc Regulation of HMGB1 release by inflammasomes
    Ben Lu
    Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Protein Cell 4:163-7. 2013
    ..Together, these studies not only unravel novel mechanisms of HMGB1 release during inflammation, but also provide potential therapeutic targets to treat HMGB1-related inflammatory diseases...
  56. ncbi request reprint Adrenomedullin and adrenomedullin binding protein-1 prevent acute lung injury after gut ischemia-reperfusion
    Amit J Dwivedi
    Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, NY, USA
    J Am Coll Surg 205:284-93. 2007
    ..We hypothesized that administration of AM/AMBP-1 after intestinal I/R prevents acute lung injury through downregulation of proinflammatory cytokines...
  57. pmc Role of HMGB1 in cardiovascular diseases
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    Curr Opin Pharmacol 6:130-5. 2006
    ....
  58. pmc High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger Molecule
    Huan Yang
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America
    Mol Med 21:S6-S12. 2015
    ..We here describe advances in the understanding of HMGB1 biology with focus on recent findings of its mission as a DAMP in danger sensing and as a therapeutic target in inflammatory diseases...
  59. pmc Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis
    Weng Lang Yang
    Department of Surgery, Hofstra North Shore LIJ School of Medicine, Manhasset, NY, 11030, USA
    Crit Care 19:375. 2015
    ..We hypothesized that MFG-E8-derived short peptides (MSP) flanking its RGD motif could provide protection against organ injury in sepsis...
  60. ncbi request reprint HMG-1 rediscovered as a cytokine
    H Yang
    Laboratory of Biomedical Science, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 15:247-53. 2001
    ..When released by activated monocytes, it participates in the development of lethality and it activates downstream cytokine release. This review covers the general features of HMG-1 and its newly appreciated role as a cytokine...
  61. ncbi request reprint HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  62. pmc Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury
    Maria Entezari
    Department of Pharmaceutical Sciences, St John s University, College of Pharmacy and Health Sciences, Queens, NY 11439, USA The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA Department of Natural Science, LaGuardia Community College City University of New York, Queens, NY 11101, USA
    Redox Biol 2:314-22. 2014
    ..If these results can be translated to humans, they suggest that HMGB1 inhibitors provide treatment regimens for oxidative inflammatory lung injury in patients receiving hyperoxia through mechanical ventilation. ..
  63. ncbi request reprint Fetuin, a negative acute phase protein, attenuates TNF synthesis and the innate inflammatory response to carrageenan
    M Ombrellino
    Department of Surgery, North Shore University Hospital-New York University School of Medicine, Manhasset, New York 11030, USA
    Shock 15:181-5. 2001
    ..These results now reveal a previously unrecognized anti-inflammatory role of fetuin in counter-regulating the innate immune response, and suggest that it may be possible to use fetuin as an experimental anti-inflammatory agent...
  64. ncbi request reprint Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Nature 405:458-62. 2000
    ..Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock...
  65. ncbi request reprint Dual roles for HMGB1: DNA binding and cytokine
    C J Czura
    Laboratory of Biomedical Science, North Shore/Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 7:315-21. 2001
    ..The delayed kinetics of HMGB1 release indicate that it may be useful to target this toxic cytokine in the development of future therapies...
  66. pmc Spermine inhibition of monocyte activation and inflammation
    M Zhang
    The Picower Institute for Medical Research, Manhasset, New York 11030, USA
    Mol Med 5:595-605. 1999
    ..Administration of BAP in vivo significantly augmented the development of carrageenan-induced paw edema and nitric oxide release. Thus, endogenous spermine normally inhibits the innate inflammatory response by restraining macrophages...
  67. ncbi request reprint CNI-1493 attenuates hemodynamic and pro-inflammatory responses to LPS
    P E Molina
    Department of Surgery, North Shore University Hospital, Manhasset, New York 11030, USA
    Shock 10:329-34. 1998
    ..These results suggest diverse effects of CNI-1493 that are tissue specific and that confer protection against the hemodynamic and inflammatory responses to LPS...
  68. ncbi request reprint HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
    Davide Agnello
    Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
    Cytokine 18:231-6. 2002
    ..In a model of endotoxemia, passive immunization with anti-HMG-1 antibodies attenuated the development of hypophagia, indicating that HMG-1 is a mediator of sickness behaviour associated with endotoxemia...
  69. ncbi request reprint Lipid unites disparate syndromes of sepsis
    Haichao Wang
    Nat Med 10:124-5. 2004
  70. ncbi request reprint Activation of gene expression in human neutrophils by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 284:C870-9. 2003
    ..These findings indicate that HMGB1 is an effective stimulus of neutrophil activation that can contribute to development of a proinflammatory phenotype in diseases characterized by excessively high levels of HMGB1...
  71. ncbi request reprint Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration
    Madhuri Pahuja
    Department of Cell Biology, University of Medicine and Dentistry, NJ School of Osteopathic Medicine, Stratford, NJ 08084, USA
    Shock 29:754-60. 2008
    ....
  72. pmc A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
    Stanimir Ivanov
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    Blood 110:1970-81. 2007
    ..However, lack of intracellular TLR9-associated HMGB1 can be compensated by extracellular HMGB1. Thus, the DNA-binding protein HMGB1 shuttles in and out of immune cells and regulates inflammatory responses to CpG-DNA...
  73. pmc Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release
    Daolin Tang
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Changsha, Hunan, People s Republic of China
    J Immunol 178:7376-84. 2007
    ..Taken together, these experimental data support a novel role for nuclear Hsp72 as a negative regulator of oxidative stress-induced HMGB1 cytoplasmic translocation and release...
  74. pmc Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
    Daolin Tang
    Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Leukoc Biol 81:741-7. 2007
    ..Together, these data establish an important role for oxidative stress in inducing active HMGB1 release, potentially through a MAPK- and CRM1-dependent mechanism...
  75. pmc Role of HMGB1 in apoptosis-mediated sepsis lethality
    Shixin Qin
    Critical Therapeutics, Inc, Lexington, MA 02421, USA
    J Exp Med 203:1637-42. 2006
    ..Thus, our data indicate that HMGB1 production is downstream of apoptosis on the final common pathway to organ damage in severe sepsis...
  76. ncbi request reprint Interferon-gamma inhibition attenuates lethality after cecal ligation and puncture in rats: implication of high mobility group box-1
    Kingsley Yin
    Department of Cell Biology, UMDNJ School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Shock 24:396-401. 2005
    ..These results suggest that the attenuation of mortality in IFN-gamma antibody-treated rats was associated with a decrease in HMGB1 release...
  77. ncbi request reprint Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock
    Jessica Jones-Carson
    Departments of Medicine, and Microbiology, University of Colorado Health Sciences Center, Denver, USA
    J Infect Dis 192:1039-46. 2005
    ..These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia...
  78. pmc The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages
    Daolin Tang
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Changsha, People s Republic of China
    J Immunol 179:1236-44. 2007
    ..Our experimental data provide important insights into the anti-inflammatory mechanisms of heat shock protein protection...
  79. ncbi request reprint Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects
    Kevin A O'Connor
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA
    Cytokine 24:254-65. 2003
    ..Nonetheless, these data suggest that HMGB1 may play a role as an endogenous pyrogen and support the concept that HMGB1 has proinflammatory characteristics within the central nervous system...
  80. ncbi request reprint A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis
    Daolin Tang
    Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, PR China
    Crit Care Med 36:291-5. 2008
    ..To determine whether cerebrospinal fluid (CSF) levels of high mobility group box 1 (HMGB1) or heat shock protein 72 (Hsp72) are elevated in patients with meningitis...
  81. pmc Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis
    Sachin Yende
    The Clinical Research, Investigation, and Systems Modeling of Acute Illness CRISMA Laboratory, Department of Critical Care Medicine, Graduate School of Pubic Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Respir Crit Care Med 177:1242-7. 2008
    ..Survivors of hospitalization for community-acquired pneumonia (CAP) are at increased risk of cardiovascular events, repeat infections, and death in the following months but the cause is unknown...
  82. doi request reprint Hyperglycemia aggravates endotoxin-induced high mobility group box 1 protein release: yet another reason not to be too sweet
    Haichao Wang
    Crit Care Med 36:2475-6. 2008

Research Grants1

  1. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..