Yajaira Suarez

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation
    Yajaira Suarez
    Department of Immunobiology and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    J Immunol 184:21-5. 2010
  2. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
  3. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
  4. pmc Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    Carlos Fernandez-Hernando
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:48-54. 2009
  5. pmc Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
    Jun Yu
    Department of Pharmacology, Amistad Research Building, Yale University School of Medicine, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 106:17511-6. 2009
  6. pmc Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
    Michael Schleicher
    Department of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 180:101-12. 2008
  7. pmc miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice
    Leigh Goedeke
    Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA
    Atherosclerosis 243:499-509. 2015
  8. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
  9. pmc miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
    Carlos Stahlhut
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 139:4356-64. 2012
  10. pmc MicroRNAs in lipid metabolism
    Carlos Fernandez-Hernando
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Lipidol 22:86-92. 2011

Collaborators

Detail Information

Publications23

  1. pmc Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation
    Yajaira Suarez
    Department of Immunobiology and Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    J Immunol 184:21-5. 2010
    ..Conversely, transfections with mimics of these miRNAs decreased neutrophil adhesion to endothelial cells. These data suggest that miRNAs provide negative feedback control of inflammation...
  2. pmc MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function
    Sebastian Albinsson
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 30:1118-26. 2010
    ..Here, we investigated the role of miRNAs in VSM by deleting the rate-limiting enzyme in miRNA synthesis, Dicer...
  3. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
    ..Thus, endothelial miRNAs regulate postnatal angiogenesis and VEGF induces the expression of miRNAs implicated in the regulation of an integrated angiogenic response...
  4. pmc Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis
    Carlos Fernandez-Hernando
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Metab 10:48-54. 2009
    ..In summary, this unique model provides physiological evidence supporting the important role of endothelial Cav-1 expression in regulating the entry of LDL into the vessel wall and the initiation of atherosclerosis...
  5. pmc Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
    Jun Yu
    Department of Pharmacology, Amistad Research Building, Yale University School of Medicine, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 106:17511-6. 2009
    ..Thus, endogenous Nogo coordinates macrophage-mediated inflammation with arteriogenesis, wound healing, and blood flow control...
  6. pmc Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence
    Michael Schleicher
    Department of Pharmacology, and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 180:101-12. 2008
    ..Collectively, our results provide evidence that PHB1 is important for mitochondrial function and prevents reactive oxygen species-induced senescence and thereby maintains the angiogenic capacity of endothelial cells...
  7. pmc miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice
    Leigh Goedeke
    Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, 06520, USA
    Atherosclerosis 243:499-509. 2015
    ..As such, here we set out to further characterize the role of miR-27b in regulating cholesterol metabolism in vitro and to determine the effect of miR-27b overexpression and inhibition on circulating and hepatic lipids in mice...
  8. pmc MicroRNAs as novel regulators of angiogenesis
    Yajaira Suarez
    Vascular Biology and Therapuetics Program corrected Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA
    Circ Res 104:442-54. 2009
    ....
  9. pmc miR-1 and miR-206 regulate angiogenesis by modulating VegfA expression in zebrafish
    Carlos Stahlhut
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Development 139:4356-64. 2012
    ..These findings uncover a novel function for miR-1/206 in the control of developmental angiogenesis through the regulation of VegfA, and identify a key role for miRNAs as regulators of cross-tissue signaling...
  10. pmc MicroRNAs in lipid metabolism
    Carlos Fernandez-Hernando
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    Curr Opin Lipidol 22:86-92. 2011
    ..This review summarizes the evidence for a critical role of miRNAs in regulating lipid metabolism...
  11. pmc microRNAs and cholesterol metabolism
    Kathryn J Moore
    Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Trends Endocrinol Metab 21:699-706. 2010
    ..These new data suggest important roles of microRNAs in the epigenetic regulation of cholesterol metabolism and have opened new avenues for the treatment of dyslipidemias...
  12. pmc The role of microRNAs in cholesterol efflux and hepatic lipid metabolism
    Kathryn J Moore
    Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA
    Annu Rev Nutr 31:49-63. 2011
    ..These findings have highlighted the complexity of lipid homeostasis and the important role that miRNAs play in these processes, potentially opening new avenues for the treatment of dyslipidemias...
  13. pmc Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking
    Kenneth D Harrison
    Department of Pharmacology and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Metab 10:208-18. 2009
    ..These data identify NgBR as an NPC2-interacting protein and provide evidence of a role for NgBR in intracellular cholesterol trafficking...
  14. pmc Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease
    Carlos Fernandez-Hernando
    Department of Pharmacology and Vascular Biology and Therapeutics, Amistad Building, 10 Amistad St, Yale University School of Medicine, New Haven, CT 06511, USA
    Cell Metab 6:446-57. 2007
    ..The presence of coronary lesions in ApoE(-/-)Akt1(-/-) mice provides a new model for studying the mechanisms of acute coronary syndrome in humans...
  15. ncbi request reprint Alloimmunity to human endothelial cells derived from cord blood progenitors
    Yajaira Suarez
    Department of Immunobiology, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7488-96. 2007
    ..These findings have significant implications for the use of cord blood EPCs in regenerative medicine or tissue engineering...
  16. ncbi request reprint Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells
    Yajaira Suarez
    Department of Pathology, Yale University School of Medicine, New Haven, Conn 06536, USA
    Circ Res 100:1164-73. 2007
    ..Collectively, these results indicate that maintenance and regulation of endogenous miRNA levels via Dicer mediated processing is critical for EC gene expression and functions in vitro...
  17. pmc VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis
    Aranzazu Chamorro-Jorganes
    From the Vascular Biology and Therapeutics Program A C J, M Y L, E A, M F F, M S, J Y, C F H, W C S, Y S, Section of Comparative Medicine A C J, E A, M F F, M S, M Q R, C F H, Y S, Departments of Pathology A C J, E A, M F F, M S, C F H, Y S Pharmacology M Y L, S L E, W C S, and Internal Medicine, Section of Cardiovascular Medicine J Y, Yale University School of Medicine, New Haven, CT and Department of Medicine, New York University School of Medicine C S
    Circ Res 118:38-47. 2016
    ..The miR-17-92 cluster has been linked to tumor development and angiogenesis, but its role in vascular endothelial growth factor-induced endothelial cell (EC) functions is unclear and its regulation is unknown...
  18. pmc MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
    Leigh Goedeke
    Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Med 21:1280-9. 2015
    ....
  19. pmc ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
    Binod Aryal
    Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Commun 7:12313. 2016
    ..Altogether, these findings demonstrate that haematopoietic ANGPTL4 deficiency increases atherogenesis through regulating myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation...
  20. pmc The miR-199-dynamin regulatory axis controls receptor-mediated endocytosis
    Juan F Aranda
    Integrative Cell Signaling and Neurobiology of Metabolism Program, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06510, USA Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA
    J Cell Sci 128:3197-209. 2015
    ..In particular, we demonstrate that the DNM, miR-199a-5p and miR-199b-5p genes act as a bifunctional locus that regulates endocytosis, thus adding an unexpected layer of complexity in the regulation of intracellular trafficking. ..
  21. pmc Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake
    Jonathan W Haskins
    Department of Pathology and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Sci Signal 8:ra111. 2015
    ..The connections of EGFR and ERBB4 signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB-regulated developmental processes and may contribute to metabolic remodeling in ERBB-driven cancers. ..
  22. pmc SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
    Nathan L Price
    Section of Comparative Medicine, Department of Pathology, Program in Integrative Cell Signaling and Neurobiology of Metabolism and Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, USA Departments of Medicine and Cell Biology, Leon H Charney Division of Cardiology and Cell Biology, New York University School of Medicine, New York, New York, USA
    Mol Cell Biol 36:1180-93. 2016
    ..Together, these findings demonstrate a novel role of miR-33b in the regulation of adipocyte differentiation, with important implications for the development of obesity and metabolic disease. ..
  23. ncbi request reprint Vascularization and engraftment of a human skin substitute using circulating progenitor cell-derived endothelial cells
    Benjamin R Shepherd
    Department of Pathology, Yale University School of Medicine, 295 Congress Ave, Boyer Center for Molecular Medicine Rm 454, New Haven, Connecticut 06510, USA
    FASEB J 20:1739-41. 2006
    ..We conclude that EC differentiated from circulating progenitors can be utilized to vascularize human skin substitutes even in the setting of compromised host angiogenesis/vasculogenesis...