Adam Mor

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. doi request reprint Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor
    Adam Mor
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    J Invest Dermatol 131:2040-8. 2011
  2. ncbi request reprint Drug-induced myopathies
    Adam Mor
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Bull NYU Hosp Jt Dis 67:358-69. 2009
  3. pmc PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.
    Marianne Strazza
    Proc Natl Acad Sci U S A 114:2693-2698. 2017
  4. ncbi request reprint Immunomodulatory properties of farnesoids: the new steroids?
    A Mor
    Department of Medicine, New York University School of Medicine, 450 E 29th Street, New York, NY 10016, USA
    Curr Med Chem 20:1218-24. 2013
  5. doi request reprint Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 450 E 29th Street, New York, NY 10016, USA
    Inflammation 35:1706-14. 2012
  6. doi request reprint Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release
    Adam Mor
    Department of Neurobiology, The George Weise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 61390, Israel
    Inflammation 34:314-8. 2011
  7. doi request reprint Characterization of ERK activation in human mast cells stimulated by contact with T cells
    Adam Mor
    The Laboratory of Allergy and Clinical Immunology, Meir Medical Center, Kfar Saba, Israel
    Inflammation 33:119-25. 2010
  8. pmc Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane
    Adam Mor
    The Cancer Institute, NYU School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 29:3297-306. 2009
  9. doi request reprint T cell-induced mast cell activation: a role for microparticles released from activated T cells
    Irit Shefler
    Laboratory of Allergy and Clinical Immunology, Department of Medicine, Meir Medical Center, Kfar Saba, Israel
    J Immunol 185:4206-12. 2010
  10. pmc Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
    Joseph P Wynne
    Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    J Cell Biol 199:317-30. 2012

Collaborators

Detail Information

Publications32

  1. doi request reprint Inhibition of contact sensitivity by farnesylthiosalicylic acid-amide, a potential Rap1 inhibitor
    Adam Mor
    Department of Medicine, New York University School of Medicine, New York, New York, USA
    J Invest Dermatol 131:2040-8. 2011
    ..Moreover, FTS-A inhibited Rap1 and contact sensitivity far better than FTS. We suggest that FTS-A may serve as a possible therapeutic tool in contact sensitivity in particular and T-cell-mediated inflammation in general...
  2. ncbi request reprint Drug-induced myopathies
    Adam Mor
    Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Bull NYU Hosp Jt Dis 67:358-69. 2009
    ..Earlier diagnosis and drug discontinuation raises the likelihood of resolution and recovery...
  3. pmc PLCε1 regulates SDF-1α-induced lymphocyte adhesion and migration to sites of inflammation.
    Marianne Strazza
    Proc Natl Acad Sci U S A 114:2693-2698. 2017
    ..Our results reveal a signaling pathway where SDF-1α induces T-cell adhesion through activation of PLCε1, suggesting that PLCε1 is a specific potential target in treating conditions involving migration of T cells to inflamed organs...
  4. ncbi request reprint Immunomodulatory properties of farnesoids: the new steroids?
    A Mor
    Department of Medicine, New York University School of Medicine, 450 E 29th Street, New York, NY 10016, USA
    Curr Med Chem 20:1218-24. 2013
    ..In this review we summarize our (and others) published data, and conclude that FTS has great potential as a safe anti-inflammatory drug...
  5. doi request reprint Celecoxib enhances the anti-inflammatory effects of farnesylthiosalicylic acid on T cells independent of prostaglandin E(2) production
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, 450 E 29th Street, New York, NY 10016, USA
    Inflammation 35:1706-14. 2012
    ..The inhibitory effects, moreover, were independent of prostaglandin E(2) secretion. These data point to the promising potential of combined treatment with celecoxib and FTS for inflammatory disorders involving lymphocytes...
  6. doi request reprint Inhibitory effect of farnesylthiosalicylic acid on mediators release by mast cells: preferential inhibition of prostaglandin D(2) and tumor necrosis factor-α release
    Adam Mor
    Department of Neurobiology, The George Weise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 61390, Israel
    Inflammation 34:314-8. 2011
    ..This data suggests that FTS may have an inhibitory effect on MC mediated allergic inflammation, and thus may be considered as a possible therapeutic modality...
  7. doi request reprint Characterization of ERK activation in human mast cells stimulated by contact with T cells
    Adam Mor
    The Laboratory of Allergy and Clinical Immunology, Meir Medical Center, Kfar Saba, Israel
    Inflammation 33:119-25. 2010
    ..Thus, retaining ERK in the nucleus might be a mechanism utilized by human mast cells to generate different cytokines from a single signaling cascade...
  8. pmc Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane
    Adam Mor
    The Cancer Institute, NYU School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 29:3297-306. 2009
    ..Our data support a model whereby PLD1 regulates Rap1 activity by controlling exocytosis of a stored, vesicular pool of Rap1 that can be activated by C3G upon delivery to the plasma membrane...
  9. doi request reprint T cell-induced mast cell activation: a role for microparticles released from activated T cells
    Irit Shefler
    Laboratory of Allergy and Clinical Immunology, Department of Medicine, Meir Medical Center, Kfar Saba, Israel
    J Immunol 185:4206-12. 2010
    ..By extension, microparticles might affect the activity of mast cells, which are usually not in direct contact with T cells at the inflammatory site...
  10. pmc Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector
    Joseph P Wynne
    Cancer Institute, NYU School of Medicine, New York, NY 10016, USA
    J Cell Biol 199:317-30. 2012
    ..Thus, the RA-PH domains of RIAM function as a proximity detector for activated Rap1 and PI(4,5)P(2)...
  11. pmc Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1
    Yoel Kloog
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Mol Cell Biol 34:978-88. 2014
    ..These findings point to C3G and Hck as promising potential therapeutic targets for the treatment of T-cell-dependent autoimmune disorders. ..
  12. doi request reprint Drugs causing muscle disease
    Adam Mor
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, 301 East 17th Street Room 1410, New York, NY 10003, USA
    Rheum Dis Clin North Am 37:219-31, vi. 2011
    ..In this article, some of the commonly used drugs that may induce myopathies, as well as the clinical phenotypes, diagnosis, and management of these syndromes are reviewed...
  13. doi request reprint Ras chaperones: new targets for cancer and immunotherapy
    Yoel Kloog
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel Electronic address
    Enzymes 33:267-89. 2013
    ..We conclude that FTS has a great potential both as a safe anticancer drug and as a promising immune modulator agent. ..
  14. ncbi request reprint Small GTPases and LFA-1 reciprocally modulate adhesion and signaling
    Adam Mor
    Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Immunol Rev 218:114-25. 2007
    ..We have recently shown that Ras is also downstream of LFA-1 engagement: LFA-1 signaling through phospholipase D (PLD) to RasGRP1 was required for Ras activation on the plasma membrane following stimulation of TCR...
  15. ncbi request reprint The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
    Adam Mor
    Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
    Nat Cell Biol 9:713-9. 2007
    ..PLD2 and phosphatidic acid phosphatase (PAP) were required for Ras activation on the plasma membrane. Thus, LFA-1 acts through PLD2 to reshape the pattern of Ras activation downstream of the TCR...
  16. ncbi request reprint Familial Mediterranean fever successfully treated with etanercept
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, New York, NY 10003, USA
    J Clin Rheumatol 13:38-40. 2007
    ..This case adds to a growing body of evidence suggesting that tumor necrosis factor (TNF) blockade may result in resolution and prevention of further FMF attacks...
  17. doi request reprint Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis
    Michael Peled
    The Department of Medicine, New York University School of Medicine, 450 E 29th Street, New York, NY, 10016, USA
    Inflammation 38:1573-9. 2015
    ..These findings suggest that PD-1 might serve as a biomarker for disease activity in PsA and highlight the need for additional studies in order to establish the role of PD-1 in PsA pathogenesis. ..
  18. doi request reprint Drug-induced arthritic and connective tissue disorders
    Adam Mor
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10003, USA
    Semin Arthritis Rheum 38:249-64. 2008
    ..We assess the strength of the reported associations, discuss diagnostic features and treatment implications, and consider possible mechanisms for drug-induced genesis of rheumatic conditions...
  19. pmc Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe
    Latasha P Wright
    NYU Cancer Institute and Departments of Medicine, Cell Biology, and Pharmacology, NYU School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 29:1826-33. 2009
    ..Icmt is a target for anticancer drug discovery, and these data may facilitate efforts to develop small-molecule inhibitors...
  20. pmc Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
    Marianne Strazza
    Department of Medicine, New York University School of Medicine
    J Vis Exp . 2016
    ..Additionally, this assay can be expanded beyond T cell signaling to any adhesive leukocyte population and any integrin-adhesion molecule pair. ..
  21. ncbi request reprint T cell chemokine receptor patterns as pathogenic signatures in autoimmunity
    Marianne Strazza
    Division of Rheumatology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Discov Med 19:117-25. 2015
    ..We also discuss the implications for chemokine receptor signatures in autoimmune pathogenesis, and how these may provide novel targets for therapeutic intervention. ..
  22. ncbi request reprint The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis
    Adam Mor
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, the NYU Hospital for Joint Diseases, NY 10003, USA
    Clin Immunol 125:215-23. 2007
    ..In this manuscript, we review the basic biology of Ras in T lymphocytes, and the ways in which T lymphocyte Ras abnormalities may contribute to the development of a lupus phenotype...
  23. ncbi request reprint Neurologic manifestations as presenting symptoms of endocarditis
    Adaya Weissler
    Department of Medicine, Meir Medical Center, Kfar Saba, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Isr Med Assoc J 12:472-6. 2010
    ..A prompt diagnosis should be reached and antibiotic treatment initiated as soon as possible...
  24. doi request reprint Programmed death-1 pathway in cancer and autoimmunity
    Ariel Pedoeem
    Department of Medicine, New York University School of Medicine, NY, USA
    Clin Immunol 153:145-52. 2014
    ..We propose that future research on PD-1 may lead to the translation of fundamental regulatory pathways into the development of practical new approaches for the treatment of autoimmune diseases and cancer. ..
  25. doi request reprint CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane
    Marianne Strazza
    Department of Medicine, New York University School of Medicine, New York, NY 10016
    J Immunol 194:2871-7. 2015
    ..CAPRI trafficking to the plasma membrane was secondary to calcium influx and was mediated by its C2A and C2B domains. We conclude that CD28 inhibits Rap1-mediated adhesion by recruiting the protein CAPRI to the plasma membrane. ..
  26. ncbi request reprint Cellular therapy in 2010: focus on autoimmune and cardiac diseases
    Leor Perl
    Department of Medicine B, Meir Medical Center, Kfar Saba, Israel
    Isr Med Assoc J 12:110-5. 2010
    ....
  27. pmc Structure-function analysis of nucleolin and ErbB receptors interactions
    Keren Farin
    Department of Neurobiology, Tel Aviv University, Ramat Aviv, Israel
    PLoS ONE 4:e6128. 2009
    ..Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail. Overexpression of ErbB1 and nucleolin leads to receptor phosphorylation, dimerization and anchorage independent growth...
  28. ncbi request reprint Syphilis mimicking Reiter's syndrome in an HIV-positive patient
    Mitsumasa Kishimoto
    Division of Rheumatology, NYU School of Medicine Hospital for Joint Diseases, New York, New York 10016, USA
    Am J Med Sci 332:90-2. 2006
    ..Because the initial presentation was difficult to distinguish from the symptoms of Reiter's syndrome, a high degree of clinical suspicion was required to accurately diagnose syphilis, a curable and potentially fatal disease...
  29. ncbi request reprint Relapsing oligoarticular septic arthritis during etanercept treatment of rheumatoid arthritis
    Adam Mor
    Division of Rheumatology, New York University School of Medicine Hospital for Joint Diseases, 301 East 17th Street, Rm 1410, New York, NY 10003, USA
    J Clin Rheumatol 12:87-9. 2006
    ..Our case underscores the advisability of discontinuing TNF-alpha blockade in patients with septic arthritis during prolonged antimicrobial therapy...
  30. doi request reprint Autoimmunity and mast cell-related diseases
    Eyal Reinstein
    Department of Medicine B, Meir General Hospital, Kfar Saba 44281, Israel
    Expert Rev Clin Immunol 4:267-74. 2008
    ..The involvement of the main effectors of the immune system - mast cells, T lymphocytes, antibodies and cytokines - in both conditions is also discussed...
  31. ncbi request reprint Compartmentalized Ras/MAPK signaling
    Adam Mor
    Department of Medicine, New York University Medical Center, New York, NY 10016 6402, USA
    Annu Rev Immunol 24:771-800. 2006
    ..Thus, the Ras/MAPK pathway represents a clear example of compartmentalized signaling...
  32. ncbi request reprint PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
    Trever G Bivona
    Department of Cell Biology, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Mol Cell 21:481-93. 2006
    ..These data demonstrate that the location and function of K-Ras are regulated directly by PKC and suggest an approach to therapy of K-Ras-dependent tumors with agents that stimulate phosphorylation of S181...