S Warach

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials
    Steven Warach
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Curr Control Trials Cardiovasc Med 2:38-44. 2001
  2. pmc Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients
    Tanya Bogoslovsky
    Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1401, USA
    J Transl Med 9:145. 2011
  3. pmc Rising statin use and effect on ischemic stroke outcome
    Sung Sug Yoon
    Stroke Neuroscience Unit, NINDS NIH, Bethesda, MD 20892, USA
    BMC Med 2:4. 2004
  4. ncbi request reprint Measurement of the ischemic penumbra with MRI: it's about time
    Steven Warach
    National Institute of Neurological Disorders and Stroke, 10 Center Dr, MSC 1063, Bldg 10, Rm B1D733, Bethesda, MD 20892 1063, USA
    Stroke 34:2533-4. 2003
  5. ncbi request reprint Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption
    Steven Warach
    National Institute of Neurological Disorders and Stroke, 10 Center Drive, MSC 1063, Building 10, Room B1D733, Bethesda, MD 20892 1063, USA
    Stroke 35:2659-61. 2004
  6. ncbi request reprint Neuroimaging
    Steven Warach
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, NINDS, 10 Center Drive, MSC 1063, Building 10, Rm B1D733, Bethesda, MD 20892 4129, USA
    Stroke 35:351-3. 2004
  7. ncbi request reprint Stroke neuroimaging
    Steven Warach
    Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 4129, USA
    Stroke 34:345-7. 2003
  8. ncbi request reprint Diagnostic and prognostic value of early MR Imaging vessel signs in hyperacute stroke patients imaged <3 hours and treated with recombinant tissue plasminogen activator
    Peter D Schellinger
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    AJNR Am J Neuroradiol 26:618-24. 2005
  9. pmc Distal hyperintense vessels on FLAIR: an MRI marker for collateral circulation in acute stroke?
    K Y Lee
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892 1063, USA
    Neurology 72:1134-9. 2009
  10. ncbi request reprint Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience
    Susan Unipan Lattimore
    Stroke Branch, National Institute of Neurological Disorders and Stroke, 10 Center Dr, MSC 1063, Building 10, Room B1D733, Bethesda, MD 20892 1063, USA
    Stroke 34:e55-7. 2003

Detail Information

Publications73

  1. pmc Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials
    Steven Warach
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    Curr Control Trials Cardiovasc Med 2:38-44. 2001
    ....
  2. pmc Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients
    Tanya Bogoslovsky
    Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1401, USA
    J Transl Med 9:145. 2011
    ....
  3. pmc Rising statin use and effect on ischemic stroke outcome
    Sung Sug Yoon
    Stroke Neuroscience Unit, NINDS NIH, Bethesda, MD 20892, USA
    BMC Med 2:4. 2004
    ..The aim of this study was to determine if patients taking statins before hospital admission for stroke had an improved clinical outcome...
  4. ncbi request reprint Measurement of the ischemic penumbra with MRI: it's about time
    Steven Warach
    National Institute of Neurological Disorders and Stroke, 10 Center Dr, MSC 1063, Bldg 10, Rm B1D733, Bethesda, MD 20892 1063, USA
    Stroke 34:2533-4. 2003
  5. ncbi request reprint Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruption
    Steven Warach
    National Institute of Neurological Disorders and Stroke, 10 Center Drive, MSC 1063, Building 10, Room B1D733, Bethesda, MD 20892 1063, USA
    Stroke 35:2659-61. 2004
    ....
  6. ncbi request reprint Neuroimaging
    Steven Warach
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, NINDS, 10 Center Drive, MSC 1063, Building 10, Rm B1D733, Bethesda, MD 20892 4129, USA
    Stroke 35:351-3. 2004
  7. ncbi request reprint Stroke neuroimaging
    Steven Warach
    Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 4129, USA
    Stroke 34:345-7. 2003
  8. ncbi request reprint Diagnostic and prognostic value of early MR Imaging vessel signs in hyperacute stroke patients imaged <3 hours and treated with recombinant tissue plasminogen activator
    Peter D Schellinger
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    AJNR Am J Neuroradiol 26:618-24. 2005
    ..We assessed the diagnostic and prognostic strength of early MR imaging vessel signs in AIS patients treated with intravenous thrombolysis (IVT) within 3 hours of the onset of symptoms...
  9. pmc Distal hyperintense vessels on FLAIR: an MRI marker for collateral circulation in acute stroke?
    K Y Lee
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room B1D733, Bethesda, MD 20892 1063, USA
    Neurology 72:1134-9. 2009
    ..However, the exact mechanism and clinical implications of this sign have not yet been clearly defined. The features of HV and its relevance to other imaging factors are presented here...
  10. ncbi request reprint Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience
    Susan Unipan Lattimore
    Stroke Branch, National Institute of Neurological Disorders and Stroke, 10 Center Dr, MSC 1063, Building 10, Room B1D733, Bethesda, MD 20892 1063, USA
    Stroke 34:e55-7. 2003
    ..We evaluated the use of thrombolytic therapy before and after institution of a primary stroke center in a community hospital...
  11. ncbi request reprint More accurate identification of reversible ischemic injury in human stroke by cerebrospinal fluid suppressed diffusion-weighted imaging
    Julie L Bykowski
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Stroke 35:1100-6. 2004
    ..This study tested the hypothesis that the accuracy of differentiating reversible from irreversible ischemic injury could be improved by CSF suppression at image acquisition...
  12. ncbi request reprint The association between neurological deficit in acute ischemic stroke and mean transit time: comparison of four different perfusion MRI algorithms
    Peter D Schellinger
    Section on Stroke Diagnostics and Therapeutics, NINDS, NIH, Bethesda, MD 20892, USA
    Neuroradiology 48:69-77. 2006
    ..Larger sample sizes which allow comparison between imaging and clinical outcomes are needed to refine the choice of best perfusion parameter in pMRI...
  13. pmc Blood-brain barrier disruption after cardiac surgery
    J G Merino
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA
    AJNR Am J Neuroradiol 34:518-23. 2013
    ..The objective of this study was to determine the prevalence of MR imaging-detected BBB disruption (HARM) and DWI lesions after cardiac surgery...
  14. ncbi request reprint A three-item scale for the early prediction of stroke recovery
    A E Baird
    National Institute of Neurological Disorders and Stroke, 20892 4129, Bethesda, MD, USA
    Lancet 357:2095-9. 2001
    ..We aimed to assess whether the extent of ischaemic brain injury on magnetic reasonance diffusion-weighted imaging (MR DWI) could provide additional prognostic information to clinical factors...
  15. pmc Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling
    T L Barr
    National Institute of Nursing Research, Tissue Injury Unit Building, Bethesda, MD 20812, USA
    Neurology 75:1009-14. 2010
    ..The objective of this study was to provide insight into the molecular mechanisms of acute ischemic cerebrovascular syndrome (AICS) through gene expression profiling and pathway analysis...
  16. pmc Reliability of MR perfusion-weighted and diffusion-weighted imaging mismatch measurement methods
    M Luby
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    AJNR Am J Neuroradiol 28:1674-8. 2007
    ..We investigated 2 methods of measuring MR imaging perfusion-diffusion mismatch to determine whether reliability is improved by direct measurement on a single, blended map...
  17. pmc Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats
    Erica C Henning
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room B1D733, 10 Center Drive, MSC 1063, Bethesda, MD 20892, USA
    J Cereb Blood Flow Metab 30:827-36. 2010
    ..This model should be useful for studying the relationship between chronic hypertension and subsequent stroke, both in terms of primary and secondary prevention...
  18. ncbi request reprint Induced hypertension improves cerebral blood flow in acute ischemic stroke
    Julio A Chalela
    Stroke Diagnostics and Therapeutics Section, NINDS NIH, 10 Center Dr, Room B1D733, MSC 1063, Bethesda, MD 20892, USA
    Neurology 64:1979. 2005
  19. pmc Visual perfusion-diffusion mismatch is equivalent to quantitative mismatch
    Marie Luby
    Section on Stroke Diagnostics and Therapeutics, 10 Center Drive, MSC 1063, Building 10, Room B1D733, Bethesda, MD 20892 1063, USA
    Stroke 42:1010-4. 2011
    ..The purpose of this study is to determine the reliability of the qualitative method and compare it with quantitative mismatch measurement in thrombolytic-treated patients...
  20. pmc Intra- and interrater reliability of ischemic lesion volume measurements on diffusion-weighted, mean transit time and fluid-attenuated inversion recovery MRI
    Marie Luby
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Rm B1D733, MSC 1063, Bethesda, MD 20892, USA
    Stroke 37:2951-6. 2006
    ..We investigated the intra- and interrater reliability of ischemic lesion volumes measurements assessed by different MRI sequences at various times from onset...
  21. pmc Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9
    Taura L Barr
    National Institute of Nursing Research, Bethesda, MD, USA
    Stroke 41:e123-8. 2010
    ..We hypothesized that plasma concentrations of MMP-9 are associated with a marker of BBB disruption in patients evaluated for acute stroke...
  22. ncbi request reprint Silent ischemic lesion recurrence on magnetic resonance imaging predicts subsequent clinical vascular events
    Dong Wha Kang
    Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Arch Neurol 63:1730-3. 2006
    ..Previous studies identified a high frequency of silent ischemic lesion recurrence on magnetic resonance imaging (MRI) after an index stroke...
  23. pmc Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from nonresponders
    Jose G Merino
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D 733, MSC 1063, Bethesda, MD 20892, USA
    Stroke 38:2919-23. 2007
    ....
  24. pmc Verification of enhancement of the CSF space, not parenchyma, in acute stroke patients with early blood-brain barrier disruption
    Erica C Henning
    Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 28:882-6. 2008
    ..Enhancing regions were found to have low parenchymal volume fractions and high ADC values, approaching that of pure CSF. These findings suggest that contrast enhancement on FLAIR occurs predominately in the CSF space, not parenchyma...
  25. pmc Measurement of glutathione in normal volunteers and stroke patients at 3T using J-difference spectroscopy with minimized subtraction errors
    Li An
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20814, USA
    J Magn Reson Imaging 30:263-70. 2009
    ..To develop and optimize a (1)H magnetic resonance spectroscopy (MRS) method for measuring brain glutathione (GSH) levels...
  26. pmc Development and validation of a simple conversion model for comparison of intracerebral hemorrhage volumes measured on CT and gradient recalled echo MRI
    Richard E Burgess
    Department of Neurology, Georgetown University Hospital, 3800 Reservoir Road, NW, 7th Floor PHC Bldg, Washington, DC 20007, USA
    Stroke 39:2017-20. 2008
    ..However, because of the differences in the signal parameter being detected, apparent hemorrhage size is expected to vary by imaging modality, with GRE providing larger volumes attributable to susceptibility effects...
  27. pmc Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma
    Erica C Henning
    Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Stroke 39:3405-10. 2008
    ..In this study, we used multimodal magnetic resonance imaging to investigate the incidence and severity of reperfusion-based HT in spontaneously hypertensive rats after ischemia/reperfusion...
  28. pmc Feridex preloading permits tracking of CNS-resident macrophages after transient middle cerebral artery occlusion
    Erica C Henning
    Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Building 10, Room B1D733, 10 Center
    J Cereb Blood Flow Metab 29:1229-39. 2009
    ..Further refinement of this method should permit noninvasive monitoring of inflammation and potential evaluation of antiinflammatory therapies in preclinical models of stroke...
  29. ncbi request reprint Acute stroke patients are being underfed: a nitrogen balance study
    Julio A Chalela
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurocrit Care 1:331-4. 2004
    ..We sought to assess nitrogen balance in patients with acute stroke and to determine the variables associated with negative nitrogen balance...
  30. ncbi request reprint Reversal of perfusion and diffusion abnormalities after intravenous thrombolysis for a lacunar infarction
    Julio A Chalela
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Section on Stroke Diagnostics and Therapeutics, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 4129, USA
    J Neuroimaging 13:152-4. 2003
    ..This case suggests that perfusion and diffusion MRI may be informative in patients with lacunar infarction who are candidates for thrombolysis...
  31. ncbi request reprint Early magnetic resonance imaging findings in patients receiving tissue plasminogen activator predict outcome: Insights into the pathophysiology of acute stroke in the thrombolysis era
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 55:105-12. 2004
    ..We propose MTT lesion volume decrease more than 30% 2 hours after tPA as an early marker of long-term clinical benefit of thrombolytic therapy...
  32. ncbi request reprint Cerebral spinal fluid contamination of the measurement of the apparent diffusion coefficient of water in acute stroke
    Lawrence L Latour
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20878, USA
    Magn Reson Med 48:478-86. 2002
    ..This suggests that FLAIR-DWI ADC measurements are more accurate than conventional ADC maps...
  33. ncbi request reprint Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892 1063, USA
    J Neuroimaging 14:54-7. 2004
    ..Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs)...
  34. ncbi request reprint Early blood-brain barrier disruption in human focal brain ischemia
    Lawrence L Latour
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20878, USA
    Ann Neurol 56:468-77. 2004
    ....
  35. pmc Higher prevalence of cortical lesions observed in patients with acute stroke using high-resolution diffusion-weighted imaging
    K Benameur
    Section on Stroke Diagnostics and Therapeutics, National Institute on Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    AJNR Am J Neuroradiol 27:1987-9. 2006
    ..Modest improvements to imaging resulted in increased conspicuity, potentially affecting diagnosis, suspected pathogenic mechanism, and therapeutic decision...
  36. pmc Establishing final infarct volume: stroke lesion evolution past 30 days is insignificant
    Martin R Gaudinski
    Section on Stroke Diagnostics and Therapeutics, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA
    Stroke 39:2765-8. 2008
    ..However, lesion volumes vary over time because of edema and tissue loss. This study aims to determine if lesion volumes measured at 30 and 90 days after ictus significantly differ...
  37. ncbi request reprint Early ischemic lesion recurrence within a week after acute ischemic stroke
    Dong Wha Kang
    Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Ann Neurol 54:66-74. 2003
    ..026). These results may indicate a prolonged state of increased ischemic risk over the first week and suggest DWI as a possible surrogate measure for recurrent stroke...
  38. ncbi request reprint MRI screening before standard tissue plasminogen activator therapy is feasible and safe
    Dong Wha Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892 1063, USA
    Stroke 36:1939-43. 2005
    ..We hypothesized that times to treatment and outcomes in a stroke center with immediate MRI access and interpretation would not differ from those of the typical clinical practice...
  39. ncbi request reprint Update on stroke
    Julio A Chalela
    Section on Stroke Diagnosis and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Neurol 17:447-51. 2004
    ..This review highlights some advances in the areas of epidemiology, therapy, and imaging of acute stroke...
  40. ncbi request reprint Early and late recurrence of ischemic lesion on MRI: evidence for a prolonged stroke-prone state?
    D W Kang
    Stroke Branch, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Neurology 63:2261-5. 2004
    ....
  41. ncbi request reprint Association of ischemic lesion patterns on early diffusion-weighted imaging with TOAST stroke subtypes
    Dong Wha Kang
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1063, USA
    Arch Neurol 60:1730-4. 2003
    ..Different topographic patterns in patients who experience an acute ischemic stroke may be related to specific stroke causes...
  42. pmc Increased plasma and tissue MMP levels are associated with BCSFB and BBB disruption evident on post-contrast FLAIR after experimental stroke
    Ayush Batra
    Stroke Diagnostics and Therapeutics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 30:1188-99. 2010
    ..The methods presented herein should be useful in understanding the link between MMPs, barrier integrity, and subsequent hemorrhagic transformation...
  43. pmc Hyperintense vessel sign on fluid-attenuated inversion recovery MR imaging is reduced by gadolinium
    K A Dani
    Section on Stroke Diagnostics and Therapeutics, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    AJNR Am J Neuroradiol 33:E112-4. 2012
    ..Both blinded and comparative unblinded analyses showed significantly reduced HVS detection on postcontrast images. We suggest that assessment for this sign should be performed on images acquired prior to contrast administration...
  44. ncbi request reprint Elevated pro-inflammatory CD4+CD28- lymphocytes and stroke recurrence and death
    Z G Nadareishvili
    Stroke Branch, National Institute of Neurologic Disorders and Stroke, NIH, 10 Center Dr, Bethesda, MD 20892 1294, USA
    Neurology 63:1446-51. 2004
    ..This subset of the peripheral blood T-cell lymphocyte population has a strong pro-inflammatory and tissue-damaging potential...
  45. ncbi request reprint New imaging strategies for patient selection for thrombolytic and neuroprotective therapies
    S Warach
    National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-4129, USA
    Neurology 57:S48-52. 2001
    ..As the field of stroke clinical trials examines opportunities for improving trial design, positive imaging diagnoses in patient selection are likely to assume an increasingly useful role...
  46. ncbi request reprint Interleukin-6 174G/C polymorphism and ischemic stroke: a systematic review
    Amy R Tso
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Rm B1D733, MSC 1063, Bethesda, MD 20892, USA
    Stroke 38:3070-5. 2007
    ..This review summarizes the current literature and discusses methodological considerations for future studies...
  47. pmc Optimizing stroke clinical trial design: estimating the proportion of eligible patients
    Alexis Taylor
    Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892 1063, USA
    Stroke 41:2236-8. 2010
    ..In this study, we developed a tool to calculate the proportion of patients who would meet a specific trial's age, baseline severity, and time to treatment inclusion criteria...
  48. ncbi request reprint Myocardial injury in acute stroke: a troponin I study
    Julio A Chalela
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Neurocrit Care 1:343-6. 2004
    ..We sought to describe the findings in a cohort of patients who had an acute stroke in whom Troponin I (TI) was sampled to determine the presence of associated myocardial damage...
  49. pmc Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy
    Steven Warach
    National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892 1063, USA
    Cerebrovasc Dis 21:106-11. 2006
    ..A planned MRI substudy within these trials investigated the effect of gavestinel on infarct volume...
  50. pmc Evidence-based guideline: The role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    P D Schellinger
    National Institutes of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA
    Neurology 75:177-85. 2010
    ..To assess the evidence for the use of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) in the diagnosis of patients with acute ischemic stroke...
  51. ncbi request reprint Comparison of MRI and CT for detection of acute intracerebral hemorrhage
    Chelsea S Kidwell
    UCLA Stroke Center, Los Angeles, Calif, USA
    JAMA 292:1823-30. 2004
    ..However, the accuracy of MRI relative to CT for the detection of hyperacute intracerebral hemorrhage has not been demonstrated...
  52. ncbi request reprint Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials
    Antoni Davalos
    Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain
    Stroke 33:2850-7. 2002
    ....
  53. ncbi request reprint Significance of early CT signs in acute stroke. A CT scan-diffusion MRI study
    Assia Jaillard
    Department of Clinical and Biological Neurosciences, Stroke Unit University Hospital, Grenoble, France
    Cerebrovasc Dis 13:47-56. 2002
    ..To study the pathophysiology of early CT signs...
  54. ncbi request reprint Editorial comment--Is there a perihematomal ischemic penumbra? More questions and an overlooked clue
    Steven Warach
    Stroke 34:1680. 2003
  55. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  56. pmc Reperfusion half-life: a novel pharmacodynamic measure of thrombolytic activity
    Jose G Merino
    Stroke 39:2148-50. 2008
    ..We hypothesized that the probability of reperfusion can be modeled by an exponential decay (ie, half-life) function and that this reperfusion half-life is decreased by thrombolytic treatment...
  57. ncbi request reprint The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase
    Werner Hacke
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Stroke 36:66-73. 2005
    ....
  58. ncbi request reprint Therapeutic time window of thrombolytic therapy following stroke
    Peter D Schellinger
    Neurologische Universitatsklinik, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Curr Atheroscler Rep 6:288-94. 2004
    ....
  59. ncbi request reprint Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset
    Anthony J Furlan
    Department of Neurology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Stroke 37:1227-31. 2006
    ..This study evaluated safety and efficacy of intravenous (IV) desmoteplase in patients with perfusion/diffusion mismatch on MRI 3 to 9 hours after onset of acute ischemic stroke...
  60. ncbi request reprint Validation of an acute ischemic stroke model: does diffusion-weighted imaging lesion volume offer a clinically significant improvement in prediction of outcome?
    Karen C Johnston
    Department of Neurology, University of Virginia, Charlottesville, VA 22908 0394, USA
    Stroke 38:1820-5. 2007
    ..The purpose of this study was to combine acute clinical data and DWI lesion volume for ischemic stroke patients to determine whether DWI improves the prediction of clinical outcome...
  61. ncbi request reprint CT-NIHSS mismatch does not correlate with MRI diffusion-perfusion mismatch
    Steven R Messe
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 38:2079-84. 2007
    ..However, MRI has limited availability in many hospitals. We investigated whether mismatch between the Alberta Stroke Program Early CT Score (ASPECTS) and the NIH Stroke Scale (NIHSS) correlates with MRI diffusion-perfusion mismatch...
  62. pmc Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison
    Julio A Chalela
    Medical University of South Carolina, Charleston, SC, USA
    Lancet 369:293-8. 2007
    ..We aimed to prospectively compare CT and MRI for emergency diagnosis of acute stroke...
  63. doi request reprint Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke
    Chelsea S Kidwell
    Department of Neurology, Georgetown University, Washington, DC 20010, USA
    Cerebrovasc Dis 25:338-43. 2008
    ..Early barrier opening caused by focal cerebral ischemia in human stroke can be assessed by the presence of gadolinium enhancement of cerebrospinal fluid, termed 'Hyperintense Acute Injury Marker' (HARM)...
  64. ncbi request reprint Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke
    Randall T Higashida
    University of California, San Francisco Medical Center, Department of Radiology, 505 Parnassus Ave, Rm L 352, San Francisco, CA 94143 0628, USA
    Stroke 34:e109-37. 2003
    ....
  65. ncbi request reprint Patterns of perfusion-weighted imaging in patients with carotid artery occlusive disease
    Claudia J Chaves
    Department of Neurology, Lahey Clinic, Burlington, Mass 01805, USA
    Arch Neurol 60:237-42. 2003
    ..The importance of hemodynamic factors in the pathophysiology of stroke and transient ischemic attacks in patients with internal carotid artery (ICA) stenosis or occlusion remains controversial...
  66. ncbi request reprint Imaging
    Jean Claude Baron
    Department of Neurology, Cambridge University, Cambridge, UK
    Stroke 36:196-9. 2005
  67. ncbi request reprint Telephone assessment of stroke outcome is reliable
    Jose G Merino
    Stroke 36:232-3. 2005
  68. ncbi request reprint Thrombolysis in stroke beyond three hours: Targeting patients with diffusion and perfusion MRI
    Steven Warach
    Ann Neurol 51:11-3. 2002
  69. ncbi request reprint Advances in imaging 2005
    Steven Warach
    Western General Hospital, Edinburgh, UK
    Stroke 37:297-8. 2006
  70. ncbi request reprint The redefinition of TIA: the uses and limitations of DWI in acute ischemic cerebrovascular syndromes
    Steven Warach
    Neurology 62:359-60. 2004
  71. ncbi request reprint Acute ischemic cerebrovascular syndrome: diagnostic criteria
    Chelsea S Kidwell
    University of California at Los Angeles Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, USA
    Stroke 34:2995-8. 2003
    ..Diagnostic certainty of the ischemic pathology based on supportive or refuting laboratory or radiological evidence has been of secondary importance...
  72. ncbi request reprint The Virtual International Stroke Trials Archive
    Myzoon Ali
    University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, UK
    Stroke 38:1905-10. 2007
    ..The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses...
  73. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...