Dan R Littman

Summary

Affiliation: New York University
Country: USA

Publications

  1. doi request reprint Releasing the Brakes on Cancer Immunotherapy
    Dan R Littman
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA The Howard Hughes Medical Institute Electronic address
    Cell 162:1186-90. 2015
  2. pmc Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    Jose U Scher
    Department of Medicine, New York University School of Medicine and Hospital for Joint Diseases, New York, United States
    elife 2:e01202. 2013
  3. pmc Role of the commensal microbiota in normal and pathogenic host immune responses
    Dan R Littman
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 10:311-23. 2011
  4. doi request reprint Th17 and regulatory T cells in mediating and restraining inflammation
    Dan R Littman
    Howard Hughes Medical Institute, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, 10016, USA
    Cell 140:845-58. 2010
  5. pmc ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    Takeshi Egawa
    Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nat Immunol 9:1131-9. 2008
  6. pmc The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
    Mark M W Chong
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:2005-17. 2008
  7. pmc Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
    Mark M W Chong
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 24:659-69. 2010
  8. pmc Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    Dipayan Rudra
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA
    Nat Immunol 10:1170-7. 2009
  9. ncbi request reprint IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
  10. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008

Detail Information

Publications70

  1. doi request reprint Releasing the Brakes on Cancer Immunotherapy
    Dan R Littman
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA The Howard Hughes Medical Institute Electronic address
    Cell 162:1186-90. 2015
    ..This has led to development of multiple "immune checkpoint therapies" that are prolonging and saving the lives of thousands of cancer patients...
  2. pmc Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis
    Jose U Scher
    Department of Medicine, New York University School of Medicine and Hospital for Joint Diseases, New York, United States
    elife 2:e01202. 2013
    ..This work identifies a potential role for P. copri in the pathogenesis of RA. DOI: http://dx.doi.org/10.7554/eLife.01202.001. ..
  3. pmc Role of the commensal microbiota in normal and pathogenic host immune responses
    Dan R Littman
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 10:311-23. 2011
    ..Our growing appreciation of this delicate host-microbe relationship promises to influence our understanding of inflammatory diseases and infection by microbial pathogens and to provide new therapeutic opportunities...
  4. doi request reprint Th17 and regulatory T cells in mediating and restraining inflammation
    Dan R Littman
    Howard Hughes Medical Institute, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, 10016, USA
    Cell 140:845-58. 2010
    ....
  5. pmc ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage
    Takeshi Egawa
    Molecular Pathogenesis Program, The Helen and Martin Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Nat Immunol 9:1131-9. 2008
    ..Our results suggest that MHC class II-selected thymocytes are directed toward the CD4(+) lineage independently of ThPOK but require ThPOK to prevent Runx-dependent differentiation toward the CD8(+) lineage...
  6. pmc The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
    Mark M W Chong
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:2005-17. 2008
    ..Thus, miRNA-dependent regulation is critical for preventing spontaneous inflammation and autoimmunity...
  7. pmc Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells
    Mark M W Chong
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 24:659-69. 2010
    ..Thus, E4(P) is responsible for establishing an epigenetically inherited active Cd4 locus in the helper T-cell lineage. To our knowledge, this is the first genetic demonstration of active transcriptional memory in mammalian cells...
  8. pmc Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    Dipayan Rudra
    Howard Hughes Medical Institute, University of Washington, Seattle, Washington, USA
    Nat Immunol 10:1170-7. 2009
    ..Thus, Runx-CBFbeta complexes maintain stable high expression of Foxp3 and serve as an essential determinant of T(reg) cell lineage stability...
  9. ncbi request reprint IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  10. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  11. pmc GPR15-mediated homing controls immune homeostasis in the large intestine mucosa
    Sangwon V Kim
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Science 340:1456-9. 2013
    ..Our findings thus describe a T cell-homing receptor for LILP and indicate that GPR15 plays a role in mucosal immune tolerance largely by regulating the influx of Tregs. ..
  12. pmc Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    Ivaylo I Ivanov
    Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Cell Host Microbe 4:337-49. 2008
    ..Our results suggest that composition of intestinal microbiota regulates the Th17:Treg balance in the LP and may thus influence intestinal immunity, tolerance, and susceptibility to inflammatory bowel diseases...
  13. pmc Susceptibility of human Th17 cells to human immunodeficiency virus and their perturbation during infection
    Aimee El Hed
    Departments of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Infect Dis 201:843-54. 2010
    ..Identification of the Th17 T cell subset as important mediators of host defense and pathology prompted us to determine their susceptibility to human immunodeficiency virus (HIV) infection...
  14. pmc Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells
    Gretchen E Diehl
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 494:116-20. 2013
    ....
  15. pmc Induction of intestinal Th17 cells by segmented filamentous bacteria
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 139:485-98. 2009
    ..Thus, manipulation of this commensal-regulated pathway may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease...
  16. pmc Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells
    Jonathan M Weiss
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 209:1723-42, S1. 2012
    ..In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease...
  17. pmc Dynamic microRNA gene transcription and processing during T cell development
    Francis F Kirigin
    Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 188:3257-67. 2012
    ..The longest was pri-mir-29b-1/29a at ∼168 kb. All the long pri-miRNAs also displayed extensive splicing. Our findings indicate that miRNA expression during T cell development is both a highly dynamic and a highly regulated process...
  18. pmc RUNX proteins in transcription factor networks that regulate T-cell lineage choice
    Amélie Collins
    The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 9:106-15. 2009
    ....
  19. pmc A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    Nicolas Manel
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 467:214-7. 2010
    ..The virulence of HIV-1 may be related to evasion of this response, the manipulation of which may be necessary to generate an effective HIV-1 vaccine...
  20. pmc CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
    Randy S Longman
    The Kimmel Center for Biology and Medicine of the Skirball Institute and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016 The Jill Roberts Center for IBD, Department of Medicine, Weill Cornell Medical College, New York, NY 10021
    J Exp Med 211:1571-83. 2014
    ..Collectively, these results reveal a critical role for CX₃CR1⁺ mononuclear phagocytes in integrating microbial signals to regulate colonic ILC3 function in IBD...
  21. pmc Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
    Yi Yang
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 510:152-6. 2014
    ..These findings have significant implications for understanding how commensal microbiota contribute to organ-specific autoimmunity and for developing novel mucosal vaccines. ..
  22. pmc Myd88 is required for an antibody response to retroviral infection
    Edward P Browne
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, New York, United States of America
    PLoS Pathog 5:e1000298. 2009
    ..Furthermore, passive transfer of immune serum from wild-type mice to Myd88 knockout mice rescued control of F-MLV. These results identify TLR signaling and CD11c(+) DCs as playing critical roles in the humoral response to retroviruses...
  23. pmc DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions
    Wendy Huang
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 528:517-22. 2015
    ....
  24. pmc RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation
    Amélie Collins
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Immunity 34:303-14. 2011
    ..Communication between Cd4 and Cd8 thus appears to enable long-range epigenetic regulation to ensure that expression of one excludes the other in mature CD4 or CD8 single-positive (SP) cells...
  25. doi request reprint Plasticity of CD4+ T cell lineage differentiation
    Liang Zhou
    The Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Immunity 30:646-55. 2009
    ..Here, we will discuss recent findings that demonstrate the plasticity of CD4(+) T cell differentiation and the biological implications of this flexibility...
  26. pmc The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    Nicolas Manel
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 9:641-9. 2008
    ..Our studies identify RORgammat as having a central function in the differentiation of human T(H)-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans...
  27. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  28. ncbi request reprint Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 305:248-51. 2004
    ..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
  29. pmc Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor
    Christopher N Parkhurst
    Molecular Neurobiology Program, The Kimmel Center for Biology and Medicine at the Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA
    Cell 155:1596-609. 2013
    ..Together, our findings reveal that microglia serve important physiological functions in learning and memory by promoting learning-related synapse formation through BDNF signaling. ..
  30. pmc The inducible deletion of Drosha and microRNAs in mature podocytes results in a collapsing glomerulopathy
    Olga Zhdanova
    Skirball Institute for Biomolecular Medicine, New York University Langone Medical Center, New York, New York, USA
    Kidney Int 80:719-30. 2011
    ..Identifying these miRNAs may provide new insight into disease pathogenesis and novel therapeutic targets in various podocytopathies...
  31. pmc A validated regulatory network for Th17 cell specification
    Maria Ciofani
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 151:289-303. 2012
    ..This interconnected network can be used to investigate new therapeutic approaches to manipulate Th17 functions in the setting of inflammatory disease...
  32. pmc Canonical and alternate functions of the microRNA biogenesis machinery
    Mark M W Chong
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 24:1951-60. 2010
    ..Together, these findings extend the range of function of RNaseIII enzymes beyond canonical miRNA biogenesis, and help explain the nonoverlapping phenotypes caused by Drosha and Dicer deficiency...
  33. pmc Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    Melissa A Kinnebrew
    Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 36:276-87. 2012
    ..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria...
  34. pmc Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
    Takeshi Egawa
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 108:14873-8. 2011
    ..Our results suggest that AP4 contributes to Cd4 silencing both in DN and CD8(+) T cells by enforcing checkpoints for appropriate timing of CD4 expression and its epigenetic silencing...
  35. pmc Transcriptional regulatory networks in Th17 cell differentiation
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, Howard Hughes Medical Institute, Department of Microbiology and Pathology, New York University School of Medicine, New York, NY 10016, USA
    Curr Opin Immunol 21:146-52. 2009
    ....
  36. pmc Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells
    Jing xin Zhang
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 3:e2035. 2008
    ..This study also highlights the differences between primary T cells and cell lines regarding pre-integration steps in the HIV-1 replication cycle...
  37. pmc Modulation of immune homeostasis by commensal bacteria
    Ivaylo I Ivanov
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Curr Opin Microbiol 14:106-14. 2011
    ....
  38. pmc The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1945-57. 2007
    ..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...
  39. pmc Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
    Sergio A Quezada
    Howard Hughes Medical Institute and the Ludwig Center for Cancer Immunotherapy, Department of Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Exp Med 205:2125-38. 2008
    ..The data demonstrate a dissociation between measurable systemic responses and tumor rejection during CD25-directed T reg cell depletion, and suggest an alternative, clinically applicable strategy for the treatment of established tumors...
  40. ncbi request reprint Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell 10:1083-96. 2002
    ....
  41. pmc Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages
    MacLean Sellars
    1 The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York, USA 2 Howard Hughes Medical Institute, New York University School of Medicine, New York, New York, USA
    Nat Immunol 16:746-54. 2015
    ..Our findings suggest that stage-specific methylation and demethylation events in Cd4 regulate its heritable expression in response to the distinct signals that dictate lineage 'choice' during T cell development. ..
  42. pmc Microbiota: host interactions in mucosal homeostasis and systemic autoimmunity
    Randy S Longman
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016 The Jill Roberts Center for Inflammatory Bowel Disease, Department of Medicine, Weill Cornell Medical College, New York, New York 10021
    Cold Spring Harb Symp Quant Biol 78:193-201. 2013
    ....
  43. pmc Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping
    Takeshi Egawa
    Molecular Pathogenesis Program, The Helen L and Martin S Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York, USA
    PLoS ONE 3:e1512. 2008
    ....
  44. ncbi request reprint Selection and lineage specification in the thymus: commitment 4-stalled
    Amélie Collins
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 23:4-5. 2005
    ..The result highlights the distinction between positive selection and lineage commitment and provides new impetus for reexamining lineage models...
  45. ncbi request reprint The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunol Rev 195:81-90. 2003
    ..We propose that RORgammat, together with the inhibitor of basic helix-loop-helix transcription factor Id2, ensures generation and survival of fetal LTi cells necessary for the development of LNs and PPs...
  46. pmc Virus-host interactions: new insights from the small RNA world
    Edward P Browne
    Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Genome Biol 6:238. 2005
    ....
  47. pmc An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses
    Teruyuki Sano
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 163:381-93. 2015
    ..This highlights the critical role of tissue microenvironment in activating effector functions of committed Th17 cells, which may have important implications for how these cells contribute to inflammatory disease...
  48. pmc Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
    Jun R Huh
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 472:486-90. 2011
    ..These data indicate that derivatives of digoxin can be used as chemical templates for the development of RORγt-targeted therapeutic agents that attenuate inflammatory lymphocyte function and autoimmune disease...
  49. ncbi request reprint Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse
    Tasha N Sims
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Cell 129:773-85. 2007
    ..WASp(-/-) T cells displayed normal IS formation but were unable to reform IS after migration unless PKCtheta was inhibited. Thus, opposing effects of PKCtheta and WASp control IS stability through pSMAC symmetry breaking and reformation...
  50. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  51. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  52. ncbi request reprint Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
    ..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells...
  53. pmc The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression
    Manolis Gialitakis
    Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Curr Top Microbiol Immunol 356:165-88. 2012
    ..We examine here novel insights into epigenetic mechanisms that have arisen through the study of these genes...
  54. pmc The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment
    Andrew Sczesnak
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, USA
    Cell Host Microbe 10:260-72. 2011
    ..However, SFB are functionally distinct from all 1200 examined genomes, indicating a gene complement representing biology relatively unique to their role as a gut commensal closely tied to host metabolism and immunity...
  55. pmc Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases
    Zaruhi Hovhannisyan
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 140:957-65. 2011
    ..We studied Th17 and Treg cells isolated from intestinal lamina propria of patients with IBD to investigate their role in pathogenesis...
  56. pmc The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity
    Randy S Longman
    Department of Medicine, Jill Roberts Institute for IBD Research, Weill Cornell Medical College, New York, New York, USA
    Curr Opin Rheumatol 27:381-7. 2015
    ..This review will highlight recent advances functionally linking the gut microbiome with mucosal and systemic immune cell activation underlying autoimmunity...
  57. pmc Sparse and compositionally robust inference of microbial ecological networks
    Zachary D Kurtz
    Departments of Microbiology and Medicine, New York University School of Medicine, New York, New York, United States of America
    PLoS Comput Biol 11:e1004226. 2015
    ..SPIEC-EASI also reproducibly predicts previously unknown microbial associations using data from the American Gut project. ..
  58. pmc CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance
    Lauren A Pitt
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA Department of Pathology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cancer Cell 27:755-68. 2015
    ..Our data identify a T-ALL niche and suggest targeting CXCL12/CXCR4 signaling as a powerful therapeutic approach for T-ALL...
  59. pmc Small molecule inhibitors of RORγt: targeting Th17 cells and other applications
    Jun R Huh
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Eur J Immunol 42:2232-7. 2012
    ..Recent studies from multiple groups have reported the activities of such inhibitors. In this mini review, we describe how RORγt inhibitors were identified and how they may contribute to our understanding about RORγt and its biology...
  60. ncbi request reprint The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  61. ncbi request reprint Immunology. Asymmetry and immune memory
    Dan R Littman
    Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 315:1673-4. 2007
  62. ncbi request reprint Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    ..These findings raise the potential for novel therapeutic strategies in inflammatory diseases...
  63. ncbi request reprint An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  64. pmc Dendritic cell-mediated trans-enhancement of human immunodeficiency virus type 1 infectivity is independent of DC-SIGN
    Cesar Boggiano
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Virol 81:2519-23. 2007
    ..Thus, DC-SIGN is not required for DC-mediated trans-enhancement of HIV infectivity...
  65. ncbi request reprint Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Biol 13:1252-8. 2003
    ..Together, these results show that CARMA1 has a central role in antigen receptor signaling that results in activation and proliferation of both B and T lymphocytes...
  66. pmc Species-specific restriction of apobec3-mediated hypermutation
    Edward P Browne
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, 540 First Ave, Second Floor, New York, NY 10016, USA
    J Virol 82:1305-13. 2008
    ..These results suggest that MLV has evolved specific mechanisms to block the ability of Apobec proteins to mediate deaminase-dependent hypermutation...
  67. ncbi request reprint Protein kinase C-theta;: signaling from the center of the T-cell synapse
    Christopher W Arendt
    Howard Hughes Medical Institute and Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Curr Opin Immunol 14:323-30. 2002
    ....
  68. ncbi request reprint HIV's vagina travelogue
    Cesar Boggiano
    Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Immunity 26:145-7. 2007
    ..In this issue of Immunity, Hladik et al. (2007) describe an organ culture system for imaging HIV-1 interaction with vaginal epithelial T cells and Langerhans cells early after infection...
  69. ncbi request reprint DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
    Douglas S Kwon
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 16:135-44. 2002
    ..We propose that HIV binds to DC-SIGN to gain access to an intracellular compartment that contributes to augmentation or retention of viral infectivity...
  70. pmc After Hrs with HIV
    Ali Amara
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 162:371-5. 2003
    ..In contrast to T cells, where HIV budding occurs at the plasma membrane, virus buds into vacuoles of macrophages, a process that may facilitate its spread within the infected host...