Hong Zhao

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. doi request reprint Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation
    Hong Zhao
    Department of Pharmacology, New York Medical College, 95 Grasslands Road, Valhalla, NY 10595, United States
    Eur J Pharmacol 590:29-35. 2008
  2. pmc Cell fixation in zinc salt solution is compatible with DNA damage response detection by phospho-specific antibodies
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 79:470-6. 2011
  3. ncbi request reprint Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty
    Hong Zhao
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H2973-81. 2007
  4. pmc Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
    H Dorota Halicka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 4:952-65. 2012
  5. pmc Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, USA
    Methods Cell Biol 103:115-47. 2011
  6. pmc Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry"
    Hong Zhao
    Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Cytometry A 79:897-902. 2011
  7. pmc Berberine suppresses gero-conversion from cell cycle arrest to senescence
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 5:623-36. 2013
  8. pmc DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes
    Ellen D Jorgensen
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, USA
    Cell Cycle 9:2170-6. 2010
  9. pmc Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling
    H Dorota Halicka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 3:1028-38. 2011
  10. pmc DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, 10595
    Cytometry A 83:979-88. 2013

Collaborators

Detail Information

Publications76

  1. doi request reprint Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation
    Hong Zhao
    Department of Pharmacology, New York Medical College, 95 Grasslands Road, Valhalla, NY 10595, United States
    Eur J Pharmacol 590:29-35. 2008
    ..These results provide a rational explanation for the beneficial effects of PDE inhibitors...
  2. pmc Cell fixation in zinc salt solution is compatible with DNA damage response detection by phospho-specific antibodies
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 79:470-6. 2011
    ..Analysis of cells by flow cytometry revealed that ZBF fixation of lymphoblastoid TK6 cells led to about 60 and 33% higher intensity of the side and forward light scatter, respectively, compared to formaldehyde fixed cells...
  3. ncbi request reprint Differential effects of phosphodiesterase PDE-3/PDE-4-specific inhibitors on vasoconstriction and cAMP-dependent vasorelaxation following balloon angioplasty
    Hong Zhao
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H2973-81. 2007
    ..These results suggest that increased PDE-3 activity after BAL may promote a vasospastic state and that the reduction in cAMP may, possibly, influence vessel remodeling...
  4. pmc Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling
    H Dorota Halicka
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 4:952-65. 2012
    ..The data suggest that combined assessment of constitutive γH2AX expression, mitochondrial activity (ROS, ΔΨm) and mTOR signaling provides an adequate gamut of cell responses to evaluate effectiveness of gero-suppressive agents...
  5. pmc Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, USA
    Methods Cell Biol 103:115-47. 2011
    ..The new microfluidic Lab-on-a-Chip platforms for interrogation of individual cells offer a novel approach for DDR cytometric analysis...
  6. pmc Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using "click chemistry"
    Hong Zhao
    Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Cytometry A 79:897-902. 2011
    ....
  7. pmc Berberine suppresses gero-conversion from cell cycle arrest to senescence
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 5:623-36. 2013
    ....
  8. pmc DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes
    Ellen D Jorgensen
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, USA
    Cell Cycle 9:2170-6. 2010
    ..Since DSBs are potentially carcinogenic our data indicate that smoking tobacco and nicotine-free cigarettes is at least as hazardous as smoking cigarettes containing tobacco and nicotine...
  9. pmc Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling
    H Dorota Halicka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 3:1028-38. 2011
    ....
  10. pmc DNA damage signaling, impairment of cell cycle progression, and apoptosis triggered by 5-ethynyl-2'-deoxyuridine incorporated into DNA
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, 10595
    Cytometry A 83:979-88. 2013
    ....
  11. pmc Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 81:45-51. 2012
    ..The confocal analysis of the association between DNA replication sites and the sites of DSBs (γH2AX foci) opens a new approach for mechanistic studies of the involvement of DNA replication in induction of DNA damage...
  12. pmc Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3
    H Dorota Halicka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Aging (Albany NY) 4:270-8. 2012
    ....
  13. pmc DNA damage response induced by tobacco smoke in normal human bronchial epithelial and A549 pulmonary adenocarcinoma cells assessed by laser scanning cytometry
    Hong Zhao
    New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 75:840-7. 2009
    ..The cytometric assessment of CS-induced DDR provides a means to estimate the genotoxicity of CS and to explore the mechanisms of the response as a function of cell cycle phase and cell type...
  14. pmc DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Crit Rev Clin Lab Sci 49:199-217. 2012
    ..Critically assessed is interpretation of the data as to whether the observed DDS events report induction of a particular type of DNA lesion...
  15. pmc In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, 10595
    Cytometry A 85:386-99. 2014
    ..Discussed is cytometric analysis of cell size and heterogeneity of size as a potential biomarker used to asses gero-suppressive agents and longevity...
  16. pmc Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence
    Elise McKenna
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY, USA
    Cell Cycle 11:3132-40. 2012
    ..It is reasonable to expect that tumors having constitutive activation of oncogenes triggering mTOR signaling may be particularly predisposed to undergoing senescence following prolonged treatment with low doses of DNA damaging drugs...
  17. pmc Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry
    Zbigniew Darzynkiewicz
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, 10595, Valhalla, NY, USA
    Methods Mol Biol 761:85-96. 2011
    ..Concurrent measurement of cellular DNA content and phosphorylated proteins followed by multiparameter cytometric analysis allows one to correlate extent of their phosphorylation with cell cycle phase...
  18. pmc Cytometry of DNA replication and RNA synthesis: Historical perspective and recent advances based on "click chemistry"
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 79:328-37. 2011
    ..Several examples are presented that illustrate incorporation of EdU or EU in cells subjected to DNA damage detected as histone H2AX phosphorylation that have been analyzed by flow or laser scanning cytometry...
  19. pmc Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, NY
    Oncotarget 6:11735-50. 2015
    ..Discussed is also usefulness of these markers as indicators of proliferative activity in cancer tissues that may bear information on tumor progression and have a prognostic value...
  20. pmc NFAT5 is protective against ischemic acute kidney injury
    Shoujin Hao
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595
    Hypertension 63:e46-52. 2014
    ..Collectively, the data suggest that NFAT5 is part of a protective mechanism that limits renal damage induced by IRI. ..
  21. pmc Biomarkers of cell senescence assessed by imaging cytometry
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, NY, USA
    Methods Mol Biol 965:83-92. 2013
    ..These biomarker indices can be expressed in quantitative terms ("senescence indices") as a fraction of the same markers of the exponentially growing cells in control cultures...
  22. pmc New biomarkers probing depth of cell senescence assessed by laser scanning cytometry
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 77:999-1007. 2010
    ....
  23. pmc Rationale for the real-time and dynamic cell death assays using propidium iodide
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York, USA
    Cytometry A 77:399-405. 2010
    ..The overall responses of cells to cytotoxic agents were also not affected by the growth in the presence PI. Our data lend further support to the notion that PI can be effectively used in real-time, kinetic viability assays...
  24. ncbi request reprint Synergy of 2-deoxy-D-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis
    H Dorota Halicka
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, BSB 438, Valhalla, NY, 10595, USA
    Apoptosis . 2016
    ..The data show that the cell subpopulation undergoing apoptosis has increased side (right-angle) light scatter likely due to the presence of the crosslinked (solid state) proteins, the consequence Tgase activation...
  25. pmc A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phase
    Sufang Zhang
    From the Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595
    J Biol Chem 288:29550-61. 2013
    ..The formation of Pol δ3 in S phase as a normal aspect of cell cycle progression leads to the novel implications that it is involved in DNA replication as well as DNA repair. ..
  26. pmc Analysis of cellular DNA content by flow and laser scanning cytometry
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute at NYMC, Department of Pathology, BSB 438, Valhalla, New York 10595, USA
    Adv Exp Med Biol 676:137-47. 2010
    ..Described also are controls used to ensure accuracy of DNA ploidy determination, the principles in ploidy assessment and possible pitfalls in analysis...
  27. pmc Analysis of apoptosis by cytometry using TUNEL assay
    Zbigniew Darzynkiewicz
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Basic Sciences Building, Valhalla, NY 10595, USA
    Methods 44:250-4. 2008
    ..Concurrent staining of DNA with propidium or 4',6-diamidino-2-phenylindole (DAPI) and multiparameter analysis of cells by flow- or laser scanning cytometry enables one to correlate induction of apoptosis with the cell cycle phase...
  28. ncbi request reprint DNA Damage Response Resulting from Replication Stress Induced by Synchronization of Cells by Inhibitors of DNA Replication: Analysis by Flow Cytometry
    Dorota Halicka
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, 40 Sunshine Cottage Road, Valhalla, NY, 10595, USA
    Methods Mol Biol 1524:107-119. 2017
    ..Concurrent measurement of cellular DNA content followed by multiparameter analysis allows one to correlate the extent of phosphorylation of these proteins in response to aphidicolin with the cell cycle phase...
  29. pmc Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling and induces senescence in papillary thyroid carcinoma cells
    Theodore S Nowicki
    Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA
    Cell Cycle 10:100-7. 2011
    ....
  30. pmc Cytometric detection of chromatin relaxation, an early reporter of DNA damage response
    H Dorota Halicka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Cell Cycle 8:2233-7. 2009
    ..The method offers a rapid and simple means of detecting genotoxic insult on cells...
  31. pmc Disruption of mutated BRAF signaling modulates thyroid cancer phenotype
    Elyse K Hanly
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York 10595, USA
    BMC Res Notes 7:187. 2014
    ..Our laboratory evaluated cellular phenotypic effects in response to treatment with PLX4032, a BRAFV600E-specific inhibitor, in normal BRAF-wild-type thyroid cells and in BRAFV600E-positive papillary thyroid cancer cells...
  32. doi request reprint Measuring the impact of cigarette smoke on the UPR
    Hong Zhao
    Department of Pathology, New York Medical College, Valhalla, New York, USA
    Methods Enzymol 489:147-64. 2011
    ..We hereby provide a detailed description of methods for assessing the degree and timing of cellular response to CS with respect to the three major UPR pathways...
  33. pmc Induction of DNA damage response by the supravital probes of nucleic acids
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 75:510-9. 2009
    ..The data indicate that supravital use of Ho 42, DRAQ5, and DCV induces various degrees of DDR, including activation of ATM, Chk2 and p53, which may have significant consequences on regulatory cell cycle pathways and apoptosis...
  34. pmc Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells
    Soyoung Park
    Department of Pathology, School of Medicine, New York Medical College, Valhalla, NY, USA
    Oncotarget 7:8916-30. 2016
    ..We propose that in addition to its role in the canonical EGFR signaling pathway and other signaling pathways, Gene 33 may also inhibit Cr(VI)-induced lung carcinogenesis by reducing DNA damage triggered by Cr(VI). ..
  35. pmc Attenuation of replication stress-induced premature cellular senescence to assess anti-aging modalities
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York
    Curr Protoc Cytom 69:9.47.1-9.47.10. 2014
    ..The multivariate analysis of senescence markers by laser scanning cytometry offers a promising tool to explore the potential anti-aging properties of a variety agents...
  36. doi request reprint Reduced expression of the androgen receptor by third generation of antisense shows antitumor activity in models of prostate cancer
    Yixian Zhang
    Department of Pharmacology, Enzon Pharmaceuticals, Inc, 20 Kingsbridge Road, Piscataway, NJ 08854, USA
    Mol Cancer Ther 10:2309-19. 2011
    ..These data, together with the continued dependency of CRPC on the AR signaling pathway, justify the ongoing phase I evaluation of EZN-4176 in patients with CRPC...
  37. pmc (D)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha
    Christian K Nickl
    Department of Pharmacology, University of Vermont, College of Medicine, HSRF 330, 149 Beaumont Avenue, Burlington, VT 05405, USA
    Biochim Biophys Acta 1804:524-32. 2010
    ....
  38. pmc Kinetics of the UV-induced DNA damage response in relation to cell cycle phase. Correlation with DNA replication
    Hong Zhao
    Department of Pathology, Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 77:285-93. 2010
    ....
  39. pmc Detection of DNA strand breaks in apoptotic cells by flow- and image-cytometry
    Zbigniew Darzynkiewicz
    Department of Pathology, New York Medical College, Brander Cancer Research Institute, Valhalla, NY, USA
    Methods Mol Biol 682:91-101. 2011
    ..The protocol can be applied to the cells growing in vitro, treated ex vivo with cytotoxic drugs as well as to clinical samples...
  40. pmc Differential regulation of NFAT5 by NKCC2 isoforms in medullary thick ascending limb (mTAL) cells
    Shoujin Hao
    Department of Pharmacology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Renal Physiol 300:F966-75. 2011
    ..These findings suggest that NKCC2A and NKCC2F exhibit differential effects on NFAT5 expression and transcriptional activity in response to hypertonicity produced by high NaCl concentration...
  41. pmc Protective effect of hyaluronate on oxidative DNA damage in WI-38 and A549 cells
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:1159-67. 2008
    ..Since no significant degradation of HA upon its exposure in tissue culture medium to H2O2 was detected the scavenging may occur intracellularly...
  42. pmc Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
    Toshiki Tanaka
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:648-61. 2007
    ....
  43. pmc Oxidative stress induces cell cycle-dependent Mre11 recruitment, ATM and Chk2 activation and histone H2AX phosphorylation
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 7:1490-5. 2008
    ..g., maximal pixel) offers unique advantage in studies of the response of different cell constituents in relation to cell cycle position...
  44. pmc Phosphorylation of p53 on Ser15 during cell cycle caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation
    Hong Zhao
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 7:3048-55. 2008
    ..The respective kinetics of p53-Ser15 phosphorylation versus ATM and Chk2 activation suggest that in response to DNA damage by TPT or MXT, Chk2 rather than ATM mediates p53 phosphorylation...
  45. doi request reprint Kinetics of histone H2AX phosphorylation and Chk2 activation in A549 cells treated with topotecan and mitoxantrone in relation to the cell cycle phase
    Hong Zhao
    Brander Cancer Research Institute, Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 73:480-9. 2008
    ....
  46. pmc Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes
    Hong Zhao
    Brander Cancer Research Institute, New York Medical College, Valhalla, New York 10595, USA
    Cytometry A 71:905-14. 2007
    ..Cytometric analysis of CHP and CAA provides the means to measure the effectiveness of exogenous factors, which either through lowering aerobic metabolism or neutralizing radicals may protect DNA from such damage...
  47. ncbi request reprint Decreased hypothalamic aromatization in female rats of true precocious puberty
    Zhan zhuang Tian
    Department of Neurobiology and Integrative Medicine, Shanghai Medical Center, Fudan University, P O Box 291, 138 Yi Xue Yuan Road, Shanghai 200032, PR China
    Neurosci Lett 366:92-6. 2004
    ..05). The results suggested that the hypothalamic aromatization might diminish in the onset of true precocious puberty of female rats...
  48. ncbi request reprint 14-3-3sigma mediation of cell cycle progression is p53-independent in response to insulin-like growth factor-I receptor activation
    Yang Zhang
    Section on Molecular and Cellular Physiology, Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Bethesda, MD 20892 1758, USA
    J Biol Chem 279:34353-60. 2004
    ..This effect was also associated with a reduction in IGF-I-induced cyclin D1 expression. Taken together, these results suggest that 14-3-3sigma positively mediates IGF-I-induced cell cycle progression...
  49. ncbi request reprint PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
    Hong Zhao
    Diabetes Branch, NIDDK, National Institute of Health, Room 8D12, Bldg 10, Bethesda, MD 20892 1758, USA
    Oncogene 23:786-94. 2004
    ..These results have important implications for understanding the roles of PTEN and the IGF-IR in prostate cancer cell tumorigenesis...
  50. ncbi request reprint Multiple signaling pathways are involved in the regulation of IGF-I receptor inhibition of PTEN-enhanced apoptosis
    Yiping Wu
    Chief Diabetes Branch, Room 8D12, Bldg 10, Bethesda, MD 20892 1758, USA
    Growth Horm IGF Res 14:52-8. 2004
    ..Furthermore, IGF-I receptor abrogation of this apoptotic effect was inhibited by both PI3' kinase and by specific inhibitors of p38 MAP kinase. Thus, we show for the first time that p38 MAP kinase is involved in this process...
  51. ncbi request reprint Homochiral Zn and Cd coordination polymers containing amino acid-tetrazole ligands
    Zhi Rong Qu
    Coordination Chemistry Institute, The State Key Laboratory of Coordination Chemistry, Nanjing University, 210093 Nanjing, P R China
    Inorg Chem 42:7710-2. 2003
    ..The structure of these coordination polymers gives new insight into Sharpless' reaction of chiral 5-substituted 1H-tetrazole and homochiral supramolecular array constructions...
  52. ncbi request reprint Neuroprotective effect of Alpinia oxyphylla Miq. fruits against glutamate-induced apoptosis in cortical neurons
    Xinyu Yu
    Institute of Bioengineering, Dalian University of Technology, 2 Lingong Road, Dalian 116024, China
    Toxicol Lett 144:205-12. 2003
    ..These results suggest the neuroprotective potential of A. oxyphylla fruits against glutamate-induced neuronal apoptosis...
  53. ncbi request reprint Comparative study on apoptosis induction of SMMC7721 and Vero cells by Clostridium difficile toxin A
    Jin Zhao
    The Fifth Department, Medical College of Northwest Minorities University, Lanzhou, Gansu, 730000, PR China
    Ai Zheng 22:719-24. 2003
    ..This study was designed to investigate whether Clostridium difficile toxin A might induce apoptosis on human hepatoma cell line SMMC7721 and African green monkey kidney Vero cells...
  54. ncbi request reprint Comparative studies of LFA-1/ICAM-1 interaction by micropipette and flow chamber techniques
    Hong Zhao
    Cell and Tissue Engineering and Mechanics, LEMTA UMR 7563 CNRS and IFR111 Bioengineering, Faculte de Medecine, 54500, Vandoeuvre les Nancy, France
    Biorheology 40:179-87. 2003
    ....
  55. ncbi request reprint Preliminary in vivo study of an intra-aortic impeller pump driven by an extracorporeal whirling magnet
    Guorong Li
    Division of Assisted Circulation and Heart Valve, Department of Cardiac Surgery, Fu Wai Heart Hospital and Cardiovascular Institute, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Artif Organs 26:890-3. 2002
    ..The novel left ventricular assist device (LVAD) concept of an intra-aortic impeller pump, driven by an extracorporeal magnetic device, is feasible...
  56. ncbi request reprint Effects of testosterone and 17-beta-estradiol on TNF-alpha-induced E-selectin and VCAM-1 expression in endothelial cells. Analysis of the underlying receptor pathways
    Xuan Zhang
    Laboratory of Molecular Biology, Shanxi Medical University, 030001 Taiyuan, Shanxi, PR China
    Life Sci 71:15-29. 2002
    ..The implications of these results for the facilitory effects of both sex hormones on immune reactions are discussed...
  57. ncbi request reprint The effect of C-terminal helix stabilization on specific DNA binding by monomeric GCN4 peptides
    Min Zhang
    Rutgers University, Department of Chemistry and Chemical Biology, Piscataway, NJ 08854, USA
    J Pept Sci 8:125-36. 2002
    ..Our fluorescence assay should also prove useful for determining dissociation constants for CRE binding by other GCN4 basic region analogues under equilibrium conditions and physiological salt concentrations...
  58. ncbi request reprint Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate
    Hong Zhao
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    Biochem Biophys Res Commun 292:482-91. 2002
    ..This is the first report to demonstrate differential gene and protein expression of growth factors in dorsal and ventral lobes is associated with aging rat prostate, suggesting their role in pathogenesis of prostatic diseases with aging...
  59. ncbi request reprint Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen
    Kazuo Ikeda
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 277:19206-12. 2002
    ..The data support a model in which Src and the DDR2 receptor cooperate in a regulated fashion to direct the phosphorylation of both the receptor and its targets...
  60. ncbi request reprint Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes
    Hong Zhao
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Diabetes 53:2901-9. 2004
    ..These results suggest that glucotoxicity plays little or no role in the worsening of insulin resistance that occurs in the MKR mouse model of type 2 diabetes...
  61. ncbi request reprint Region 752-761 of STAT3 is critical for SRC-1 recruitment and Ser727 phosphorylation
    Hong Zhao
    Department of Immunology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 325:541-8. 2004
    ..Thus, the conserved STAT3 region from 752 to 761, called STAT3 CR2, plays critical roles in STAT3-dependent transcription by recruiting SRC-1 and allowing Ser727 phosphorylation...
  62. ncbi request reprint p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling
    Leon Tourian
    Fraser Laboratories, Department of Medicine, McGill University Health Centre and Royal Victoria Hospital, Montreal, Quebec, H3A 1A1, Canada
    J Cell Sci 117:6459-71. 2004
    ....
  63. doi request reprint A quantitative study of factors affecting in vivo bioluminescence imaging
    Kemi Cui
    Department of Radiology, The Methodist Hospital, Weill Cornell University, Houston, TX 77030, USA
    Luminescence 23:292-5. 2008
    ..The data indicate that a carefully designed BLI experiment is required to generate optimal and consistent results...
  64. doi request reprint Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model
    Puja Sapra
    Enzon Pharmaceuticals, Inc, Piscataway, New Jersey 08854, USA
    Clin Cancer Res 14:1888-96. 2008
    ..We have developed a novel polymer-drug conjugate, EZN-2208, made by linking SN38 with a multiarm polyethylene glycol via a glycine linker...
  65. ncbi request reprint Synthesis of genistein derivatives and determination of their protective effects against vascular endothelial cell damages caused by hydrogen peroxide
    Xiao Hua Fu
    College of Medicine, Hunan Normal University, Changsha, Hunan 410006, PR China
    Bioorg Med Chem Lett 18:513-7. 2008
    ..Among these derivatives, 7-difluoromethyl-5,4'-dimethoxygenistein exhibited the strongest activity against hydrogen peroxide induced apoptosis of HUVE-12 cells...
  66. doi request reprint In situ hydrothermal synthesis of tetrazole coordination polymers with interesting physical properties
    Hong Zhao
    Ordered Matter Science Research Center, College of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China
    Chem Soc Rev 37:84-100. 2008
    ..The direct coordination chemistry of tetrazoles to metal ions and in situ synthesis of tetrazole through cycloaddition between organotin azide and organic cyano group will be not discussed in this review...
  67. ncbi request reprint Effect of ghrelin on human endothelial cells apoptosis induced by high glucose
    Hong Zhao
    Department of Endocrinology, First Hospital of China Medical University, Shenyang 110001, China
    Biochem Biophys Res Commun 362:677-81. 2007
    ..This peptide may have potential in preventing diabetic complications, especially in obese patients...
  68. ncbi request reprint Potential mechanisms and significance of acute pancreatitis-associated liver injury
    Xiangdong Wang
    Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, China
    Scand J Gastroenterol 41:604-13. 2006
  69. ncbi request reprint Evaluation of electroacupuncture on ovariectomized rats: implications of modern scientific mechanisms on acupuncture curing woman perimenopausal syndrome
    Hong Zhao
    Department of Neurobiology and Integrative Medicine, Institute of Acupuncture Research WHO Collaborating Center for Traditional Medicine, Shanghai Medical College of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, Shanghai, China
    Acupunct Electrother Res 30:275-88. 2005
    ....
  70. ncbi request reprint Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta
    Sung Sik Park
    Department of Anesthesiology, The University of North Carolina at Chapel Hill, 27599, USA
    J Mol Cell Cardiol 40:708-16. 2006
    ..The PI3-kinase/Akt pathway and ERK, but not the mTOR/p70s6K pathway account for the suppression of GSK-3beta by bradykinin...
  71. ncbi request reprint Metabolic effects of IGF-I deficiency: lessons from mouse models
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Pediatr Endocrinol Rev 3:11-9. 2005
    ..In the present review we will summarize the role of GH and IGF in somatic growth and focus on the metabolic effects of IGF-I deficiency as assessed in various mouse models...
  72. ncbi request reprint Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus
    Robert H Carter
    University of Alabama at Birmingham, Birmingham VA Medical Center, Alabama, USA
    Arthritis Rheum 52:3943-54. 2005
    ..To determine whether receptors for B lymphocyte stimulator (BLyS) are altered on B cells of patients with systemic lupus erythematosus (SLE)...
  73. pmc Evaluation of the true precocious puberty rats induced by neonatal administration of Danazol: therapeutic effects of nourishing "Yin"-Removing "Fire" Chinese herb mixture
    Zhanzhuang Tian
    Department of Neurobiology and Integrative Medicine, Shanghai Medical College, Fudan University, PO Box 291, 200032 Shanghai, PR China
    Reprod Biol Endocrinol 3:38. 2005
    ....
  74. ncbi request reprint Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice
    Matthias Sausbier
    Pharmakologie und Toxikologie, Pharmazeutisches Institut der Universität Tübingen, Tubingen, Germany
    Circulation 112:60-8. 2005
    ..However, the BK channel may also affect blood pressure by regulating salt and fluid homeostasis, particularly by adjusting the renin-angiotensin-aldosterone system...
  75. pmc STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation
    Hirotada Kojima
    Department of Immunology, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Proc Natl Acad Sci U S A 102:4524-9. 2005
    ..Together, these results indicate that STAT3 enhances the efficiency of its own Ser-727 phosphorylation by acting as a scaffold for the TAK1-NLK kinases, specifically in the YXXQ motif-derived pathway...
  76. ncbi request reprint Studies on single-cell adhesion probability between lymphocytes and endothelial cells with micropipette technique
    Hong Zhao
    Institute of Clinical Medical Sciences, China Japan Friendship Hospital, Beijing, 100029, China
    Microvasc Res 63:218-26. 2002
    ..These results indicate that the micropipette technique is a useful model for investigating single-cell adhesion probability between lymphocytes and endothelial cells in vitro...