Edouard I Azzam

Summary

Affiliation: New Jersey
Country: USA

Publications

  1. ncbi request reprint Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures
    Edouard I Azzam
    Department of Cancer Cell Biology, Laboratory of Radiobiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:5436-42. 2002
  2. ncbi request reprint Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses
    Edouard I Azzam
    Laboratory of Radiobiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Res 63:7128-35. 2003
  3. ncbi request reprint The radiation-induced bystander effect: evidence and significance
    Edouard I Azzam
    Department of Radiology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Hum Exp Toxicol 23:61-5. 2004
  4. ncbi request reprint Characterization of cell-cycle progression and growth of WB-F344 normal rat liver epithelial cells following gamma-ray exposure
    Bogdan I Gerashchenko
    Department of Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Cytometry A 61:134-41. 2004
  5. ncbi request reprint Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
    Edouard I Azzam
    Department of Radiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103
    Oncogene 22:7050-7. 2003
  6. pmc Role of the translationally controlled tumor protein in DNA damage sensing and repair
    Jie Zhang
    Departments of Radiology, Pharmacology and Physiology, and Biochemistry and Molecular Biology, New Jersey Medical School Cancer Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103
    Proc Natl Acad Sci U S A 109:E926-33. 2012
  7. pmc The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells
    Narongchai Autsavapromporn
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey 07103, USA
    Radiat Res 175:347-57. 2011
  8. pmc Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress
    Manuela Buonanno
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey 07103, USA
    Radiat Res 175:405-15. 2011
  9. pmc Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
    Edouard I Azzam
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, 07103, United States
    Cancer Lett 327:48-60. 2012
  10. ncbi request reprint Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism
    Sonia M De Toledo
    Department of Radiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07101, USA
    Radiat Res 166:849-57. 2006

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures
    Edouard I Azzam
    Department of Cancer Cell Biology, Laboratory of Radiobiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 62:5436-42. 2002
    ....
  2. ncbi request reprint Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses
    Edouard I Azzam
    Laboratory of Radiobiology, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Res 63:7128-35. 2003
    ..In contrast, the response after UV radiation varied and was cell type-dependent. Overall, these data suggest a critical role for genes involved in intercellular communication in mediating the cellular responses to a variety of stresses...
  3. ncbi request reprint The radiation-induced bystander effect: evidence and significance
    Edouard I Azzam
    Department of Radiology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Hum Exp Toxicol 23:61-5. 2004
    ..Potential similarities between factors that mediate the radiation-induced bystander and adaptive responses are highlighted...
  4. ncbi request reprint Characterization of cell-cycle progression and growth of WB-F344 normal rat liver epithelial cells following gamma-ray exposure
    Bogdan I Gerashchenko
    Department of Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Cytometry A 61:134-41. 2004
    ..Here, the distribution of phases in the cell-cycle and the proliferation ability of WB-F344 cells are characterized at various time points after the cells have been irradiated with different doses of gamma-rays...
  5. ncbi request reprint Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect
    Edouard I Azzam
    Department of Radiology, UMDNJ, New Jersey Medical School, Newark, NJ 07103
    Oncogene 22:7050-7. 2003
    ..Our current knowledge of the biochemical and molecular events involved in the latter two processes is reviewed in this article...
  6. pmc Role of the translationally controlled tumor protein in DNA damage sensing and repair
    Jie Zhang
    Departments of Radiology, Pharmacology and Physiology, and Biochemistry and Molecular Biology, New Jersey Medical School Cancer Center, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103
    Proc Natl Acad Sci U S A 109:E926-33. 2012
    ..It also attenuated the radiation-induced G(1) delay but prolonged the G(2) delay. TCTP therefore may play a critical role in maintaining genomic integrity in response to DNA-damaging agents...
  7. pmc The role of gap junction communication and oxidative stress in the propagation of toxic effects among high-dose α-particle-irradiated human cells
    Narongchai Autsavapromporn
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey 07103, USA
    Radiat Res 175:347-57. 2011
    ....
  8. pmc Long-term consequences of radiation-induced bystander effects depend on radiation quality and dose and correlate with oxidative stress
    Manuela Buonanno
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey 07103, USA
    Radiat Res 175:405-15. 2011
    ..They are relevant to estimates of health risks from exposures to space radiation and the emergence of second malignancies after radiotherapy...
  9. pmc Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury
    Edouard I Azzam
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, 07103, United States
    Cancer Lett 327:48-60. 2012
    ..These include short and long-term in vitro and in vivo effects on mitochondrial DNA, mitochondrial protein import and metabolic and antioxidant enzymes...
  10. ncbi request reprint Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism
    Sonia M De Toledo
    Department of Radiology, UMDNJ New Jersey Medical School, Newark, New Jersey 07101, USA
    Radiat Res 166:849-57. 2006
    ..Expression of connexin 43, a constitutive protein of gap junctions, and the G(1) checkpoint were more sensitive to regulation by gamma rays in cells maintained in a three-dimensional than in a two-dimensional configuration...
  11. pmc Investigation of adaptive responses in bystander cells in 3D cultures containing tritium-labeled and unlabeled normal human fibroblasts
    Massimo Pinto
    Department of Radiology, Division of Radiation Research, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey 07103, USA
    Radiat Res 174:216-27. 2010
    ..Higher dose rates and/or higher LET may be required to observe stressful bystander effects in this experimental system, whereas lower dose rates and challenge doses may be required to detect adaptive bystander responses...
  12. pmc Human umbilical-cord-blood mononucleated cells enhance the survival of lethally irradiated mice: dosage and the window of time
    Olga A Kovalenko
    Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Radiat Res 54:1010-4. 2013
    ..01). Compared with earlier studies, the increased dose of HUCB mononucleated cells, coupled with early use of an antibiotic, extended the window of time for effective treatment of severe radiation injury from 4 to 24-52 h after exposure. ..
  13. pmc In vivo space radiation-induced non-targeted responses: late effects on molecular signaling in mitochondria
    Mohit R Jain
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Cancer Center, Newark, NJ 07103, USA
    Curr Mol Pharmacol 4:106-14. 2011
    ..They further demonstrate that 'network analyses' is an effective tool towards characterizing the signaling pathways that mediate the long-term biological effects of space radiation...
  14. ncbi request reprint Normal human fibroblasts exposed to high- or low-dose ionizing radiation: differential effects on mitochondrial protein import and membrane potential
    Badri N Pandey
    Department of Radiology, UMDNJ New Jersey Medical School, Newark, 07101, USA
    Antioxid Redox Signal 8:1253-61. 2006
    ..The strategy described here may serve as novel end points to study radiation-induced effects...
  15. pmc Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations
    Geraldine Gonon
    Department of Radiology, UMDNJ New Jersey Medical School Cancer Center, Newark, New Jersey, USA
    Radiat Res 179:444-57. 2013
    ..Thus, the latter are unlikely to significantly contribute to stressful effects in cells not targeted by primary HZE particles...
  16. pmc Induction of lethal bystander effects in human breast cancer cell cultures by DNA-incorporated Iodine-125 depends on phenotype
    John M Akudugu
    Division of Radiation Research, Department of Radiology, New Jersey Medical School Cancer Center, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Int J Radiat Biol 88:1028-38. 2012
    ..These breast cancer cell lines respectively form metastatic xenografts in nude mice in an estrogen-dependent and independent manner...
  17. pmc A multi-port low-fluence alpha-particle irradiator: fabrication, testing and benchmark radiobiological studies
    Prasad V S V Neti
    Department of Radiology, Division of Radiation Research, New Jersey Medical School, Newark, New Jersey 07103, USA
    Radiat Res 161:732-8. 2004
    ..Clonogenic cell survival experiments with AG1522 human fibroblasts indicate that the RBE of the alpha particles compared to (137)Cs gamma rays is about 7.6 for this biological end point...
  18. pmc Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions
    Manuela Buonanno
    Department of Radiology, New Jersey Medical School Cancer Center, Rutgers University, 205 South Orange Avenue, Newark, NJ 07103, USA Present address Center for Radiological Research, Columbia University Medical Center, 630 West 168th Street, New York, NY 10032, USA
    J Radiat Res 56:502-8. 2015
    ..They show that protective adaptive responses can spread from cells targeted by low-LET space radiation to bystander cells in their vicinity. The findings are relevant to understanding the health hazards of space travel. ..
  19. pmc Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely ionizing radiation
    Manuela Buonanno
    Department of Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School Cancer Center, Newark, New Jersey, United States of America
    PLoS ONE 6:e21540. 2011
    ....
  20. pmc Expression of (NES-)hTERT in cancer cells delays cell cycle progression and increases sensitivity to genotoxic stress
    Olga A Kovalenko
    Department of Pharmacology and Physiology, New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 5:e10812. 2010
    ....
  21. pmc A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
    Jason D Domogauer
    Department of Radiology, New Jersey Medical School, Rutgers University
    J Vis Exp . 2016
    ....
  22. doi request reprint Delayed activation of human microglial cells by high dose ionizing radiation
    Hongxin Chen
    Department of Neurology and Neurosciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, United States
    Brain Res 1646:193-8. 2016
    ..Together, the results show that human CHME5 microglia are relatively resistant to low and moderate doses of γ rays, but are sensitive to acute high doses, and that CHME5 cells are a useful tool for in vitro study of human microglia. ..
  23. pmc Is Ionizing Radiation Harmful at any Exposure? An Echo That Continues to Vibrate
    Edouard I Azzam
    Department of Radiology, New Jersey Medical School, Rutgers University, Newark, NJ 07103
    Health Phys 110:249-51. 2016
    ....
  24. pmc The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining
    Raghavendra A Shamanna
    Departments of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, and Graduate School of Biomedical Sciences, UMDNJ, Newark, New Jersey 07101 1709, USA
    Mol Cell Biol 31:4832-43. 2011
    ..Further, NF90/NF45 knockdown reduced end-joining activity in vivo. These results identify the NF90/NF45 complex as a regulator of DNA damage repair mediated by DNA-PK and suggest that structured RNA may modulate this process...
  25. doi request reprint The effect of human cord blood therapy on the intestinal tract of lethally irradiated mice: possible use for mass casualties
    Edouard I Azzam
    Department of Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Int J Radiat Biol 86:467-75. 2010
    ..To evaluate the recovery of the gastrointestinal tract in lethally irradiated mice treated with human cord blood and antibiotics...
  26. ncbi request reprint High-LET ion radiolysis of water: visualization of the formation and evolution of ion tracks and relevance to the radiation-induced bystander effect
    Yusa Muroya
    Departement de Medecine Nucleaire et de Radiobiologie, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Radiat Res 165:485-91. 2006
    ..The calculations reveal that the ion track structure is completely lost by approximately 1 micros...
  27. ncbi request reprint Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology
    Douglas R Spitz
    B180 Medical Laboratories, Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer Metastasis Rev 23:311-22. 2004
    ....
  28. ncbi request reprint Cell cycle deregulation and xeroderma pigmentosum group C cell transformation
    Edouard I Azzam
    Laboratory of Radiobiology, Department of Cancer Cell Biology, Harvard School of Public Health, Boston, MA 02115, USA
    J Invest Dermatol 119:1350-4. 2002
    ....