Jin Zhou

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 25:878-86. 2005
  2. ncbi request reprint Angiotensin II AT1 receptor antagonism downregulates stress-related gene expression in brain microvessels from spontaneously hypertensive and normotensive rats
    J Zhou
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, MSC 1514, Bldg 10, Room 2D57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:480-6. 2004
  3. ncbi request reprint AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats
    Jin Zhou
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 37:1271-6. 2006
  4. ncbi request reprint Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain
    Hiromichi Ando
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:345-50. 2004
  5. ncbi request reprint Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cell Mol Neurobiol 26:1099-111. 2006
  6. pmc Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen
    Enrique Sanchez-Lemus
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1376-84. 2009
  7. ncbi request reprint Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats
    Hiromichi Ando
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 35:1726-31. 2004
  8. ncbi request reprint Angiotensin II: multitasking in the brain
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Hypertens Suppl 24:S131-7. 2006
  9. ncbi request reprint Prospect of neuroscience in China
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Cell Mol Neurobiol 28:3-4. 2008
  10. pmc Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats
    Miroslava Macova
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Neuroendocrinology 88:276-86. 2008

Collaborators

  • Julius Benicky
  • Jaroslav Pavel
  • Ines Armando
  • Enrique Sanchez-Lemus
  • Xiao He Lu
  • Juan M Saavedra
  • B F Yang
  • Hans Imboden
  • Simon Swingler
  • Hiromichi Ando
  • Yuanyan Wei
  • Jianhai Jiang
  • Miroslava Macova
  • Mario Stevenson
  • Yanjie Lu
  • Catherine Swingler
  • Xiaojing Yun
  • Xiaoning Chen
  • Jianxin Gu
  • Si Zhang
  • Dan Liu
  • Hongliang Zong
  • Lin Zhu
  • Stefan Zorad
  • Ran Meng
  • Sen Tao Dang
  • Rui Wang
  • Xi Can Tang
  • Lai Shuan Wang
  • Paul Jolicoeur
  • Huixian Lin
  • Gustavo Baiardi
  • Dmitri Tyurmin
  • Zhiguo Wang
  • Ann Dauphin
  • Chaoqian Xu
  • Ignacio M Larrayoz-Roldan
  • Thomas Greenough
  • Jiening Xiao
  • Yanzhong Yang
  • Jialin Shen
  • Angela M Mann
  • Min Chen
  • Xiangfei Kong
  • Ze Lan Hu
  • Ji Xin Shi
  • Meng Qi
  • Wei Yan
  • Ting Jia Lu
  • Chun Hua Hang
  • Jing Tao Dou
  • Jian ping Jia
  • Li Min Li
  • Katarina Tybitanclova
  • Daniel Hutanu
  • Xun Ming Ji
  • Lang Bai
  • Miroslava Jezova
  • Beda Brichacek
  • Catherine Ulich
  • Jean Marc Jacque
  • Xiao Mei Shao

Detail Information

Publications27

  1. ncbi request reprint Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 25:878-86. 2005
    ..These compounds might be considered as potential therapeutic agents against ischemic and inflammatory diseases of the brain...
  2. ncbi request reprint Angiotensin II AT1 receptor antagonism downregulates stress-related gene expression in brain microvessels from spontaneously hypertensive and normotensive rats
    J Zhou
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, MSC 1514, Bldg 10, Room 2D57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:480-6. 2004
    ..In addition, AT(1) receptor regulation of stress-related genes in brain microvessels may explain the proposed association between stress and ischemic disorders of the brain...
  3. ncbi request reprint AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats
    Jin Zhou
    Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 37:1271-6. 2006
    ..In this study, we tried to clarify the presence and regulation of the local renin-angiotensin system (RAS) in brain microvessels in hypertension...
  4. ncbi request reprint Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain
    Hiromichi Ando
    Section on Pharmacology, DIRP, NIMH, NIH, DHHS, 10 Center Drive, Bldg 10, Room 2D 57, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 1018:345-50. 2004
    ..The anti-inflammatory effects of AT(1) receptor antagonists may be an important mechanism for protection against ischemia and could participate in the anti-stress properties of this class of compounds...
  5. ncbi request reprint Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain
    Juan M Saavedra
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Cell Mol Neurobiol 26:1099-111. 2006
    ..8. These results strongly suggest that inhibition of AT(1) receptors should be considered as a preventive therapeutic measure to protect the brain from ischemia, and as a possible novel therapy of inflammatory conditions of the brain...
  6. pmc Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen
    Enrique Sanchez-Lemus
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1376-84. 2009
    ..We postulate that ARBs may have therapeutic effects on inflammatory conditions...
  7. ncbi request reprint Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats
    Hiromichi Ando
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Stroke 35:1726-31. 2004
    ..We studied whether AT1 receptor antagonists could exert antiinflammatory effects in the brain vasculature as a mechanism for their protective effects against ischemia...
  8. ncbi request reprint Angiotensin II: multitasking in the brain
    Juan M Saavedra
    Section on Pharmacology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Hypertens Suppl 24:S131-7. 2006
    ..Additional preclinical studies and controlled clinical trials are necessary to confirm the efficacy of this novel therapeutic approach...
  9. ncbi request reprint Prospect of neuroscience in China
    Jin Zhou
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Cell Mol Neurobiol 28:3-4. 2008
    ..This article depicted how a young Chinese scientist got her training in China, how her training had impact on her scientific career in the US, and how she felt the prospect of Neuroscience in China...
  10. pmc Estrogen reduces aldosterone, upregulates adrenal angiotensin II AT2 receptors and normalizes adrenomedullary Fra-2 in ovariectomized rats
    Miroslava Macova
    Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Neuroendocrinology 88:276-86. 2008
    ..The AT2 receptor upregulation and the decrease in AT1 receptor function and in the production of the fluid-retentive, pro-inflammatory hormone aldosterone partially explain the protective effects of estrogen therapy...
  11. pmc Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma
    Stefan Zorad
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Eur J Pharmacol 552:112-22. 2006
    ..The decrease in the pro-inflammatory cytokine TNFalpha and the increase in the anti-inflammatory adipokine adiponectin indicate that Candesartan cilexetil may exert significant anti-inflammatory properties...
  12. doi request reprint Cdc34-mediated degradation of ATF5 is blocked by cisplatin
    Yuanyan Wei
    Gene Research Center, Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Ministry of Public Health, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai, China
    J Biol Chem 283:18773-81. 2008
    ..In summary, a down-regulation of proteasome-mediated degradation of ATF5 might contribute to cisplatin-induced apoptosis, providing a new mechanism of cisplatin-induced apoptosis...
  13. doi request reprint Salvicine inactivates beta 1 integrin and inhibits adhesion of MDA-MB-435 cells to fibronectin via reactive oxygen species signaling
    Jin Zhou
    Division of Anti tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
    Mol Cancer Res 6:194-204. 2008
    ....
  14. pmc Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    Simon Swingler
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA
    Cell Host Microbe 4:63-76. 2008
    ..Collectively, these results indicate that the HIV-1 Nef protein carries a pathogenic determinant that governs B cell defects in HIV-1 infection...
  15. doi request reprint JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes
    Yanjie Lu
    Department of Pharmacology State Province key lab of China, Harbin Medical University, Harbin, PR China
    Cell Physiol Biochem 21:305-14. 2008
    ....
  16. doi request reprint Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis
    Jin Zhou
    Key Laboratory of Glycoconjuates Research, Ministry of Public Health and Gene Research Center, Shanghai Medical College of Fudan University, Shanghai, People s Republic of China
    J Biochem 143:547-54. 2008
    ..Collectively, these results suggested that beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, which elucidated a new mechanism of p53-mediated cell apoptosis...
  17. ncbi request reprint Alterations of pulmonary zinc homeostasis and cytokine production following traumatic brain injury in rats
    Lin Zhu
    Department of Neurosurgery, Jinling Hospital, 305 East Zhongshan Road, Nanjing, 210002, P R China
    Ann Clin Lab Sci 37:356-61. 2007
    ..The results suggest that TBI induces rapid increases of labile zinc and inflammatory mediators in lung, which may participate in the pathogenesis of acute lung injury...
  18. pmc Functional interaction of E1AF and Sp1 in glioma invasion
    Jianhai Jiang
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Health, Gene Research Center, Shanghai Medical College and Institutes of Biomedical Sciences of Fudan University, Shanghai 200032, People s Republic of China
    Mol Cell Biol 27:8770-82. 2007
    ..This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors...
  19. pmc Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein
    Simon Swingler
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Pathog 3:1281-90. 2007
    ..The anti-cancer agent Imatinib inhibited M-CSF receptor activation and restored the apoptotic sensitivity of HIV-1-infected macrophages, suggesting a novel strategy to curtail viral persistence in the macrophage reservoir...
  20. ncbi request reprint [The diagnosis and treatment of polycythemia rubra vera manifesting as acute cerebral stroke]
    Ran Meng
    Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
    Zhonghua Nei Ke Za Zhi 45:366-8. 2006
    ..To analyze the particularities of diagnosis and treatment of acute cerebral stroke secondary to polycythemia vera (PV)...
  21. ncbi request reprint [Experimental study on effects of Shenshuai compound medicine on acute renal failure rats and secretion cell factors]
    Jin Zhou
    The PLA General Hospital, Beijing, China
    Zhongguo Zhong Yao Za Zhi 31:425-8. 2006
    ..To observe the effect of the experiential compound prescription Shenshuai compound medicine (SSCM) on acute renal failure (ARF) rats, and expose its mechanism...
  22. pmc Effects of estrogen treatment on expression of brain-derived neurotrophic factor and cAMP response element-binding protein expression and phosphorylation in rat amygdaloid and hippocampal structures
    Jin Zhou
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Neuroendocrinology 81:294-310. 2005
    ....
  23. ncbi request reprint [Effects of 1alpha, 25-dihydroxyvitamin D3 on the acute immune rejection and corneal neovascularization in high-risk penetrating keratoplasty in rats]
    Sen Tao Dang
    Department of Ophthalmology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China
    Di Yi Jun Yi Da Xue Xue Bao 24:892-6, 903. 2004
    ....
  24. ncbi request reprint HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    Simon Swingler
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 424:213-9. 2003
    ..Our results reveal a mechanism by which Nef expands the cellular reservoir of HIV-1 by permitting the infection of resting T lymphocytes...
  25. ncbi request reprint Gene expression profiles at different stages of human esophageal squamous cell carcinoma
    Jin Zhou
    National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
    World J Gastroenterol 9:9-15. 2003
    ..To characterize the gene expression profiles in different stages of carcinogenesis of esophageal epithelium...
  26. ncbi request reprint Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells
    Rui Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Tai Yuan Road, Shanghai 200031, PR China
    Brain Res Mol Brain Res 107:1-8. 2002
    ..The present findings suggest that tacrine exert significant protection against H(2)O(2)-induced apoptosis possibly through inhibiting expression of pro-apoptosis genes...
  27. ncbi request reprint Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia
    Lai Shuan Wang
    Department of Pediatrics, Children s Hospital of Fudan University, 183 Feng Lin Road, Shanghai 200032, China
    Brain Res 949:162-70. 2002
    ..1 mg/kg. These findings suggest that huperzine A might be beneficial in the treatment of hypoxic-ischemic encephalopathy in neonates...