Gilla Kaplan

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. pmc A metabolic biosignature of early response to anti-tuberculosis treatment
    Sebabrata Mahapatra
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Infect Dis 14:53. 2014
  2. pmc Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease
    Eddie M Wampande
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Infect Dis 13:484. 2013
  3. pmc Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI Center at the University of Medicine and Dentistry of New Jersey UMDNJ, 225 Warren Street, 07103, Newark, NJ, USA
    Cell Commun Signal 11:16. 2013
  4. pmc Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages
    Mi Sun Koo
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI at the University of Medicine and Dentistry of New Jersey UNDNJ, 225 Warren Street, Newark, New Jersey 07103, USA
    Cell Commun Signal 10:2. 2012
  5. pmc Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth
    Helen A Fletcher
    Jenner Institute, ORCRB, University of Oxford, Churchill Hospital, Oxford, OX3 7DQ, UK
    BMC Med Genomics 2:10. 2009
  6. pmc Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute PHRI at the University of Medicine and Dentistry of New Jersey UMDNJ, Newark, New Jersey, United States of America
    PLoS Pathog 7:e1002262. 2011
  7. pmc Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Pathol 179:289-301. 2011
  8. pmc Spontaneous latency in a rabbit model of pulmonary tuberculosis
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, USA
    Am J Pathol 181:1711-24. 2012
  9. pmc Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
    Infect Immun 74:2392-401. 2006
  10. pmc Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection
    Claudia Manca
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute PHRI, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers The State University of New Jersey, Newark, New Jersey, United States of America
    PLoS ONE 8:e74082. 2013

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc A metabolic biosignature of early response to anti-tuberculosis treatment
    Sebabrata Mahapatra
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Infect Dis 14:53. 2014
    ..However, proof-of-concept of this approach has not been provided for a TB-early treatment response biosignature (TB-ETRB)...
  2. pmc Long-term dominance of Mycobacterium tuberculosis Uganda family in peri-urban Kampala-Uganda is not associated with cavitary disease
    Eddie M Wampande
    Department of Medical Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda
    BMC Infect Dis 13:484. 2013
    ..Using a well characterized patient population, this study sought to determine whether there are clinical and patient characteristics associated with the success of the MTB Uganda family in Kampala...
  3. pmc Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI Center at the University of Medicine and Dentistry of New Jersey UMDNJ, 225 Warren Street, 07103, Newark, NJ, USA
    Cell Commun Signal 11:16. 2013
    ..However, besides nonhuman primates, rabbits are the only animal model that fully recapitulates the pathological features of human TB, including progressive disease with necrosis and cavitation or establishment of spontaneous latency...
  4. pmc Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages
    Mi Sun Koo
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI at the University of Medicine and Dentistry of New Jersey UNDNJ, 225 Warren Street, Newark, New Jersey 07103, USA
    Cell Commun Signal 10:2. 2012
    ..These strains have previously been shown to differ in their virulence/immunogenicity in the mouse and rabbit models of pulmonary TB...
  5. pmc Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth
    Helen A Fletcher
    Jenner Institute, ORCRB, University of Oxford, Churchill Hospital, Oxford, OX3 7DQ, UK
    BMC Med Genomics 2:10. 2009
    ..However, our understanding of the complexity of immunity to BCG in infants is inadequate, making interpretation of vaccine-induced immune responses difficult...
  6. pmc Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, the Public Health Research Institute PHRI at the University of Medicine and Dentistry of New Jersey UMDNJ, Newark, New Jersey, United States of America
    PLoS Pathog 7:e1002262. 2011
    ..These findings provide a basis for exploring the potential use of adjunctive immune modulation with PDE4 inhibitors to enhance the efficacy of existing anti-TB treatment...
  7. pmc Phosphodiesterase-4 inhibition combined with isoniazid treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Am J Pathol 179:289-301. 2011
    ..These findings support the potential for adjunctive immune modulation to improve the treatment of pulmonary TB and reduce the risk of chronic respiratory impairment...
  8. pmc Spontaneous latency in a rabbit model of pulmonary tuberculosis
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, USA
    Am J Pathol 181:1711-24. 2012
    ..In addition, bacillary control was associated with down-regulation of several metalloprotease genes and an absence of lung fibrosis. This model will be used to characterize molecular markers of protective immunity and reactivation...
  9. pmc Evaluation of the Mtb72F polyprotein vaccine in a rabbit model of tuberculous meningitis
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA
    Infect Immun 74:2392-401. 2006
    ..Interestingly, Mtb72F+AS01B induced better protection against leukocytosis and weight loss, suggesting that the polyprotein in this adjuvant may boost immunity without exacerbating inflammation in previously BCG-vaccinated individuals...
  10. pmc Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection
    Claudia Manca
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute PHRI, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers The State University of New Jersey, Newark, New Jersey, United States of America
    PLoS ONE 8:e74082. 2013
    ..In addition, our results suggest that inclusion or exclusion of PZA in the TB treatment regimen could potentially affect the biomarker signature detected in the circulation of TB patients. ..
  11. pmc Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model
    Selvakumar Subbian
    Public Health Research Institute PHRI of Rutgers Biomedical and Health Sciences RBHS, Newark, NJ, USA
    EBioMedicine 4:104-14. 2016
    ....
  12. ncbi request reprint Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway
    Claudia Manca
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren Street, Newark, NJ 07103 3535, USA
    J Interferon Cytokine Res 25:694-701. 2005
    ..Taken together, these results suggest that increased type I IFNs may be deleterious for survival of M. tuberculosis-infected mice in association with reduced Th1 immunity...
  13. pmc Chronic pulmonary cavitary tuberculosis in rabbits: a failed host immune response
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI Center at the University of Medicine and Dentistry of New Jersey UMDNJ, Newark, NJ 07103, USA
    Open Biol 1:110016. 2011
    ..Thus, the outcome of HN878 infection of rabbits was determined early during infection by a suboptimal activation of innate immunity and delayed T-cell activation...
  14. pmc Phosphodiesterase 4 inhibition reduces innate immunity and improves isoniazid clearance of Mycobacterium tuberculosis in the lungs of infected mice
    Mi Sun Koo
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute Center at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America
    PLoS ONE 6:e17091. 2011
    ..This novel strategy of combining anti-TB drugs with an immune modulating molecule, if applied appropriately to patients, may shorten the duration of TB treatment and improve clinical outcome...
  15. ncbi request reprint Mycobacterium tuberculosis H37Ra and H37Rv differential growth and cytokine/chemokine induction in murine macrophages in vitro
    Sherry Freeman
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, Newark, NJ 07103, USA
    J Interferon Cytokine Res 26:27-33. 2006
    ..tuberculosis strains determine the ability of the cells to control the growth of the intracellular bacilli...
  16. ncbi request reprint Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute, Newark, New Jersey 07103, USA
    J Infect Dis 192:98-106. 2005
    ....
  17. pmc Modulation of the cytokine response in human monocytes by mycobacterium leprae phenolic glycolipid-1
    Claudia Manca
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute at the International Center for Public Health, Newark, New Jersey 07103 3535, USA
    J Interferon Cytokine Res 32:27-33. 2012
    ..leprae. Thus, PGL-1 may play an important role in the development of the anergic clinical forms of disease and in tissue damage seen in lepromatous patients and during the reactional states of leprosy...
  18. ncbi request reprint Mycobacterium leprae inhibits dendritic cell activation and maturation
    Rose Ann Murray
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, Newark, NJ 07103, USA
    J Immunol 178:338-44. 2007
    ..leprae. Our data suggest that M. leprae does not induce and probably suppresses in vitro DC maturation/activation, whereas Mtb and BCG are stimulatory...
  19. pmc Pharmacologic Inhibition of Host Phosphodiesterase-4 Improves Isoniazid-Mediated Clearance of Mycobacterium tuberculosis
    Selvakumar Subbian
    The Public Health Research Institute PHRI, Rutgers Biomedical and Health Sciences RBHS, Rutgers University, Newark, NJ, USA
    Front Immunol 7:238. 2016
    ..This important confirmatory study will be used to help design upcoming human clinical trials with CC-11050 as an HDT for TB treatment. ..
  20. pmc Mycobacterium leprae actively modulates the cytokine response in naive human monocytes
    Daniel Sinsimer
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, International Center for Public Health, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA
    Infect Immun 78:293-300. 2010
    ..leprae plays an active role to control the release of cytokines from monocytes by providing both positive and negative regulatory signals via multiple signaling pathways involving PI3K, NF-kappaB, and caspase-1...
  21. pmc Epidemiologic consequences of microvariation in Mycobacterium tuberculosis
    Barun Mathema
    Public Health Research Institute, Newark, NJ, USA
    J Infect Dis 205:964-74. 2012
    ..We studied 5 closely related Mycobacterium tuberculosis strains that collectively caused extensive disease (n = 862), particularly among US-born tuberculosis patients...
  22. ncbi request reprint Tuberculosis: integrating host and pathogen biology. A summary of the 2005 Keystone Symposia
    Dorothy Fallows
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren Street, Newark, NJ 07103 3535, USA
    Tuberculosis (Edinb) 86:144-8. 2006
  23. pmc Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute PHRI, Rutgers Biomedical and Health Sciences, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America
    PLoS ONE 10:e0132249. 2015
    ..Our data highlight the formidable challenges facing ongoing efforts to identify peripheral blood biomarkers due to the diversity of lesion types and complexity of local immune responses in the lung. ..
  24. ncbi request reprint Strain-specific mycobacterial lipids and the stimulation of protective immunity to tuberculosis
    Marc Mendelson
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, Newark, NJ, USA
    Tuberculosis (Edinb) 85:407-13. 2005
    ..tuberculosis affect that strain's ability to direct innate immunity, and ultimately influence whether infection is controlled or active disease develops...
  25. ncbi request reprint Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response
    Rose Ann Murray
    Public Health Research Institute, Newark, NJ 07103, USA
    J Immunol 177:5647-51. 2006
    ..Incubation of whole blood with M. tuberculosis also caused CD8+ T cell IFN-gamma expression. We conclude that BCG induces a robust CD8+ T cell response, which may contribute to vaccination-induced protection against tuberculosis...
  26. pmc Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis
    Claudia Manca
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, 225 Warren St, Newark, NJ 07103 3535, USA
    Infect Immun 72:5511-4. 2004
    ..The differential cytokine-chemokine response was mediated by extracted lipids, suggesting that these molecules regulate host responses to infection...
  27. pmc The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence
    Daniel Sinsimer
    Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute Center, University of Medicine and Dentistry of New Jersey, 225 Warren St, Newark, NJ 07103, USA
    Infect Immun 76:3027-36. 2008
    ..tuberculosis, it probably acts in concert with other bacterial factors which seem to be dependent on the background of the strain...
  28. pmc Quantitative and functional differences between peripheral blood myeloid dendritic cells from patients with pleural and parenchymal lung tuberculosis
    Marc Mendelson
    Laboratory of Mycobcterial Immunity and Pathogenesis, Public Health Research Institute, International Center for Public Health, Newark, New Jersey 07103 3535, USA
    Clin Vaccine Immunol 13:1299-306. 2006
    ..Our findings suggest important differences in innate immunity between patients with different forms of active TB, and this may contribute to the differences in natural history observed between the two groups...
  29. pmc Factors affecting tuberculosis strain success over 10 years in a high TB- and HIV-burdened community
    Keren Middelkoop
    Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, New York, USA, Public Health Research Institute, Tuberculosis Center, New Jersey Medical School, Rutgers, State University of New Jersey, Newark, USA, Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa, National Health Laboratory Service, Cape Town, South Africa, Division of Medical Microbiology, Department of Clinical Laboratory Sciences, University of Cape Town, Cape Town, South Africa and Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, USADesmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa, Department of Epidemiology, Mailman School of Public Health, Columbia University, Australia
    Int J Epidemiol 43:1114-22. 2014
    ..Factors associated with Mycobacterium tuberculosis (Mtb) strain success over time in high burdened communities are unknown...
  30. ncbi request reprint Rational vaccine development--a new trend in tuberculosis control
    Gilla Kaplan
    Public Health Research Institute, International Center for Public Health, Newark, NJ, USA
    N Engl J Med 353:1624-5. 2005
  31. pmc Antibody profiles characteristic of Mycobacterium tuberculosis infection state
    Amy Davidow
    University of Medicine and Dentistry of New Jersey, Newark, USA
    Infect Immun 73:6846-51. 2005
    ..tuberculosis antigens varied during infection. Together, the data indicate that antigen composition of tubercle bacilli varies with stage of infection and that immunoprofiling can distinguish between tuberculosis states...
  32. pmc Mycobacterium tuberculosis growth at the cavity surface: a microenvironment with failed immunity
    Gilla Kaplan
    Laboratory of Mycobacterial Immunity and Pathogenesis, Newark, New Jersey, USA
    Infect Immun 71:7099-108. 2003
    ....
  33. pmc BCG vaccination confers poor protection against M. tuberculosis HN878-induced central nervous system disease
    Liana Tsenova
    Laboratory of Mycobacterial Immunity and Pathogenesis, The Public Health Research Institute PHRI, 225 Warren Street, Newark, NJ 07103, USA
    Vaccine 25:5126-32. 2007
    ..tuberculosis H37Rv but also with different clinical isolates including the highly virulent strains of the W-Beijing family...
  34. pmc Detection of Mycobacterium tuberculosis in latently infected lungs by immunohistochemistry and confocal microscopy
    Selvakumar Subbian
    Laboratory of Mycobacterial Immunity and Pathogenesis, Rutgers University, Newark, NJ, USA Public Health Research Institute PHRI, Rutgers Biomedical and Health Sciences, Rutgers University, Newark, NJ, USA
    J Med Microbiol 63:1432-5. 2014
    ..tuberculosis in latently infected rabbit lungs where no acid-fast-stained organisms were seen and no cultivable bacilli were obtained by the agar-plating method. ..

Research Grants2

  1. Regulation of Early Cytokine Receptors to TB Infection
    Gilla Kaplan; Fiscal Year: 2006
    ..abstract_text> ..
  2. Host-Pathogen Interactions and M.tb Drug Resistance
    Gilla Kaplan; Fiscal Year: 2009
    ..Results of these studies can contribute to improved TB control strategies aimed at reducing the emergence of MDR- TB and the development of new therapeutic approaches for combating this deadly disease. ..