DEBORAH L YELON

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Cardiac patterning and morphogenesis in zebrafish
    D Yelon
    Developmental Genetics Program, Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 222:552-63. 2001
  2. ncbi request reprint Pattern formation: swimming in retinoic acid
    Deborah Yelon
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Curr Biol 12:R707-9. 2002
  3. pmc Vessel and blood specification override cardiac potential in anterior mesoderm
    Jeffrey J Schoenebeck
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:254-67. 2007
  4. ncbi request reprint Vertebrate organogenesis: getting the heart into shape
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Curr Biol 14:R152-3. 2004
  5. pmc Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:472-82. 2009
  6. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
  7. ncbi request reprint Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    Nathalia Glickman Holtzman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 134:2379-86. 2007
  8. pmc Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:1207-13. 2009
  9. ncbi request reprint Retinoic acid signaling restricts the cardiac progenitor pool
    Brian R Keegan
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 307:247-9. 2005
  10. ncbi request reprint Organization of cardiac chamber progenitors in the zebrafish blastula
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 131:3081-91. 2004

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Cardiac patterning and morphogenesis in zebrafish
    D Yelon
    Developmental Genetics Program, Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 222:552-63. 2001
    ..Altogether, these data provide a substantial foundation for future investigations of cardiac patterning, cardiac morphogenesis, and the relationship between these processes...
  2. ncbi request reprint Pattern formation: swimming in retinoic acid
    Deborah Yelon
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Curr Biol 12:R707-9. 2002
    ..Recent studies in zebrafish extend this model by demonstrating the influence of retinoic acid on endoderm regionalization...
  3. pmc Vessel and blood specification override cardiac potential in anterior mesoderm
    Jeffrey J Schoenebeck
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 13:254-67. 2007
    ..This regulatory relationship between cardiovascular pathways suggests strategies for directing progenitor cell differentiation to facilitate cardiac regeneration...
  4. ncbi request reprint Vertebrate organogenesis: getting the heart into shape
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Curr Biol 14:R152-3. 2004
    ..Recent mutant analysis in zebrafish points to an important role for oriented cell division in cardiac chamber formation and reveals its molecular control by a novel signal from the heart's interior...
  5. pmc Differential requirement for BMP signaling in atrial and ventricular lineages establishes cardiac chamber proportionality
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:472-82. 2009
    ..Together, our studies uncover a new role for BMP signaling in the regulation of chamber size, supporting a model in which differential reception of cardiac inductive signals establishes chamber proportion...
  6. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb...
  7. ncbi request reprint Endocardium is necessary for cardiomyocyte movement during heart tube assembly
    Nathalia Glickman Holtzman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 134:2379-86. 2007
    ..Together, our data reveal a dynamic cellular mechanism by which tissue interactions establish organ architecture...
  8. pmc Increased Hox activity mimics the teratogenic effects of excess retinoic acid signaling
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 238:1207-13. 2009
    ..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart...
  9. ncbi request reprint Retinoic acid signaling restricts the cardiac progenitor pool
    Brian R Keegan
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Science 307:247-9. 2005
    ..Thus, retinoic acid signaling creates a balance between cardiac and noncardiac identities, thereby refining the dimensions of the cardiac progenitor pool...
  10. ncbi request reprint Organization of cardiac chamber progenitors in the zebrafish blastula
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 131:3081-91. 2004
    ..Indeed, via fate mapping, we demonstrate that Nodal signaling promotes ventricular fate specification near the margin, thereby playing an important early role during myocardial patterning...
  11. ncbi request reprint Coordinating morphogenesis: epithelial integrity during heart tube assembly
    Nathalia S Glickman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 6:311-2. 2004
    ....
  12. pmc Illuminating cardiac development: Advances in imaging add new dimensions to the utility of zebrafish genetics
    Jeffrey J Schoenebeck
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Semin Cell Dev Biol 18:27-35. 2007
    ..Future enrichment of the arsenal of experimental strategies available for zebrafish should continue the yield of high returns from such a small source...
  13. ncbi request reprint Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    Eli Berdougo
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Development 130:6121-9. 2003
    ..These findings are relevant to our understanding of congenital defects in cardiac chamber morphogenesis...
  14. pmc Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number
    KIMARA L TARGOFF
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 322:314-21. 2008
    ..Our data suggest that morphogenetic errors could originate during early stages of heart tube assembly in patients with NKX2-5 mutations...
  15. ncbi request reprint The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo
    Brian R Keegan
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Development 129:1623-32. 2002
    ..This study provides the first genetic evidence for parallel functions of Spt6 and Spt5 in metazoans and establishes a system for the future analysis of transcription elongation during development...
  16. ncbi request reprint Cardiovascular system
    Deborah Yelon
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Results Probl Cell Differ 40:298-321. 2002
  17. pmc Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    Natalie A Thomas
    Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA
    Development 135:3789-99. 2008
    ..Thus, Hh signaling plays an essential early role in defining the optimal number of cardiomyocytes, making it an attractive target for manipulation of multipotent progenitor cells...
  18. pmc Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 321:397-406. 2008
    ..Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion...
  19. ncbi request reprint Cardiac development in zebrafish: coordination of form and function
    Nathalia S Glickman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Semin Cell Dev Biol 13:507-13. 2002
    ..These processes ensure proper cardiac function; likewise, cardiac function may influence aspects of cardiac morphogenesis...
  20. pmc Functional modulation of cardiac form through regionally confined cell shape changes
    Heidi J Auman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Biol 5:e53. 2007
    ..Together, these data establish regionally confined cell shape change as a cellular mechanism for chamber emergence and as a link in the relationship between form and function during organ morphogenesis...
  21. ncbi request reprint Comparison of the expression patterns of newly identified zebrafish retinoic acid and retinoid X receptors
    Joshua S Waxman
    Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Dev Dyn 236:587-95. 2007
    ..By representing what is potentially the complete set of zebrafish RARs and RXRs, this study provides a valuable reference for future functional studies of the individual zebrafish RARs and RXRs...

Research Grants2

  1. Comparative genetics of cardiac chamber formation
    Deborah Yelon; Fiscal Year: 2006
    ..Furthermore, by capitalizing on the complementary advantages of two model organisms, the PIs will develop a new approach for functional annotation of cardiac gene expression profiles. ..
  2. Regulation of cardiac chamber morphogenesis in zebrafish
    Deborah Yelon; Fiscal Year: 2008
    ..Together, these studies will reveal essential regulatory mechanisms of cardiogenesis and also enrich our understanding of general paradigms for organ formation. ..