CATARINA HIOE

Summary

Affiliation: New York University School of Medicine
Country: USA

Publications

  1. pmc The use of immune complex vaccines to enhance antibody responses against neutralizing epitopes on HIV-1 envelope gp120
    Catarina E Hioe
    Department of Pathology, New York University School of Medicine, New York, NY 10010, United States
    Vaccine 28:352-60. 2009
  2. pmc HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA)
    Catarina E Hioe
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
    PLoS ONE 6:e23202. 2011
  3. pmc Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes
    Catarina E Hioe
    Department of Pathology, New York University Langone School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e10254. 2010
  4. pmc In vivo alteration of humoral responses to HIV-1 envelope glycoprotein gp120 by antibodies to the CD4-binding site of gp120
    Maria Luisa Visciano
    Department of Pathology, New York University School of Medicine, New York, NY 10010, USA
    Virology 372:409-20. 2008
  5. ncbi request reprint Characterization of antibodies that inhibit HIV gp120 antigen processing and presentation
    Michael Tuen
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    Eur J Immunol 35:2541-51. 2005
  6. pmc Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing
    Peter C Chien
    Department of Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, New York, NY 10010, USA
    J Virol 78:7645-52. 2004
  7. ncbi request reprint Identification of an N-linked glycosylation in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes
    Hualin Li
    Department of Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    J Immunol 180:4011-21. 2008
  8. pmc Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infection
    Gurvinder Kaur
    Department of Veterans Affairs New York Harbor Healthcare System and Department of Pathology, New York University School of Medicine, New York, NY, USA
    Virology 369:214-25. 2007
  9. pmc Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells
    Gaia Vasiliver-Shamis
    VA Medical Center, 423 E 23rd St, Room 18 124 North, New York, NY 10010, USA
    J Virol 82:9445-57. 2008
  10. pmc Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse
    Gaia Vasiliver-Shamis
    Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Virol 83:11341-55. 2009

Collaborators

Detail Information

Publications13

  1. pmc The use of immune complex vaccines to enhance antibody responses against neutralizing epitopes on HIV-1 envelope gp120
    Catarina E Hioe
    Department of Pathology, New York University School of Medicine, New York, NY 10010, United States
    Vaccine 28:352-60. 2009
    ..Overall this study shows the potential use of gp120/Ab complexes to augment the immunogenicity of HIV-1 envelope gp120, but further improvements are needed to elicit virus-neutralizing Ab responses with higher potency and breadth...
  2. pmc HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA)
    Catarina E Hioe
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, Manhattan Campus, New York, New York, United States of America
    PLoS ONE 6:e23202. 2011
    ....
  3. pmc Anti-V3 monoclonal antibodies display broad neutralizing activities against multiple HIV-1 subtypes
    Catarina E Hioe
    Department of Pathology, New York University Langone School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e10254. 2010
    ..Despite this evidence of V3 conservation, the ability of anti-V3 Abs to neutralize a significant proportion of HIV-1 isolates from different subtypes (clades) has remained controversial...
  4. pmc In vivo alteration of humoral responses to HIV-1 envelope glycoprotein gp120 by antibodies to the CD4-binding site of gp120
    Maria Luisa Visciano
    Department of Pathology, New York University School of Medicine, New York, NY 10010, USA
    Virology 372:409-20. 2008
    ..These results indicate that the anti-CD4bs antibodies alter the antigenicity and immunogenicity of gp120, leading to enhanced production of anti-gp120 antibodies directed particularly against the V3 region...
  5. ncbi request reprint Characterization of antibodies that inhibit HIV gp120 antigen processing and presentation
    Michael Tuen
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    Eur J Immunol 35:2541-51. 2005
    ..The presence of such antibodies could contribute to the dearth of anti-gp120 T helper responses in chronically HIV-1-infected patients...
  6. pmc Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing
    Peter C Chien
    Department of Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, New York, NY 10010, USA
    J Virol 78:7645-52. 2004
    ..Antibodies to other gp120 regions do not confer this effect. Thus, HIV may evade anti-viral T-helper responses by inducing and exploiting antibodies that conceal the virus envelope antigens from T cells...
  7. ncbi request reprint Identification of an N-linked glycosylation in the C4 region of HIV-1 envelope gp120 that is critical for recognition of neighboring CD4 T cell epitopes
    Hualin Li
    Department of Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
    J Immunol 180:4011-21. 2008
    ..Hence, N-linked glycans are critical determinants that can profoundly influence CD4 T cell recognition of HIV-1 gp120...
  8. pmc Antigen stimulation induces HIV envelope gp120-specific CD4(+) T cells to secrete CCR5 ligands and suppress HIV infection
    Gurvinder Kaur
    Department of Veterans Affairs New York Harbor Healthcare System and Department of Pathology, New York University School of Medicine, New York, NY, USA
    Virology 369:214-25. 2007
    ..Such responses would protect virus-specific CD4(+) T cells from HIV infection and preserve their critical functions in mounting and maintaining long-lasting immunity against the virus...
  9. pmc Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells
    Gaia Vasiliver-Shamis
    VA Medical Center, 423 E 23rd St, Room 18 124 North, New York, NY 10010, USA
    J Virol 82:9445-57. 2008
    ..The virological synapse was formed transiently, with the initiation of migration within 30 min. Thus, HIV-1 gp120-presenting surfaces induce a transient stop signal and supramolecular segregation in noninfected CD4(+) T cells...
  10. pmc Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse
    Gaia Vasiliver-Shamis
    Program in Molecular Pathogenesis, Marty and Helen Kimmel Center for Biology and Medicine, Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Virol 83:11341-55. 2009
    ..We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events...
  11. ncbi request reprint HIV-1-infected patients with envelope-specific lymphoproliferation or long-term nonprogression lack antibodies suppressing glycoprotein 120 antigen presentation
    Peter C Chien
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, New York, New York 10010, USA
    J Infect Dis 189:852-61. 2004
    ..In the absence of these antibodies, however, anti-envelope T helper responses might be maintained...
  12. ncbi request reprint Propagation of CD4+ T cells specific for HIV type 1 envelope gp120 from chronically HIV type 1-infected subjects
    Sandra Cohen
    Veteran Affairs New York Harbor Healthcare System and Department of Pathology, New York University School of Medicine, New York, New York 10010, USA
    AIDS Res Hum Retroviruses 19:793-806. 2003
    ....
  13. ncbi request reprint High levels of antibodies to the CD4 binding domain of human immunodeficiency virus type 1 glycoprotein 120 are associated with faster disease progression
    Peter C Chien
    Department of Pathology, New York University School of Medicine, and Veterans Affairs New York Harbor Healthcare System, New York, New York, USA
    J Infect Dis 186:205-13. 2002
    ..These findings document a novel mechanism of HIV pathogenesis mediated by anti-gp120(CD4bd) Abs exhibiting suppressive activity on gp120 presentation...

Research Grants2

  1. HIV Vaccines that Elicit Immune Responses to Virus Env
    Catarina E Hioe; Fiscal Year: 2010
    ..These studies will provide information about how to design more immunogenic forms of gp120, how to better stimulate gp120-specific CD4 T cell responses, and how to use the mutated gp120 constructs as HIV vaccines. ..
  2. CC Chemokine Secretion to Protect Antigen-Specific CD4 T Cells from HIV
    Catarina E Hioe; Fiscal Year: 2010
    ..Data from this study will provide information about the types of CD4 T cell responses need for protection against HIV and thus should be directly applicable to the development of the much needed HIV vaccines. ..