X Yang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi cDNA cloning of canine common alpha gene and its co-expression with canine thyrotropin beta gene in baculovirus expression system
    X Yang
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 18:379-93. 2000
  2. ncbi Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates
    X Yang
    Inositide Signaling Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:35434-40. 1999
  3. ncbi Canine thyrotropin beta-subunit gene: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and transient expression in the Chinese hamster ovary cells
    X Yanga
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 18:363-78. 2000
  4. ncbi Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate
    X Yang
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:18973-80. 1999
  5. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
  6. ncbi Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family
    J J Caffrey
    Inositide Signaling Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:12730-6. 2000
  7. ncbi Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
    X Xu
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:1868-74. 2000
  8. pmc A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
    S T Safrany
    Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, PO Box 12233, NC 27709, USA
    EMBO J 17:6599-607. 1998
  9. ncbi Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically
    P Chen
    Laboratory of Cellular and Molecular Biology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 276:29440-9. 2001
  10. pmc Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase
    X Yang
    Inositide Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 351:551-5. 2000

Collaborators

Detail Information

Publications76

  1. ncbi cDNA cloning of canine common alpha gene and its co-expression with canine thyrotropin beta gene in baculovirus expression system
    X Yang
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 18:379-93. 2000
    ..The expressed recombinant protein was purified from the culture medium with an affinity column that was coupled with IgG purified from the polyclonal antibodies generated against the partially purified native canine TSH...
  2. ncbi Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates
    X Yang
    Inositide Signaling Group, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:35434-40. 1999
    ..This new information helps define DIPP's structural, functional, and evolutionary relationships to Nudix hydrolases...
  3. ncbi Canine thyrotropin beta-subunit gene: cloning and expression in Escherichia coli, generation of monoclonal antibodies, and transient expression in the Chinese hamster ovary cells
    X Yanga
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA
    Domest Anim Endocrinol 18:363-78. 2000
    ....
  4. ncbi Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate
    X Yang
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:18973-80. 1999
    ..7 microM), thereby suggesting a new strategy for the rational design of therapeutically useful kinase inhibitors. Overall, our data provide new information to support the idea that Ins(1,3,4)P3 acts in an important signaling cascade...
  5. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
    ..Without these inhibition signals, chondrocytes break quiescent state and undergo abnormal terminal differentiation, ultimately leading to osteoarthritis...
  6. ncbi Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family
    J J Caffrey
    Inositide Signaling Group, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:12730-6. 2000
    ..Thus, cells can recruit sophisticated molecular processes to regulate diphosphoinositol polyphosphate turnover...
  7. ncbi Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
    X Xu
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, MD 20892, USA
    Oncogene 19:1868-74. 2000
    ..These studies demonstrate that Smad4 functions as a tumor suppressor in the gastrointestinal tract and also provide a valuable model for screening factors that promote or prevent gastric tumorigenesis...
  8. pmc A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
    S T Safrany
    Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, PO Box 12233, NC 27709, USA
    EMBO J 17:6599-607. 1998
    ..Because overlapping substrate specificity is a feature of this class of proteins, our data provide new directions for future studies of higher inositol phosphates...
  9. ncbi Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically
    P Chen
    Laboratory of Cellular and Molecular Biology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 276:29440-9. 2001
    ..Our studies provided a mechanistic explanation for the substrate preference of MKP-2 and suggest that catalytic activation of MKP-2 upon binding to its substrates is crucial for its function...
  10. pmc Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase
    X Yang
    Inositide Signaling Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 351:551-5. 2000
    ..1 microM; V(max)=780 pmol/min per microg) actively compete for phosphorylation in vivo. This competition empowers the kinase with multitasking capability in several key aspects of inositol phosphate signalling...
  11. ncbi myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line
    M A Carew
    Inositide Signaling Section, Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 275:26906-13. 2000
    ..These studies provide the first demonstration that, in a physiologically relevant context of a polarized monolayer, there is an apical, Ins(3,4,5,6)P(4)-inhibited CaCC...
  12. ncbi Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development
    C Deng
    Laboratory of Biochemistry and Metabolism, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Biol 185:42-54. 1997
    ..Thus, FGFR-1 plays a role in neurulation, suggesting that there may be a connection between FGFR-1-mediated signal pathways and neural tube defects, the most common malformations in the human central nervous system...
  13. pmc A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    L J Baier
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85016, USA
    J Clin Invest 106:R69-73. 2000
    ..A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons...
  14. pmc Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover
    S Lin
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Cell Biol 20:7903-13. 2000
    ..Our data demonstrate that PGA(2) down-regulates cyclin D1 expression by decreasing cyclin D1 mRNA stability and implicates a 390-base element in the 3'UTR in this regulation...
  15. ncbi decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm
    X Yang
    Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Development 127:3695-702. 2000
    ....
  16. pmc Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis
    L Chen
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:1517-25. 1999
    ..These data reveal an essential role for FGF/FGFR3 signals in both chondrogenesis and osteogenesis during endochondral ossification...
  17. pmc Modification of osteoarthritis in the guinea pig with pulsed low-intensity ultrasound treatment
    I Gurkan
    Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, USA
    Osteoarthritis Cartilage 18:724-33. 2010
    ..We investigated whether the application of pulsed low-intensity ultrasound (PLIUS) to the Hartley guinea pig joint would prevent or attenuate the progression of this degenerative process...
  18. ncbi Proteinases in renal cell death
    X Yang
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, USA
    J Toxicol Environ Health 48:319-32. 1996
    ..The observation that E-64 was only protective after some cell death had occurred suggests that lysosomal cathepsins are released from dying cells and subsequently attack the remaining viable cells...
  19. pmc Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence
    W Wang
    Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mol Cell Biol 21:5889-98. 2001
    ..Our studies highlight a critical role for HuR during the process of replicative senescence...
  20. ncbi Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
    M Weinstein
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 11:49-58. 2000
    ..Combinatorial genetics has also revealed functions of Smads in left/right isomerism and liver development...
  21. pmc Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, 10 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:9378-83. 1998
    ..Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction...
  22. pmc Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo
    H Chi
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Cell Biol 20:6496-507. 2000
    ....
  23. ncbi dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD
    S Hu
    Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 275:30761-4. 2000
    ..dFADD and DREDD are stabilized by their interaction. The structural and functional similarities between dFADD and FADD suggest the existence of a FADD-like apoptosis pathway in Drosophila...
  24. ncbi Identification and characterization of differentially expressed genes in the early response phase during liver regeneration
    W Xu
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China
    Biochem Biophys Res Commun 278:318-25. 2000
    ..5 h after 2/3 partial hepatectomy, reaching a maximum at 2 h. This gene is similar to human alpha-1-beta-glycoprotein (40%). These results suggest a role of these genes in the early response phase of liver regeneration...
  25. ncbi The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth
    S M Bahri
    Institute of Molecular and Cell Biology, 30 Medical Drive, 117609, Singapore
    Mech Dev 100:291-301. 2001
    ..This indicates a requirement for Dalf function in the nervous system for maintaining gene expression and the facilitation of normal growth...
  26. ncbi Telomerase activity in early bovine embryos derived from parthenogenetic activation and nuclear transfer
    J Xu
    Department of Animal Science, University of Connecticut, Storrs, Connecticut 06269, USA
    Biol Reprod 64:770-4. 2001
    ..Telomerase activity was detected in embryos at all stages examined, with the highest level in the blastocyst stage, regardless of the method of embryo production...
  27. ncbi Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women
    X Fan
    Hypertension Division, Department of Cardiology, Ministry of Education and Sino German Laboratory for Molecular Medicine, Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Pharmacol Ther 82:187-96. 2007
    ..3 mm Hg lower in ACE2 T allele carriers than in CC genotype carriers (P=0.019) in women. We conclude that the ACE2 T allele confers a high risk for hypertension and reduced antihypertensive response to ACE inhibitors...
  28. ncbi Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells
    R Yang
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Gene Ther 13:1714-23. 2006
    ..Infusion of SWNTs+ carrying SOCS1siRNA reduced SOCS1 expression and retarded the growth of established B16 tumor in mice, indicating the possibility of in vivo immunotherapeutics using SWNTs-based siRNA transfer system...
  29. ncbi [cDNA cloning, sequencing and expression of recombinant human prorelaxin]
    C Ding
    National Laboratory of Molecular Virology and Genetic Engineering, Beijing
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:319-21. 1997
    ..The SDS-PAGE analysis revealed that the expressed protein accounted for about 30% of the total cell protein, its MW was approximately 20 kD and conformed soluble protein...
  30. ncbi IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells
    M Tsuzaki
    Department of Orthopaedics, University of North Carolina, 277 Burnett Womack Bldg, CB 7055, Chapel Hill, NC 27599 7055, USA
    J Orthop Res 21:256-64. 2003
    ..Endogenous IL-1 beta might contribute to the process through a positive feedback loop by stimulating expression and accumulation of MMPs in the tendon matrix...
  31. ncbi Microarray profiling of skeletal muscle tissues from equally obese, non-diabetic insulin-sensitive and insulin-resistant Pima Indians
    X Yang
    Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetologia 45:1584-93. 2002
    ..This approach also complemented the ongoing genomic linkage analyses to identify genes linked to insulin resistance and diabetes in Pima Indians...
  32. ncbi Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students
    T Takeshita
    Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Alcohol Clin Exp Res 25:1264-9. 2001
    ....
  33. ncbi Effects of intravenous insulin-like growth factor-I and insulin administration on insulin-like growth factor-binding proteins in the ovine fetus
    W H Shen
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 699 West Drive, Indianapolis, Indiana 46202, USA
    J Endocrinol 171:143-51. 2001
    ..The responses of IGFBP-1 and IGFBP-3 to increased plasma IGF-I and insulin may serve to protect the fetus from exaggerated anabolic effects and to blunt the hypoglycemic potential of circulating IGFs and insulin...
  34. ncbi Functional isolation of the Candida albicans FCR3 gene encoding a bZip transcription factor homologous to Saccharomyces cerevisiae Yap3p
    X Yang
    , , , Canada H2W 1R7
    Yeast 18:1217-25. 2001
    ..4 kb RNA transcript in C. albicans, suggesting that the FCR3 mRNA contains long 5' and/or 3' untranslated regions. The nucleotide sequence of the FCR3 gene has been deposited at GenBank under Accession No. AF342983...
  35. ncbi Invasiveness of hepatocellular carcinoma cell lines: contribution of hepatocyte growth factor, c-met, and transcription factor Ets-1
    Y Jiang
    Beijing Institute of Radiation Medicine, Beijing, 100850, People's Republic of China
    Biochem Biophys Res Commun 286:1123-30. 2001
    ..These results strongly suggest that Ets-1 has a crucial role in the invasive property in hepatoma cell lines, and there may exist a loop to enhance the invasive ability of hepatoma cell lines...
  36. ncbi Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1
    B Gao
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Nat Genet 28:386-8. 2001
    ..The three mutant amino acids, which are conserved across all vertebrates and invertebrates studied so far, are predicted to be adjacent on the surface of IHH...
  37. ncbi Human and mouse ABCA1 comparative sequencing and transgenesis studies revealing novel regulatory sequences
    Y Qiu
    Genome Science Department, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genomics 73:66-76. 2001
    ..The identified conserved noncoding sequences invite further investigation to elucidate ABCA1 regulation...
  38. ncbi Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms
    X Yang
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Mol Genet Metab 73:111-3. 2001
    ..The expression levels of the major isoforms, calpain-10a and -10f, were positively correlated with the total calpain-10 mRNA levels, indicating a cumulative effect...
  39. ncbi Role of retinoid receptor coactivator pockets in cofactor recruitment and transcriptional regulation
    C Leo
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 276:23127-34. 2001
    ..These results indicate a differential role for each retinoid receptor to the overall binding of cofactors and regulation of transcription by the retinoid receptor heterodimer...
  40. ncbi Characterization and functional analysis of a novel gene cluster involved in biphenyl degradation in Rhodococcus sp. strain R04
    X Yang
    State Key Laboratories of Transducer Technology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
    J Appl Microbiol 103:2214-24. 2007
    ..Isolation of the genes relative to PCB biodegradation and identification of the bph gene function in Rhodococcus sp. R04...
  41. ncbi In vivo regulation of apoptosis in metaphyseal trabecular bone of young rats by synthetic human parathyroid hormone (1-34) fragment
    D Stanislaus
    Lilly Research Laboratories, Indianapolis, IN, USA
    Bone 27:209-18. 2000
    ....
  42. ncbi Alternative splicing in a novel tyrosine phosphatase gene (DPTP4E) of Drosophila melanogaster generates two large receptor-like proteins which differ in their carboxyl termini
    S H Oon
    Drosophila Neurobiology Laboratory, National University of Singapore
    J Biol Chem 268:23964-71. 1993
    ..The possible implications of these findings are discussed...
  43. ncbi Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system
    X Yang
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    J Neurosci 13:3006-17. 1993
    ..Together, these expression studies suggest a role for JAK1 kinase in the differentiation or function of a subset of CNS neurons...
  44. pmc Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response
    P Lesage
    Department of Genetics and Development, Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Mol Cell Biol 16:1921-8. 1996
    ..These findings suggest that the SNF1 kinase interacts with a transcriptional activator to modulate its activity and provide the first direct evidence for a role of SNF1 in activating transcription in response to glucose limitation...
  45. ncbi Flk-1, a receptor for vascular endothelial growth factor (VEGF), is expressed by retinal progenitor cells
    X Yang
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 16:6089-99. 1996
    ..Thus, the Flk-1 receptor protein kinase is expressed on the surface of neural progenitors in mouse retina and may play a critical role in neurogenesis as well as in vasculogenesis...
  46. pmc Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast
    M Benli
    Department of Molecular Genetics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    EMBO J 15:6460-75. 1996
    ..From the phenotypic alterations observed in ypt31 and ypt32 mutants, it seems likely that the two GTPases are involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment...
  47. pmc Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10
    Y Yi
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada
    Infect Immun 65:1669-74. 1997
    ..Switches in cytokine production patterns may mediate the pathogenesis of hsp60-associated diseases such as C. trachomatis immunopathology...
  48. ncbi Masquerade: a novel secreted serine protease-like molecule is required for somatic muscle attachment in the Drosophila embryo
    B Murugasu-Oei
    Institute of Molecular and Cell Biology, National University of Singapore
    Genes Dev 9:139-54. 1995
    ..We propose that mas acts via its modified serine protease motif, either as a novel adhesion molecule and/or as a competitive antagonist of serine proteases, to stabilize muscle attachment...
  49. ncbi Inscuteable and Staufen mediate asymmetric localization and segregation of prospero RNA during Drosophila neuroblast cell divisions
    P Li
    Developmental Neurobiology Laboratory, Institute of Molecular and Cell Biology, National University of Singapore
    Cell 90:437-47. 1997
    ..Stau, as one component of this complex, is required only for RNA localization. Hence staufen also acts zygotically, downstream of inscuteable, to effect aspects of neuroblast asymmetry...
  50. pmc A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex
    X Yang
    Department of Genetics, College of Physicians and Surgeons of Columbia University, New York, NY 10032
    EMBO J 13:5878-86. 1994
    ..We propose that SIP1, SIP2 and GAL83 act as adaptors that promote the activity of SNF1 towards specific targets...
  51. ncbi The quinone-binding site in succinate-ubiquinone reductase from Escherichia coli. Quinone-binding domain and amino acid residues involved in quinone binding
    X Yang
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Biol Chem 273:31916-23. 1998
    ..The hydroxyl group, but not the size of the amino acid side chain, at position 33 of SdhC is also important, because Ser-33 can be substituted with threonine but not with alanine...
  52. ncbi Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21
    P Gregor
    Molecular Neurobiology Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224
    Hum Genet 94:565-70. 1994
    ..Such studies may provide insights concerning the possible role of GLUR5 in Down syndrome...
  53. ncbi New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice
    X Yang
    Department of Cell Biology, Albert Einstein College of Medicine, New York, New York 10461, USA
    Cancer Res 60:3313-9. 2000
    ..The combined data provide strong evidence that retarded progression of tumors in mice lacking GlcNAc-TIII is due to the absence of the bisecting GlcNAc residue on N-glycans of a circulating glycoprotein(s) from a tissue other than liver...
  54. ncbi Streptolydigin resistance can be conferred by alterations to either the beta or beta' subunits of Bacillus subtilis RNA polymerase
    X Yang
    Department of Food Science and Technology, University of California, Davis 95616, USA
    J Biol Chem 270:23930-3. 1995
    ..Together these results suggest that beta and beta' interact to form an Stl binding site, and that this site is important for transcription elongation...
  55. ncbi Cloning and characterization of the human retinoid X receptor alpha gene: conservation of structure with the mouse homolog
    G Li
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biochem Biophys Res Commun 269:54-7. 2000
    ..These results provide information necessary to generate constructs for targeting the RXRalpha gene in human cell lines, which may eventually lead to an understanding of the function of RXRalpha in human cancer...
  56. ncbi Molecular cloning of rat Wilms' tumor complementary DNA and a study of messenger RNA expression in the urogenital system and the brain
    P M Sharma
    Molecular Biology of Breast Cancer Laboratory, Salk Institute of Biological Studies, La Jolla, California 92037
    Cancer Res 52:6407-12. 1992
    ..The second is the area postrema in the brain where localized expression continues through adulthood, suggesting a functional role for WT-1 in rat brain...
  57. ncbi Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption
    R Pei
    Laboratory of Electroanalytical Chemistry and National Analytical Research Center of Electrochemistry and Spectroscopy, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China
    Biomacromolecules 2:463-8. 2001
    ..The kinetics of the adsorption of DNA on PDDA surface was also studied by the real-time BIAcore technique; the observed rate constant was calculated using a Langmuir model (k(obs) = (1.28 +/- 0.08) x 10(-2) s(-1)...
  58. ncbi Hepatopoietin acts as an autocrine growth factor in hepatoma cells
    Y Li
    Department of Genomics and Proteomics, Beijing Institute of Radiation Medicine, Chinese National Human Genome Center in Beijing, Beijing, P R China
    DNA Cell Biol 20:791-5. 2001
    ..Furthermore, it was shown that HPO-neutralizing antibody has an inhibitory effect on the uptake of tritiated thymidine by hepatoma cells. The results strongly suggest that HPO acts as an autocrine factor for hepatoma cells in vitro...
  59. ncbi A protein kinase substrate identified by the two-hybrid system
    X Yang
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032
    Science 257:680-2. 1992
    ..Thus, the two-hybrid system, which is applicable to any cloned gene, can be used to detect physical interactions between protein kinases and functionally related substrate proteins...
  60. ncbi Cloning of a novel cDNA homologous to CHIP28 water channel from ocular ciliary epithelium
    R V Patil
    Department of Ophthalmology, Washington University School of Medicine, St Louis, MO
    Biochem Biophys Res Commun 204:861-6. 1994
    ..8 Kb size expressed in bovine ciliary epithelium. The results presented here confirm the presence of water channel gene in the bovine ciliary epithelium, a primary site for the aqueous humor production...
  61. ncbi Identification of a novel HLA-DRB1 allele (DRB1*1147)* by sequence-based typing in eight siblings
    Y Li
    Guangzhou Cord Blood Bank, Guangzhou Maternal and Neonatal Hospital, Guangzhou, China
    Tissue Antigens 64:102-5. 2004
    ..The new allele is identical to DRB1*110601 at exon 2 except for a single-nucleotide substitution at codon 37 (TAC-->TCC), changing the encoded tyrosine to serine...
  62. ncbi Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Beh├žet's disease
    X Yang
    Gastroenterology Unit, University of Oxford, Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UK
    Eur J Immunogenet 31:11-4. 2004
    ..While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51...
  63. ncbi Partial response to biotin therapy in a patient with holocarboxylase synthetase deficiency: clinical, biochemical, and molecular genetic aspects
    R Santer
    Department of General Pediatrics, University Children s Hospital Kiel, Germany
    Mol Genet Metab 79:160-6. 2003
    ..This case illustrates mechanisms involved in the genotype-phenotype correlation that unequivocally exists in HCS deficiency...
  64. ncbi Vegetative incompatibility in Neurospora: its effect on horizontal transfer of mitochondrial plasmids and senescence in natural populations
    F Debets
    Department of Genetics, Agricultural University, Wageningen, The Netherlands
    Curr Genet 26:113-9. 1994
    ..intermedia population of the Hawaiian island of Kauai. However, the observed incompatibility did not completely prevent cytoplasmic exchange, and in several cases plasmid transfer could be detected...
  65. pmc Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1
    K Su
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 348:281-9. 2000
    ..However, hSug1 is not the factor limiting Sp1 degradation in the cells treated with glucosamine. This and other considerations suggest that hSug1 co-operation with other molecules is necessary to target Sp1 for proteasome degradation...
  66. pmc A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting
    H Matern
    Department of Molecular Genetics, Max Planck Institute for Biophysical Chemistry, 37070 Gottingen, Germany
    EMBO J 19:4485-92. 2000
    ..Genetic analyses suggest that Yif1p acts downstream of Yip1p. It is inferred that Ypt GTPase binding to the Yip1p-Yif1p complex is essential for and precedes vesicle docking and fusion...
  67. ncbi The iron oxidation and hydrolysis chemistry of Escherichia coli bacterioferritin
    X Yang
    Department of Chemistry, University of New Hampshire, Durham, New Hampshire 03824, USA
    Biochemistry 39:4915-23. 2000
    ..Iron oxidation is inhibited by the presence of Zn(2+) ions. The patterns of phase 2 and phase 3 inhibition are different, though inhibition of both phases is complete at 48 Zn(2+)per 24mer, i.e., 2 Zn(2+) per ferroxidase center...
  68. ncbi Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants
    X Yang
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, 300 Prince Philip Drive, St John s, Newfoundland, Canada, A1B 3V6
    Oncogene 18:4546-53. 1999
    ..These results indicated that we have isolated the functional constitutive BAG-1 promoter. Furthermore, the data suggested that overexpression of BAG-1 in some tumors may be due to upregulation of the human BAG-1 promoter by mutant p53...
  69. ncbi Posttranscriptional destabilization of the bradykinin B1 receptor messenger RNA: cloning and functional characterization of the 3'-untranslated region
    X Zhou
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol Res Commun 1:29-35. 1999
    ..The data presented provide compelling evidence that the 3'-UTR is participating in the regulation of BKB1R mRNA stability and its ultimate expression...
  70. ncbi Threonine phosphorylation of modulator protein RsbR governs its ability to regulate a serine kinase in the environmental stress signaling pathway of Bacillus subtilis
    T A Gaidenko
    Department of Food Science and Technology, University of California, Davis 95616, USA
    J Mol Biol 288:29-39. 1999
    ....
  71. ncbi Food deprivation limits insulin secretory capacity in postpubertal rats
    P Vuguin
    Department of Pediatric Endocrinology, Albert Einstein College of Medicine, Children's Hospital at Montefiore Medical Center, Bronx, New York 10461
    Pediatr Res 49:468-73. 2001
    ..We hypothesize that puberty has an important role in beta-cell maturation and any major nutrient modification may have deleterious consequences later in life...
  72. pmc The apeE gene of Salmonella typhimurium encodes an outer membrane esterase not present in Escherichia coli
    M E Carinato
    Department of Microbiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Bacteriol 180:3517-21. 1998
    ..Southern blot analysis indicates that Escherichia coli K-12 does not contain a close analog of apeE, and it appears that the apeE gene is contained in a region of DNA present in Salmonella but not in E. coli...
  73. ncbi Klumpfuss, a putative Drosophila zinc finger transcription factor, acts to differentiate between the identities of two secondary precursor cells within one neuroblast lineage
    X Yang
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 11:1396-408. 1997
    ....
  74. ncbi Structural and functional organization of the DNA polymerase of bacteriophage T7
    X Yang
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:24207-12. 1996
    ..coli thioredoxin. Thioredoxin protects this region from proteolysis, and alteration of this region reduces the ability of thioredoxin to stimulate polymerase activity...
  75. pmc Analysis of the SIP3 protein identified in a two-hybrid screen for interaction with the SNF1 protein kinase
    P Lesage
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032
    Nucleic Acids Res 22:597-603. 1994
    ..Taken together, these genetic data suggest that SIP3 is functionally related to the SNF1 protein kinase pathway...
  76. ncbi Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-beta (TGF-beta). Mapping of the OPG promoter region that mediates TGF-beta effects
    K Thirunavukkarasu
    Gene Regulation, Bone and Inflammation Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Biol Chem 276:36241-50. 2001
    ..Collectively, these studies indicate the involvement and possible interaction of Cbfa1 and Smad proteins in mediating the effects of TGF-beta on OPG transcription...