L H Sigal

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme d
    L H Sigal
    Department of Medicine, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    Cell Mol Neurobiol 21:477-95. 2001
  2. ncbi request reprint Misconceptions about Lyme disease: confusions hiding behind ill-chosen terminology
    Leonard H Sigal
    UMDNJ Robert Wood Johnson Medical School New Brunswick, NJ 08903, USA
    Ann Intern Med 136:413-9. 2002
  3. pmc Psychiatric comorbidity and other psychological factors in patients with "chronic Lyme disease"
    Afton L Hassett
    Division of Rheumatology and Connective Tissue Research, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Am J Med 122:843-50. 2009
  4. ncbi request reprint Molecular biology and immunology for clinicians 25: defense collagens
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Departments of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    J Clin Rheumatol 9:267-72. 2003
  5. ncbi request reprint Molecular biology and immunology for clinicians 17: T-cell signal transduction
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    J Clin Rheumatol 8:113-6. 2002
  6. ncbi request reprint Molecular biology and immunology for clinicians 21: The innate immune system: an introduction
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:350-3. 2002
  7. ncbi request reprint Molecular biology and immunology for clinicians 18: Heat shock proteins/chaperonins
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:174-80. 2002
  8. ncbi request reprint Molecular biology and immunology for clinicians 15: Antigen presenting cells--class I
    L H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 7:406-7. 2001
  9. ncbi request reprint Molecular biology and immunology for clinicians 16: Dendritic cells and their role in immunology
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:57-60. 2002
  10. ncbi request reprint Molecular biology and immunology for clinicians 19: Protein purification and synthesis technology
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:228-31. 2002

Collaborators

Detail Information

Publications32

  1. ncbi request reprint H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme d
    L H Sigal
    Department of Medicine, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    Cell Mol Neurobiol 21:477-95. 2001
    ..H9724's effect is the first evidence that HSP60 may play a role in peptide-hormone-receptor function and demonstrates the modulatory potential of a monoclonal antibody on living cells...
  2. ncbi request reprint Misconceptions about Lyme disease: confusions hiding behind ill-chosen terminology
    Leonard H Sigal
    UMDNJ Robert Wood Johnson Medical School New Brunswick, NJ 08903, USA
    Ann Intern Med 136:413-9. 2002
  3. pmc Psychiatric comorbidity and other psychological factors in patients with "chronic Lyme disease"
    Afton L Hassett
    Division of Rheumatology and Connective Tissue Research, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Am J Med 122:843-50. 2009
    ..burgdorferi. The objective of this study was to assess the medical and psychiatric status of such patients and compare these findings to those from patients without CMI...
  4. ncbi request reprint Molecular biology and immunology for clinicians 25: defense collagens
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Departments of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    J Clin Rheumatol 9:267-72. 2003
    ..Thus, they are good targets for studies to better understand our diseases and to craft therapeutic manipulations in the future...
  5. ncbi request reprint Molecular biology and immunology for clinicians 17: T-cell signal transduction
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    J Clin Rheumatol 8:113-6. 2002
    ..However, taming the T-cell is crucial in transplantation and in controlling autoimmunity. Behind the jargon is a fascinating, albeit confusing, set of mechanisms that already offer therapeutic promise...
  6. ncbi request reprint Molecular biology and immunology for clinicians 21: The innate immune system: an introduction
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:350-3. 2002
    ..Future contributions to this series will provide details about some of the specific innate immune systems. This article serves as an introduction to this underappreciated (until recently) aspect of human immune defenses...
  7. ncbi request reprint Molecular biology and immunology for clinicians 18: Heat shock proteins/chaperonins
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:174-80. 2002
    ..The highly conserved nature of heat shock proteins means that the immune response to heat shock proteins of pathogens or malignant cells may recognize and then react with host heat shock proteins and produce autoimmune disease...
  8. ncbi request reprint Molecular biology and immunology for clinicians 15: Antigen presenting cells--class I
    L H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 7:406-7. 2001
    ..The mechanisms by which peptides interact with and are expressed by class I complexes on the surface of APCs is described and contrasted with the circumstances of class II antigen presentation...
  9. ncbi request reprint Molecular biology and immunology for clinicians 16: Dendritic cells and their role in immunology
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:57-60. 2002
    ..There is sure to be more about dendritic cells in the oncology, clinical immunology, and rheumatology literature over the coming years as we learn to control dendritic cell function...
  10. ncbi request reprint Molecular biology and immunology for clinicians 19: Protein purification and synthesis technology
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:228-31. 2002
    ..And now we can make chimeric proteins, like the mythical animal, with the head of one protein, the tail of another, and perhaps the body of a third--as many components as you like, the sky is the limit...
  11. ncbi request reprint Molecular biology and immunology for clinicians 20: Angiogenesis and vascular growth factors and signals
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 8:281-3. 2002
    ..Many growth factors and local tissue conditions help to determine blood vessel growth, there being pro- and anti-angiogenetic influences. Thus, this is fertile ground for therapeutic molecular manipulations...
  12. ncbi request reprint Molecular biology and immunology for clinicians 23: autoimmunity and the superfamilies of tumor necrosis factor and tumor necrosis factor receptor
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    J Clin Rheumatol 9:119-25. 2003
    ..Thus, multiple labs, multiple names for the same protein (recall Ro/SS-A, La/SS-B). Thus, special attention is paid below to acronyms and their synonyms...
  13. ncbi request reprint Molecular biology and immunology for clinicians 24: phylogeny of the immune system
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    J Clin Rheumatol 9:200-6. 2003
    ..A future article in this series will focus more on the innate system and how it interdigitates with the adaptive system...
  14. ncbi request reprint Molecular biology and immunology for clinicians, 14: Antigen presenting cells--Class II
    L H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    J Clin Rheumatol 7:354-7. 2001
    ..So, now on to antigen processing and presentation of proteins...
  15. ncbi request reprint Antibiotics for the treatment of rheumatologic syndromes
    L H Sigal
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, USA
    Rheum Dis Clin North Am 25:861-81, viii. 1999
    ..This article reviews the effectiveness of antibiotics against rheumatologic syndromes, including rheumatoid arthritis and Lyme disease...
  16. pmc Contributions of societal and geographical environments to "chronic Lyme disease": the psychopathogenesis and aporology of a new "medically unexplained symptoms" syndrome
    Leonard H Sigal
    Division of Rheumatology and Connective Tissue Research, Department of Medicine, Lyme Disease Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903 0019, USA
    Environ Health Perspect 110:607-11. 2002
    ....
  17. ncbi request reprint Immune complexes from serum of patients with lyme disease contain Borrelia burgdorferi antigen and antigen-specific antibodies: potential use for improved testing
    M Brunner
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    J Infect Dis 182:534-9. 2000
    ..This is the first study to show ICs containing Bb antigen identified by immunoblot with anti-Bb monoclonal antibody. ICs may be a useful source of antigen and antibody for development of more-accurate testing for LD...
  18. ncbi request reprint Unforeseen consequences of terrorism: medically unexplained symptoms in a time of fear
    Afton L Hassett
    Departments of Medicine, Family Medicine, and Psychiatry, Division of Rheumatology and Connective Tissue Research, UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place, MEB 484, New Brunswick, NJ 08903, USA
    Arch Intern Med 162:1809-13. 2002
  19. ncbi request reprint A pilot study of the efficacy of heart rate variability (HRV) biofeedback in patients with fibromyalgia
    Afton L Hassett
    Department of Medicine, Division of Rheumatology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School UMDNJ RWJMS, P O Box 19, MEB 484, New Brunswick, NJ, USA
    Appl Psychophysiol Biofeedback 32:1-10. 2007
    ..An open label trial of biofeedback training was conducted to manipulate suboptimal heart rate variability (HRV), a key marker of autonomic dysfunction...
  20. doi request reprint The relationship between affect balance style and clinical outcomes in fibromyalgia
    Afton L Hassett
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Division of Rheumatology and Connective Tissue Research, New Brunswick, NJ 80903 0019, USA
    Arthritis Rheum 59:833-40. 2008
    ..Affect balance styles and their relationship to clinical outcomes were compared between patients with fibromyalgia (FM) and controls...
  21. doi request reprint Role of psychiatric comorbidity in chronic Lyme disease
    Afton L Hassett
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903 0019, USA
    Arthritis Rheum 59:1742-9. 2008
    ..To evaluate the prevalence and role of psychiatric comorbidity and other psychological factors in patients with chronic Lyme disease (CLD)...
  22. ncbi request reprint Lyme disease: a clinical update
    L H Sigal
    Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick, USA
    Hosp Pract (Minneap) 36:31-2, 35-7, 41-2, 47. 2001
    ....
  23. ncbi request reprint Commentary: 'What's in a name? That which we call a rose by any other name would smell as sweet.' Shakespeare W. Romeo and Juliet, II, ii(47-48)
    Leonard H Sigal
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Int J Epidemiol 34:1345-7. 2005
  24. ncbi request reprint Rheumatic fever
    E Rullan
    Department of Medicine, Division of Rheumatology, UMDNJ Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, PO Box 19, MEB 484, New Brunswick, NJ 08903 0019, USA
    Curr Rheumatol Rep 3:445-52. 2001
    ..Penicillin is the most appropriate primary and secondary prophylaxis. Anti- inflammatory agents provide symptomatic relief but do not prevent rheumatic heart disease...
  25. pmc Use of serum immune complexes in a new test that accurately confirms early Lyme disease and active infection with Borrelia burgdorferi
    M Brunner
    Department of Medicine, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    J Clin Microbiol 39:3213-21. 2001
    ..e., EMIBA identified seroreactivity indicating a clinical circumstance requiring antibiotic therapy. Thus, EMIBA is a promising new assay for accurate serologic confirmation of early and/or active LD...
  26. ncbi request reprint Lyme arthritis synovial gammadelta T cells instruct dendritic cells via fas ligand
    Cheryl Collins
    Immunobiology Program, Department of Medicine, The University of Vermont College of Medicine, Burlington, VT 50405, USA
    J Immunol 175:5656-65. 2005
    ..They also underscore the view that as levels of c-FLIP increase, Fas signaling can be diverted from induction of apoptosis to pathways leading to cell effector function...
  27. ncbi request reprint Reactive arthritis
    Danielle Lauren Petersel
    Division of Rheumatology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, MEB484, PO Box 19, New Brunswick, NJ 08903 0019, USA
    Infect Dis Clin North Am 19:863-83. 2005
    ..Diagnosis usually can be made by clinical examination and history. The current standard therapy is NSAIDs and physiotherapy, but molecular biologic treatment may ultimately become the mainstay in recalcitrant and severe ReA...
  28. ncbi request reprint High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis
    Karen Roessner
    Department of Medicine Immunobiology, The University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Immunol 170:2702-10. 2003
    ..In this capacity, certain gamma delta T cell subsets may serve as cytolytic sentinels at sites of inflammation, and perhaps at epithelial barriers...
  29. doi request reprint Basic science for the clinician 48: tyrosine kinases in disease: the potential for inhibitors in the treatment of immunologic diseases
    Leonard H Sigal
    Research and Development Bristol Myers Squibb, J 3100, PO Box 4000, Princeton, NJ 08543 4000, USA
    J Clin Rheumatol 14:45-8. 2008
    ..This is another example of "Better living (and curing!) through chemistry" that we as clinicians need to master to render optimal care...
  30. ncbi request reprint Toward a more complete appreciation of the clinical spectrum of Borrelia burgdorferi infection: early Lyme disease without erythema migrans
    Leonard H Sigal
    Am J Med 114:74-5. 2003
  31. ncbi request reprint Vaccination for Lyme disease: cost-effectiveness versus cost and value
    Leonard H Sigal
    Arthritis Rheum 46:1439-42. 2002
  32. ncbi request reprint Basic science for the clinician 46. Molecular biologic agents in development: possible clinical consequences to rheumatologists
    Leonard H Sigal
    Pharmaceutical Research Institute, Bristol Myers Squibb, Princeton, NJ 08543 4000, USA
    J Clin Rheumatol 13:286-90. 2007
    ..Small molecules will not be reviewed, the emphasis here being on antibodies and larger molecules, cytokines among them...