Luis Ulloa

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc Novel insights for systemic inflammation in sepsis and hemorrhage
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Mediators Inflamm 2010:642462. 2010
  2. pmc Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock
    Gal Levy
    Department of General Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Shock 39:39-44. 2013
  3. pmc Survival and inflammatory responses in experimental models of hemorrhage
    Bolin Cai
    Department of Surgery, Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Surg Res 169:257-66. 2011
  4. pmc β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system
    Gergely Vida
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    FASEB J 25:4476-85. 2011
  5. pmc JAK2 inhibition prevents innate immune responses and rescues animals from sepsis
    Geber Peña
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Medical Science Building F 673, 185 South Orange Avenue, P O Box 1709, Newark, NJ 07103, USA
    J Mol Med (Berl) 88:851-9. 2010
  6. pmc Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 187:718-25. 2011
  7. pmc α7-cholinergic receptor mediates vagal induction of splenic norepinephrine
    Gergely Vida
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:4340-6. 2011
  8. pmc Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage
    WeiHong Dong
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 34:205-13. 2010
  9. pmc Ethyl pyruvate improves survival in awake hemorrhage
    Bolin Cai
    Center of Immunity and Infection, UMDNJ New Jersey Medical School, Newark, 07103, USA
    J Mol Med (Berl) 87:423-33. 2009
  10. pmc Vagal nerve stimulation modulates gut injury and lung permeability in trauma-hemorrhagic shock
    Gal Levy
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    J Trauma Acute Care Surg 73:338-42; discussion 342. 2012

Research Grants

  1. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2009
  2. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. pmc Novel insights for systemic inflammation in sepsis and hemorrhage
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Mediators Inflamm 2010:642462. 2010
    ..Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes...
  2. pmc Parasympathetic stimulation via the vagus nerve prevents systemic organ dysfunction by abrogating gut injury and lymph toxicity in trauma and hemorrhagic shock
    Gal Levy
    Department of General Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ, USA
    Shock 39:39-44. 2013
    ..This protective effect of VNS was not dependent on the spleen but appeared to involve a cholinergic nicotinic receptor, because its beneficial effects could be replicated with nicotine...
  3. pmc Survival and inflammatory responses in experimental models of hemorrhage
    Bolin Cai
    Department of Surgery, Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Surg Res 169:257-66. 2011
    ..Here, we compared alternative models of hemorrhage and analyzed the effects of resuscitation with Hextend...
  4. pmc β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system
    Gergely Vida
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA
    FASEB J 25:4476-85. 2011
    ..These results indicate that β2-adrenoceptors in regulatory lymphocytes are critical for the anti-inflammatory potential of the parasympathetic vagus nerve, and they represent a potential pharmacological target for sepsis...
  5. pmc JAK2 inhibition prevents innate immune responses and rescues animals from sepsis
    Geber Peña
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Medical Science Building F 673, 185 South Orange Avenue, P O Box 1709, Newark, NJ 07103, USA
    J Mol Med (Berl) 88:851-9. 2010
    ..Our study is the first experimental evidence that JAK2 inhibitors may provide a pharmacological advantage for the treatment of sepsis in a clinically relevant time frame...
  6. pmc Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 187:718-25. 2011
    ..The study results revealed these new regulatory lymphocytes as, to our knowledge, the first known physiological target for neuromodulation of the innate immune responses and a potential therapeutic target for sepsis...
  7. pmc α7-cholinergic receptor mediates vagal induction of splenic norepinephrine
    Gergely Vida
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 186:4340-6. 2011
    ..7nAChR represents a unique molecular link between the parasympathetic and sympathetic system to control inflammation...
  8. pmc Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage
    WeiHong Dong
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 34:205-13. 2010
    ....
  9. pmc Ethyl pyruvate improves survival in awake hemorrhage
    Bolin Cai
    Center of Immunity and Infection, UMDNJ New Jersey Medical School, Newark, 07103, USA
    J Mol Med (Berl) 87:423-33. 2009
    ..Ethyl pyruvate may attenuate systemic inflammatory responses during resuscitation and improve survival in experimental models of awake hemorrhage...
  10. pmc Vagal nerve stimulation modulates gut injury and lung permeability in trauma-hemorrhagic shock
    Gal Levy
    Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA
    J Trauma Acute Care Surg 73:338-42; discussion 342. 2012
    ..Therefore, we explored whether stimulation of the vagus nerve can protect the gut and recover lung permeability in trauma-hemorrhagic shock (THS)...
  11. pmc Mast cell stabilization improves survival by preventing apoptosis in sepsis
    Laura Ramos
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
    J Immunol 185:709-16. 2010
    ..Our study provides the first evidence that MCs have major immunological implications regulating cell death in sepsis and represent a pharmacological target for infectious disorders in a clinically realistic time frame...
  12. pmc Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis
    Geber Peña
    Laboratory of Immunity and Infection, Department of Surgery, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Eur J Immunol 40:2580-9. 2010
    ..Stattic also prevented the production of late mediators of sepsis and improved survival in established sepsis. These results reveal the immunological implications of tyrosine-unphosphorylated STAT3 in infectious diseases...
  13. pmc Alpha7 cholinergic-agonist prevents systemic inflammation and improves survival during resuscitation
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    J Cell Mol Med 13:3774-85. 2009
    ..Our studies suggest that GTS provides significant advantages as compared with non-specific nicotinic agonists, and it could be a promising anti-inflammatory supplement to improve survival during resuscitation...
  14. pmc Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming
    Diego C Reino
    Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey 07103, USA
    Shock 38:107-14. 2012
    ..However, the T/HS-associated effects of TLR4 on gut barrier dysfunction can be uncoupled from the T/HS lymph-associated effects of TLR4 on PMN priming...
  15. pmc Anti-inflammatory resuscitation improves survival in hemorrhage with trauma
    Bolin Cai
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Center of Immunity and Infection, UMDNJ New Jersey Medical School, Newark, New Jersey 07103, USA
    J Trauma 66:1632-9; discussion 1639-40. 2009
    ..Here, we analyzed whether ethyl pyruvate could provide a therapeutic anti-inflammatory potential during resuscitation in experimental hemorrhage with trauma...
  16. pmc Dopamine mediates vagal modulation of the immune system by electroacupuncture
    Rafael Torres-Rosas
    1 Laboratory of Anti inflammatory Signaling, Department of Surgery, Rutgers University New Jersey Medical School, Newark, New Jersey, USA 2 Medical Research Unit on Immunochemistry, National Medical Center Siglo XXI, Mexico City, Mexico
    Nat Med 20:291-5. 2014
    ....
  17. pmc Scientific and clinical challenges in sepsis
    Luis Ulloa
    Laboratory of Anti inflammatory Signaling and Surgical Immunology, Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Curr Pharm Des 15:1918-35. 2009
    ..This article reviews novel inflammatory molecular aspects and the experimental anti-inflammatory strategies for sepsis, as they may represent particular pathological processes in specific subsets of patients...
  18. ncbi request reprint The neuronal strategy for inflammation
    Luis Ulloa
    Feinstein Institute of Biomedical Research, Department of Surgery, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Novartis Found Symp 280:223-33; discussion 233-7. 2007
    ..Similar to the development of selective agonists for adrenergic receptors, selective nicotinic agonists for the alpha7nAChR may represent a promising pharmacological strategy against infectious and inflammatory diseases...
  19. pmc Neuroimmune perspectives in sepsis
    Luis Ulloa
    Department of Surgery, UMDNJ New Jersey Medical School, 185 South Orange Avenue, PO Box 1709, Newark, NJ 07103, USA
    Crit Care 13:133. 2009
    ..Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis...
  20. ncbi request reprint Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis
    Xinchun Lin
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Am J Physiol Lung Cell Mol Physiol 289:L583-90. 2005
    ..These data demonstrate that alpha-chemokine receptor inhibition can reduce HMGB1-induced lung injury and lethality in established sepsis and may provide a novel treatment in this devastating disease...

Research Grants3

  1. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2009
    ..Our goal is to determine the molecular mechanism by which cholinergic agonists restrain systemic inflammation in sepsis. These studies will allow the design of novel pharmacological strategies to improve survival in sepsis ..
  2. Cholinergic regulation of NF-kB in sepsis
    Luis Ulloa; Fiscal Year: 2010
    ..Our goal is to determine the molecular mechanism by which cholinergic agonists restrain systemic inflammation in sepsis. These studies will allow the design of novel pharmacological strategies to improve survival in sepsis ..