Patricia M Legler

Summary

Affiliation: Naval Medical Center
Country: USA

Publications

  1. pmc Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain
    Patricia M Legler
    Center for Bio Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:90-3. 2013
  2. pmc Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies
    Patricia M Legler
    a US Naval Research Laboratory, Washington, DC, USA
    MAbs 9:43-57. 2017
  3. doi request reprint Label free checkerboard assay to determine overlapping epitopes of Ebola virus VP-40 antibodies using surface plasmon resonance
    George P Anderson
    Naval Research Laboratory, Center for Biomolecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC 20375, USA
    J Immunol Methods . 2017
  4. pmc Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody
    Dan Zabetakis
    Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC, United States of America
    PLoS ONE 9:e115405. 2014
  5. doi request reprint Comparison of immunoreactivity of staphylococcal enterotoxin B mutants for use as toxin surrogates
    George P Anderson
    Center for Bio Molecular Science and Engineering, Naval Research Laboratory, 4555 Overlook Ave SW, Washington, D C 20375, USA
    Anal Chem 84:5198-203. 2012

Detail Information

Publications5

  1. pmc Structure of a low-melting-temperature anti-cholera toxin: llama V(H)H domain
    Patricia M Legler
    Center for Bio Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 69:90-3. 2013
    ..A DALI structural similarity search showed that this CDR3 conformation is uncommon...
  2. pmc Stability of isolated antibody-antigen complexes as a predictive tool for selecting toxin neutralizing antibodies
    Patricia M Legler
    a US Naval Research Laboratory, Washington, DC, USA
    MAbs 9:43-57. 2017
    ..This method may have utility for the characterization or rapid screening of other Ab that act to prevent conformational changes or unfolding as part of their mechanism of action...
  3. doi request reprint Label free checkerboard assay to determine overlapping epitopes of Ebola virus VP-40 antibodies using surface plasmon resonance
    George P Anderson
    Naval Research Laboratory, Center for Biomolecular Science and Engineering, 4555 Overlook Ave SW, Washington, DC 20375, USA
    J Immunol Methods . 2017
    ..Additionally, the analysis presented here enabled the identification pairs of anti-VP40 antibodies which could potentially be utilized in sandwich type immunoassays for the detection of Ebola virus...
  4. pmc Evaluation of disulfide bond position to enhance the thermal stability of a highly stable single domain antibody
    Dan Zabetakis
    Center for Bio Molecular Science and Engineering, US Naval Research Laboratory, Washington, DC, United States of America
    PLoS ONE 9:e115405. 2014
    ..This study further demonstrates that even single domain antibodies with extremely high melting points can be further stabilized by addition of disulfide bonds. ..
  5. doi request reprint Comparison of immunoreactivity of staphylococcal enterotoxin B mutants for use as toxin surrogates
    George P Anderson
    Center for Bio Molecular Science and Engineering, Naval Research Laboratory, 4555 Overlook Ave SW, Washington, D C 20375, USA
    Anal Chem 84:5198-203. 2012
    ....