Dagan Wells

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Cytogenetics in reproductive medicine: the contribution of comparative genomic hybridization (CGH)
    Dagan Wells
    The Institute for Reproductive Medicine and Science, St Barnabas Medical Center, New Jersey 07052, USA
    Bioessays 25:289-300. 2003
  2. ncbi request reprint Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates
    Jacques Cohen
    Reprogenetics LLC, West Orange, New Jersey, USA
    Fertil Steril 87:496-503. 2007
  3. doi request reprint Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States
    Cristina Gutiérrez-Mateo
    Reprogenetics LLC, Livingston, New Jersey, USA
    Fertil Steril 92:1544-56. 2009
  4. ncbi request reprint Maternal age-related differential global expression profiles observed in human oocytes
    Nury M Steuerwald
    ART Institute of New York and New Jersey, Livingston, New Jersey 07039, USA
    Reprod Biomed Online 14:700-8. 2007
  5. ncbi request reprint First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy
    Dagan Wells
    Department of Obstetrics and Gynaecology, University College London, United Kingdom
    Fertil Steril 78:543-9. 2002
  6. ncbi request reprint Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis
    Santiago Munne
    The Institute of Reproductive Medicine and Science, Saint Barnabas Medical Center, West Orange, New Jersey 07052, USA
    Fertil Steril 80:871-2; discussion 875. 2003
  7. ncbi request reprint Advances in preimplantation genetic diagnosis
    Dagan Wells
    The Institute for Reproductive Medicine and Science, St Barnabas Medical Center, 101, Old Short Hills Road, NJ 07052, USA
    Eur J Obstet Gynecol Reprod Biol 115:S97-101. 2004
  8. ncbi request reprint Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis
    Mercedes G Bermudez
    The Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, West Orange, NJ 07052, USA
    Prenat Diagn 23:669-77. 2003
  9. ncbi request reprint Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls
    Elpida Fragouli
    Fertil Steril 88:247-8; author reply 248-9. 2007
  10. doi request reprint Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy: case report
    Albert Obradors
    Unitat de Biologia Cel lular i Genètica Mèdica, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Hum Reprod 23:1949-56. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Cytogenetics in reproductive medicine: the contribution of comparative genomic hybridization (CGH)
    Dagan Wells
    The Institute for Reproductive Medicine and Science, St Barnabas Medical Center, New Jersey 07052, USA
    Bioessays 25:289-300. 2003
    ..The clinical application of CGH for the purposes of PGD and the future extensions of the methodology, including DNA microarrays, are discussed...
  2. ncbi request reprint Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates
    Jacques Cohen
    Reprogenetics LLC, West Orange, New Jersey, USA
    Fertil Steril 87:496-503. 2007
    ..To evaluate whether differences in results between studies that involve preimplantation genetic diagnosis for chromosome testing are affected by technology, such as the number of cells to be biopsied or by differences in study design...
  3. doi request reprint Preimplantation genetic diagnosis of single-gene disorders: experience with more than 200 cycles conducted by a reference laboratory in the United States
    Cristina Gutiérrez-Mateo
    Reprogenetics LLC, Livingston, New Jersey, USA
    Fertil Steril 92:1544-56. 2009
    ..To evaluate trends and outcomes from preimplantation genetic diagnosis (PGD) cycles...
  4. ncbi request reprint Maternal age-related differential global expression profiles observed in human oocytes
    Nury M Steuerwald
    ART Institute of New York and New Jersey, Livingston, New Jersey 07039, USA
    Reprod Biomed Online 14:700-8. 2007
    ..These results are corroborated by a complementary extensive study using mouse oocytes...
  5. ncbi request reprint First clinical application of comparative genomic hybridization and polar body testing for preimplantation genetic diagnosis of aneuploidy
    Dagan Wells
    Department of Obstetrics and Gynaecology, University College London, United Kingdom
    Fertil Steril 78:543-9. 2002
    ..To develop a preimplantation genetic diagnosis (PGD) protocol that allows any form of chromosome imbalance to be detected...
  6. ncbi request reprint Questions concerning the suitability of comparative genomic hybridization for preimplantation genetic diagnosis
    Santiago Munne
    The Institute of Reproductive Medicine and Science, Saint Barnabas Medical Center, West Orange, New Jersey 07052, USA
    Fertil Steril 80:871-2; discussion 875. 2003
  7. ncbi request reprint Advances in preimplantation genetic diagnosis
    Dagan Wells
    The Institute for Reproductive Medicine and Science, St Barnabas Medical Center, 101, Old Short Hills Road, NJ 07052, USA
    Eur J Obstet Gynecol Reprod Biol 115:S97-101. 2004
    ..This paper discusses technical innovations that have improved the scope and accuracy of PGD, as well as the emergence of new indications for PGD that are sometimes considered controversial (e.g. HLA-typing)...
  8. ncbi request reprint Single-cell sequencing and mini-sequencing for preimplantation genetic diagnosis
    Mercedes G Bermudez
    The Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, West Orange, NJ 07052, USA
    Prenat Diagn 23:669-77. 2003
    ..Small amplicons experience low allele dropout (ADO) rates, and consequently this approach could potentially improve the reliability of PGD...
  9. ncbi request reprint Single cell diagnosis using comparative genomic hybridization after preliminary DNA amplification still needs more tweaking: too many miscalls
    Elpida Fragouli
    Fertil Steril 88:247-8; author reply 248-9. 2007
  10. doi request reprint Birth of a healthy boy after a double factor PGD in a couple carrying a genetic disease and at risk for aneuploidy: case report
    Albert Obradors
    Unitat de Biologia Cel lular i Genètica Mèdica, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Hum Reprod 23:1949-56. 2008
    ..3849 + 10 KbC > T mutation. Embryo 3 was transferred achieving pregnancy and a healthy boy was born. This strategy may lead to increased pregnancy rates by allowing preferential transfer of euploid embryos...
  11. ncbi request reprint Reliability of comparative genomic hybridization to detect chromosome abnormalities in first polar bodies and metaphase II oocytes
    Cristina Gutiérrez-Mateo
    Departament de Biologia Cel lular, Fisiologia i Immunologia, Unitat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Hum Reprod 19:2118-25. 2004
    ..However, the number of chromosomes that can be analyzed is a clear limitation. We evaluate the reliability of using comparative genomic hybridization (CGH) to detect the whole set of chromosomes, as an alternative to PGD using FISH...
  12. ncbi request reprint Expression profiles of individual human oocytes using microarray technology
    Mercedes G Bermudez
    Gamete and Embryo Research Laboratory, Institute for Reproductive Medicine and Science of Saint Barnabas, West Orange, NJ 07052, USA
    Reprod Biomed Online 8:325-37. 2004
    ..The amplification strategy consistently produced a complex representative cDNA population. A catalogue of 1361 transcripts expressed in human oocytes was identified, of which 406 have been independently confirmed using other methods...
  13. ncbi request reprint Preimplantation genetic diagnosis for single gene disorders: experience with five single gene disorders
    Joyce C Harper
    Department of Obstetrics and Gynaecology, University College London, London, UK
    Prenat Diagn 22:525-33. 2002
    ....
  14. ncbi request reprint Association of abnormal morphology and altered gene expression in human preimplantation embryos
    Dagan Wells
    Department of Obstetrics and Gynecology, Yale University Medical School, New Haven, Connecticut 06520, USA
    Fertil Steril 84:343-55. 2005
    ..We set out to characterize the expression of nine genes in human preimplantation embryos and determine whether abnormal morphology is associated with altered gene activity...
  15. ncbi request reprint Complete cytogenetic investigation of oocytes from a young cancer patient with the use of comparative genomic hybridisation reveals meiotic errors
    Elpida Fragouli
    UCL Centre for Preimplantation Genetic Diagnosis, Department of Obstetrics and Gynaecology, 86 96 Chenies Mews, University College London, London, WC1E 6HX, UK
    Prenat Diagn 26:71-6. 2006
    ..The complete cytogenetic investigation of human oocytes and the corresponding first polar bodies (PBs) derived from an 18-year old female cancer patient...
  16. ncbi request reprint A successful strategy for Preimplantation Genetic Diagnosis of beta-thalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR
    Wirawit Piyamongkol
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Chiang Mai University, Thailand
    J Med Assoc Thai 89:918-27. 2006
    ..The objective of the present study was to develop and apply quick, sensitive and accurate single cell PCR protocols for PGD of beta-thalassemia and Down's syndrome detection...
  17. ncbi request reprint BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases
    Susan J Ramus
    Department of Oncology, Strangeways Research Laboratories, Cambridge, United Kingdom
    Cancer Res 63:417-23. 2003
    ....
  18. ncbi request reprint Preimplantation genetic diagnosis: an alternative to prenatal diagnosis
    Joy D A Delhanty
    Expert Rev Mol Diagn 2:395-9. 2002
  19. doi request reprint Gene expression profiling of human oocytes at different maturational stages and after in vitro maturation
    Dagan Wells
    Department of Obstetrics and Gynecology, University of Oxford, Oxford, United Kingdom
    Am J Obstet Gynecol 198:455.e1-9; discussion 455.e9-11. 2008
    ..The purpose of this study was to catalog genes expressed in human oocytes at germinal vesicle (GV) or metaphase II (MII) stage and to compare gene profiles between oocytes matured in vivo (in vivo-MII) and in vitro (IVM-MII)...
  20. ncbi request reprint Preimplantation genetic diagnosis
    Santiago Munne
    Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, West Orange, New Jersey, USA
    Curr Opin Obstet Gynecol 14:239-44. 2002
    ....