Horacio Kaufmann

Summary

Affiliation: New York University
Country: USA

Publications

  1. doi request reprint The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
    Horacio Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Clin Auton Res 22:79-90. 2012
  2. doi request reprint L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience
    Horacio Kaufmann
    Dysautonomia Research Laboratory, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Clin Auton Res 18:19-24. 2008
  3. doi request reprint Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients
    Jose M Martinez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychosom Med 72:442-9. 2010
  4. pmc Afferent baroreflex failure in familial dysautonomia
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, NY, USA
    Neurology 75:1904-11. 2010
  5. ncbi request reprint Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
  6. ncbi request reprint Electrical activation of the human vestibulo-sympathetic reflex
    Andrei Voustianiouk
    Mount Sinai School of Medicine, New York, NY, USA
    Exp Brain Res 171:251-61. 2006
  7. doi request reprint Cyclic vomiting associated with excessive dopamine in Riley-day syndrome
    Lucy J Norcliffe-Kaufmann
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA
    J Clin Gastroenterol 47:136-8. 2013
  8. doi request reprint Usefulness of tilt-induced heart rate changes in the differential diagnosis of vasovagal syncope and chronic autonomic failure
    Maria J Téllez
    Dysautonomia Center, Department of Neurology, NYU School of Medicine, New York, 10016, USA
    Clin Auton Res 19:375-80. 2009
  9. doi request reprint The Natural History of Pure Autonomic Failure: a U.S. Prospective Cohort
    Horacio Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY
    Ann Neurol . 2017
  10. pmc Progressive retinal structure abnormalities in multiple system atrophy
    Carlos E Mendoza-Santiesteban
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA
    Mov Disord 30:1944-53. 2015

Research Grants

Collaborators

Detail Information

Publications54

  1. doi request reprint The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale
    Horacio Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY 10016, USA
    Clin Auton Res 22:79-90. 2012
    ..Validation analyses were then performed on the two scales and a composite score of the OHQ...
  2. doi request reprint L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US experience
    Horacio Kaufmann
    Dysautonomia Research Laboratory, New York University School of Medicine, 530 First Avenue, New York, NY 10016, USA
    Clin Auton Res 18:19-24. 2008
    ..This mechanism of action makes droxidopa effective in patients with central and peripheral autonomic disorders...
  3. doi request reprint Heart rate and blood pressure changes during autonomic nervous system challenge in panic disorder patients
    Jose M Martinez
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychosom Med 72:442-9. 2010
    ....
  4. pmc Afferent baroreflex failure in familial dysautonomia
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, NY, USA
    Neurology 75:1904-11. 2010
    ..Familial dysautonomia (FD) is due to a genetic deficiency of the protein IKAP, which affects development of peripheral neurons. Patients with FD display complex abnormalities of the baroreflex of unknown cause...
  5. ncbi request reprint Norepinephrine precursor therapy in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Circulation 108:724-8. 2003
    ..In patients with neurogenic orthostatic hypotension (NOH), the availability of the sympathetic neurotransmitter norepinephrine (NE) in the synaptic cleft is insufficient to maintain blood pressure while in the standing posture...
  6. ncbi request reprint Electrical activation of the human vestibulo-sympathetic reflex
    Andrei Voustianiouk
    Mount Sinai School of Medicine, New York, NY, USA
    Exp Brain Res 171:251-61. 2006
    ....
  7. doi request reprint Cyclic vomiting associated with excessive dopamine in Riley-day syndrome
    Lucy J Norcliffe-Kaufmann
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA
    J Clin Gastroenterol 47:136-8. 2013
    ..To analyze the neurochemical profile during the recurrent attacks of nausea and vomiting in patients with Riley-day syndrome...
  8. doi request reprint Usefulness of tilt-induced heart rate changes in the differential diagnosis of vasovagal syncope and chronic autonomic failure
    Maria J Téllez
    Dysautonomia Center, Department of Neurology, NYU School of Medicine, New York, 10016, USA
    Clin Auton Res 19:375-80. 2009
    ..To determine whether the heart rate changes during tilt table testing could be used in the differential diagnosis between vasovagal syncope and chronic autonomic failure...
  9. doi request reprint The Natural History of Pure Autonomic Failure: a U.S. Prospective Cohort
    Horacio Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY
    Ann Neurol . 2017
    ..To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy...
  10. pmc Progressive retinal structure abnormalities in multiple system atrophy
    Carlos E Mendoza-Santiesteban
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, New York, USA
    Mov Disord 30:1944-53. 2015
    ..We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression...
  11. pmc Hyperdopaminergic crises in familial dysautonomia: a randomized trial of carbidopa
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, NY, USA
    Neurology 80:1611-7. 2013
    ....
  12. doi request reprint Familial dysautonomia (Riley-Day syndrome): when baroreceptor feedback fails
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, NY 10016, USA
    Auton Neurosci 172:26-30. 2012
    ..We outline the main consequences of a failure to receive information from arterial baroreceptors, including the characteristic "autonomic storms" and severe end-organ target damage...
  13. ncbi request reprint Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance
    Steven T Moore
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Acta Astronaut 56:867-76. 2005
    ..More data is necessary to evaluate this hypothesis, but if it were proven correct, in-flight short-radius centrifugation may help counteract orthostatic intolerance after space flight...
  14. ncbi request reprint Cerebral autoregulation and symptoms of orthostatic hypotension in familial dysautonomia
    Cristina Fuente Mora
    Department of Neurology, New York University School of Medicine, New York, USA
    J Cereb Blood Flow Metab . 2016
    ..Patients born with baroreflex deafferentation retain the ability to buffer wide fluctuations in BP and auto-regulate cerebral blood flow. This explains how they can tolerate extremely low BPs standing that would otherwise induce syncope...
  15. doi request reprint Autonomic Findings in Takotsubo Cardiomyopathy
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, New York University School of Medicine, New York, New York
    Am J Cardiol 117:206-13. 2016
    ..Impaired baroreflex control may therefore play a role in TC...
  16. pmc Orthostatic hypotension in Parkinson disease: how much you fall or how low you go?
    Jose Alberto Palma
    Dysautonomia Center, Department of Neurology, New York University Medical Center, New York, New York, USA
    Mov Disord 30:639-45. 2015
    ..A mean standing BP below 75 mmHg appears to be a useful benchmark when deciding whether the benefits of initiating pharmacological treatment of OH outweigh the risks of exacerbating supine hypertension...
  17. doi request reprint Selective retinal ganglion cell loss in familial dysautonomia
    Carlos E Mendoza-Santiesteban
    Dysautonomia Center, Langone Medical Center, New York University, New York, USA
    J Neurol 261:702-9. 2014
    ..This raises the possibility that reduced IKAP levels may affect mitochondrial proteins and their function in the nervous system, particularly in the retina...
  18. pmc Cerebellar and parkinsonian phenotypes in multiple system atrophy: similarities, differences and survival
    Dusan Roncevic
    Department of Neurology, Dysautonomia Center, New York University School of Medicine, 530 First Avenue, Suite 9Q, New York, NY, 10016, USA
    J Neural Transm (Vienna) 121:507-12. 2014
    ..We conclude that patients with both motor phenotypes have mostly similar survivals and demographic distributions. The differences here identified could help counseling of patients with MSA...
  19. doi request reprint Autonomic dysfunction in Parkinson disease
    Horacio Kaufmann
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, NY, USA Electronic address
    Handb Clin Neurol 117:259-78. 2013
    ..Recognition of autonomic impairment is important because symptomatic treatment is frequently effective. ..
  20. pmc A rating scale for the functional assessment of patients with familial dysautonomia (Riley Day syndrome)
    Felicia B Axelrod
    Department of Pediatrics, New York University School of Medicine, New York, NY, USA
    J Pediatr 161:1160-5. 2012
    ..To develop a reliable rating scale to assess functional capacity in children with familial dysautonomia, evaluate changes over time, and determine whether severity within a particular functional category at a young age affected survival...
  21. ncbi request reprint Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Ann Neurol 52:342-5. 2002
    ..02). These results indicate that midodrine significantly improves orthostatic tolerance during head-up tilt in patients with recurrent neurally mediated syncope...
  22. pmc Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia
    Felicia B Axelrod
    Department of Pediatrics, New York University School of Medicine, New York, New York 10016, USA
    Pediatr Res 70:480-3. 2011
    ..This is the first report of a drug that produces in vivo mRNA splicing changes in individuals with FD and supports future long-term trials to determine whether kinetin will prove therapeutic in FD patients...
  23. doi request reprint Preserved emotional modulation of motor response time despite psychomotor slowing in young-old adults
    Thomas D Hälbig
    Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA
    Int J Neurosci 121:430-6. 2011
    ..This result suggests that the specific effects of implicitly processed emotional valence and arousal information on behavioral response time are preserved in young-old adults despite significant age-related psychomotor decline...
  24. doi request reprint Tachyarrythmias with elevated cardiac enzymes in Münchausen syndrome
    Lucy Norcliffe-Kaufmann
    Department of Physiology and Neuroscience, Dysautonomia Center, New York University, 530 First Avenue, Suite 9Q, New York, NY 10016, USA
    Clin Auton Res 20:259-61. 2010
    ..We report the case of a woman with Münchausen syndrome who surreptitiously injected epinephrine causing recurrent ventricular tachyarrhythmias accompanied by dramatically high plasma levels of epinephrine and normal norepinephrine levels...
  25. ncbi request reprint Autonomic failure in neurodegenerative disorders
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Semin Neurol 23:351-63. 2003
    ..These phenomena were not previously recognized because of the buffering capacity of the baroreflex, but were unmasked in autonomic failure patients...
  26. doi request reprint Effect of medication and psychotherapy on heart rate variability in panic disorder
    Amir Garakani
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Depress Anxiety 26:251-8. 2009
    ..Low HRV has been associated with elevated risk for cardiovascular disease. Our aim was to investigate the effects of treatment on heart rate (HR) in patients with PD through a hyperventilation challenge...
  27. ncbi request reprint Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Neurology 63:1093-5. 2004
    ..These cases suggest that neurodegeneration in PD and DLB may begin outside the CNS in autonomic postganglionic neurons, a finding with potential diagnostic and therapeutic implications...
  28. pmc Dexmedetomidine for refractory adrenergic crisis in familial dysautonomia
    Ryan C Dillon
    Department of Pharmacy, NYU Langone Medical Center, New York, NY, USA
    Clin Auton Res . 2016
    ..We evaluated the preliminary effectiveness and safety of intravenous dexmedetomidine in the treatment of refractory adrenergic crisis in patients with FD...
  29. doi request reprint Familial dysautonomia: History, genotype, phenotype and translational research
    Lucy Norcliffe-Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY, USA
    Prog Neurobiol . 2016
    ..We also discuss the challenges of conducting controlled clinical trials in this rare medically fragile population. Meanwhile, the search for better treatments as well as a neuroprotective agent is ongoing...
  30. pmc Droxidopa in neurogenic orthostatic hypotension
    Horacio Kaufmann
    Department of Neurology, New York University School of Medicine, New York, NY, USA
    Expert Rev Cardiovasc Ther 13:875-91. 2015
    ..This article summarizes the pharmacological properties of droxidopa, its mechanism of action, and the efficacy and safety results of clinical trials. ..
  31. pmc Increased frequency of rhabdomyolysis in familial dysautonomia
    Jose Alberto Palma
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, 530 First Avenue, Suite 9Q, New York, New York, 10016, USA
    Muscle Nerve 52:887-90. 2015
    ..After 3 FD patients presented with rhabdomyolysis in a short time span, we aimed to determine the frequency of rhabdomyolysis is this population...
  32. pmc Chewing-induced hypertension in afferent baroreflex failure: a sympathetic response?
    Cristina Fuente Mora
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, New York, NY, USA
    Exp Physiol 100:1269-79. 2015
    ..The chewing pressor response may be useful as a counter-manoeuvre to raise blood pressure and prevent symptomatic orthostatic hypotension in patients with FD...
  33. pmc Mother-induced hypertension in familial dysautonomia
    Lucy Norcliffe-Kaufmann
    Dysautonomia Center, Department of Neurology, New York University, New York, NY, 10016, USA
    Clin Auton Res 26:79-81. 2016
    ..The case highlights how the reaction to maternal stress becomes amplified when catecholamine release is no longer under baroreflex control...
  34. pmc Current treatments in familial dysautonomia
    Jose Alberto Palma
    New York University School of Medicine, Dysautonomia Center, Department of Neurology, 530 First Avenue, Suite 9Q New York, NY 10016, USA 1 212 263 7225
    Expert Opin Pharmacother 15:2653-71. 2014
    ..Diminished pain and temperature perception result in neuropathic joints and thermal injuries. Impaired proprioception leads to gait ataxia. Optic neuropathy and corneal opacities lead to progressive visual loss...
  35. pmc Autonomic disorders predicting Parkinson's disease
    Jose Alberto Palma
    Dysautonomia Center, Department of Neurology, New York University Medical Center, New York, USA
    Parkinsonism Relat Disord 20:S94-8. 2014
    ..The sensitivity and specificity of these features has yet to be accurately assessed. We briefly review the evidence for autonomic dysfunction as biomarker of premotor PD. ..
  36. doi request reprint Clinical neuro-ophthalmic findings in familial dysautonomia
    Carlos E Mendoza-Santiesteban
    Dysautonomia Center, NYU Langone Medical Center, New York University, New York, NY, USA
    J Neuroophthalmol 32:23-6. 2012
    ..To define the clinical neuro-ophthalmic abnormalities of patients with familial dysautonomia (FD)...
  37. pmc Renal transplantation in familial dysautonomia: report of two cases and review of the literature
    Yelena Rekhtman
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Clin J Am Soc Nephrol 5:1676-80. 2010
    ..By age 25, nearly one-half of all patients with FD will have reached stage 3 CKD. Furthermore, dialysis for ESRD in FD patients is associated with multiple complications and poor outcomes...
  38. doi request reprint The R3 component of the electrically elicited blink reflex is present in patients with congenital insensitivity to pain
    Maria J Téllez
    Dysautonomia Research Laboratory, Department of Neurology, NYU School of Medicine, 530 First Avenue, 9Q, New York, NY 10016, USA
    Pain 141:178-80. 2009
    ..The R3 responses were elicited in both sides in both the patients at all intensities, strongly suggesting that the R3 component of the blink reflex is not a nociceptive response...
  39. ncbi request reprint Pharmacological treatment of reflex syncope
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Clin Auton Res 14:71-5. 2004
    ..None of these agents has shown a consistent therapeutic benefit in clinical trials...
  40. doi request reprint Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension
    Horacio Kaufmann
    Department of Neurology, New York University, New York, NY, USA Electronic address
    J Am Soc Hypertens 10:819-826. 2016
    ..These data demonstrate that ambulatory BP monitoring is useful to evaluate the circadian BP profile after initiating treatment with a pressor agent...
  41. pmc Vascular endothelial function and blood pressure regulation in afferent autonomic failure
    Qurat ul ain Jelani
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York University Langone Medical Center, New York, New York
    Am J Hypertens 28:166-72. 2015
    ..Whether vascular endothelial dysfunction contributes to defective vasomotor control in this form of afferent autonomic failure is not known...
  42. pmc Novel therapeutic approaches in multiple system atrophy
    Jose Alberto Palma
    Department of Neurology, Dysautonomia Center, New York University School of Medicine, 530 First Av, Suite 9Q, New York, NY, 10016, USA
    Clin Auton Res 25:37-45. 2015
    ..These and other potential therapeutic strategies for MSA are summarized in this review. ..
  43. pmc Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis
    Jose Alberto Palma
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, 530 First Avenue, Suite 9Q, New York, NY, 10016, USA
    Clin Auton Res 25:69-75. 2015
    ..Whether questionnaires alone are sufficient to diagnose RBD is also unknown...
  44. doi request reprint Is ambulatory blood pressure monitoring useful in patients with chronic autonomic failure?
    Lucy Norcliffe-Kaufmann
    Department of Neurology, Dysautonomia Research Center, New York University, New York, NY, 10016, USA
    Clin Auton Res 24:189-92. 2014
    ..Therefore, BP [corrected] ambulatory monitoring is useful to gauge the true severity of hypotension in patients with autonomic failure...
  45. doi request reprint Seropositive myasthenia and autoimmune autonomic ganglionopathy: cross reactivity or subclinical disease?
    Mitchell G Miglis
    Dysautonomia Center, Department of Neurology, New York University School of Medicine, 530 First Avenue Suite 9Q, New York, NY, 10016, USA
    Auton Neurosci 164:87-8. 2011
    ..We presume that his skeletal muscle nAChR seropositivity was a false positive, perhaps due to the cross reactivity of the patient's ganglionic nAChR antibodies with skeletal nAChR subtypes...
  46. ncbi request reprint Primary hyperhidrosis--evidence for autosomal dominant inheritance
    Horacio Kaufmann
    Dept of Neurology, Mount Sinai School of Medicine, New York, USA
    Clin Auton Res 13:96-8. 2003
    ..The pattern of inheritance suggests an autosomal dominant mode of transmission with incomplete disease penetrance...
  47. ncbi request reprint Syncope: a clinically guided diagnostic algorithm
    Horacio Kaufmann
    Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Clin Auton Res 14:87-90. 2004
    ..The tilt test and carotid sinus massage are useful to reproduce reflex syncope. An insertable subcutaneous loop recorder can provide prolonged ECG monitoring...
  48. ncbi request reprint Treatment of patients with orthostatic hypotension and syncope
    Horacio Kaufmann
    Mount Sinai School of Medicine, Department of Neurology, New York, New York 10029, USA
    Clin Neuropharmacol 25:133-41. 2002
  49. doi request reprint Complicated peptic ulcer disease in three patients with familial dysautonomia
    David W Wan
    Division of Gastroenterology, Department of Medicine, NYU Langone Medical Center, New York, NY, USA
    J Clin Gastroenterol 45:611-3. 2011
    ..Here, we present the first 3 instances of gastric ulcers in patients with FD and discuss their common presenting features and the special management that was required...
  50. ncbi request reprint Brain magnetic resonance imaging in multiple-system atrophy and Parkinson disease: a diagnostic algorithm
    Kirsty Bhattacharya
    Department of Neurology, Mount Sinai School of Medicine, Campus Box 1052, New York, NY 10029, USA
    Arch Neurol 59:835-42. 2002
    ....
  51. ncbi request reprint Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure
    David S Goldstein
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, MD 20892 1620, USA
    Clin Auton Res 14:363-8. 2004
    ....
  52. ncbi request reprint L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy
    Christopher H Gibbons
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 65:1104-6. 2005
    ..L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies...
  53. doi request reprint Neurogenic orthostatic hypotension: new prospects in treatment. Introduction
    Horacio Kaufmann
    Clin Auton Res 18:1. 2008
  54. ncbi request reprint [Pure autonomic failure. Bradbury Eggleston Syndrome. Case report]
    Juan Idiaquez
    Catedra de Neurologia, Universidad de Valparaiso, Hospital Naval Almirante Nef, Viña del Mar Chile
    Rev Med Chil 133:215-8. 2005
    ..Treatment with fludrocortisone and midodrine improved orthostatic tolerance...

Research Grants2

  1. OTOLITH INFLUENCES ON SYMPATHETIC ACTIVITY
    Horacio Kaufmann; Fiscal Year: 2004
    ..abstract_text> ..
  2. Carbidopa for the treatment of nausea and vomiting in familial dysautonomiaIND #
    Horacio Kaufmann; Fiscal Year: 2010
    ..Their long-term goal is to treat nausea effectively and without side effects, a therapeutic intervention that will markedly improve the quality of life of patients with FD. ..