Ena Wang

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint A global approach to tumor immunology
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Cell Mol Immunol 1:256-65. 2004
  2. pmc Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    Marianna Sabatino
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, MD, USA
    J Clin Oncol 27:2645-52. 2009
  3. ncbi request reprint Quiescent phenotype of tumor-specific CD8+ T cells following immunization
    Vladia Monsurro
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:1970-8. 2004
  4. ncbi request reprint Overview of melanoma vaccines and promising approaches
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bldg 10, R 1C711, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Oncol Rep 6:414-20. 2004
  5. pmc Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies
    Ping Jin
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 8:4. 2010
  6. ncbi request reprint A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, Bethesda, MD 20892 1502, USA
    Cells Tissues Organs 177:124-31. 2004
  7. pmc Quality controls in cellular immunotherapies: rapid assessment of clinical grade dendritic cells by gene expression profiling
    Luciano Castiello
    Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 21:476-84. 2013
  8. pmc Antitumor vaccines, immunotherapy and the immunological constant of rejection
    Ena Wang
    National Institutes of Health, Department of Transfusion Medicine, Building 10, Room 1C711, Clinical Center, Bethesda, MD 20892, USA
    IDrugs 12:297-301. 2009
  9. pmc GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells
    Silvia Selleri
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 6:17. 2008
  10. pmc Gene expression profiling of cutaneous wound healing
    Kavita Deonarine
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 5:11. 2007

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi request reprint A global approach to tumor immunology
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Cell Mol Immunol 1:256-65. 2004
    ..In this review we will explore this hypothesis by reporting and summarizing most of our recent work in the frame of available literature on the subject...
  2. pmc Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    Marianna Sabatino
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, NIH, Bethesda, MD, USA
    J Clin Oncol 27:2645-52. 2009
    ..High-dose interleukin-2 (IL-2) induces durable therapeutic responses in a small subset of patients with metastatic melanoma and renal cell carcinoma, but simple pretreatment predictors of response have not been identified...
  3. ncbi request reprint Quiescent phenotype of tumor-specific CD8+ T cells following immunization
    Vladia Monsurro
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 104:1970-8. 2004
    ..In addition, the activation of TA-specific T cells by in vitro antigen recall and IL-2 suggests that a complete effector phenotype might be reinstated in vivo to fulfill the potential of anticancer vaccine protocols...
  4. ncbi request reprint Overview of melanoma vaccines and promising approaches
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bldg 10, R 1C711, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Oncol Rep 6:414-20. 2004
    ....
  5. pmc Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies
    Ping Jin
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 8:4. 2010
    ....
  6. ncbi request reprint A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, Bethesda, MD 20892 1502, USA
    Cells Tissues Organs 177:124-31. 2004
    ....
  7. pmc Quality controls in cellular immunotherapies: rapid assessment of clinical grade dendritic cells by gene expression profiling
    Luciano Castiello
    Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Ther 21:476-84. 2013
    ..In conclusion, using high-throughput technology we developed a method for the characterization of cellular therapies and the discovery of novel candidate quality assurance markers...
  8. pmc Antitumor vaccines, immunotherapy and the immunological constant of rejection
    Ena Wang
    National Institutes of Health, Department of Transfusion Medicine, Building 10, Room 1C711, Clinical Center, Bethesda, MD 20892, USA
    IDrugs 12:297-301. 2009
    ....
  9. pmc GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells
    Silvia Selleri
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 6:17. 2008
    ..Whether this secretion affects in an autocrine loop the CTLs themselves is unknown...
  10. pmc Gene expression profiling of cutaneous wound healing
    Kavita Deonarine
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 5:11. 2007
    ..Genome wide transcriptional analysis tools promise to further define the global picture of this complex progression of events...
  11. pmc Plerixafor (AMD3100) and granulocyte colony-stimulating factor (G-CSF) mobilize different CD34+ cell populations based on global gene and microRNA expression signatures
    Robert E Donahue
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 114:2530-41. 2009
    ..Plerixafor-mobilized CD34(+) cells include more B-, T-, and mast cell precursors, whereas G-CSF-mobilized cells have more neutrophil and mononuclear phagocyte precursors...
  12. ncbi request reprint Common cancer biomarkers
    Christopher F Basil
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, National Cancer Institute, NIH, Bethesda, Maryland 20892 1184, USA
    Cancer Res 66:2953-61. 2006
    ....
  13. pmc Molecular signatures associated with HCV-induced hepatocellular carcinoma and liver metastasis
    Valeria De Giorgi
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e56153. 2013
    ..Also characteristic gene signatures were identified of HCV-HCC progression for early HCC diagnosis...
  14. pmc IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors
    Sid P Kerkar
    Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1502, USA
    J Clin Invest 121:4746-57. 2011
    ....
  15. pmc The stable traits of melanoma genetics: an alternate approach to target discovery
    Tara L Spivey
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 13:156. 2012
    ..We hypothesized that genes steadily expressed by 15 melanoma cell lines (CMs) and their parental tissues (TMs) should be critical for oncogenesis and their expression most frequently influenced by their respective copy number...
  16. ncbi request reprint Mechanism of immune response during immunotherapy
    Monica C Panelli
    Immunogenetics Section of the Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    Yonsei Med J 45:15-7. 2004
    ....
  17. pmc Polarized monocyte response to cytokine stimulation
    Dirk Nagorsen
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1502, USA
    Genome Biol 6:R15. 2005
    ..Therefore, we tested whether polarized responses of MPs to pathogens are related to the influence of selected cytokines or represent a mandatory molecular switch through which most cytokines operate...
  18. pmc Evaluation of normalization methods for two-channel microRNA microarrays
    Yingdong Zhao
    Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 8:69. 2010
    ..Findings from previous studies have sometimes been inconclusive or contradictory. Further studies to determine optimal normalization methods for miR microarrays are needed...
  19. ncbi request reprint Active-specific immunization against melanoma: is the problem at the receiving end?
    Vladia Monsurro
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, Bldg 10, R 1C711 National Institutes of Health, Bethesda, MD, USA
    Semin Cancer Biol 13:473-80. 2003
    ....
  20. pmc Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology
    Zoltan Pos
    1 Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA 2 Hungarian Academy of Sciences Semmelweis University Lendület Experimental and Translational Immunomics Research Group, Budapest, Hungary 3 Department of Genetics, Cell, and Immunobiology, Semmelweis University, Budapest, Hungary
    J Invest Dermatol 134:1389-96. 2014
    ....
  21. pmc Selection and validation of endogenous reference genes using a high throughput approach
    Ping Jin
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH Bethesda, MD 20892, USA
    BMC Genomics 5:55. 2004
    ..Whether this assumption is correct it is, however, still matter of debate. In this study, we searched for stably expressed genes in 384 cDNA array hybridization experiments encompassing different tissues and cell lines...
  22. pmc IRF5 gene polymorphisms in melanoma
    Lorenzo Uccellini
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 10:170. 2012
    ....
  23. pmc MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells
    Jiaqiang Ren
    Department of Transfusion Medicine, Clinical Center, National Institute of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    J Transl Med 7:20. 2009
    ..Non-coding microRNAs (miRNA) which regulate mRNA cleavage and inhibit encoded protein translation exhibit temporal or tissue-specific expression patterns and they play an important role in development timing...
  24. pmc Genomic scale analysis of racial impact on response to IFN-alpha
    Zoltan Pos
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, and Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:803-8. 2010
    ....
  25. doi request reprint Conservation of genetic alterations in recurrent melanoma supports the melanoma stem cell hypothesis
    Marianna Sabatino
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Warren G Magnuson Clinical Center, Biometrics Research Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892 1184, USA
    Cancer Res 68:122-31. 2008
    ..Our study provides important insights about the dynamics of cancer progression and supports the development of targeted anticancer therapies aimed against stable genetic factors that are maintained throughout the end stage of disease...
  26. pmc A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon
    Ena Wang
    Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e40805. 2012
    ..The current study attempts to identify genetic markers likely to be associated with benefit from IFN-a2b treatment and predictive for survival...
  27. pmc HCV RNA levels in a multiethnic cohort of injection drug users: human genetic, viral and demographic associations
    Lorenzo Uccellini
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 56:86-94. 2012
    ..In an adjusted analysis, age, gender, racial ancestry, HIV-1 infection, HCV genotype, and IL28B rs12979860 genotype were all independently associated with HCV RNA...
  28. pmc 15 kDa Granulysin versus GM-CSF for monocytes differentiation: analogies and differences at the transcriptome level
    Luciano Castiello
    Cell Processing Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:41. 2011
    ..Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a growth factor widely used in immunotherapy both for in vivo and ex vivo applications, especially for its proliferative effects...
  29. ncbi request reprint Gene expression signatures of interleukin-2 in vivo and in vitro and their relation to anticancer therapy
    Ping Jin
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Rev Immunol 27:437-48. 2007
    ..This information will not only lead to a better utilization of this biological agent in clinical practice but it may also provide important information about how immune-mediated tissue rejection occurs...
  30. ncbi request reprint Analysis of vaccine-induced T cells in humans with cancer
    Stefanie L Slezak
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 684:178-88. 2010
    ..Recently, the usefulness and success of active-specific immunization (ASI) against TAAs as a means ofeliciting a tumor-specific immune response leading to tumor regression and clearance has been a topic of debate and discussion...
  31. pmc Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets
    Ping Jin
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 4:26. 2006
    ..This observation may provide a roadmap for the interpretation of the discrepant biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities...
  32. doi request reprint The immunologic constant of rejection
    Ena Wang
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 29:256-62. 2008
    ..Understanding this final effector pathway may suggest novel strategies for the induction or inhibition of tissue-specific destruction with therapeutic intent in cancer and other immune pathologies...
  33. pmc Associations between HLA class I alleles and the prevalence of nasopharyngeal carcinoma (NPC) among Tunisians
    Xin Li
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 5:22. 2007
    ..In addition, we identified a putative haplotype rare in Tunisian patients with NPC that may serve as a genetic marker for further susceptibility studies...
  34. ncbi request reprint Vaccination with T cell-defined antigens
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 4:697-707. 2004
    ....
  35. pmc Differentiation of two types of mobilized peripheral blood stem cells by microRNA and cDNA expression analysis
    Ping Jin
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 6:39. 2008
    ..The HSCs were compared to peripheral blood leukocytes (PBLs) from 7 subjects...
  36. pmc Gene-expression profiling in vaccine therapy and immunotherapy for cancer
    Davide Bedognetti
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, and Trans NIH Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Rev Vaccines 9:555-65. 2010
    ..We believe that the description of how the mechanism of immune-mediated tissue destruction occurs would contribute to our understanding of why it happens, thereby allowing us to develop more effective immune therapeutic strategies...
  37. ncbi request reprint The requirements for CTL-mediated rejection of cancer in humans: NKG2D and its role in the immune responsiveness of melanoma
    Ena Wang
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD 20892 1502, USA
    Clin Cancer Res 13:7228-31. 2007
  38. pmc Molecular immune signatures of HIV-1 vaccines in human PBMCs
    Alessandro Monaco
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health Bethesda, MD, USA
    FEBS Lett 583:3004-8. 2009
    ..This ex vivo screening strategy represents an efficient tool for guiding modifications/optimizations of vaccination strategies and understanding failures in individuals enrolled in clinical trials...
  39. ncbi request reprint Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions
    Sara Deola
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunol 180:1362-72. 2008
    ..This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo...
  40. pmc The immune-related role of BRAF in melanoma
    Sara Tomei
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, MD 20892, USA Department of Genetic Medicine, Weill Cornell Medical College in Qatar, PO Box 24144, Doha, Qatar Sidra Medical and Research Center, P O Box 26999, Doha, Qatar Electronic address
    Mol Oncol 9:93-104. 2015
    ..BRAF and NRAS mutations are commonly acquired during melanoma progression. Here we explored the role of BRAF and NRAS mutations in influencing the immune phenotype based on a classification previously identified by our group...
  41. ncbi request reprint Gene expression profiling of anticancer immune responses
    Ena Wang
    National Institutes of Health, Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Mol Ther 6:288-95. 2004
    ..As reviews on technological aspects of the genomic analysis of cancer are already available, this review will provide a speculative discussion about their potential usefulness...
  42. doi request reprint Common pathways to tumor rejection
    Ena Wang
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, MD, USA
    Ann N Y Acad Sci 1284:75-9. 2013
    ..Here, we summarize progress in the understanding of its genesis, outline the difficulties, and propose a strategy for understanding the causes of tumor rejection...
  43. pmc Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
    Maria Libera Ascierto
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and trans NIH Center of Human Immunology, National Institutes of Health, Bethesda, MD, USA
    BMC Cancer 11:451. 2011
    ....
  44. pmc Functional heterogeneity of vaccine-induced CD8(+) T cells
    Vladia Monsurro
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:5933-42. 2002
    ..In addition, CD45RA/CD27 expression may be more informative about the status of activation of circulating T cells than their status of differentiation...
  45. ncbi request reprint Understanding the response to immunotherapy in humans
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1184, USA
    Springer Semin Immunopathol 27:105-17. 2005
    ....
  46. pmc Stem cells in melanoma development
    Marianna Sabatino
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, 9000 Rockville Pike, Building 10 Room 1C711, Bethesda, MD 20892, United States
    Cancer Lett 279:119-25. 2009
    ..In this review, we provide an overview of findings and advances in CSCs research that are relevant to the initiation, natural history, and the response to treatment of malignant melanoma...
  47. ncbi request reprint The pathway to biomarker discovery: carbonic anhydrase IX and the prediction of immune responsiveness
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
    Clin Cancer Res 11:3601-3. 2005
  48. pmc Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a
    Stefanie Slezak
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 7:39. 2009
    ..disorders (MPDs) we compared molecular changes in neutrophils from patients with polycythemia vera (PV) and essential thrombocythosis (ET), to neutrophils stimulated by G-CSF administration and to normal unstimulated neutrophils..
  49. ncbi request reprint Ontogeny and oncogenesis balance the transcriptional profile of renal cell cancer
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Cancer Res 64:7279-87. 2004
    ..Finally, a small subset of genes is associated with lineage-specific oncogenesis, and these may provide information regarding the biological behavior of RCCs and facilitate diagnostic classification of RCCs...
  50. pmc "Sequencing-grade" screening for BRCA1 variants by oligo-arrays
    Alessandro Monaco
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Transl Med 6:64. 2008
    ..This system is particularly useful for the screening of long genomic regions with relatively infrequent but clinically relevant variants, while drastically cutting time and costs in comparison to high-throughput sequencing...
  51. pmc Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center National Institutes of Health, Bethesda, MD 20892, USA
    Genome Biol 8:R8. 2007
    ..We hypothesized that the characterization of the early transcriptional events induced by imiquimod may provide insights about immunological events preceding acute tissue and/or tumor rejection...
  52. pmc Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis
    Tara L Spivey
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 9:174. 2011
    ..The role of NK cell, B cell and T-regulatory cell signatures are also addressed...
  53. pmc Delayed polarization of mononuclear phagocyte transcriptional program by type I interferon isoforms
    David F Stroncek
    Department of Transfusion Medicine, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 3:24. 2005
    ..This study utilized global transcript analysis to characterize the effects of the entire type I IFN family in comparison to a broad panel of other cytokines on MP previously exposed to Lipopolysaccharide (LPS) stimulation in vitro...
  54. pmc Effects of Systemically Administered Hydrocortisone on the Human Immunome
    Matthew J Olnes
    Trans NIH Center for Human Immunology, Autoimmunity, and Inflammation CHI, National Institutes of Health NIH, Bethesda, MD, 20892, USA
    Sci Rep 6:23002. 2016
    ..Our study is the first to systematically characterize the effects of corticosteroids on the human immunome, and we demonstrate that HC exerts differential effects on B and T lymphocytes and natural killer cells in humans. ..
  55. pmc Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration
    Monica C Panelli
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Biol 3:RESEARCH0035. 2002
    ..In this study, we compared early changes in transcriptional profiles of circulating mononuclear cells with those occurring within the microenvironment of melanoma metastases following systemic IL-2 administration...
  56. ncbi request reprint Tumor microenvironment: what have we learned studying the immune response in this puzzling battlefield?
    Simone Mocellin
    Immunnogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Tumori 88:437-44. 2002
    ..As a model, we will discuss the observed immune response to tumor antigen -specific immunization and its relationship with the systemic administration of IL-2...
  57. ncbi request reprint Gene profiling of immune responses against tumors
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Opin Immunol 17:423-7. 2005
    ..Future investigations should reframe scientific thinking when applied to humans, utilizing descriptive tools to generate novel hypotheses relevant to human disease...
  58. pmc Global transcriptional analysis for biomarker discovery and validation in cellular therapies
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Diagn Ther 13:181-93. 2009
    ..Potency testing, the complexities associated with potency testing of cellular therapies, and the potential role of gene and miRNA expression microarrays in potency testing of cellular therapies are discussed...
  59. ncbi request reprint Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, NIH, Bethesda, Maryland 20892, USA
    Clin Cancer Res 11:113-22. 2005
    ..To study the role of the peritoneum in fostering tumor invasion, we analyzed differences between the transcriptional repertoires of peritoneal tissue lacking detectable cancer in patients with EOC versus benign gynecologic disease...
  60. pmc MicroRNA expression differentiates histology and predicts survival of lung cancer
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7236, USA
    Clin Cancer Res 16:430-41. 2010
    ..The molecular drivers that determine histology in lung cancer are largely unknown. We investigated whether microRNA (miR) expression profiles can differentiate histologic subtypes and predict survival for non-small cell lung cancer...
  61. ncbi request reprint Cytokine polymorphism and its possible impact on cancer
    Ping Jin
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Immunol Res 30:181-90. 2004
    ..These sequence variations can still affect gene expression and function. In this review will we summarize the current knowledge about the role of cytokine polymorphism in disease and more specifically in cancer...
  62. ncbi request reprint Transcriptional analysis of tumor-specific T-cell responses in cancer patients
    Dirk Nagorsen
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1502, USA
    Crit Rev Immunol 22:449-62. 2002
    ..Recent work discussed in this review summarizes the complementarity of transcriptional analysis as an essential tool that, in addition to conventional methods, may deepen and broaden the characterization of tumor-specific T cells...
  63. pmc Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
    Ena Wang
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, Maryland 20892, USA
    BMC Med Genomics 4:38. 2011
    ..Animal studies documented a decrease in global toxicity and an increase in therapeutic effectiveness of chemotherapy when combined with PHY906...
  64. ncbi request reprint Spontaneous and treatment-induced cancer rejection in humans
    Ena Wang
    National Institutes of Health, Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, Bethesda, Maryland, 20892, USA
    Expert Opin Biol Ther 8:337-49. 2008
    ..On the other hand, it is also well documented that on rare occasions tumors can be dramatically destroyed by the host's immune response...
  65. ncbi request reprint Tumor microenvironment and the immune response
    Silvia Selleri
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Surg Oncol Clin N Am 16:737-53, vii-viii. 2007
    ..We emphasize the critical role that future clinical investigations, led by surgical oncologists, may have for the assessment of the validity of the disparate hypotheses so far formulated at the bench side...
  66. pmc BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
    Rahul Roychoudhuri
    Center for Cancer Research, National Cancer Institute, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nature 498:506-10. 2013
    ..These findings identify BACH2 as a key regulator of CD4(+) T-cell differentiation that prevents inflammatory disease by controlling the balance between tolerance and immunity. ..
  67. pmc A signature of immune function genes associated with recurrence-free survival in breast cancer patients
    Maria Libera Ascierto
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine and Center for Human Immunology, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res Treat 131:871-80. 2012
    ..These data suggest that neoadjuvant immunotherapy in patients with high risk of relapse may reduce tumor recurrence by inducing the immune function genes...
  68. ncbi request reprint Tumors as elusive targets of T-cell-based active immunotherapy
    Francesco M Marincola
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Trends Immunol 24:335-42. 2003
    ..Furthermore, we will discuss the information still required in order to understand the mechanism(s) governing tumor rejection by the immune system in response to TA-specific immunization...
  69. pmc Evaluation of gene expression profiles of immature dendritic cells prepared from peripheral blood mononuclear cells
    Jeong Won Shin
    Department of Transfusion Medicine, NIH Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1184, USA
    Transfusion 48:647-57. 2008
    ....
  70. pmc Let-7 microRNAs are developmentally regulated in circulating human erythroid cells
    Seung Jae Noh
    Molecular Medicine Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Transl Med 7:98. 2009
    ....
  71. pmc New take on comparative immunology: relevance to immunotherapy
    Ena Wang
    Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, Clinical Center and Center for Human Immunology NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunotherapy 1:355-66. 2009
    ..Commonalities among diseases can, in turn, be segregated from disease-specific patterns uncovering essential mechanisms that may represent universal targets for immunotherapy...
  72. pmc Potency analysis of cellular therapies: the emerging role of molecular assays
    David F Stroncek
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 5:24. 2007
    ..Potency testing, the complexities associated with potency testing of cellular therapies, and the potential role of gene and microRNA expression microarrays in potency testing of cellular therapies is discussed...
  73. pmc Quality assessment of cellular therapies: the emerging role of molecular assays
    David F Stroncek
    Cellular Therapy and Immunogenetics Sections, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD, USA
    Korean J Hematol 45:14-22. 2010
    ..Several examples of the use of gene expression analysis for assessing cellular therapies are presented...
  74. ncbi request reprint Redirecting migration of T cells to chemokine secreted from tumors by genetic modification with CXCR2
    Michael H Kershaw
    Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Gene Ther 13:1971-80. 2002
    ..This study demonstrates the feasibility of redirecting the migration properties of T cells toward chemokines secreted by tumors...
  75. ncbi request reprint Characterization of CD8(-) HLA class I/epitope tetrameric complexes binding T cells
    Dirk Nagorsen
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland 20982 1502, USA
    J Immunother 25:379-84. 2002
    ..These findings, suggest that the nonspecific binding of tHLA to non-TCR-expressing T cells requires a careful interpretation of results and further steps in preparation of sample for tHLA-based sorting of epitope specific T cells...
  76. pmc Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:3581-6. 2002
    ..001). Analysis of their annotations denoted that approximately half of them were related to T-cell regulation, suggesting that immune responsiveness might be predetermined by a tumor microenvironment conducive to immune recognition...
  77. pmc An immunologic portrait of cancer
    Maria Libera Ascierto
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 9:146. 2011
    ..Here we reflect on commonalities and discrepancies among studies and on the genetic or somatic conditions that may cause this schism in cancer behavior...
  78. ncbi request reprint Infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissue
    Concepcion Conejero-Goldberg
    Stanley Brain Research Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Biotechniques 39:741-51. 2005
    ..This method may be used to provide evidence of viral infection in postmortem tissue from psychiatric patients as well as a wide range of other diagnostic categories...
  79. pmc Frequency of MART-1/MelanA and gp100/PMel17-specific T cells in tumor metastases and cultured tumor-infiltrating lymphocytes
    Simone Seiter
    Department of Transfusion Medicine, Center for Cancer Research, National Cancer Institute, Building 10, Room 2B42, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Immunother 25:252-63. 2002
    ..These data provide direct enumeration of MART-1/MelanA and gp100/pMel17 reactivity ex vivo and in vitro in the context of HLA-A*0201...
  80. pmc Strengths and limitations of laboratory procedures for microRNA detection
    Jill Koshiol
    Infections and Immunepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7070, Rockville, MD 20852 7248, USA
    Cancer Epidemiol Biomarkers Prev 19:907-11. 2010
    ..MicroRNAs (miR) are endogenous, noncoding RNAs involved in many cellular processes and have been associated with the development and progression of cancer. There are many different ways to evaluate miRs...
  81. pmc Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy
    Andrea Worschech
    Genelux Corporation, San Diego Science Center, San Diego, California, USA
    BMC Genomics 10:301. 2009
    ..GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression...
  82. ncbi request reprint 18th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer. 30 October-2 November 2003, Bethesda, Maryland, USA
    Francesco M Marincola
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, NIH, Bldg 10, R 1C711, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 4:107-14. 2004
    ..The President of the Society is Dr Michael B Atkins from Beth Israel Deaconess Medical Center, Boston, MA and the Vice President is Ulrich Keilholz from UKBF, Free University Berlin, Germany...
  83. ncbi request reprint The role of quantitative PCR for the immune monitoring of cancer patients
    Monica C Panelli
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Expert Opin Biol Ther 2:557-64. 2002
    ....
  84. pmc Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation
    Jiaqiang Ren
    Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 5:1. 2007
    ..We will review islet transplantation, as well as the mechanisms underlying insulin transcription, translation and glucose stimulated insulin release...
  85. ncbi request reprint Clonal persistence and evolution during a decade of recurrent melanoma
    Ena Wang
    Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Invest Dermatol 126:1372-7. 2006
    ..Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies...
  86. pmc Deciphering the molecular machinery of stem cells: a look at the neoblast gene expression profile
    Leonardo Rossi
    Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Universita di Pisa, Pisa, Italy
    Genome Biol 8:R62. 2007
    ..Planarian regeneration depends on adult pluripotent stem cells--the neoblasts. These cells can be selectively destroyed using X-rays, enabling comparison of organisms lacking stem cells with wild-type worms...
  87. ncbi request reprint Complementary techniques: RNA amplification for gene profiling analysis
    Ena Wang
    Adv Exp Med Biol 593:39-53. 2007
    ..These methods are suitable for high-throughput transcriptional profiling studies...
  88. pmc Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma
    Howard L Kaufman
    Department of Surgery, Columbia University, New York, NY 10032, USA
    J Clin Invest 115:1903-12. 2005
    ..The local delivery of vaccinia virus expressing B7.1 was well tolerated and represents an innovative strategy for altering the local tumor microenvironment in patients with melanoma...
  89. pmc Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China
    Weiyi Fang
    Cancer Research Institute of Southern Medical University, Key Lab for Transcriptomics and Proteomics of Human Fatal Diseases Supported by Ministry of Education and Guangdong Province, 510515, PR China
    J Transl Med 6:32. 2008
    ....
  90. pmc Gene expression profile of peripheral blood mononuclear cells in response to HIV-VLPs stimulation
    Luigi Buonaguro
    Lab, Viral Oncogenesis and Immunotherapies and AIDS Reference Center, Department of Experimental Oncology, Istituto Nazionale Tumori Fond, G, Pascale, 80131 Napoli, Italy
    BMC Bioinformatics 9:S5. 2008
    ..Baculovirus-expressed HIV-1 Pr55gag Virus-Like Particles (HIV-VLPs) induce maturation and activation of monocyte-derived dendritic cells (MDDCs) with a production of Th1- and Th2-specific cytokines...
  91. pmc Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors
    Andrea Worschech
    Department of Microbiology and Immunology, Virginia Commonwealth University School of Medicine, Massey Cancer Center, Richmond, VA 23298, USA
    Cancer Res 68:2436-46. 2008
    ..These data provide a road map for the identification of novel biomarkers of immune responsiveness in clinical trials...
  92. ncbi request reprint Comparative analysis of peritoneum and tumor eicosanoids and pathways in advanced ovarian cancer
    Ralph S Freedman
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230, USA
    Clin Cancer Res 13:5736-44. 2007
    ..To describe the eicosanoid profile and differentially expressed eicosanoid and arachidonic acid pathway genes in tissues from patients with advanced epithelial ovarian cancer (EOC)...
  93. ncbi request reprint Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals
    Maurizio Provenzano
    Immune Oncology Section, Department of Surgery, University Hospital ZLF, Hebelstrasse 20, 4031 Basel, Switzerland
    Cancer Immunol Immunother 56:1047-63. 2007
    ..We believe that the usefulness of these epitopes occurring naturally in non-cancer bearing patients as reagents for the immunization of patients with early or advanced stage NPC deserves further evaluation...
  94. ncbi request reprint Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health
    Michael T Lotze
    Translational Research, University of Pittsburgh Molecular Medicine Institute, Pittsburgh, Pennsylvania, USA
    J Immunother 28:79-119. 2005
    ..Concrete recommendations for current application and enabling further development in cancer biometrics are summarized. This will allow a more informed, rapid, and accurate assessment of novel cancer therapies...
  95. ncbi request reprint DNA array-based gene profiling in tumor immunology
    Simone Mocellin
    Department of Oncological and Surgical Sciences, University of Padova, Padua, Italy
    Clin Cancer Res 10:4597-606. 2004
    ..In the present work, we summarize the main technical features and critical issues characterizing this powerful laboratory tool and review its applications in the fascinating field of cancer immunogenomics...
  96. pmc Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells
    I Caroline Le Poole
    Department of Pathology, Skin Oncology Research Program, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Bldg 112, Rm 303, 2160 S 1st Ave, Maywood, IL 60153, USA
    Am J Pathol 160:521-8. 2002
    ..Reduced MART-1 expression was frequently observed in adjacent tumor cells. Consequently, IFN-gamma may enhance inflammatory responses yet hamper effective recognition of melanoma cells...
  97. ncbi request reprint Inflammatory protein profile during systemic high dose interleukin-2 administration
    Leonardo Rossi
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Proteomics 6:709-20. 2006
    ..Overall distinct yet complementary information was obtained using different platforms, which may better illustrate complex phenomena such as the systemic response to biological response modifiers...
  98. pmc Bottom up: a modular view of immunology
    Ena Wang
    Department of Transfusion Medicine, Infectious Disease and Immunogenetics Section, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Immunity 29:9-11. 2008
    ..In this issue of Immunity, Chaussabel et al. (2008) apply an inductive approach to pathway discovery identifying modular units that govern human immune biology...
  99. ncbi request reprint The dual role of IL-10
    Simone Mocellin
    Surgery Branch, Department of Oncological and Surgical Sciences, University of Padova, I 35128 Padua, Italy
    Trends Immunol 24:36-43. 2003
    ..Additional proinflammatory stimuli might subsequently lead to maturation of "loaded" APCs that could migrate to draining lymph nodes or recruit and activate adaptive immune effectors locally...
  100. ncbi request reprint Migration deficit in monocyte-macrophages in human ovarian cancer
    Ralph S Freedman
    Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230, USA
    Cancer Immunol Immunother 57:635-45. 2008
    ..To examine the migration responses of monocyte/macrophages (MO/MA) expressing complementary receptors to chemokines produced in the tumor environment of epithelial ovarian cancer (EOC)...
  101. ncbi request reprint Autologous tumor rejection in humans: trimming the myths
    Ena Wang
    Immunogenetics Section, The Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Immunol Invest 35:437-58. 2006
    ..The purpose is to simplify the basis of immune rejection to its bare bones critically dissecting the significance of those components proposed by experimental models as harbingers of this final outcome...