Susan C Olson

Summary

Affiliation: New York Medical College
Country: USA

Publications

  1. pmc Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
    J L Bruder
    Department of Biochemistry, New York Medical College, Valhalla, New York 10595, USA
    BMC Cell Biol 2:1. 2001
  2. ncbi request reprint Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor
    Susan Olson
    Dept of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 287:L559-68. 2004
  3. ncbi request reprint Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway
    Jianyu Li
    Dept of Biochemistry, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Cell Physiol 292:C2185-96. 2007
  4. ncbi request reprint Angiotensin type 1 receptor is linked to inhibition of nitric oxide production in pulmonary endothelial cells
    Xiangmin Zhao
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Regul Pept 132:113-22. 2005
  5. pmc Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction
    Sachin A Gupte
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H1048-57. 2009
  6. ncbi request reprint Src kinase mediates angiotensin II-dependent increase in pulmonary endothelial nitric oxide synthase
    Xinmei Li
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Am J Respir Cell Mol Biol 31:365-72. 2004
  7. ncbi request reprint Threonine phosphorylation of integrin beta3 in calyculin A-treated platelets is selectively sensitive to 5'-iodotubercidin
    Kenneth M Lerea
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Biochim Biophys Acta 1773:185-91. 2007
  8. ncbi request reprint Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase
    Richard A Oeckler
    Dept of Physiology, Basic Science Bldg, Rm 604, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1017-25. 2005
  9. doi request reprint Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension
    Koko Murakami
    The Center for Pulmonary Hypertension Translational Research, New York Medical College, Valhalla, NY 10595, USA
    Exp Biol Med (Maywood) 235:805-13. 2010
  10. doi request reprint Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1290:30-6. 2013

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
    J L Bruder
    Department of Biochemistry, New York Medical College, Valhalla, New York 10595, USA
    BMC Cell Biol 2:1. 2001
    ..We further test the possibility that resveratrol acts by modulating structural and functional changes in endothelial cells lining the blood vessel wall...
  2. ncbi request reprint Angiotensin II stimulates nitric oxide production in pulmonary artery endothelium via the type 2 receptor
    Susan Olson
    Dept of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 287:L559-68. 2004
    ..This endothelial, type 2 receptor-dependent increase in nitric oxide may serve to counterbalance the angiotensin II-dependent vasoconstriction in smooth muscle cells, ultimately regulating pulmonary vascular tone...
  3. ncbi request reprint Angiotensin II type 2 receptor-dependent increases in nitric oxide synthase expression in the pulmonary endothelium is mediated via a G alpha i3/Ras/Raf/MAPK pathway
    Jianyu Li
    Dept of Biochemistry, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Cell Physiol 292:C2185-96. 2007
    ..Collectively, these data suggest that G alpha(i3), Shc, Grb2, Ras, and Raf-1 link Src to activation of MAPK and to the AT(2)-dependent increase in eNOS expression in PAECs...
  4. ncbi request reprint Angiotensin type 1 receptor is linked to inhibition of nitric oxide production in pulmonary endothelial cells
    Xiangmin Zhao
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Regul Pept 132:113-22. 2005
    ..In conclusion, Ang II downregulates eNOS protein expression via an AT1 receptor-linked pathway involving Galphaq/PLC/calcium/PKCalpha signaling pathway in BPAECs...
  5. pmc Peroxide generation by p47phox-Src activation of Nox2 has a key role in protein kinase C-induced arterial smooth muscle contraction
    Sachin A Gupte
    Department of Physiology, New York Medical College, Valhalla, New York, USA
    Am J Physiol Heart Circ Physiol 296:H1048-57. 2009
    ..Thus a p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of PKC...
  6. ncbi request reprint Src kinase mediates angiotensin II-dependent increase in pulmonary endothelial nitric oxide synthase
    Xinmei Li
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
    Am J Respir Cell Mol Biol 31:365-72. 2004
    ..These data suggest that Ang II stimulates Src tyrosine kinase via a pertussis toxin-sensitive pathway, which in turn activates the MAPK pathway, resulting in increased eNOS protein expression in BPAECs...
  7. ncbi request reprint Threonine phosphorylation of integrin beta3 in calyculin A-treated platelets is selectively sensitive to 5'-iodotubercidin
    Kenneth M Lerea
    Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA
    Biochim Biophys Acta 1773:185-91. 2007
    ..These data dissociate threonine phosphorylation of beta(3) molecules and inhibition of platelet responses by protein phosphatase inhibitors...
  8. ncbi request reprint Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase
    Richard A Oeckler
    Dept of Physiology, Basic Science Bldg, Rm 604, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 288:L1017-25. 2005
    ..Thus pulmonary arteries possess a peroxide-elicited contractile mechanism involving ERK MAP kinase, which is stimulated by stretch and regulated through the control of Nox oxidase activity by the availability of cytosolic NADH...
  9. doi request reprint Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension
    Koko Murakami
    The Center for Pulmonary Hypertension Translational Research, New York Medical College, Valhalla, NY 10595, USA
    Exp Biol Med (Maywood) 235:805-13. 2010
    ....
  10. doi request reprint Resveratrol and its metabolites modulate cytokine-mediated induction of eotaxin-1 in human pulmonary artery endothelial cells
    Joseph M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Ann N Y Acad Sci 1290:30-6. 2013
    ..Control of eotaxin-1 gene regulation may be considered an in vitro model to evaluate agents linking cardioprotection with endothelial cell damage and inflammation. ..

Research Grants1

  1. NITRIC OXIDE PRODUCTION BY ANG II IN ENDOTHELIUM
    Susan Olson; Fiscal Year: 2004
    ..These studies are of significant medical importance to heart and pulmonary disease, which involve pathological changes in blood pressure. ..