Marjana Tomic-Canic

Summary

Affiliation: New York University
Country: USA

Publications

  1. ncbi request reprint Gene array technology and pathogenesis of chronic wounds
    Marjana Tomic-Canic
    Department of Dermatology, New York University School of Medicine, 550 First Avenue, MSB 234, New York, New York 10016, USA
    Am J Surg 188:67-72. 2004
  2. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
  3. ncbi request reprint Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors
    Sharmistha Das
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Mol Endocrinol 21:2672-86. 2007
  4. pmc Molecular markers in patients with chronic wounds to guide surgical debridement
    Harold Brem
    Columbia University College of Physicians and Surgeons, Department of Surgery, Wound Healing and Vascular Biology Laboratory, New York, NY, USA
    Mol Med 13:30-9. 2007
  5. pmc Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor
    Sasa Vukelic
    Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 285:1980-8. 2010
  6. ncbi request reprint Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation
    Olivera Stojadinovic
    Hospital for Special Surgery, Tissue Repair Laboratory, Tissue Engineering, Regeneration and Repair Program, New York, New York 10021, USA
    J Biol Chem 282:4021-34. 2007
  7. pmc Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing
    Olivera Stojadinovic
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, 550 First Ave, TH100, New York, NY 10016, USA
    Am J Pathol 167:59-69. 2005
  8. pmc Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription
    Nada Radoja
    Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 24:3168-79. 2004
  9. pmc Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF
    Harold Brem
    Department of Surgery, Division of Wound Healing and Regenerative Medicine, New York University School of Medicine, New York, NY, USA
    J Transl Med 6:75. 2008
  10. pmc Retinoid-responsive transcriptional changes in epidermal keratinocytes
    Ding Dar Lee
    New York University School of Medicine, Department of Dermatology, Biochemistry and The Cancer Institute, New York, NY, USA
    J Cell Physiol 220:427-39. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Gene array technology and pathogenesis of chronic wounds
    Marjana Tomic-Canic
    Department of Dermatology, New York University School of Medicine, 550 First Avenue, MSB 234, New York, New York 10016, USA
    Am J Surg 188:67-72. 2004
    ....
  2. pmc Cellular and molecular basis of wound healing in diabetes
    Harold Brem
    Wound Healing and Vascular Biology Laboratory, Division of Plastic Surgery, Columbia University College of Physicians and Surgeons, 5141 Broadway, New York, NY 10034, USA
    J Clin Invest 117:1219-22. 2007
    ..Thus, Gallagher et al. have identified novel potential targets for therapeutic intervention in diabetic wound healing...
  3. ncbi request reprint Farnesyl pyrophosphate is a novel transcriptional activator for a subset of nuclear hormone receptors
    Sharmistha Das
    Department of Pharmacology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Mol Endocrinol 21:2672-86. 2007
    ..This finding also has potential interesting implications that may, in part, explain the pleotropic effects of statins as well as certain actions of farnesylation inhibitors in cells...
  4. pmc Molecular markers in patients with chronic wounds to guide surgical debridement
    Harold Brem
    Columbia University College of Physicians and Surgeons, Department of Surgery, Wound Healing and Vascular Biology Laboratory, New York, NY, USA
    Mol Med 13:30-9. 2007
    ..In the future, molecular markers will be developed to identify the nonimpaired tissue, thereby making surgical debridement more accurate and more efficacious...
  5. pmc Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor
    Sasa Vukelic
    Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 285:1980-8. 2010
    ..Therefore, our findings may provide a better understanding of the pleiotropic effects of statins as well as molecular mechanisms by which they may accelerate wound healing...
  6. ncbi request reprint Novel genomic effects of glucocorticoids in epidermal keratinocytes: inhibition of apoptosis, interferon-gamma pathway, and wound healing along with promotion of terminal differentiation
    Olivera Stojadinovic
    Hospital for Special Surgery, Tissue Repair Laboratory, Tissue Engineering, Regeneration and Repair Program, New York, New York 10021, USA
    J Biol Chem 282:4021-34. 2007
    ..These results provide new insights into the beneficial and adverse effects of GCs in the epidermis, defining the participating genes and mechanisms that coordinate the cellular responses important for GC-based therapies...
  7. pmc Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing
    Olivera Stojadinovic
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, 550 First Ave, TH100, New York, NY 10016, USA
    Am J Pathol 167:59-69. 2005
    ..The presence of activated beta-catenin and c-myc in the epidermis of chronic wounds may serve as a molecular marker of impaired healing and may provide future targets for therapeutic intervention...
  8. pmc Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription
    Nada Radoja
    Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 24:3168-79. 2004
    ..Using these agents, we could boost the amounts of K15 in human epidermis. Our findings suggest that treatments based on thyroid hormone and IFN-gamma could become effective agents in therapy for patients with EBS...
  9. pmc Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF
    Harold Brem
    Department of Surgery, Division of Wound Healing and Regenerative Medicine, New York University School of Medicine, New York, NY, USA
    J Transl Med 6:75. 2008
    ..2) To describe a methodology to create fibroblast cell lines from patients with chronic wounds...
  10. pmc Retinoid-responsive transcriptional changes in epidermal keratinocytes
    Ding Dar Lee
    New York University School of Medicine, Department of Dermatology, Biochemistry and The Cancer Institute, New York, NY, USA
    J Cell Physiol 220:427-39. 2009
    ....
  11. pmc Using gene transcription patterns (bar coding scans) to guide wound debridement and healing
    Marjana Tomic-Canic
    Tissue Repair Laboratory, Tissue Engineering Regeneration and Repair Program, Weill Cornell Medical College, New York, NY, USA
    Adv Skin Wound Care 21:487-92; quiz 493-4. 2008
    ..To acquaint wound care practitioners with new information related to debridement of chronic wounds...
  12. doi request reprint Nexus between epidermolysis bullosa and transcriptional regulation by thyroid hormone in epidermal keratinocytes
    Marjana Tomic-Canic
    The Departments of Dermatology and Biochemistry, and the NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York, USA
    Clin Transl Sci 1:45-9. 2008
    ..The results suggest that topical treatment with T3 may be effective for alleviation of symptoms in patients with epidermolysis bullosa...
  13. pmc Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers
    Olivera Stojadinovic
    Hospital for Special Surgery of the Weill Cornell Medical College, Tissue Repair Lab, New York, NY 10021, USA
    J Cell Mol Med 12:2675-90. 2008
    ..We conclude that keratinocytes at the non-healing edges of venous ulcers do not execute either activation or differentiation pathway, resulting in thick callus-like formation at the edge of a venous ulcers...
  14. ncbi request reprint Streptolysin O enhances keratinocyte migration and proliferation and promotes skin organ culture wound healing in vitro
    Marjana Tomic-Canic
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    Wound Repair Regen 15:71-9. 2007
    ..Therefore, ML-05 may have potential as a wound-healing agent that promotes reepithelialization through stimulation of keratinocyte migration and proliferation...
  15. doi request reprint Keratin dressings speed epithelialization of deep partial-thickness wounds
    Patricia M Pechter
    Department of Dermatology, University of Miami Miller School of Medicine, Miami, FL, USA
    Wound Repair Regen 20:236-42. 2012
    ..We conclude that keratin-containing dressings can accelerate wound healing and closure. Further studies are needed to determine the molecular mechanisms of this activation...
  16. pmc Cortisol synthesis in epidermis is induced by IL-1 and tissue injury
    Sasa Vukelic
    Department of Medicine, Lenox Hill Hospital, New York, New York 10075, USA
    J Biol Chem 286:10265-75. 2011
    ..Inhibition of GC synthesis accelerated wound closure in vivo, providing the evidence that modulation of cortisol synthesis in epidermis may be an important regulatory mechanism during wound healing...
  17. ncbi request reprint Healing of elderly patients with diabetic foot ulcers, venous stasis ulcers, and pressure ulcers
    Harold Brem
    Wound Healing Program, Angiogenesis and Wound Healing Laboratory, The Mount Sinai Medical Center, New York, New York
    Surg Technol Int 11:161-7. 2003
    ..We hypothesize that if all elderly patients with chronic wounds are provided early treatment, morbidities (e.g., amputation, sepsis, pain) and associated costs will decrease...
  18. doi request reprint Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents, and cultured keratinocytes using DNA microarray chips
    Ding Dar Lee
    Department of Dermatology, The NYU Cancer Institute, New York University School of Medicine, New York, NY, USA
    Methods Mol Biol 585:193-223. 2010
    ..The work can be a primer for researchers embarking on skinomics, the comprehensive analysis of transcriptional changes in the skin...
  19. doi request reprint A gene signature of nonhealing venous ulcers: potential diagnostic markers
    Carlos A Charles
    Department of Dermatology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Am Acad Dermatol 59:758-71. 2008
    ..Venous leg ulcers are responsible for more than half of all lower extremity ulcerations. Significant interest has been focused on understanding the physiologic basis on which patients fail to heal with standard therapy...
  20. ncbi request reprint Role of keratinocytes in healing of chronic wounds
    Irena Pastar
    Tissue Repair Laboratory, Hospital for Special Surgery of the Weill, Cornell Medical College, New York, NY, USA
    Surg Technol Int 17:105-12. 2008
    ..This paper will review the biological and pathological properties of keratinocytes as they relate to wound healing, and the ways in which they may provide highly efficacious therapy for patients with chronic wounds...
  21. pmc The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair
    Muktar A Mahajan
    Department of Pharmacology and Medicine, New York University School of Medicine, 550 First Ave, New York, NY 10016, USA
    Mol Cell Biol 24:4994-5004. 2004
    ..Our findings reveal that NRC is a coregulator that controls many cellular and physiologic processes ranging from growth and development to reproduction and wound repair...
  22. pmc ADAM12: a potential target for the treatment of chronic wounds
    Asheesh Harsha
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery at Weill Medical College of Cornell University, New York, NY, USA
    J Mol Med (Berl) 86:961-9. 2008
    ....
  23. ncbi request reprint From an enhanceosome to a repressosome: molecular antagonism between glucocorticoids and EGF leads to inhibition of wound healing
    Brian Lee
    New York University School of Medicine, The Ronald O Perelman Department of Dermatology, 550 First Avenue, New York, NY 10016, USA
    J Mol Biol 345:1083-97. 2005
    ..Similar to clinical findings, pre-treatment of keratinocytes with RA blocks GC-mediated inhibition. In summary, our results identify complex molecular mechanisms through which RA alleviates GC-mediated inhibition of wound healing...
  24. doi request reprint Mechanism of sustained release of vascular endothelial growth factor in accelerating experimental diabetic healing
    Harold Brem
    Helen and Martin Kimmel Wound Center, Division of Wound Healing and Regenerative Medicine, Department of Surgery, New York University, New York, New York 10016, USA
    J Invest Dermatol 129:2275-87. 2009
    ..In the future, local administration and sustained, controlled release of VEGF(165) may decrease amputations in patients with diabetic foot ulcers and possibly accelerate closure of venous ulcers and pressure ulcers...
  25. ncbi request reprint The synergism of age and db/db genotype impairs wound healing
    Harold Brem
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Exp Gerontol 42:523-31. 2007
    ....
  26. ncbi request reprint The book of opposites: the role of the nuclear receptor co-regulators in the suppression of epidermal genes by retinoic acid and thyroid hormone receptors
    Sang H Jho
    The Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, New York 10016, USA
    J Invest Dermatol 124:1034-43. 2005
    ..This novel molecular mechanism of transcriptional repression conveys how RA and T3 target specific groups of epidermal genes, thus exerting intrinsic tissue specificity...
  27. doi request reprint Surgical pathology to describe the clinical margin of debridement of chronic wounds using a wound electronic medical record
    Michael S Golinko
    Helen and Martin Kimmel Wound Center, Division of Wound Healing and Regenerative Medicine, Department of Surgery, New York University School of Medicine, New York, NY 10016, USA
    J Am Coll Surg 209:254-260.e1. 2009
    ..Unlike tumor resection, however, operative wound specimens are not routinely sent for pathology. The objective of this study was to describe the pathology present in chronic wounds...
  28. doi request reprint Analysis and meta-analysis of transcriptional profiling in human epidermis
    Claudia Mimoso
    The RO Perelman Department of Dermatology, Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center, NYU Cancer Institute, 455 First Avenue, New York, NY, 10016, USA
    Methods Mol Biol 1195:61-97. 2014
    ..This work can serve as a primer for researchers embarking on skinomics, the comprehensive analysis of transcriptional changes in skin...
  29. ncbi request reprint Transcriptional profiling of epidermal keratinocytes: comparison of genes expressed in skin, cultured keratinocytes, and reconstituted epidermis, using large DNA microarrays
    Alix Gazel
    Department of Dermatology, New York University School of Medicine, New York, USA
    J Invest Dermatol 121:1459-68. 2003
    ..Cultured keratinocytes express many cell-cycle and DNA replication genes, as well as integrins and extracellular matrix proteins. These results define innate, architecture-specific, and cell-type-regulated genes in epidermis...
  30. ncbi request reprint Clinical efficacy and mechanism of bilayered living human skin equivalent (HSE) in treatment of diabetic foot ulcers
    Harold Brem
    Angiogenesis and Wound Healing Laboratory, Mount Sinai Medical Center, New York, NY, USA
    Surg Technol Int 11:23-31. 2003
    ..We hypothesize that bilayered HSE generates its effect by way of the local synthesis and release of multiple growth factors in specific combination and concentration, which improves the impaired reparative process of chronic wounds...
  31. doi request reprint Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines
    Mirjana Liovic
    National Institute of Chemistry, Ljubljana, Slovenia CRUK Cell Structure Research Group, University of Dundee College of Life Sciences, MSI WTB complex, Dundee, UK
    Exp Cell Res 314:2066-75. 2008
    ..Our findings strengthen the case for the expression of mutant keratin proteins inducing physiological stress, and this intrinsic stress may affect the cell responses to secondary stresses in patients' skin...
  32. ncbi request reprint Role of Scarf and its binding target proteins in epidermal calcium homeostasis
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, and Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:18645-53. 2007
    ....
  33. pmc Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing
    Maria I Morasso
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Cell 97:173-83. 2005
    ..This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin...